{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T02:40:40Z","timestamp":1767148840953,"version":"build-2238731810"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"EnviroTech International, Melrose Park, Illinois, USA"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.yrtph.2019.01.034","type":"journal-article","created":{"date-parts":[[2019,2,16]],"date-time":"2019-02-16T02:27:20Z","timestamp":1550284040000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["28-Day somatic gene mutation study of 1-bromopropane in female Big Blue\u00ae B6C3F1 mice via whole-body inhalation: Support for a carcinogenic threshold"],"prefix":"10.1016","volume":"104","author":[{"given":"Mark","family":"Stelljes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2019.01.034_bib1","series-title":"RecoverEaseTM DNA Isolation Kit, Instruction Manual","author":"Agilent Technologies","year":"2009"},{"key":"10.1016\/j.yrtph.2019.01.034_bib2","series-title":"\u03bb Select-cII Mutation Detection System for Big Blue\u00ae Rodents, Instruction Manual","author":"Agilent Technologies","year":"2009"},{"key":"10.1016\/j.yrtph.2019.01.034_bib3","series-title":"Transpack Packaging Extract for Lambda Transgenic Shuttle Vector Recovery","author":"Agilent Technologies","year":"2009"},{"key":"10.1016\/j.yrtph.2019.01.034_bib4","series-title":"Draft Toxicological Profile for 1-Bromopropane","author":"Agency for Toxic Substances and Disease Registry (ATSDR)","year":"2016"},{"issue":"1","key":"10.1016\/j.yrtph.2019.01.034_bib5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0165-1218(81)90048-3","article-title":"A procedure for the quantitative measurement of the mutagenicity of volatile liquids in the Ames Salmonella\/microsome assay","volume":"90","author":"Barber","year":"1981","journal-title":"Mutat. Res."},{"issue":"1","key":"10.1016\/j.yrtph.2019.01.034_bib6","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1042\/bj1000282","article-title":"Biochemical studies of toxic agents. The metabolism of 1- and 2-bromopropane in rats","volume":"100","author":"Barnsley","year":"1966","journal-title":"Biochem. J."},{"key":"10.1016\/j.yrtph.2019.01.034_bib7","series-title":"Ames Test\u2014Reverse Mutation Assay on Salmonella typhimurium. N-Propyl Bromide. HIS1005\/1005A. Study Performed by Sanofi Recherche","author":"Elf Atochem","year":"1994"},{"key":"10.1016\/j.yrtph.2019.01.034_bib8","series-title":"Micronucleus Test by Intraperitoneal Route in Mice. N-Propyl Bromide. Study No. 12122 MAS","author":"Elf Atochem","year":"1995"},{"key":"10.1016\/j.yrtph.2019.01.034_bib9","series-title":"In Vitro Mammalian Cell Gene Mutation Test in L5178Y TK+\/- Mouse Lymphoma Cells of N-Propyl Bromide. Study No. 13293","author":"Elf Atochem","year":"1996"},{"issue":"1","key":"10.1016\/j.yrtph.2019.01.034_bib10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.taap.2006.01.010","article-title":"Metabolism and disposition of 1-bromopropane in rats and mice following inhalation or intravenous administration","volume":"215","author":"Garner","year":"2006","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.yrtph.2019.01.034_bib11","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1095\/biolreprod.106.055004","article-title":"CYP2E1-Catalyzed oxidation contributes to the sperm toxicity of 1-bromopropane in mice","volume":"76","author":"Garner","year":"2006","journal-title":"Biol. Reprod."},{"issue":"7","key":"10.1016\/j.yrtph.2019.01.034_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/0748233706070312","article-title":"Toxicological assessment of industrial solvents using human cell bioassays: assessment of short-term cytotoxicity and long-term genotoxicity potential","volume":"22","author":"Hasspieler","year":"2006","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.yrtph.2019.01.034_bib13","doi-asserted-by":"crossref","DOI":"10.1093\/toxsci\/54.2.416","article-title":"Reproductive toxicity of 1-bromopropane, a newly introduced alternative to ozone layer depleting solvents, in male rats","volume":"54","author":"Ichihara","year":"2000","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.yrtph.2019.01.034_bib14","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/toxsci\/55.1.116","article-title":"1-Bromopropane, an alternative to ozone layer depleting solvents, is dose-dependently neurotoxic to rats in long-term inhalation exposure","volume":"55","author":"Ichihara","year":"2000","journal-title":"Toxicol. Sci."},{"issue":"1","key":"10.1016\/j.yrtph.2019.01.034_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1539\/joh.44.1","article-title":"Neurological disorders in three workers exposed to 1-bromopropane","volume":"44","author":"Ichihara","year":"2002","journal-title":"J. Occup. Health"},{"issue":"17","key":"10.1016\/j.yrtph.2019.01.034_bib16","doi-asserted-by":"crossref","first-page":"9073","DOI":"10.1073\/pnas.93.17.9073","article-title":"Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target","volume":"93","author":"Jakubczak","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.yrtph.2019.01.034_bib17","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3109\/00498257909042344","article-title":"The oxidative metabolism of 1-bromopropane in the