{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:26:49Z","timestamp":1786998409394,"version":"build-2736575974"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["88881.119817\/2016-01"],"award-info":[{"award-number":["88881.119817\/2016-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006162","name":"FACEPE","doi-asserted-by":"crossref","award":["BFP-0017-5.05\/18"],"award-info":[{"award-number":["BFP-0017-5.05\/18"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006162","name":"FACEPE","doi-asserted-by":"crossref","award":["BFP-0004-4.03\/16"],"award-info":[{"award-number":["BFP-0004-4.03\/16"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["427153\/2016-6"],"award-info":[{"award-number":["427153\/2016-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.yrtph.2019.02.009","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T11:28:52Z","timestamp":1550489332000},"page":"282-291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Effect of acute exposure in swiss mice (Mus musculus) to a fibrinolytic protease produced by Mucor subtilissimus UCP 1262: An histomorphometric, genotoxic and cytological approach"],"prefix":"10.1016","volume":"103","author":[{"given":"Marllyn Marques","family":"da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamiris Alves","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Feij\u00f3","family":"de Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano Aparecido","family":"Chagas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Carlos Amanaj\u00e1s","family":"de Aguiar J\u00fanior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00eamia Pereira","family":"da Silva Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Vit\u00f3ria","family":"Da Silva Sobral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Miranda","family":"do Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9346-2292","authenticated-orcid":false,"given":"Ana Cristina","family":"Lima Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Pastrana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romero Marcos Pedrosa Brand\u00e3o","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Paje\u00fa","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1571-8897","authenticated-orcid":false,"given":"Ana L\u00facia Figueiredo","family":"Porto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2019.02.009_bib1","first-page":"968","article-title":"Major bleeding risk during anticoagulation with Warfarin, dabigatran, apixaban, or rivaroxaban in patients with nonvalvular atrial fibrillation","volume":"23","author":"Adeboyeje","year":"2017","journal-title":"J. Manag. Care Spec. Pharm."},{"key":"10.1016\/j.yrtph.2019.02.009_bib2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1590\/S1517-83822002000400009","article-title":"Screening of Mucor spp. for the production of amylase, lipase, polygalacturonase and protease","volume":"33","author":"Alves","year":"2002","journal-title":"Braz. J. Microbiol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1130-1406(05)70020-6","article-title":"Detection of extracellular protease in Mucor species","volume":"22","author":"Alves","year":"2005","journal-title":"Rev. Iberoam. De. Micol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib4","series-title":"Evaluation of the Bleeding Intensity of Patients Anticoagulated with Warfarin or Dabigatran Undergoing Dental Procedures","author":"Andrade","year":"2018"},{"key":"10.1016\/j.yrtph.2019.02.009_bib5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1590\/S0066-782X2005002400007","article-title":"Mecanismos de hepatotoxicidade Mechanisms of hepatotoxicity","volume":"85","author":"Bertolami","year":"2005","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3747\/co.22.2392","article-title":"Clinical challenges in patients with cancer-associated thrombosis: Canadian expert consensus recommendations","volume":"22","author":"Carrier","year":"2015","journal-title":"Curr. Oncol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib7","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.1016\/j.biortech.2010.02.048","article-title":"Biochemical and enzymatic properties of a fibrinolytic enzyme from Pleurotus eryngii cultivated under solid-state conditions using corn cob","volume":"101","author":"Cha","year":"2010","journal-title":"Bioresour. Technol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib8","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1046\/j.1538-7836.2003.00101.x","article-title":"Assessment of recombinant factor VIIa as an antidote for bleeding induced in the rabbit by low molecular weight heparin","volume":"1","author":"Chan","year":"2003","journal-title":"J. Thromb. Haemostasis"},{"key":"10.1016\/j.yrtph.2019.02.009_bib9","first-page":"6909","article-title":"Vibrio vulnificus","volume":"187","author":"Chang","year":"2005","journal-title":"Society"},{"key":"10.1016\/j.yrtph.2019.02.009_bib11","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.ijbiomac.2017.06.025","article-title":"Purification and partial characterization of a low molecular fibrinolytic serine metalloprotease C142 from the culture supernatant of Bacillus subtilis