{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:26:04Z","timestamp":1789593964369,"version":"build-2803163510"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202991"],"award-info":[{"award-number":["81202991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["816738261"],"award-info":[{"award-number":["816738261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703790"],"award-info":[{"award-number":["81703790"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.yrtph.2019.01.010","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T01:13:05Z","timestamp":1546996385000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Isopsoralen induces different subchronic toxicities and metabolomic outcomes between male and female Wistar rats"],"prefix":"10.1016","volume":"103","author":[{"given":"Yue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-mei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-miao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-nan","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-ling","family":"Pu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-yang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-kang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-xing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2607-8052","authenticated-orcid":false,"given":"Kun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2019.01.010_bib1","first-page":"304","article-title":"Phenylketonuria: a review of current and future treatments","volume":"4","author":"AI Hafid","year":"2015","journal-title":"Transl. Pediatr."},{"issue":"6","key":"10.1016\/j.yrtph.2019.01.010_bib2","first-page":"949","article-title":"Toxicological evaluation of the aqueous extract of Felicia muricata Thunb. leaves in Wistar rats","volume":"8","author":"AOT Ashafa","year":"2009","journal-title":"Afr. J. Biotechnol."},{"key":"10.1016\/j.yrtph.2019.01.010_bib3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1080\/15563650903059136","article-title":"Liver injury associated with the use of Fructus Psoraleae (Bol-gol-zhee or Bu-gu-zhi) and its related proprietary medicine","volume":"47","author":"Cheung","year":"2009","journal-title":"Clin. Toxicol."},{"issue":"3","key":"10.1016\/j.yrtph.2019.01.010_bib4","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1440-1746.2008.05310.x","article-title":"Hepatotoxic slimming aids and other herbal hepatotoxins","volume":"23","author":"Chitturi","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.yrtph.2019.01.010_bib5","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1023\/B:AQUI.0000013322.53358.53","article-title":"Influence of the antibacterial herbs, Solanum trilobatum, Andrographis paniculata and Psoralea corylifolia on the survival, growth and bacterial load of Penaeus monodon post larvae","volume":"11","author":"Citarasu","year":"2003","journal-title":"Aquacult. Int. : journal of the European Aquaculture Society"},{"key":"10.1016\/j.yrtph.2019.01.010_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.arteri.2013.10.008","article-title":"Mecanismos b\u00e1sicos. Absorci\u00f3n y excreci\u00f3n de colesterol y otros esteroles","volume":"26","author":"Cofan Pujol","year":"2014","journal-title":"Cl\u00edn. Invest. Arterioscler."},{"key":"10.1016\/j.yrtph.2019.01.010_bib7","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/490462a","article-title":"Toxicology: the learning curve","volume":"490","author":"Fagin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.yrtph.2019.01.010_bib8","first-page":"38","article-title":"Mitochondrial proteomic analysis of ecdysterone protection against oxidative damage in human lens epithelial cells","volume":"7","author":"Feng","year":"2014","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.yrtph.2019.01.010_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.envres.2005.12.005","article-title":"Framework for gender differences in human and animal toxicology","volume":"104","author":"Gochfeld","year":"2007","journal-title":"Environ. Res."},{"key":"10.1016\/j.yrtph.2019.01.010_bib10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/ptr.972","article-title":"Antioxidative components of Psoralea corylifolia (leguminosae) phytotherapy research volume 16, issue 6","volume":"16","author":"Haraguchi","year":"2002","journal-title":"Phytother Res."},{"key":"10.1016\/j.yrtph.2019.01.010_bib11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.fitote.2003.12.018","article-title":"Antibacterial compounds from the seeds of Psoralea corylifolia","volume":"75","author":"Khatune","year":"2004","journal-title":"Fitoterapia"},{"key":"10.1016\/j.yrtph.2019.01.010_bib12","first-page":"1","article-title":"Observational studies on evaluating the safety and adverse effects of traditional Chinese medicine","volume":"2013","author":"Lai","year":"2013","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.yrtph.2019.01.010_bib13","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1017\/S0007114508066750","article-title":"Ethanol extract of Psoralea corylifolia L. and its main constituent, bakuchiol, reduce bone loss in ovariectomised Sprague-Dawley rats","volume":"101","author":"Lim","year":"2009","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.yrtph.2019.01.010_bib14","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF02978259","article-title":"Cytotoxic constituents of Psoralea corylifolia","volume":"24","author":"Mar","year":"2001","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.yrtph.2019.01.010_bib15","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3109\/03602539808996322","article-title":"Sex-dependent metabolism of xenobiotics","volume":"30","author":"Mugford","year":"1998","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.yrtph.2019.01.010_bib16","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1081\/CLT-200068863","article-title":"A case of acute cholestatic hepatitis associated with the seeds of Psoralea corylifolia (Boh-Gol-Zhee)","volume":"43","author":"Nam","year":"2005","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.yrtph.2019.01.010_bib17","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/004982599238047","article-title":"'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data","volume":"29","author":"Nicholson","year":"1999","journal-title":"Xenobiotica; the fate of foreign compounds in biological systems"},{"key":"10.1016\/j.yrtph.2019.01.010_bib18","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrd1157","article-title":"Understanding 