{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:01:55Z","timestamp":1777003315398,"version":"3.51.4"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.yrtph.2016.06.006","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T07:36:05Z","timestamp":1467963365000},"page":"295-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Developing a framework for assessing chemical respiratory sensitization: A workshop report"],"prefix":"10.1016","volume":"80","author":[{"given":"Colin M.","family":"North","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janine","family":"Ezendam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon A.","family":"Hotchkiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohji","family":"Aoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Enoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Goetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Kimber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Karjalainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Pauluhn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin L.","family":"Roggen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MaryJane","family":"Selgrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Tarlo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3704-9866","authenticated-orcid":false,"given":"Connie L.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2016.06.006_bib1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/toxsci\/kfs071","article-title":"Differential gene expression responses distinguish contact and respiratory sensitizers and nonsensitizing irritants in the local lymph node assay","volume":"126","author":"Adenuga","year":"2012","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2016.06.006_bib2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00204-011-0693-2","article-title":"Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010","volume":"85","author":"Adler","year":"2011","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib3","first-page":"129","article-title":"Structure activity hypotheses in occupational asthma caused by low molecular weight substances","volume":"35","author":"Agius","year":"1991","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.yrtph.2016.06.006_bib4","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/2050-6511-15-5","article-title":"Skin sensitizers differentially regulate signaling pathways in MUTZ-3 cells in relation to their individual potency","volume":"15","author":"Albrekt","year":"2014","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib5","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.tiv.2007.01.008","article-title":"Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein","volume":"21","author":"Aleksic","year":"2007","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1016\/j.yrtph.2016.06.006_bib6","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/etc.34","article-title":"Adverse outcome pathways: a conceptual framework to support ecotoxicology research and risk assessment","volume":"29","author":"Ankley","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.yrtph.2016.06.006_bib7","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/toxsci\/kfn199","article-title":"The respiratory local lymph node assay as a tool to study respiratory sensitizers","volume":"106","author":"Arts","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2016.06.006_bib8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/026119291003800403","article-title":"A\u00a0comparative evaluation of in\u00a0vitro skin sensitisation tests: the human cell-line activation test (h-CLAT) versus the local lymph node assay (LLNA)","volume":"38","author":"Ashikaga","year":"2010","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.yrtph.2016.06.006_bib9","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1164\/rccm.167.5.787","article-title":"American thoracic society statement: occupational contribution to the burden of airway disease","volume":"167","author":"Balmes","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.yrtph.2016.06.006_bib10","first-page":"397","article-title":"5.21 - Contact hypersensitivity","volume":"vol. 5","author":"Basketter","year":"2010"},{"key":"10.1016\/j.yrtph.2016.06.006_bib11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/026119290703500124","article-title":"Skin sensitisation and epidermal disposition: the relevance of epidermal disposition for sensitisation hazard identification and risk assessment. The report and recommendations of ECVAM workshop 59","volume":"35","author":"Basketter","year":"2007","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.yrtph.2016.06.006_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1745-6673-8-15","article-title":"A\u00a0compendium of causative agents of occupational asthma","volume":"8","author":"Baur","year":"2013","journal-title":"J.\u00a0Occup. Med. Toxicol."