{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T13:00:29Z","timestamp":1774702829512,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Incyte Corporation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.yrtph.2016.09.016","type":"journal-article","created":{"date-parts":[[2016,9,17]],"date-time":"2016-09-17T21:02:55Z","timestamp":1474146175000},"page":"305-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Results from oral gavage carcinogenicity studies of ruxolitinib in Tg.rasH2 mice and Sprague-Dawley (Crl:CD) rats"],"prefix":"10.1016","volume":"81","author":[{"given":"Dana L.","family":"Shuey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gongfu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2016.09.016_bib1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/019262390908371","article-title":"Carcinogenicity evaluation: comparison of tumor data from dual control groups in the Sprague-Dawley rat","volume":"33","author":"Baldrick","year":"2005","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2016.09.016_bib2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/01926230390173923","article-title":"Significance of hepatic preneoplasia in risk identification and early detection of neoplasia","volume":"31","author":"Bannasch","year":"2003","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2016.09.016_bib3","doi-asserted-by":"crossref","first-page":"e23828","DOI":"10.4161\/jkst.23828","article-title":"Targeting the tumor microenvironment. JAK-STAT3 signaling","volume":"2","author":"Bournazou","year":"2013","journal-title":"JAK-STAT"},{"key":"10.1016\/j.yrtph.2016.09.016_bib4","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1053\/j.gastro.2006.01.006","article-title":"Ubiquitous activation of Ras and Jak\/Stat pathways in human HCC","volume":"130","author":"Calvisi","year":"2006","journal-title":"Gastroenterol"},{"key":"10.1016\/j.yrtph.2016.09.016_bib5","series-title":"Toxicologic Pathology. Nonclinical Safety Assessment","article-title":"Liver, Gallbladder, and Exocrine Pancreas","author":"Cattley","year":"2013"},{"key":"10.1016\/j.yrtph.2016.09.016_bib6","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2307\/2528490","article-title":"New tables for multiple comparisons with a control","volume":"20","author":"Dunnett","year":"1964","journal-title":"Biometrics"},{"key":"10.1016\/j.yrtph.2016.09.016_bib7","series-title":"Histopathology of Preclinical Toxicology Studies","author":"Greaves","year":"2007"},{"key":"10.1016\/j.yrtph.2016.09.016_bib8","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/jat.1723","article-title":"Preclinical risk assessment of drug induced hypo- or hyperprolactemia","volume":"31","author":"Hargreaves","year":"2011","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.yrtph.2016.09.016_bib9","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1177\/0192623312444621","article-title":"A\u00a0review of the incidence and coincidence of uterine and mammary tumors in Wistar and Sprague-Dawley rats based on the RITA database and the role of prolactin","volume":"40","author":"Harleman","year":"2012","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2016.09.016_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/0269881107082624","article-title":"Adverse effects of prolactin in rodents and humans: breast and prostate cancer","volume":"22","author":"Harvey","year":"2008","journal-title":"J.\u00a0Psychopharmacol."},{"key":"10.1016\/j.yrtph.2016.09.016_bib10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0272-0590(83)80148-1","article-title":"A\u00a0reexamination of false-positive rates for carcinogenesis studies","volume":"3","author":"Haseman","year":"1983","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.yrtph.2016.09.016_bib11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1289\/ehp.8458385","article-title":"Statististical issues in the designs, analysis and interpretation of animal carcinogenicity studies","volume":"58","author":"Hasemen","year":"1984","journal-title":"Environ. Health Persp"},{"key":"10.1016\/j.yrtph.2016.09.016_bib39","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/019262339702500302","article-title":"Body weight-tumor incidence correlations in long-term rodent carcinogenicity studies","volume":"25","author":"Haseman","year":"1997","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2016.09.016_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/toxsci\/58.1.195","article-title":"The effects of diet, ad libitum feeding, and moderate and severe dietary restriction on body weight, survival, clinical pathology parameters and cause of death in control Sprague-Dawley rats","volume":"58","author":"Hubert","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2016.09.016_bib15","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1095\/biolreprod57.4.894","article-title":"In\u00a0vivo study of prolactin (PRL) intracellular signaling during lactogenesis in the rat: JAK\/STAT pathway is activated by PRL in the mammary gland but not in the liver","volume":"57","author":"Jahn","year":"1997","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.yrtph.2016.09.016_bib16","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J.\u00a0Am. Stat. Assoc."