{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:15:44Z","timestamp":1772223344623,"version":"3.50.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,10,1]],"date-time":"2012-10-01T00:00:00Z","timestamp":1349049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1016\/j.yrtph.2012.06.003","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T10:43:31Z","timestamp":1340016211000},"page":"9-16","source":"Crossref","is-referenced-by-count":18,"title":["Optimised testing strategies for skin sensitization \u2013 The LLNA and beyond"],"prefix":"10.1016","volume":"64","author":[{"given":"David","family":"Basketter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Crozier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Hubesch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Manou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Mehling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Scheel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2012.06.003_b0005","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00204-011-0693-2","article-title":"Alternative (non-animal) methods for cosmetics testing: current status and future prospects\u20142010","volume":"85","author":"Adler","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0010","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.tiv.2010.07.005","article-title":"Identifying and characterizing chemical skin sensitizers without animal testing: Colipa\u2019s research and method development program","volume":"24","author":"Aeby","year":"2010","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.yrtph.2012.06.003_b0015","doi-asserted-by":"crossref","unstructured":"Andersen, K.E., Maibach, H I., 1985. Guinea pig sensitization assays: An overview. In: Contact Allergy Predictive Tests in Guinea Pigs, Current Problems in Dermatology. Eds: K.E. Andersen and H.I. Maibach, Vol. 14, pp 59\u2013106. New York: Karger.","DOI":"10.1159\/000411617"},{"key":"10.1016\/j.yrtph.2012.06.003_b0020","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.yrtph.2011.04.006","article-title":"The regulatory use of the local lymph node assay for the notification of new chemicals in Europe","volume":"60","author":"Angers-Loustau","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yrtph.2007.10.008","article-title":"Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients","volume":"52","author":"Api","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0030","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.yrtph.2011.05.007","article-title":"Evaluating the sensitization potential of surfactants: integrating data from the local lymph node assay, guinea pig maximization test, and in vitro methods in a weight-of-evidence approach","volume":"60","author":"Ball","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0035","first-page":"366","article-title":"Statement on the validity of the local lymph node assay for skin sensitization testing. ECVAM Joint Research Centre, European Commission","volume":"28","author":"Balls","year":"2000","journal-title":"Ispra. Altern. Lab. Animals"},{"key":"10.1016\/j.yrtph.2012.06.003_b0065","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2133.2008.08625.x","article-title":"Skin sensitisation: strategies for risk assessment and risk management","volume":"159","author":"Basketter","year":"2008","journal-title":"Brit. J. Dermatol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0040","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/0278-6915(95)00072-0","article-title":"The validation of skin sensitisation assays","volume":"33","author":"Basketter","year":"1995","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0536.2007.01009.x","article-title":"Information derived from sensitisation test methods: test sensitivity, false positives and false negatives","volume":"56","author":"Basketter","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.06.003_b0080","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0278-6915(97)00158-0","article-title":"Strategies for identifying false positive responses in predictive skin sensitization tests","volume":"36","author":"Basketter","year":"1998","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0100","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1600-0536.2006.00930.x","article-title":"Identification and classification of skin sensitisers: identifying false positives and false negatives","volume":"55","author":"Basketter","year":"2006","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.06.003_b0050","first-page":"243","article-title":"An evaluation of performance standards and non-radioactive endpoints for the local lymph node assay","volume":"36","author":"Basketter","year":"2008","journal-title":"ATLA"},{"key":"10.1016\/j.yrtph.2012.06.003_b0055","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000135635","article-title":"Skin irritation and sensitization: mechanisms and new approaches for risk assessment. Part II: skin sensitization","volume":"21","author":"Basketter","year":"2008","journal-title":"Skin Pharmacol. Physiol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0070","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yrtph.2009.06.005","article-title":"Application