},{"issue":"4","key":"10.1016\/j.yrtph.2016.06.006_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00420-013-0866-9","article-title":"Allergens causing occupational asthma: an evidence-based evaluation of the literature","volume":"87","author":"Baur","year":"2014","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.yrtph.2016.06.006_bib14","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.tiv.2011.02.008","article-title":"Toxicology in the 21st century\u2013working our way towards a visionary reality","volume":"25","author":"Berg","year":"2011","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1016\/j.yrtph.2016.06.006_bib15","series-title":"Definition and Classification of Asthma in the Workplace. Asthma in the Workplace","author":"Bernstein","year":"2013"},{"key":"10.1016\/j.yrtph.2016.06.006_bib16","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/toxsci\/kfn247","article-title":"Evaluation of a toxicogenomic approach to the local lymph node assay (LLNA)","volume":"107","author":"Boverhof","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2016.06.006_bib17","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/JOM.0b013e3182122376","article-title":"Reduction in diisocyanate and non-diisocyanate sensitizer-induced occupational asthma in Ontario","volume":"53","author":"Buyantseva","year":"2011","journal-title":"J.\u00a0Occup. Environ. Med."},{"key":"10.1016\/j.yrtph.2016.06.006_bib18","first-page":"839682","article-title":"Haptenation: chemical reactivity and protein binding","volume":"2011","author":"Chipinda","year":"2011","journal-title":"J.\u00a0Allergy (Cairo)"},{"key":"10.1016\/j.yrtph.2016.06.006_bib19","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1124\/dmd.110.034462","article-title":"Prediction of efficacious inhalation lung doses via the use of in silico lung retention quantitative structure-activity relationship models and in\u00a0vitro potency screens","volume":"38","author":"Cooper","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.yrtph.2016.06.006_bib20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/oemed-2011-100399","article-title":"Workplace interventions for treatment of occupational asthma: a Cochrane systematic review","volume":"69","author":"de Groene","year":"2012","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.yrtph.2016.06.006_bib21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.tox.2009.04.057","article-title":"Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure","volume":"261","author":"De Jong","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2016.06.006_bib22","first-page":"545","article-title":"Differential cytokine production following chronic exposure of mice to chemical respiratory and contact allergens","volume":"86","author":"Dearman","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/j.yrtph.2016.06.006_bib23","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.taap.2009.02.004","article-title":"Progress on the development of human in\u00a0vitro dendritic cell based assays for assessment of the sensitizing potential of a compound","volume":"236","author":"dos Santos","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib24","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1136\/oemed-2012-100826","article-title":"Occupational exposure to cleaning products and asthma in hospital workers","volume":"69","author":"Dumas","year":"2012","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.yrtph.2016.06.006_bib25","series-title":"Guidance on the Application of the CLP Criteria \u2013 Guidance to Regulation (EC) No 1272\/2008 on Classification, Labelling and Packaging (CLP) of Substances and Mixtures","author":"ECHA","year":"2013"},{"key":"10.1016\/j.yrtph.2016.06.006_bib26","series-title":"Identification of Substances as SVHCs Due to Equivalent Level of Concern to CMRs (Article 57(f)) \u2013 Sensitisers as an Example","author":"ECHA","year":"2013"},{"key":"10.1016\/j.yrtph.2016.06.006_bib27","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1021\/tx9001463","article-title":"Electrophilic reaction chemistry of low molecular weight respiratory sensitizers","volume":"22","author":"Enoch","year":"2009","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib28","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1021\/tx100218h","article-title":"Mechanistic category formation for the prediction of respiratory sensitization","volume":"23","author":"Enoch","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib29","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1021\/tx3003092","article-title":"Development of mechanism-based structural alerts for respiratory sensitization hazard identification","volume":"25","author":"Enoch","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib30","doi-asserted-by":"crossref","first-page":"5868","DOI":"10.1021\/pr100638m","article-title":"Proteome analysis of multiple compartments in a mouse model of chemical-induced asthma","volume":"9","author":"Haenen","year":"2010","journal-title":"J.\u00a0Proteome Res."},{"issue":"Suppl.\u00a01","key":"10.1016\/j.yrtph.2016.06.006_bib31","first-page":"S41","article-title":"An impaired alveolar-capillary barrier in\u00a0vitro: effect of proinflammatory cytokines and consequences on nanocarrier interaction","volume":"7","author":"Hermanns","year":"2010","journal-title":"J.