{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:34:34Z","timestamp":1791272074067,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.yrtph.2013.02.008","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T19:02:03Z","timestamp":1361991723000},"page":"24-29","source":"Crossref","is-referenced-by-count":29,"title":["Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors"],"prefix":"10.1016","volume":"66","author":[{"given":"G.","family":"Cruzan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hotchkiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Yost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Banton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sarang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2013.02.008_b0005","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1097\/JOM.0b013e3181ad49b2","article-title":"Epidemiological studies of styrene and cancer: a review of the literature","volume":"51","author":"Boffetta","year":"2009","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.yrtph.2013.02.008_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01926230290105866","article-title":"4-Vinylphenol-induced pneumotoxicity and hepatotoxicity in mice","volume":"30","author":"Carlson","year":"2002","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2013.02.008_b0150","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1080\/15287390490443696","article-title":"Influence of selected inhibitors on the metabolism of the styrene metabolite 4-vinylphenol in wild-type and CYP2E1 knockout mice","volume":"67","author":"Carlson","year":"2004","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.yrtph.2013.02.008_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2008.09.017","article-title":"Critical appraisal of the expression of cytochrome P450 enzymes in human lung, evaluation of the possibility that such expression provides evidence of potential styrene tumorigenicity in humans","volume":"254","author":"Carlson","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2013.02.008_b0010","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.tox.2012.02.006","article-title":"Modification of the metabolism and toxicity of styrene and styrene oxide in hepatic cytochrome P450 reductase deficient mice and CYP2F2 deficient mice","volume":"294","author":"Carlson","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2013.02.008_b0015","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1124\/jpet.108.141242","article-title":"Humanized mouse lines and their application for prediction of human drug metabolism and toxicological risk assessment","volume":"327","author":"Cheung","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1\u20132","key":"10.1016\/j.yrtph.2013.02.008_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10937400252972162","article-title":"A comprehensive evaluation of the potential health risks associated with occupational and environmental exposure to styrene","volume":"5","author":"Cohen","year":"2002","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"10.1016\/j.yrtph.2013.02.008_b0160","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/EDE.0b013e318281a30f","article-title":"Cancer mortality of workers exposed to styrene in the US reinforced plastics and composite industry","volume":"24","author":"Collins","year":"2013","journal-title":"Epidemiology"},{"key":"10.1016\/j.yrtph.2013.02.008_b0030","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/toxsci\/46.2.266","article-title":"Chronic toxicity\/oncogenicity study of styrene in CD rate by inhalation exposure for 104 weeks","volume":"46","author":"Cruzan","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2013.02.008_b0035","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/jat.737","article-title":"Chronic toxicity\/oncogenicity study of styrene in CD-I mice by inhalation exposure for 104 weeks","volume":"21","author":"Cruzan","year":"2001","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.yrtph.2013.02.008_b0040","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1006\/rtph.2002.1545","article-title":"Styrene respiratory tract toxicity and mouse lung tumors are mediated by CYP2F-generated metabolites","volume":"35","author":"Cruzan","year":"2002","journal-title":"Reg. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2013.02.008_b0045","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1080\/15287390590890464","article-title":"Ring-oxidized metabolites of styrene contribute to styrene-induced Clara cell toxicity in mice","volume":"68","author":"Cruzan","year":"2005","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.yrtph.2013.02.008_b0050","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.yrtph.2009.07.002","article-title":"Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: an endpoint\/toxic response where data from multiple chemicals converge to support a mode of action","volume":"55","author":"Cruzan","year":"2009","journal-title":"Reg. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2013.02.008_b0055","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.yrtph.2011.10.007","article-title":"CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors","volume":"62","author":"Cruzan","year":"2012","journal-title":"Reg. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2013.02.008_b0060","first-page":"432","article-title":"Immune responses in the lung and local lymph node of A\/J mice to intranasal sensitization and challenge with adjuvant-free ovalbumin","volume":"31","author":"Farraj","year":"2003","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2013.02.008_b0065","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0300-483X(01)00488-7","article-title":"The role of cytochromes P-450 in styrene induced pulmonary toxicity and carcinogenicity","volume":"169","author":"Green","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2013.02.008_b0165","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0022-3565(24)37529-9","article-title":"Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes","volume":"285","author":"Gu","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.yrtph.2013.02.008_b0070","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/taap.1996.8055","article-title":"Kinetics of nasal epithelial cell loss and proliferation in F344 rats following a single exposure to 0.5ppm ozone","volume":"143","author":"Hotchkiss","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yrtph.2013.02.008_b0080","series-title":"Styrene. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","volume":"vol. 60","author":"IARC","year":"1994"},{"key":"10.1016\/j.yrtph.2013.02.008_b0085","series-title":"Styrene IARC Monographs on the Evaluation of Carcinogenic Risks to Humans","volume":"vol. 82","author":"IARC","year":"2002"},{"key":"10.1016\/j.yrtph.2013.02.008_b0170","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.yrtph.2005.01.002","article-title":"Effects of styrene and its metabolites on different lung compartments of the mouse\u2013cell proliferation and histomorphology","volume":"42","author":"Kaufmann","year":"2005","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2013.02.008_b0075","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2307\/3001469","article-title":"Extension of multiple range tests to group means with unequal numbers of replications","volume":"12","author":"Kramer","year":"1956","journal-title":"Biometrics"},{"key":"10.1016\/j.yrtph.2013.02.008_b0090","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/S0090-9556(24)15228-2","article-title":"Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells","volume":"27","author":"Lanza","year":"1999","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.yrtph.2013.02.008_b0095","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1289\/ehp.0800319","article-title":"The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential","volume":"117","author":"Li","year":"2009","journal-title":"Environ. Health Perspec."},{"key":"10.1016\/j.yrtph.2013.02.008_b0100","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1124\/jpet.111.184671","article-title":"Generation and characterization of a Cyp2f2-null mouse and studies on the role of CYP2F2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa","volume":"339","author":"Li","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.yrtph.2013.02.008_b0105","first-page":"62","article-title":"CYP2F1 expression and activity toward naphthalene in a CYP2A13\/2F1-humanized mouse model","volume":"132","author":"Li","year":"2013","journal-title":"Toxi. Sci."},{"key":"10.1016\/j.yrtph.2013.02.008_b0110","first-page":"471","article-title":"Rat and mouse forestomach tumors induced by chronic oral administration of styrene oxide","volume":"77","author":"Lijinsky","year":"1986","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.yrtph.2013.02.008_b0115","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/bdrb.20061","article-title":"NTP-CERHR Expert Panel Report on the Reproductive and Developmental Toxicity of Styrene","volume":"77","author":"Luderer","year":"2005","journal-title":"Birth Defects Res., Part B"},{"key":"10.1016\/j.yrtph.2013.02.008_b0120","series-title":"Report on Carcinogens","author":"NTP","year":"2011"},{"key":"10.1016\/j.yrtph.2013.02.008_b0125","series-title":"Linear Models","author":"Searle","year":"1971"},{"key":"10.1016\/j.yrtph.2013.02.008_b0130","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1124\/jpet.104.068171","article-title":"Bioactivation of 1,1-dichloroethylene by CYP2E1 and CYP2F2 in murine lung","volume":"310","author":"Simmonds","year":"2004","journal-title":"J. Pharmacol. Expt. Ther."},{"key":"10.1016\/j.yrtph.2013.02.008_b0180","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/carcin\/bgh348","article-title":"Effects of 8-methoxypsoralen on cytochrome P450 2A13","volume":"26","author":"von Weymarn","year":"2005","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yrtph.2013.02.008_b0175","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1124\/dmd.112.044826","article-title":"Generation and characterization of a CYP2A13\/2B6\/2F1-transgenic mouse model","volume":"40","author":"Wei","year":"2012","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.yrtph.2013.02.008_b0185","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3109\/00498254.2010.523735","article-title":"In vitro metabolism, glutathione conjugation, and CYP isoform specificity of epoxidation of 4-vinylphenol","volume":"41","author":"Zhang","year":"2011","journal-title":"Xenobiotica"}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230013000263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230013000263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T22:19:40Z","timestamp":1745965180000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230013000263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0273230013000263"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2013.02.008","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}