of a weight of evidence approach to analysing discordant sensitization datasets: implication for REACH","volume":"55","author":"Basketter","year":"2009","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0105","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0536.2008.01444.x","article-title":"Nothing is perfect, not even the local lymph node assay. A commentary and the implications for REACH","volume":"60","author":"Basketter","year":"2009","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.06.003_b0060","doi-asserted-by":"crossref","unstructured":"Basketter, D.A., Kolle, S.N., Schrage, A., Honarvar, N., Gamer, A.O., van Ravenzwaay, B., Landseidel, R., in press. Experience with local lymph node assay performance standards using standard radioactivity and non-radioactive cell count measurements. J. Appl. Toxicol.","DOI":"10.1002\/jat.1684"},{"key":"10.1016\/j.yrtph.2012.06.003_b0075","doi-asserted-by":"crossref","first-page":"5","DOI":"10.14573\/altex.2012.1.003","article-title":"A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing","volume":"29","author":"Basketter","year":"2012","journal-title":"ALTEX"},{"key":"10.1016\/j.yrtph.2012.06.003_b0110","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.tiv.2011.05.030","article-title":"Intralaboratory validation of four in vitro assays for the prediction of the skin sensitizing potential of chemicals","volume":"25","author":"Bauch","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.yrtph.2012.06.003_b0115","doi-asserted-by":"crossref","unstructured":"Bauch, C., Kolle, S.N., Ramirez, T., Eltze, T., Fabian, E., Mehling, A., Teubner, W., van Ravenzwaay, B., Landsiedel, R., 2012. Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials (under revision).","DOI":"10.1016\/j.yrtph.2012.05.013"},{"key":"10.1016\/j.yrtph.2012.06.003_b0120","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.yrtph.2008.05.013","article-title":"On the skin sensitisation potential of rosin and oxidised rosin","volume":"52","author":"Botham","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0125","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1001\/archderm.1965.01600080079017","article-title":"Delayed contact hypersensitivity in the guinea pig","volume":"91","author":"Buehler","year":"1965","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0315","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/026119290903700313","article-title":"Selection of chemicals for the development and evaluation of in vitro methods for skin sensitisation testing","volume":"37","author":"Casati","year":"2009","journal-title":"Altern. Lab. Animals"},{"key":"10.1016\/j.yrtph.2012.06.003_b0130","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1191\/0960327106ht640oa","article-title":"The local lymph node assay in practice: a current regulatory perspective","volume":"25","author":"Cockshott","year":"2006","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0135","unstructured":"Commission of the European Communities. Regulation (EC)., 2006. No. 1907\/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999\/45\/EC and repealing Council Regulation (EEC) No 793\/93 and Commission Regulation (EC) No 1488\/94 as well as Council Directive 76\/769\/EEC and Commission Directives 91\/155\/EEC, 93\/67\/EEC,93\/105\/EC and 2000\/21\/EC. Off J Eur Union, L 396\/1 of 30.12.2006."},{"key":"10.1016\/j.yrtph.2012.06.003_b0140","unstructured":"Commission Regulation (EU) No 286\/2011 of 10 March 2011 amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272\/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures. Off J Eur Union, L 83, 54."},{"key":"10.1016\/j.yrtph.2012.06.003_b0145","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1006\/rtph.2001.1497","article-title":"ICCVAM evaluation of the murine local lymph node assay. II. Conclusions and recommendations of an independent scientific peer review panel","volume":"34","author":"Dean","year":"2001","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0150","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.tox.2005.04.010","article-title":"An European inter-laboratory validation of alternative endpoints of the murine local lymph node assay: first round","volume":"212","author":"Ehling","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2012.06.003_b0155","unstructured":"EU, 2003. Directive 2003\/15\/EC of the European Parliament and of the Council of 27 February 2003 amending Council Directive 76\/768\/EEC on the approximation of the laws of the Member States relating to cosmetic products (\u201c7th Amendment to the European Cosmetics Directive\u201d). Official Journal of the European Union L 66, 26-35."},{"key":"10.1016\/j.yrtph.2012.06.003_b0160","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.yrtph.2008.08.018","article-title":"Local lymph node assay (LLNA): comparison of different protocols by testing skin-sensitizing epoxy resin system components","volume":"52","author":"Gamer","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0165","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.yrtph.2010.06.016","article-title":"Comparative testing for the identification of skin-sensitizing potentials of nonionic sugar lipid surfactants","volume":"58","author":"Garcia","year":"2010","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0180","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S1046-199X(00)90027-7","article-title":"Local lymph node assay: validation assessment for regulatory purposes","volume":"11","author":"Gerberick","year":"2000","journal-title":"Am. J. Contact Derm."