},{"key":"10.1016\/j.yrtph.2016.09.016_bib17","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1177\/019262339402200308","article-title":"The effects of overfeeding and dietary restriction on Sprague-Dawley rat survival and early pathology biomarkers of aging","volume":"22","author":"Keenan","year":"1994","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2016.09.016_bib18","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/019262339502300305","article-title":"Diet, overfeeding and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms","volume":"23","author":"Keenan","year":"1995","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2016.09.016_bib19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/019262339502300306","article-title":"Diet, overfeeding and moderate dietary restriction in control Sprague-Dawley rats: II. Effects on age-related proliferative and degenerative lesions","volume":"23","author":"Keenan","year":"1995","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.yrtph.2016.09.016_bib36","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3109\/08977194.2012.660936","article-title":"Biology and significance of the JAK\/STAT signalling pathways","volume":"30","author":"Kiu","year":"2012","journal-title":"Growth Factors"},{"key":"10.1016\/j.yrtph.2016.09.016_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2012.00069","article-title":"Cytokines and STATs in liver fibrosis","volume":"3","author":"Kong","year":"2012","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.yrtph.2016.09.016_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10543409808835216","article-title":"Overall false positive rates in tests for linear trend in tumor incidence in animal carcinogenicity studies of new drugs","volume":"8","author":"Lin","year":"1998","journal-title":"J.\u00a0Biopharm. Stat."},{"key":"10.1016\/j.yrtph.2016.09.016_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1476-9255-7-41","article-title":"Anti-inflammatory activity and neutrophil reductions mediated by the JAK1\/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis","volume":"7","author":"Meyer","year":"2010","journal-title":"J.\u00a0Inflamm."},{"key":"10.1016\/j.yrtph.2016.09.016_bib23","series-title":"Guide for the Care and Use of Laboratory Animals, Institute of Laboratory Animal Resources","author":"National Research Council","year":"1996"},{"key":"10.1016\/j.yrtph.2016.09.016_bib24","series-title":"Pathology of Laboratory Rodents and Rabbits","author":"Percy","year":"2007"},{"key":"10.1016\/j.yrtph.2016.09.016_bib25","series-title":"Guidelines for Simple, Sensitive Significance Tests for Carcinogenic Effects in Long-term Animal Experiments. In Long-term and Short-term Screening Assays for Carcinogenesis: a Critical Appraisal","first-page":"311","author":"Peto","year":"1980"},{"key":"10.1016\/j.yrtph.2016.09.016_bib26","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.1182\/blood-2009-04-214957","article-title":"Preclinical characterization of the selective JAK 1\/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms","volume":"115","author":"Quint\u00e1s-Cardama","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.yrtph.2016.09.016_bib27","doi-asserted-by":"crossref","first-page":"20059","DOI":"10.1074\/jbc.R700016200","article-title":"JAK-STAT signaling: from interferons to cytokines","volume":"282","author":"Schindler","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.yrtph.2016.09.016_bib28","series-title":"Statistical Methods","first-page":"215","article-title":"One-way classifications; analysis of variance","author":"Snedecor","year":"2007"},{"key":"10.1016\/j.yrtph.2016.09.016_bib29","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3324\/haematol.2015.132142","article-title":"JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications","volume":"100","author":"Springuel","year":"2015","journal-title":"Haematol"},{"key":"10.1016\/j.yrtph.2016.09.016_bib30","series-title":"Principles and Procedures of Statistics, a Biometrical Approach","first-page":"504","author":"Steel","year":"1980"},{"key":"10.1016\/j.yrtph.2016.09.016_bib31","series-title":"The Laboratory Rat","author":"Suckow","year":"2006"},{"key":"10.1016\/j.yrtph.2016.09.016_bib32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/bjc.2015.233","article-title":"The role of JAK\/STAT signaling in the pathogenesis, prognosis and treatment of solid tumors","volume":"113","author":"Thomas","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.yrtph.2016.09.016_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/ror.0.0010001","article-title":"Prolactin signal transduction mechanisms in the mammary gland: the role of the Jak\/Stat pathway","volume":"1","author":"Watson","year":"1996","journal-title":"Rev. Reprod."},{"key":"10.1016\/j.yrtph.2016.09.016_bib34","first-page":"2310","article-title":"Increased incidence of spontaneous mammary tumors in female rats with induced hypothalamic lesions","volume":"30","author":"Welsch","year":"1970","journal-title":"Cancer Res."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230016302641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230016302641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T10:23:56Z","timestamp":1536402236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230016302641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":35,"alternative-id":["S0273230016302641"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2016.09.016","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Results from oral gavage carcinogenicity studies of ruxolitinib in Tg.rasH2 mice and Sprague-Dawley (Crl:CD) rats","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2016.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}