\u00a0R. Soc. Interface"},{"key":"10.1016\/j.yrtph.2016.06.006_bib32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/toxsci\/kfj074","article-title":"Assessing the potential to induce respiratory hypersensitivity","volume":"91","author":"Holsapple","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2016.06.006_bib33","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/jat.2869","article-title":"Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice","volume":"33","author":"Jaworska","year":"2013","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib34","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3346\/jkms.2005.20.4.579","article-title":"Proteomic analysis of differently expressed proteins in a mouse model for allergic asthma","volume":"20","author":"Jeong","year":"2005","journal-title":"J.\u00a0Korean Med. Sci."},{"key":"10.1016\/j.yrtph.2016.06.006_bib35","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/1471-2164-12-399","article-title":"A\u00a0genomic biomarker signature can predict skin sensitizers using a cell-based in\u00a0vitro alternative to animal tests","volume":"12","author":"Johansson","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.yrtph.2016.06.006_bib36","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1177\/026119290703500212","article-title":"Chemical respiratory allergy: opportunities for hazard identification and characterisation. The report and recommendations of ECVAM workshop 60","volume":"35","author":"Kimber","year":"2007","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.yrtph.2016.06.006_bib37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0300-483X(02)00299-8","article-title":"Chemical respiratory allergy: role of IgE antibody and relevance of route of exposure","volume":"181\u2013182","author":"Kimber","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2016.06.006_bib38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/01.all.0000162302.82233.93","article-title":"What makes a chemical a respiratory sensitizer?","volume":"5","author":"Kimber","year":"2005","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2014.02.001","article-title":"Chemical respiratory allergy: reverse engineering an adverse outcome pathway","volume":"318","author":"Kimber","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2016.06.006_bib40","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1177\/096032719801701002","article-title":"Chemical respiratory allergy, IgE and the relevance of predictive test methods: a commentary","volume":"17","author":"Kimber","year":"1998","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib41","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0140-6736(07)61164-7","article-title":"Exposure to substances in the workplace and new-onset asthma: an international prospective population-based study (ECRHS-II)","volume":"370","author":"Kogevinas","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.yrtph.2016.06.006_bib42","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1177\/0192623308327410","article-title":"Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats","volume":"36","author":"Kuper","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib43","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.tox.2011.08.017","article-title":"Oxazolone (OXA) is a respiratory allergen in Brown Norway rats","volume":"290","author":"Kuper","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2016.06.006_bib44","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.tox.2008.01.013","article-title":"The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat","volume":"246","author":"Kuper","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2016.06.006_bib45","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.tiv.2012.10.016","article-title":"Reactivity of chemical respiratory allergens in the peroxidase peptide reactivity assay","volume":"27","author":"Lalko","year":"2013","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1016\/j.yrtph.2016.06.006_bib46","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1365-2567.2005.02274.x","article-title":"Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells","volume":"117","author":"Larsson","year":"2006","journal-title":"Immunology"},{"key":"10.1016\/j.yrtph.2016.06.006_bib47","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.tiv.2013.12.016","article-title":"Assessment of immunotoxicity induced by chemicals in human precision-cut lung slices (PCLS)","volume":"28","author":"Lauenstein","year":"2014","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1016\/j.yrtph.2016.06.006_bib48","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4137\/BMI.S9776","article-title":"Biomarkers of disease and treatment in murine and cynomolgus models of chronic asthma","volume":"7","author":"Louten","year":"2012","journal-title":"Biomark Insights"},{"key":"10.1016\/j.yrtph.2016.06.006_bib49","doi-asserted-by":"crossref","first-page":"e52875","DOI":"10.1371\/journal.pone.0052875","article-title":"Transcriptional profiling of human dendritic cell populations and models\u2013unique profiles of in\u00a0vitro dendritic cells and implications on functionality and applicability","volume":"8","author":"Lundberg","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.yrtph.2016.06.006_bib50","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/08916930500124122","article-title":"Immunosteroid as a regulator for Th1\/Th2 balance: its possible role in autoimmune