},{"key":"10.1016\/j.yrtph.2012.06.003_b0320","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/toxsci\/kfh213","article-title":"Development of a peptide reactivity assay for screening contact allergens","volume":"81","author":"Gerberick","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2012.06.003_b0325","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/toxsci\/kfm064","article-title":"Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach","volume":"97","author":"Gerberick","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2012.06.003_b0170","first-page":"215","article-title":"Chemical reactivity measurement and the predictive identification of skin sensitisers","volume":"36","author":"Gerberick","year":"2008","journal-title":"ATLA"},{"key":"10.1016\/j.yrtph.2012.06.003_b0185","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.yrtph.2009.04.006","article-title":"Skin sensitization and possible groupings for \u2018read across\u2019 for rosin based substances","volume":"54","author":"Illing","year":"2009","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0190","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00204-009-0460-9","article-title":"Feasibility study to support a threshold of sensitization concern concept in risk assessment based on human data","volume":"83","author":"Keller","year":"2009","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0278-6915(92)90153-C","article-title":"The murine local lymph node assay: a commentary on collaborative trials and new directions","volume":"30","author":"Kimber","year":"1992","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0195","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/toxsci\/kfq346","article-title":"Chemical allergy: translating biology into hazard characterisation","volume":"120","author":"Kimber","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2012.06.003_b0205","unstructured":"Kirk, M.K., Broomhead Y, DiDonato L., DeGeorge, G.L., 2007. Use of an Enhanced Local Lymph Node Assay to Correctly Classify Irritants and False Positive Substances. <http:\/\/www.mbresearch.com\/posters\/2007\/ELLNA_SOT_2007.pdf>."},{"key":"10.1016\/j.yrtph.2012.06.003_b0210","unstructured":"Kolle, S., Basketter, D., Schrage, A., Gamer, A.O., van Ravenzwaay, B., Landseidel, R., in press. Further experience with the local lymph node assay using stand radioactive and non-radioactive cell count measurements. J. Appl. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0215","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/j.fct.2008.01.019","article-title":"Comparison of the skin sensitizing potential of unsaturated compounds and assessed by the murine local lymph node assay (LLNA) and the guinea pig maximization test (GPMT)","volume":"46","author":"Kreiling","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0220","unstructured":"Magnusson, B., Kligman, A.M., 1970. Allergic Contact Dermatitis in the Guinea Pig: Identification of Contact Allergens, 141pp. Springfield, IL, USA: Charles C. Thomas."},{"key":"10.1016\/j.yrtph.2012.06.003_b0225","doi-asserted-by":"crossref","first-page":"50","DOI":"10.14573\/altex.2011.1.050","article-title":"Skin sensitisation: the Colipa strategy for developing and evaluating non-animal test methods for risk assessment","volume":"28","author":"Maxwell","year":"2011","journal-title":"ALTEX"},{"key":"10.1016\/j.yrtph.2012.06.003_b0230","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.tox.2007.06.002","article-title":"The murine local lymph node assay: Regulatory and potency consideration under REACH","volume":"238","author":"McGarry","year":"2007","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2012.06.003_b0235","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3109\/15569527.2010.483869","article-title":"A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE\/EpRE-mediated gene expression in human skin cells","volume":"29","author":"McKim","year":"2010","journal-title":"Cut. Ocul. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0240","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jphotobiol.2004.11.014","article-title":"Evaluation of phototoxic and photoallergic potentials of 13 compounds by different in vitro and in vivo methods","volume":"79","author":"Neumann","year":"2005","journal-title":"J. Photochem. Photobiol., B"},{"key":"10.1016\/j.yrtph.2012.06.003_b0245","unstructured":"OECD, 2002. Local Lymph Node Assay. Test Guideline No 429, Organisation for Economic Cooperation and Development, Paris."},{"key":"10.1016\/j.yrtph.2012.06.003_b0255","unstructured":"OECD, 2010a. Organisation for Economic Cooperation and Development. Test Guideline 429: The Local Lymph Node Assay. Paris, France."},{"key":"10.1016\/j.yrtph.2012.06.003_b0260","unstructured":"OECD, 2010b. Organisation for Economic Cooperation and Development. Guidelines for Test of Chemicals No 442a and 442b. Paris, France."