{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:51:35Z","timestamp":1790520695289,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.yrtph.2012.10.004","type":"journal-article","created":{"date-parts":[[2012,10,13]],"date-time":"2012-10-13T00:46:27Z","timestamp":1350089187000},"page":"459-465","source":"Crossref","is-referenced-by-count":35,"title":["Quantitative risk assessment for skin sensitisation: Consideration of a simplified approach for hair dye ingredients"],"prefix":"10.1016","volume":"64","author":[{"given":"Carsten","family":"Goebel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Diepgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Krasteva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Schlatter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Francois","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunhilde","family":"Bl\u00f6meke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter Jan","family":"Coenraads","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schnuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquemine","family":"Pungier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Fautz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Schuh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Frank","family":"Gerberick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Kimber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2012.10.004_b0005","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/jid.2008.209","article-title":"Skin Sensitization to p-phenylenediamine: The diverging roles of oxidation and N-acetylation for dendritic cell activation and the immune response","volume":"129","author":"Aeby","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1600-0536.2011.01992.x","article-title":"Quantification of p-phenylenediamine and 2-hydroxy-1,4-naphthoquinone in henna tattoos","volume":"66","author":"Almeida","year":"2011","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yrtph.2007.10.008","article-title":"Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients","volume":"52","author":"Api","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0020","first-page":"615","article-title":"Sensitization to resorcinol due to an anti-wart ointment: unusual clinical features and occurrence","volume":"128","author":"Barbaud","year":"2001","journal-title":"Ann. Dermatol. Venerol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0025","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1365-2133.2008.08625.x","article-title":"Skin sensitization: strategies for the assessment and management of risk","volume":"159","author":"Basketter","year":"2008","journal-title":"Br. J. Deramtol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0105-1873.2003.00149.x","article-title":"Nickel, chromium and cobalt in consumer products revisiting safe levels in the new millennium","volume":"49","author":"Basketter","year":"2003","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0035","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.0105-1873.2005.00707.x","article-title":"Predictive identification of human skin sensitization thresholds","volume":"53","author":"Basketter","year":"2005","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0040","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-0536.2007.01141.x","article-title":"The local lymph node assay and the assessment of relative potency: status of validation","volume":"7","author":"Basketter","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0045","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1600-0536.2006.01008.x","article-title":"The skin sensitization potential of resorcinol: experience with the local lymph node assay","volume":"56","author":"Basketter","year":"2007","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0050","doi-asserted-by":"crossref","first-page":"20","DOI":"10.2310\/6620.2008.07018","article-title":"Preservatives and skin sensitization quantitative risk assessment","volume":"19","author":"Basketter","year":"2008","journal-title":"Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0055","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1365-2133.2009.09417.x","article-title":"Consumer available permanent hair dye products cause major allergic immune activation in an animal model","volume":"162","author":"Bonefeld","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0060","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/ajcd.2002.30466","article-title":"Identification and quantification of para-phenylenediamine in a temporary black henna tattoo","volume":"13","author":"Brancaccio","year":"2002","journal-title":"Am. J. Contact Dermat."},{"key":"10.1016\/j.yrtph.2012.10.004_b0065","first-page":"361","article-title":"Studies concerning the reactions of oxidation dye intermediates","volume":"19","author":"Brody","year":"1968","journal-title":"J. Soc. Cosmet. Chem."},{"key":"10.1016\/j.yrtph.2012.10.004_b0070","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.0105-1873.2006.00872.x","article-title":"Fragrance allergy: assessing the risk from fabric washing products","volume":"55","author":"Corea","year":"2006","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0075","unstructured":"EU Commission Communication IP\/07\/439, 29 March 2007."