{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:25:25Z","timestamp":1790360725977,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.yrtph.2014.05.008","type":"journal-article","created":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T11:30:24Z","timestamp":1400326224000},"page":"434-442","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["A new method for generating distributions of biomonitoring equivalents to support exposure assessment and prioritization"],"prefix":"10.1016","volume":"69","author":[{"given":"Martin B.","family":"Phillips","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon R.","family":"Sobus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory","family":"Conolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Mei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.yrtph.2014.05.008_b0005","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1080\/15287390802361755","article-title":"Derivation of biomonitoring equivalent (BE) values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds: a screening tool for interpretation of biomonitoring data in a risk assessment context","volume":"71","author":"Aylward","year":"2008","journal-title":"J. Toxicol. Environ. Health A"},{"issue":"3","key":"10.1016\/j.yrtph.2014.05.008_b0010","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.yrtph.2009.09.001","article-title":"Derivation of biomonitoring equivalents for di(2-ethylhexyl)phthalate (CAS No. 117-81-7)","volume":"55","author":"Aylward","year":"2009","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"4","key":"10.1016\/j.yrtph.2014.05.008_b0015","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/jes.2012.35","article-title":"Interpreting variability in population biomonitoring data: role of elimination kinetics","volume":"22","author":"Aylward","year":"2012","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"3","key":"10.1016\/j.yrtph.2014.05.008_b0020","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1289\/ehp.1205740","article-title":"Evaluation of biomonitoring data from the CDC National Exposure Report in a risk assessment context: perspectives across chemicals","volume":"121","author":"Aylward","year":"2013","journal-title":"Environ. Health Perspect."},{"issue":"4","key":"10.1016\/j.yrtph.2014.05.008_b0025","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/sj.jes.7500535","article-title":"Perchlorate exposure of the US Population, 2001\u20132002","volume":"17","author":"Blount","year":"2007","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"6","key":"10.1016\/j.yrtph.2014.05.008_b0030","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/15298667991429822","article-title":"Biomonitoring of industrial styrene exposures","volume":"40","author":"Fields","year":"1979","journal-title":"Am. Ind. Hyg. Assoc. J."},{"key":"10.1016\/j.yrtph.2014.05.008_b0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1476-069X-7-55","article-title":"Concentrations versus amounts of biomarkers in urine: a comparison of approaches to assess pyrethroid exposure","volume":"7","author":"Fortin","year":"2008","journal-title":"Environ. Health"},{"issue":"9","key":"10.1016\/j.yrtph.2014.05.008_b0040","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1289\/ehp.02110927","article-title":"Health effects assessment for environmental perchlorate contamination: the dose response for inhibition of thyroidal radioiodine uptake in humans","volume":"110","author":"Greer","year":"2002","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.yrtph.2014.05.008_b0045","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.yrtph.2006.08.004","article-title":"Biomonitoring equivalents: a screening approach for interpreting biomonitoring results from a public health risk perspective","volume":"47","author":"Hays","year":"2007","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.yrtph.2014.05.008_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yrtph.2010.06.002","article-title":"Biomonitoring equivalents for inorganic arsenic","volume":"58","author":"Hays","year":"2010","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"4","key":"10.1016\/j.yrtph.2014.05.008_b0055","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/jes.2010.31","article-title":"Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data","volume":"21","author":"Huber","year":"2011","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"7","key":"10.1016\/j.yrtph.2014.05.008_b0060","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1021\/tx3000939","article-title":"Update on EPA\u2019s ToxCast program: providing high throughput decision support tools for chemical risk management","volume":"25","author":"Kavlock","year":"2012","journal-title":"Chem. Res. Toxicol."},{"issue":"3","key":"10.1016\/j.yrtph.2014.05.008_b0065","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/jes.2008.8","article-title":"Use of a simple pharmacokinetic model to characterize exposure to perchlorate","volume":"19","author":"Lorber","year":"2009","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"3","key":"10.1016\/j.yrtph.2014.05.008_b0070","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/jes.2009.50","article-title":"Drinking water contribution to aggregate perchlorate intake of reproductive-age women in the United States estimated by dietary intake simulation and analysis of urinary excretion data","volume":"20","author":"Mendez","year":"2010","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"1","key":"10.1016\/j.yrtph.2014.05.008_b0075","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/toxsci\/kfi017","article-title":"PBPK model for radioactive iodide and perchlorate kinetics and perchlorate-induced inhibition of iodide uptake in humans","volume":"83","author":"Merrill","year":"2005","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2014.05.008_b0080","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/enfo.2001.0059","article-title":"Perchlorate: problems, detection, and