diseases","volume":"38","author":"Matsuzaki","year":"2005","journal-title":"Autoimmunity"},{"key":"10.1016\/j.yrtph.2016.06.006_bib51","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0091-6749(00)90089-7","article-title":"Exposure-effect relationship of platinum salt allergy in a catalyst production plant: conclusions from a 5-year prospective cohort study","volume":"105","author":"Merget","year":"2000","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib52","series-title":"Work-related Asthma: Most Frequently Reported Agents Associated with Work-related Asthma Cases by State, 2009\u20132010","author":"NIOSH","year":"2014"},{"key":"10.1016\/j.yrtph.2016.06.006_bib53","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/1465-9921-12-124","article-title":"Network analysis of quantitative proteomics on asthmatic bronchi: effects of inhaled glucocorticoid treatment","volume":"12","author":"O\u2019Neil","year":"2011","journal-title":"Respir. Res."},{"key":"10.1016\/j.yrtph.2016.06.006_bib54","first-page":"1","volume":"vol. 168","author":"OECD","year":"2012"},{"key":"10.1016\/j.yrtph.2016.06.006_bib55","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1002\/eji.200838384","article-title":"CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis","volume":"38","author":"Ouwehand","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib56","first-page":"1028","article-title":"Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration","volume":"90","author":"Ouwehand","year":"2011","journal-title":"Tech. Adv."},{"key":"10.1016\/j.yrtph.2016.06.006_bib57","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1586\/epr.11.4","article-title":"Application of proteomics in asthma research","volume":"8","author":"Park","year":"2011","journal-title":"Expert Rev. Proteomics"},{"key":"10.1016\/j.yrtph.2016.06.006_bib58","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/08958370252809068","article-title":"Short-term inhalation toxicity of polyisocyanate aerosols in rats: comparative assessment of irritant-threshold concentrations by bronchoalveolar lavage","volume":"14","author":"Pauluhn","year":"2002","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib59","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1080\/08958370500224631","article-title":"Brown Norway rat asthma model of diphenylmethane 4,4\u2019-diisocyanate","volume":"17","author":"Pauluhn","year":"2005","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib60","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/toxsci\/kfn098","article-title":"Brown Norway rat asthma model of diphenylmethane-4,4\u2019-diisocyanate (MDI): analysis of the elicitation dose-response relationship","volume":"104","author":"Pauluhn","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2016.06.006_bib61","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.tox.2014.02.006","article-title":"Development of a respiratory sensitization\/elicitation protocol of toluene diisocyanate (TDI) in Brown Norway rats to derive an elicitation-based occupational exposure level","volume":"319","author":"Pauluhn","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2016.06.006_bib62","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3109\/08958378.2015.1026619","article-title":"Analysis of the interrelationship of the pulmonary irritation and elicitation thresholds in rats sensitized with 1,6-hexamethylene diisocyanate (HDI)","volume":"21","author":"Pauluhn","year":"2015","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib63","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.etp.2004.10.002","article-title":"Experimental approaches to evaluate respiratory allergy in animal models","volume":"56","author":"Pauluhn","year":"2005","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib64","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.tox.2011.01.005","article-title":"Brown Norway rat asthma model of diphenylmethane-4,4\u2019-diisocyanate (MDI): determination of the elicitation threshold concentration of after inhalation sensitization","volume":"281","author":"Pauluhn","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2016.06.006_bib65","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.tiv.2012.09.019","article-title":"Application of the acquired knowledge and implementation of the Sens-it-iv toolbox for identification and classification of skin and respiratory sensitizers","volume":"27","author":"Roggen","year":"2013","journal-title":"Toxicol In\u00a0Vitro"},{"key":"10.1016\/j.yrtph.2016.06.006_bib66","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/bcpt.12202","article-title":"In\u00a0vitro approaches for detection of chemical sensitization","volume":"115","author":"Roggen","year":"2014","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib67","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.yrtph.2012.05.004","article-title":"Decision trees for evaluating skin and respiratory sensitizing potential of chemicals in accordance with European regulations","volume":"63","author":"Selgrade","year":"2012","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib68","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/all.12541","article-title":"Occupational anaphylaxis - an EAACI task force consensus