{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:05:04Z","timestamp":1778576704931,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Ministry of Food & Drug Safety of Korea","doi-asserted-by":"crossref","award":["13172MFDS987"],"award-info":[{"award-number":["13172MFDS987"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food & Drug Safety of Korea","doi-asserted-by":"crossref","award":["15181MFDS457"],"award-info":[{"award-number":["15181MFDS457"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003569","name":"Ministry of Food & Drug Safety of Korea","doi-asserted-by":"crossref","award":["16181MFDS386"],"award-info":[{"award-number":["16181MFDS386"]}],"id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.yrtph.2017.02.003","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T23:46:03Z","timestamp":1486770363000},"page":"124-131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Evaluation of radioisotopic and non-radioisotopic versions of local lymph node assays for subcategorization of skin sensitizers compliant to UN GHS rev 4"],"prefix":"10.1016","volume":"85","author":[{"given":"Soojin","family":"Ha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il Young","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-eun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Kwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soojung","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Sook","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Heo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Omori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SeungJin","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung-Min","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2017.02.003_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.yrtph.2016.06.009","article-title":"Performance standard-based validation study for local lymph node assay: 5-bromo-2-deoxyuridine-flow cytometry method","volume":"80","author":"Ahn","year":"2016","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2017.02.003_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2307\/2987937","article-title":"Measurement in medicine: the analysis of method comparison studies","author":"Altman","year":"1983","journal-title":"statistician"},{"key":"10.1016\/j.yrtph.2017.02.003_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yrtph.2007.10.008","article-title":"Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients","volume":"52","author":"Api","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2017.02.003_bib4","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/jat.1684","article-title":"Experience with local lymph node assay performance standards using standard radioactivity and nonradioactive cell count measurements","volume":"32","author":"Basketter","year":"2012","journal-title":"J.\u00a0Appl. Toxicol."},{"key":"10.1016\/j.yrtph.2017.02.003_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/DER.0000000000000003","article-title":"Categorization of chemicals according to their relative human skin sensitizing potency","volume":"25","author":"Basketter","year":"2014","journal-title":"Dermatitis"},{"key":"10.1016\/j.yrtph.2017.02.003_bib6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0278-6915(97)00158-0","article-title":"Strategies for identifying false positive responses in predictive skin sensitization tests","volume":"36","author":"Basketter","year":"1998","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"10.1016\/j.yrtph.2017.02.003_bib35","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0278-6915(99)00112-X","article-title":"Threshold for classification as a skin sensitizer in the local lymph nodeassay: a statistical evaluation","volume":"37","author":"Basketter","year":"1999","journal-title":"Food. Chem. Toxico.l"},{"key":"10.1016\/j.yrtph.2017.02.003_bib7","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"327","author":"Bland","year":"1986","journal-title":"lancet"},{"key":"10.1016\/j.yrtph.2017.02.003_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1600-0536.1986.tb01254.x","article-title":"Dose-response assessments of Kathon biocide. (II). Threshold prophetic patch testing","volume":"15","author":"Cardin","year":"1986","journal-title":"Contact Dermat."},{"key":"10.1016\/j.yrtph.2017.02.003_bib9","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1037\/h0026256","article-title":"Weighted kappa: nominal scale agreement provision for scaled disagreement or partial credit","volume":"70","author":"Cohen","year":"1968","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.yrtph.2017.02.003_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1600-0536.2011.01936.x","article-title":"Allergic contact dermatitis caused by isopropyl alcohol: a missed allergen?","volume":"65","author":"Garc\u00eda-Gav\u00edn","year":"2011","journal-title":"Contact Dermat."},{"key":"10.1016\/j.yrtph.2017.02.003_bib11","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.yrtph.2003.07.001","article-title":"Proposal for a risk assessment methodology for skin sensitization based on sensitization potency data","volume":"38","author":"Griem","year":"2003","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2017.02.003_bib12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1023\/A:1008121125755","article-title":"Estimating the number of viable animal cells in multi-well cultures based on their lactate dehydrogenase activities","volume":"32","author":"Haslam","year":"2000","journal-title":"Cytotechnology"},{"key":"10.1016\/j.yrtph.2017.02.003_bib13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1177\/00220345860650020701","article-title":"Percent agreement, Pearson's correlation, and kappa as measures of inter-examiner reliability","volume":"65","author":"Hunt","year":"1986","journal-title":"J.\u00a0Dent. Res."