rat","volume":"9","author":"Jones","year":"1979","journal-title":"Xenobiotica"},{"issue":"1","key":"10.1016\/j.yrtph.2019.01.034_bib18","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/0006-291X(91)91389-T","article-title":"1-Bromoalkanes as new potent nontoxic glutathione depletors in isolated rat hepatocytes","volume":"179","author":"Khan","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yrtph.2019.01.034_bib19","series-title":"Toxicological Studies on Inhalation of 1 Bromopropane Using Rats. Report Submitted to the Industrial Health Research Institute\u2014Korea Industrial Safety Corporation","author":"Kim","year":"1998"},{"issue":"2","key":"10.1016\/j.yrtph.2019.01.034_bib20","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1093\/toxsci\/kfq075","article-title":"Increased susceptibility of nrf2-null mice to 1-bromopropane\u2013induced hepatotoxicity","volume":"115","author":"Liu","year":"2010","journal-title":"Toxicol. Sci."},{"issue":"3","key":"10.1016\/j.yrtph.2019.01.034_bib21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1080\/15563650701226218","article-title":"Severe neurotoxicity associated with exposure to the solvent 1-bromopropane (n-Propyl bromide)","volume":"45","author":"Majersik","year":"2007","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.yrtph.2019.01.034_bib22","first-page":"1300","article-title":"Neurologic illness associated with occupational exposure to the solvent 1-bromopropane \u2013 New Jersey and Pennsylvania, 2007-2008","volume":"57","author":"MMWR","year":"2008","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.yrtph.2019.01.034_bib23","series-title":"Criteria for a Recommended Standard: Occupational Exposure to 1-Bromopropane","author":"National Institute of Occupational Safety and Health (NIOSH)","year":"2016"},{"key":"10.1016\/j.yrtph.2019.01.034_bib24","series-title":"NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of 1-Bromopropane","author":"National Toxicology Program (NTP)","year":"2003"},{"key":"10.1016\/j.yrtph.2019.01.034_bib25","series-title":"NTP Technical Report on the Toxicology and Carcinogenesis Studies of 1-Bromopropane in F344\/N Rats and B6C3F1 Mice. NTP TR 564","author":"National Toxicology Program (NTP)","year":"2011"},{"key":"10.1016\/j.yrtph.2019.01.034_bib26","series-title":"Report on Carcinogens: Monograph on 1-Bromopropane","author":"National Toxicology Program (NTP)","year":"2014"},{"key":"10.1016\/j.yrtph.2019.01.034_bib27","series-title":"OECD Guidelines for Testing of Chemicals Test Guideline 488, - Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays, Adopted 26 July 2013","author":"Organisation of Economic Co-operation and Development (OECD)","year":"2013"},{"issue":"9","key":"10.1016\/j.yrtph.2019.01.034_bib28","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1097\/JOM.0b013e318145b616","article-title":"Severe illness in furniture makers using a new glue: 1-bromopropane toxicity confounded by arsenic","volume":"49","author":"Raymond","year":"2007","journal-title":"J. Occup. Environ. Med."},{"issue":"4","key":"10.1016\/j.yrtph.2019.01.034_bib29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0165-1218(82)90125-2","article-title":"Dominant lethal studies in rats with 1,2 dibromo-3-chloropropane and its structurally related compounds","volume":"101","author":"Saito-Suzuki","year":"1982","journal-title":"Mutat. Res."},{"issue":"1","key":"10.1016\/j.yrtph.2019.01.034_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2005.08.015","article-title":"DNA damage in leukocytes of workers occupationally exposed to 1-bromopropane","volume":"603","author":"Toraason","year":"2006","journal-title":"Mutat. Res."},{"key":"10.1016\/j.yrtph.2019.01.034_bib31","series-title":"Guidelines for Carcinogen Risk Assessment. EPA\/630\/P-03\/001F. March","author":"United States Environmental Protection Agency (USEPA)","year":"2005"},{"key":"10.1016\/j.yrtph.2019.01.034_bib32","series-title":"Integrated Risk Information System","author":"U.S. Environmental Protection Agency (USEPA)","year":"2018"},{"key":"10.1016\/j.yrtph.2019.01.034_bib33","series-title":"An Inhalation Two-Generation Reproductive Toxicity Study of 1-Bromopropane in Rats. Study No. WIL-380001","author":"WIL Research Laboratories, Inc. (WIL)","year":"2001"},{"issue":"1","key":"10.1016\/j.yrtph.2019.01.034_bib34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mrgentox.2008.01.001","article-title":"Lack of dominant lethality in mice following 1-bromopropane treatment","volume":"652","author":"Yu","year":"2008","journal-title":"Mutat. Res."}],"updated-by":[{"DOI":"10.1016\/j.yrtph.2020.104814","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000}}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027323001930042X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S027323001930042X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T10:07:04Z","timestamp":1555322824000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S027323001930042X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":34,"alternative-id":["S027323001930042X"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2019.01.034","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"28-Day somatic gene mutation study of 1-bromopropane in female Big Blue\u00ae B6C3F1 mice via whole-body inhalation: Support for a carcinogenic threshold","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2019.01.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}