statement","volume":"70","author":"Siracusa","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.yrtph.2016.06.006_bib69","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3389\/fgene.2013.00308","article-title":"Allergic asthma biomarkers using systems approaches","volume":"4","author":"Sircar","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.yrtph.2016.06.006_bib70","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/j.1398-9995.2006.01233.x","article-title":"Serine proteases, their inhibitors and allergy","volume":"61","author":"Smith","year":"2006","journal-title":"Allergy"},{"key":"10.1016\/j.yrtph.2016.06.006_bib71","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.ejca.2014.01.027","article-title":"The European Cancer Observatory: a new data resource","volume":"51","author":"Steliarova-Foucher","year":"2015","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.yrtph.2016.06.006_bib72","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1189\/jlb.1104664","article-title":"Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity","volume":"78","author":"Tan","year":"2005","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib73","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1378\/chest.08-0201","article-title":"Diagnosis and management of work-related asthma: American College of chest physicians consensus statement","volume":"134","author":"Tarlo","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.yrtph.2016.06.006_bib74","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMra1301758","article-title":"Occupational asthma","volume":"370","author":"Tarlo","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.yrtph.2016.06.006_bib75","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2466-9-7","article-title":"Asthma caused by occupational exposures is common \u2013 a systematic analysis of estimates of the population-attributable fraction","volume":"9","author":"Toren","year":"2009","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.yrtph.2016.06.006_bib76","series-title":"Toxicity Testing in the 21st Century: a Vision and a Strategy","author":"US National Research Council","year":"2007"},{"key":"10.1016\/j.yrtph.2016.06.006_bib77","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.tox.2010.01.008","article-title":"Allergic inflammation in the upper respiratory tract of the rat upon repeated inhalation exposure to the contact allergen dinitrochlorobenzene (DNCB)","volume":"269","author":"van Triel","year":"2010","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2016.06.006_bib78","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tox.2010.09.018","article-title":"The respiratory allergen glutaraldehyde in the local lymph node assay: sensitization by skin exposure, but not by inhalation","volume":"279","author":"van Triel","year":"2011","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2016.06.006_bib79","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/taap.1999.8841","article-title":"Assessment of preferential T-helper 1 or T-helper 2 induction by low molecular weight compounds using the local lymph node assay in conjunction with RT-PCR and ELISA for interferon-gamma and interleukin-4","volume":"162","author":"Vandebriel","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib80","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1183\/09031936.00180313","article-title":"Specific inhalation challenge in the diagnosis of occupational asthma: consensus statement","volume":"43","author":"Vandenplas","year":"2014","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.yrtph.2016.06.006_bib81","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/all.12448","article-title":"Eaaci position paper: irritant-induced asthma","volume":"69","author":"Vandenplas","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.yrtph.2016.06.006_bib82","series-title":"IPCS Harmonization Project Document No. 10-Guidance for Immunotoxicity Risk Assessment for Chemicals","author":"WHO","year":"2012"},{"key":"10.1016\/j.yrtph.2016.06.006_bib83","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/mi.2009.138","article-title":"New insights into innate immune mechanisms underlying allergenicity","volume":"3","author":"Wills-Karp","year":"2010","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.yrtph.2016.06.006_bib84","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1021\/pr800685h","article-title":"Oxidative stress and asthma: proteome analysis of chitinase-like proteins and FIZZ1 in lung tissue and bronchoalveolar lavage fluid","volume":"8","author":"Zhang","year":"2009","journal-title":"J.\u00a0Proteome Res."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230016301647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230016301647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T12:28:15Z","timestamp":1759494495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230016301647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":84,"alternative-id":["S0273230016301647"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2016.06.006","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developing a framework for assessing chemical respiratory sensitization: A workshop report","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2016.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}