solutions","volume":"2","author":"Motzer","year":"2001","journal-title":"Environ. Forensics"},{"issue":"6","key":"10.1016\/j.yrtph.2014.05.008_b0085","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/sj.jes.7500648","article-title":"US Food and Drug Administration\u2019s Total Diet Study: dietary intake of perchlorate and iodine","volume":"18","author":"Murray","year":"2008","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"key":"10.1016\/j.yrtph.2014.05.008_b0090","series-title":"Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry","first-page":"161","article-title":"Variability, uncertainty, and sensitivity analysis","author":"Peters","year":"2012"},{"issue":"12","key":"10.1016\/j.yrtph.2014.05.008_b0095","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1080\/15287394.2013.821394","article-title":"Estimating lifetime risk from spot biomarker data and intraclass correlation coefficients (ICC)","volume":"76","author":"Pleil","year":"2013","journal-title":"J. Toxicol. Environ. Health A"},{"issue":"21","key":"10.1016\/j.yrtph.2014.05.008_b0100","doi-asserted-by":"crossref","first-page":"11635","DOI":"10.1021\/es3015277","article-title":"Perchlorate production by photodecomposition of aqueous chlorine solutions","volume":"46","author":"Rao","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.yrtph.2014.05.008_b0105","unstructured":"Rappaport, S.M., Kupper, L.L., 2008. Quantitative Exposure Assessment, Stephen Rappaport."},{"issue":"18","key":"10.1016\/j.yrtph.2014.05.008_b0110","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1080\/15287390600631367","article-title":"Use of a physiologically based pharmacokinetic model to identify exposures consistent with human biomonitoring data for chloroform","volume":"69","author":"Tan","year":"2006","journal-title":"J. Toxicol. Environ. Health A"},{"key":"10.1016\/j.yrtph.2014.05.008_b0115","unstructured":"USEPA, 1992. Guidelines for Exposure Assessment, Washington, D.C."},{"key":"10.1016\/j.yrtph.2014.05.008_b0120","unstructured":"USEPA, 2009. Inhibition of the Sodium-Iodide Symporter by Perchlorate: An Evaluation of Life Stage Sensitivity Using Physiologically Based Pharmacokinetic (PBPK) Modeling (Final Report), Washington, D.C."},{"key":"10.1016\/j.yrtph.2014.05.008_b0125","unstructured":"USEPA, 2012. Chemical Safety for Sustainability Strategic Research Action Plan 2012\u20132016, Washington, D.C."},{"key":"10.1016\/j.yrtph.2014.05.008_b0130","unstructured":"USEPA, 2013a. \u201cGlossary \u2013 Risk Assessment Portal \u2013 US EPA.\u201d Last updated July 2, 2013. <http:\/\/www.epa.gov\/risk\/glossary.htm> retrieved 31.01.2014."},{"key":"10.1016\/j.yrtph.2014.05.008_b0135","unstructured":"USEPA, 2013b. Next Generation Risk Assessment: Incorporation of Recent Advances in Molecular, Computational, and Systems Biology (External Review Draft), Washington, D.C."},{"key":"10.1016\/j.yrtph.2014.05.008_b0140","unstructured":"USEPA, 2013c. \u201cWhat is the TSCA Chemical Substance Inventory? \u2013 New Chemicals Program \u2013 US EPA.\u201d Last updated April 3, 2013. <http:\/\/www.epa.gov\/oppt\/newchems\/pubs\/invntory.htm> retrieved 22.05.2013."},{"key":"10.1016\/j.yrtph.2014.05.008_b0145","unstructured":"USEPA, 2014. \u201cVocabulary Catalog List Detail \u2013 Terminology Services \u2013 US EPA.\u201d Last updated January 31, 2014. <http:\/\/ofmpub.epa.gov\/sor_internet\/registry\/termreg\/searchandretrieve\/glossariesandkeywordlists\/search.do?details=&glossaryName=IRIS%20Glossary> Retrieved 31.01.2014."},{"key":"10.1016\/j.yrtph.2014.05.008_b0150","series-title":"Health Implications of Perchlorate Ingestion","author":"USNRC","year":"2005"},{"key":"10.1016\/j.yrtph.2014.05.008_b0155","series-title":"Human Biomonitoring for Environmental Chemicals","author":"USNRC","year":"2006"},{"key":"10.1016\/j.yrtph.2014.05.008_b0160","series-title":"Toxicity Testing in the 21st Century: A Vision and a Strategy","author":"USNRC","year":"2007"},{"key":"10.1016\/j.yrtph.2014.05.008_b0165","series-title":"Exposure Science in the 21st Century: A Vision and a Strategy","author":"USNRC","year":"2012"},{"issue":"15","key":"10.1016\/j.yrtph.2014.05.008_b0170","first-page":"8479","article-title":"High-throughput models for exposure-based chemical prioritization in the ExpoCast project","volume":"47","author":"Wambaugh","year":"2013","journal-title":"Environ. Sci. Technol."},{"issue":"1","key":"10.1016\/j.yrtph.2014.05.008_b0175","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/toxsci\/kfr254","article-title":"Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment","volume":"125","author":"Wetmore","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2014.05.008_b0180","unstructured":"WHO, 1996. Biological Monitoring of Chemical Exposure in the Workplace: Guidelines. Geneva, Switzerland."},{"issue":"8","key":"10.1016\/j.yrtph.2014.05.008_b0185","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.chemosphere.2012.03.074","article-title":"Using a physiologically based pharmacokinetic model to link urinary biomarker concentrations to dietary exposure of perchlorate","volume":"88","author":"Yang","year":"2012","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.yrtph.2014.05.008_b0190","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1289\/ehp.0900635","article-title":"Basis of the Massachusetts reference dose and drinking water standard for perchlorate","volume":"118","author":"Zewdie","year":"2010","journal-title":"Environ. Health Perspect."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230014000907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230014000907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T11:28:49Z","timestamp":1565436529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230014000907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["S0273230014000907"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2014.05.008","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A new method for generating distributions of biomonitoring equivalents to support exposure assessment and prioritization","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2014.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}