},{"key":"10.1016\/j.yrtph.2012.06.003_b0250","unstructured":"OECD, 2012. The OECD QSAR Toolbox, Version 2.2 July 18, 2011. Paris. <http:\/\/www.oecd.org\/document\/54\/0,3746,en_2649_34379_42923638_1_1_1_1,00.html>. Last accessed, 27\/01\/2012."},{"key":"10.1016\/j.yrtph.2012.06.003_b0330","doi-asserted-by":"crossref","unstructured":"Omori, T., Idehara, K., Kojima, H., Sozu, T., Arima, K., Goto, H., Hanada, T., Ikarashi, Y., Inoda, T., Kanazawa, Y., Kosaka, T., Maki, E., Morimoto, T., Shinoda, S., Shinoda, N., Takeyoshi, M., Tanaka, M., Uratani, M., Usami, M., Yamanaka, A., Yoneda. T., Yoshimura, I., Yuasa, A., 2008. Interlaboratory validation of the modified murine local lymph node assay based on adenosine triphosphate measurement. J. Pharmacol. Toxicol. Methods 58, 11\u201326. Available at: <http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18593646>.","DOI":"10.1016\/j.vascn.2008.05.001"},{"key":"10.1016\/j.yrtph.2012.06.003_b0265","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00018-011-0846-8","article-title":"Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods & regulatory aspects","volume":"69","author":"Peiser","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yrtph.2012.06.003_b0275","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.yrtph.2008.02.010","article-title":"The dermal sensitisation threshold - a TTC approach for allergic contact dermatitis","volume":"51","author":"Safford","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0270","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.yrtph.2011.03.009","article-title":"Refinement of the dermal sensitisation threshold (DST) approach using a larger dataset and incorporating mechanistic chemistry domains","volume":"60","author":"Safford","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0335","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10565-008-9059-9","article-title":"The relationship between CD86\/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test- human cell line activation test (h-CLAT)","volume":"25","author":"Sakaguchi","year":"2009","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0280","first-page":"249","article-title":"The identification of photoallergic potential in the local lymph node assay","volume":"8","author":"Scholes","year":"1992","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.yrtph.2012.06.003_b0295","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0300-483X(97)00156-X","article-title":"A modified murine local lymph node assay for the differentiation of contact photoallergy from phototoxicity by analysis of cytokine expression in skin-draining lymph node cells","volume":"125","author":"Ulrich","year":"1998","journal-title":"Toxicology"},{"issue":"76","key":"10.1016\/j.yrtph.2012.06.003_b0285","first-page":"62","article-title":"Cytokine expression profiles during murine contact allergy: T helper 2 cytokines are expressed irrespective of the type of contact allergen. Arch Toxicol. 75: 470\u2013479. Erratum in","volume":"2002","author":"Ulrich","year":"2001","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0290","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s002040000192","article-title":"Intralaboratory validation of alternative endpoints in the murine local lymph node assay for the identification of contact allergic potential: primary ear skin irritation and ear-draining lymph node hyperplasia induced by topical chemicals","volume":"74","author":"Ulrich","year":"2001","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0300","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3109\/10408440903524262","article-title":"Non-animal sensitization testing: state of the art","volume":"40","author":"Vandebriel","year":"2010","journal-title":"Crit. Rev. Toxicol."},{"issue":"10\u201311","key":"10.1016\/j.yrtph.2012.06.003_b0340","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s002040050001","article-title":"An intra-laboratory validation of the Integrated Model for the Differentiation of Skin Reactions (IMDS): discrimination between (photo)allergic and (photo)irritant skin reactions in mice","volume":"73","author":"Vohr","year":"2000","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0305","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s00204-005-0005-9","article-title":"The local lymph node assay being too sensitive?","volume":"79","author":"Vohr","year":"2005","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2012.06.003_b0310","first-page":"57","article-title":"Photoreactions detected in a modified local lymph node assay in the mouse","volume":"10","author":"Vohr","year":"1994","journal-title":"Photoderm. Photoimmunol. Photomed."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230012001122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230012001122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T10:36:34Z","timestamp":1594290994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230012001122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["S0273230012001122"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2012.06.003","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}