'global' systems biology: metabonomics and the continuum of metabolism","volume":"2","author":"Nicholson","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.yrtph.2019.01.010_bib19","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","article-title":"The current state of serum biomarkers of hepatotoxicity","volume":"245","author":"Ozer","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2019.01.010_bib20","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1002\/mrc.2461","article-title":"NMR metabolomics and drug discovery","volume":"47","author":"Powers","year":"2009","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.yrtph.2019.01.010_bib21","first-page":"836","article-title":"Toxicological and phytochemical studies of Aspidosperma subincanum Mart. stem bark (Guatambu)","volume":"64","author":"Santos","year":"2009","journal-title":"Pharmazie"},{"key":"10.1016\/j.yrtph.2019.01.010_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jchromb.2015.05.003","article-title":"Application of GC\/MS-based metabonomic profiling in studying the therapeutic effects of Huangbai\u2013Zhimu herb-pair (HZ) extract on streptozotocin-induced type 2 diabetes in mice","volume":"997","author":"Song","year":"2015","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.yrtph.2019.01.010_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ab.2005.01.024","article-title":"Sexual dimorphism in urinary metabolite profiles of Han Wistar rats revealed by nuclear-magnetic-resonance-based metabonomics","volume":"343","author":"Stanley","year":"2005","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.yrtph.2019.01.010_bib24","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.freeradbiomed.2004.03.017","article-title":"Characterization of antioxidant and antiglycation properties and isolation of active ingredients from traditional Chinese medicines","volume":"36","author":"Tang","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yrtph.2019.01.010_bib25","first-page":"989","article-title":"Safety assessment of hydroethanolic rambutan rind extract: acute and sub-chronic toxicity studies","volume":"52","author":"Thinkratok","year":"2014","journal-title":"Indian J. Exp. Biol."},{"key":"10.1016\/j.yrtph.2019.01.010_bib26","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1142\/S0192415X07005168","article-title":"Psoralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats","volume":"35","author":"Tsai","year":"2007","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.yrtph.2019.01.010_bib27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jep.2012.08.028","article-title":"Evaluation of hepatotoxicity and cholestasis in rats treated with EtOH extract of Fructus Psoraleae","volume":"144","author":"Wang","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.yrtph.2019.01.010_bib28","first-page":"210","article-title":"Urine metabonomic study for blood-replenishing mechanism of Angelica sinensis in a blood-deficient mouse model","volume":"14","author":"Wang","year":"2016","journal-title":"Chin. J. Nat. Med."},{"key":"10.1016\/j.yrtph.2019.01.010_bib29","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00726-013-1493-1","article-title":"Glycine metabolism in animals and humans: implications for nutrition and health","volume":"45","author":"Wang","year":"2013","journal-title":"Amino Acids"},{"key":"10.1016\/j.yrtph.2019.01.010_bib30","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1074\/mcp.M111.016006","article-title":"Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease","volume":"11","author":"Wang","year":"2012","journal-title":"Mol. Cell. Proteomics : MCP."},{"key":"10.1016\/j.yrtph.2019.01.010_bib31","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jep.2013.11.013","article-title":"A UPLC\u2013MS\/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract","volume":"151","author":"Wang","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.yrtph.2019.01.010_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ecam\/nen087","article-title":"Screening antitumor compounds psoralen and isopsoralen fromPsoralea corylifoliaL. Seeds","volume":"2011","author":"Wang","year":"2011","journal-title":"Evid. Based Complement Altern. Med."},{"key":"10.1016\/j.yrtph.2019.01.010_bib33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/mgme.2000.2965","article-title":"Characterization of phenylketonuria missense substitutions, distant from the phenylalanine hydroxylase active site, illustrates a paradigm for mechanism and potential modulation of phenotype","volume":"69","author":"Waters","year":"2000","journal-title":"Mol. Genet. Metabol."},{"key":"10.1016\/j.yrtph.2019.01.010_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00726-009-0269-0","article-title":"Amino acids: metabolism, functions, and nutrition","volume":"37","author":"Wu","year":"2009","journal-title":"Amino Acids"},{"key":"10.1016\/j.yrtph.2019.01.010_bib35","doi-asserted-by":"crossref","first-page":"6869452","DOI":"10.1155\/2016\/6869452","article-title":"Psoralen and isopsoralen ameliorate sex hormone deficiency-induced osteoporosis in female and male mice","volume":"2016","author":"Yuan","year":"2016","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.yrtph.2019.01.010_bib36","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1055\/s-0030-1250542","article-title":"Metabolomics: towards understanding traditional Chinese medicine","volume":"76","author":"Zhang","year":"2010","journal-title":"Planta Med."},{"key":"10.1016\/j.yrtph.2019.01.010_bib37","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jep.2005.01.033","article-title":"In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms","volume":"98","author":"Zhang","year":"2005","journal-title":"J. Ethnopharmacol."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230019300108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230019300108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T21:53:31Z","timestamp":1720907611000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230019300108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":37,"alternative-id":["S0273230019300108"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2019.01.010","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Isopsoralen induces different subchronic toxicities and metabolomic outcomes between male and female Wistar rats","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2019.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}