},{"key":"10.1016\/j.yrtph.2012.10.004_b0080","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1034\/j.1600-0536.2002.470502.x","article-title":"A review of the scientific basis for uncertainty factors for use in quantitative risk assessment for the induction of allergic contact dermatitis","volume":"47","author":"Felter","year":"2002","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0273-2300(02)00021-1","article-title":"Application of the risk assessment paradigm to the induction of allergic contact dermatitis","volume":"37","author":"Felter","year":"2003","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0090","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1600-0536.1993.tb03383.x","article-title":"Allergic reactions to hairdressers\u2019 series: results from 9 European centers","volume":"28","author":"Frosch","year":"1993","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0095","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1034\/j.1600-0536.2001.450603.x","article-title":"Understanding fragrance allergy using an exposure-based risk assessment approach","volume":"45","author":"Gerberick","year":"2001","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0100","first-page":"156","article-title":"Contact allergenic potency: correlation of human and local lymph node assay data","volume":"12","author":"Gerberick","year":"2001","journal-title":"Am. J. Contact Dermat."},{"key":"10.1016\/j.yrtph.2012.10.004_b0105","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1365-2133.2010.10009.x","article-title":"Elicitation of the immune response to p-phenylenediamine in allergic patients: the role of dose and exposure time","volume":"163","author":"Goebel","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0110","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.yrtph.2003.07.001","article-title":"Proposal for a risk assessment methodology for skin sensitization based on sensitization potency data","volume":"38","author":"Griem","year":"2003","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0115","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1365-2133.2005.06742.x","article-title":"Analysis of para-phenylenediamine allergic patients in relation to strength of patch test reaction","volume":"153","author":"Ho","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0120","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/j.fct.2004.06.017","article-title":"Thresholds of elicitation depend on induction conditions Could low level exposure induce sub-clinical allergic states that are only elicited under the severe conditions of clinical diagnosis?","volume":"42","author":"Hostynek","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0125","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000098163","article-title":"Keratinocyte\u2019s course of life Skin","volume":"20","author":"Houben","year":"2007","journal-title":"Pharmacol. Physiol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0130","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.fct.2004.02.020","article-title":"Human systemic exposure to a [14C]-para-phenylenediamine-containing oxidative hair dye and correlation with in vitro percutaneous absorption in human or pig skin","volume":"42","author":"Hueber-Becker","year":"2004","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0135","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/S0278-6915(03)00223-0","article-title":"Classification of contact allergens according to potency: proposals","volume":"41","author":"Kimber","year":"2003","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0140","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/jid.1966.67","article-title":"The identification of contact allergens by human assay III The maximization test: a procedure for screening and rating contact sensitizers","volume":"47","author":"Kligman","year":"1966","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0145","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2310\/6620.2009.08089","article-title":"Consumer allergy to oxidative hair coloring products: epidemiologic data in the literature","volume":"20","author":"Krasteva","year":"2009","journal-title":"Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0150","first-page":"1","article-title":"Contact allergy to hair colouring products: The cosmetovigilance experience of 4 companies (2003\u20132006)","volume":"20","author":"Krasteva","year":"2010","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0155","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.2042-7158.1989.tb06405.x","article-title":"Topical application of penetration enhancers to the skin of nude mice: a histopathological study","volume":"41","author":"Lashmar","year":"1989","journal-title":"Pharm. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0160","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0015-6264(74)90367-8","article-title":"The use of graded concentrations in studying skin sensitizers: experimental contact sensitization in man","volume":"12","author":"Marzulli","year":"1974","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0165","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.yrtph.2007.10.019","article-title":"A review of critical factors in the conduct and interpretation of the human repeat insult patch test","volume":"52","author":"McNamee","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0170","unstructured":"OECD, 2002. Guideline for the testing of chemicals, Test Guideline 429: Skin Sensitization: Local Lymph Node Assay."