},{"key":"10.1016\/j.yrtph.2017.02.003_bib14","series-title":"ICCVAM Test Method Evaluation Report on the Murine Local Ylmph Node Assay:BrdU-ELISA","author":"ICCVAM","year":"2010"},{"key":"10.1016\/j.yrtph.2017.02.003_bib15","series-title":"ICCVAM Test Method Evaluation Report on the Murine Local Ylmph Node Assay:DA","author":"ICCVAM","year":"2010"},{"key":"10.1016\/j.yrtph.2017.02.003_bib16","series-title":"Methods","article-title":"ICCVAM Test method evaluation report: usefulness and limitations of the murine local lymph node assay for potency categorization of chemicals causing allergic contact dermatitis in humans","author":"ICCVAM","year":"2011"},{"key":"10.1016\/j.yrtph.2017.02.003_bib36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4062\/biomolther.2015.004","article-title":"Evaluation of Eye Irritation Potential of Solid Substance with New 3D Reconstructed Human Cornea Model, MCTT HCETM","volume":"23","author":"Jang","year":"2015","journal-title":"Biomol. Ther. (Seoul)"},{"key":"10.1016\/j.yrtph.2017.02.003_bib17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.toxlet.2011.12.012","article-title":"B\u00a0cell increases and ex\u00a0vivo IL-2 production as secondary endpoints for the detection of sensitizers in non-radioisotopic local lymph node assay using flow cytometry","volume":"209","author":"Jung","year":"2012","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.yrtph.2017.02.003_bib18","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.toxlet.2009.10.024","article-title":"Comparison of flow cytometry and immunohistochemistry in non-radioisotopic murine lymph node assay using bromodeoxyuridine","volume":"192","author":"Jung","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.yrtph.2017.02.003_bib19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.vascn.2015.12.001","article-title":"Predictive capacity of a non-radioisotopic local lymph node assay using flow cytometry, LLNA: BrdU\u2013FCM: comparison of a cutoff approach and inferential statistics","volume":"78","author":"Kim","year":"2016","journal-title":"J.\u00a0Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.yrtph.2017.02.003_bib20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/jid.1966.160","article-title":"The identification of contact allergens by human assay. 3. The maximization test: a procedure for screening and rating contact sensitizers","volume":"47","author":"Kligman","year":"1966","journal-title":"J.\u00a0Invest. Dermatol"},{"key":"10.1016\/j.yrtph.2017.02.003_bib21","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/jid.1966.159","article-title":"The identification of contact allergens by human assay. II. Factors influencing the induction and measurement of allergic contact dermatitis","volume":"47","author":"Kligman","year":"1966","journal-title":"J.\u00a0Invest. Dermatol"},{"key":"10.1016\/j.yrtph.2017.02.003_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.yrtph.2017.02.003_bib23","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.yrtph.2009.08.016","article-title":"Potency values from the local lymph node assay: application to classification, labelling and risk assessment","volume":"56","author":"Loveless","year":"2010","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2017.02.003_bib24","series-title":"OECD","article-title":"Test No. 406: skin sensitisation","author":"OECD","year":"1992"},{"key":"10.1016\/j.yrtph.2017.02.003_bib25","series-title":"OECD","article-title":"Test No. 429: skin sensitisation: local lymph node assay","author":"OECD","year":"2010"},{"key":"10.1016\/j.yrtph.2017.02.003_bib26","series-title":"OECD","article-title":"Test No. 442B: skin sensitization local lymph node assay: BrdU-ELISA","author":"OECD","year":"2010"},{"key":"10.1016\/j.yrtph.2017.02.003_bib27","series-title":"OECD","article-title":"Test No. 442D: in chemico skin sensitisation: Direct Peptide reactivity assay (DPRA)","author":"OECD","year":"2015"},{"key":"10.1016\/j.yrtph.2017.02.003_bib28","series-title":"OECD","article-title":"Test No. 442D: in\u00a0vitro skin sensitisation: ARE-Nrf2 luciferase test method","author":"OECD","year":"2015"},{"key":"10.1016\/j.yrtph.2017.02.003_bib37","first-page":"259","article-title":"Fragrance raw materials monographs","volume":"17","author":"Opdyke","year":"1979","journal-title":"Citral. Food Chem Toxicol"},{"key":"10.1016\/j.yrtph.2017.02.003_bib38","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5487\/TR.2016.32.2.159","article-title":"Oral Toxicity Study and Skin Sensitization Test of a Cricket","volume":"32","author":"Ryu","year":"2016","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.yrtph.2017.02.003_bib29","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/ni.1919","article-title":"Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel","volume":"11","author":"Schmidt","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yrtph.2017.02.003_bib30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yrtph.2004.02.002","article-title":"Quantitative relationship between the local lymph node assay and human skin sensitization assays","volume":"39","author":"Schneider","year":"2004","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2017.02.003_bib31","unstructured":"United_Nations, Globally Harmonized System of Classification and Labelling of Chemicals (GHS). In: of, S.-C. o. E. o. t. G. H. S. o. C. a. L., Chemicals, (Eds.). United Nations, New York and GENEVA, 2003."},{"key":"10.1016\/j.yrtph.2017.02.003_bib32","unstructured":"United_Nations, Globally Harmonized System of Classification and Labelling of Chemicals (GHS) rev. 3. In: of, S.-C. o. E. o. t. G. H. S. o. C. a. L., Chemicals, (Eds.). United Nations, New York and GENEVA, 2009."},{"key":"10.1016\/j.yrtph.2017.02.003_bib33","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.toxlet.2015.02.014","article-title":"Appraisal of within- and between-laboratory reproducibility of non-radioisotopic local lymph node assay using flow cytometry, LLNA: BrdU-FCM: comparison of OECD TG429 performance standard and statistical evaluation","volume":"234","author":"Yang","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.yrtph.2017.02.003_bib34","doi-asserted-by":"crossref","first-page":"e37908","DOI":"10.1371\/journal.pone.0037908","article-title":"Statistical methods used to test for agreement of medical instruments measuring continuous variables in method comparison studies: a systematic review","volume":"7","author":"Zaki","year":"2012","journal-title":"PLoS One"}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230017300247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230017300247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T10:57:24Z","timestamp":1536058644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230017300247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":38,"alternative-id":["S0273230017300247"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2017.02.003","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of radioisotopic and non-radioisotopic versions of local lymph node assays for subcategorization of skin sensitizers compliant to UN GHS rev 4","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2017.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}