},{"key":"10.1016\/j.yrtph.2012.10.004_b0175","unstructured":"OECD, 2004a. Environmental Health and Safety Publications Series on Testing and Assessment No. 28. Guidance Document for the Conduct of Skin Absorption Studies."},{"key":"10.1016\/j.yrtph.2012.10.004_b0180","unstructured":"OECD, 2004b. Guideline for testing of chemicals, Test Guideline 428: Skin Absorption: In Vitro Method."},{"key":"10.1016\/j.yrtph.2012.10.004_b0185","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1034\/j.1600-0536.2000.042005251.x","article-title":"The importance of exposure estimation in the assessment of skin sensitization risk","volume":"42","author":"Robinson","year":"2000","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0190","unstructured":"SCCP (Scientific Committee on Consumer Products), 2006a. Memorandum on hair dye substances and their skin sensitising properties. Available at: <http:\/\/ec.europa.eu\/health\/ph_risk\/committees\/04_sccp\/docs\/sccp_s_05.pdf> (19.12.06)."},{"key":"10.1016\/j.yrtph.2012.10.004_b0195","unstructured":"SCCP (Scientific Committee on Consumer Products), 2006b. Opinion on p-phenylenediamine. Available at: <http:\/\/ec.europa.eu\/health\/ph_risk\/committees\/04_sccp\/docs\/sccp_o_069.pdf> (10.10.2006)."},{"key":"10.1016\/j.yrtph.2012.10.004_b0200","unstructured":"SCCP\/SCCS (Scientific Committee on Consumer Products\/Scientific Committee on Consumer Safety), Link to opinions on individual hair dye ingredients (October 2004 \u2013 February 2009). Available at: <http:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/opinions\/sccp_opinions_en.htm#2>, Link to opinions on individual hair dye ingredients (after February 2009): <http:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/opinions\/index_en.htm#id2>."},{"key":"10.1016\/j.yrtph.2012.10.004_b0205","unstructured":"SCCS (Scientific Committee on Consumer Safety), 2010a. The SCCS\u2019S Notes of Guidance for the testing of cosmetic ingredients and their safety evaluation \u2013 7th revision 14 December 2010. Available at: <http:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_s_004.pdf> (14.12.10)."},{"key":"10.1016\/j.yrtph.2012.10.004_b0210","unstructured":"SCCS (Scientific Committee on Consumer Safety), 2010b. Basic criteria for the in vitro assessment of dermal absorption of cosmetic ingredients. Available at: <http:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_s_002.pdf> (22.06.10)."},{"key":"10.1016\/j.yrtph.2012.10.004_b0215","unstructured":"SCCS (Scientific Committee on Consumer Safety), 2010c. Opinion on resorcinol. Available at: <http:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_o_015.pdf> (23.25.10)."},{"key":"10.1016\/j.yrtph.2012.10.004_b0220","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1473-2165.2007.00318.x","article-title":"An overview of hair dye safety","volume":"6","author":"Schlatter","year":"2007","journal-title":"J. Cosmetic Dermatol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0225","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yrtph.2004.02.002","article-title":"Quantitative relationship between the local lymph node assay and human skin sensitization assays","volume":"39","author":"Schneider","year":"2004","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0230","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1600-0536.2008.01427.x","article-title":"European society of contact dermatitis. Epidemiological data on consumer allergy to p-phenylenediamine","volume":"59","author":"Thyssen","year":"2008","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0235","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/jps.1077","article-title":"Effect of barrier disruption by acetone treatment on the permeability of compounds with various lipophilicities: implications for the permeability of compromised skin","volume":"90","author":"Tsai","year":"2001","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.yrtph.2012.10.004_b0240","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2310\/6620.2010.10061","article-title":"Patch-testing with hairdressing chemicals","volume":"22","author":"Wang","year":"2011","journal-title":"Dermatitis"},{"key":"10.1016\/j.yrtph.2012.10.004_b0245","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/(SICI)1099-1263(199907\/08)19:4<255::AID-JAT573>3.0.CO;2-S","article-title":"Local lymph node assay responses to paraphenylenediamine: intra- and interlaboratory evaluations","volume":"19","author":"Warbrick","year":"1999","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.yrtph.2012.10.004_b0250","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1365-2222.2006.02561.x","article-title":"p-Phenylenediamine allergy: the role of Bandrowski\u2019s base","volume":"36","author":"White","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.yrtph.2012.10.004_b0255","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/15569528609030991","article-title":"Penetration enhancers and percutaneous absorption of drugs: an update","volume":"5","author":"Woodford","year":"1986","journal-title":"J. Toxicol. Cutaneous Occular Toxicol."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230012001900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230012001900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T19:15:25Z","timestamp":1594754125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230012001900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0273230012001900"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2012.10.004","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}