C142","volume":"104","author":"Choi","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib12","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.biochi.2013.01.023","article-title":"Thrombolytic, anticoagulant and antiplatelet activities of codiase, a bi-functional fibrinolytic enzyme from Codium fragile","volume":"95","author":"Choi","year":"2013","journal-title":"Biochimie"},{"key":"10.1016\/j.yrtph.2019.02.009_bib13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/mutage\/gem051","article-title":"The comet assay: topical issues","volume":"23","author":"Collins","year":"2008","journal-title":"Mutagenesis"},{"key":"10.1016\/j.yrtph.2019.02.009_bib15","first-page":"640","article-title":"Purification and functional characterization of two","volume":"13","author":"Costa","year":"2007","journal-title":"Venom. anim. Toxins"},{"key":"10.1016\/j.yrtph.2019.02.009_bib16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1590\/S1415-52732009000400005","article-title":"Efeito da suplementa\u00e7\u00e3o com\u202f\u00e1cido linol\u00e9ico conjugado e do treinamento em nata\u00e7\u00e3o sobre a composi\u00e7\u00e3o corporal e os par\u00e2metros bioqu\u00edmicos de ratos Wistar em crescimento","volume":"22","author":"de Aquino Junior","year":"2009","journal-title":"Rev. Nutr."},{"key":"10.1016\/j.yrtph.2019.02.009_bib17","first-page":"2255","article-title":"Poly-l-lysine inhibits tumor angiogenesis and induces apoptosis in ehrlich ascites carcinoma and in sarcoma S-180 tumor","volume":"18","author":"Debnath","year":"2017","journal-title":"Asian Pac. Organ. Canc. Prev."},{"key":"10.1016\/j.yrtph.2019.02.009_bib18","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.ijbiomac.2017.11.142","article-title":"A dual-function chymotrypsin-like serine protease with plasminogen activation and fibrinolytic activities from the GRAS fungus, Neurospora sitophila","volume":"109","author":"Deng","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib19","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1021\/nl0805615","article-title":"Method for analysis of nanoparticle heolytic properties in vitro","volume":"8","author":"Dobrovolskaia","year":"2008","journal-title":"Nano Lett."},{"key":"10.1016\/j.yrtph.2019.02.009_bib20","first-page":"4","article-title":"Hepatotoxicity upon using niacin to pass a drug test: a case report","author":"Durham","year":"2018","journal-title":"J. Am. Pharmaceut. Assoc."},{"key":"10.1016\/j.yrtph.2019.02.009_bib21","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ajps.2017.11.001","article-title":"Preparation and toxicity evaluation of a novel nattokinase-tauroursodeoxycholate complex","volume":"13","author":"Feng","year":"2018","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.yrtph.2019.02.009_bib22","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0141-0229(02)00283-1","article-title":"Characterization and stability of proteases from Penicillium sp. produced by solid-state fermentation","volume":"32","author":"Germano","year":"2003","journal-title":"Enzym. Microb. Technol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib23","series-title":"Guidelines for the Use of Animals in Biomedical Research. Thrombosis and Ha6emostasis - @ F. K. SchattauerVerlagsgesellschaft mbH","first-page":"1078","volume":"vol. 58","author":"Giles","year":"1987"},{"key":"10.1016\/j.yrtph.2019.02.009_bib24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.toxicon.2013.07.025","article-title":"Functional characterization of fibrinolytic metalloproteinases (colombienases) isolated from Bothrops colombiensis venom","volume":"74","author":"Gir\u00f3n","year":"2013","journal-title":"Toxicon"},{"key":"10.1016\/j.yrtph.2019.02.009_bib25","first-page":"19","article-title":"Hemorragia cerebral en pacientes en tratamiento con anticoagulantes orales","volume":"40","author":"Gonz\u00e1lez","year":"2005","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mrgentox.2006.08.010","article-title":"In vivo erythrocyte micronucleus assay","volume":"627","author":"Hayashi","year":"2007","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.yrtph.2019.02.009_bib28","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1590\/S0104-42302000000300010","article-title":"Regenera\u00e7\u00e3o hep\u00e1tica: papel dos fatores de crescimento e nutrientes","volume":"46","author":"Jesus","year":"2000","journal-title":"Rev. Assoc. M\u00e9d. Bras."},{"key":"10.1016\/j.yrtph.2019.02.009_bib29","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.procbio.2011.04.005","article-title":"Purification and characterization of a novel, highly potent fibrinolytic enzyme from Paecilomyces tenuipes","volume":"46","author":"Kim","year":"2011","journal-title":"Process Biochem."},{"key":"10.1016\/j.yrtph.2019.02.009_bib30","first-page":"622","article-title":"A fibrinolytic enzyme from the medicinal mushroom Cordyceps militaris","volume":"44","author":"Kim","year":"2006","journal-title":"J. Microbiol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.yrtph.2016.12.003","article-title":"Comparative subcutaneous repeated toxicity study of enoxaparin products in rats","volume":"84","author":"Kobbi","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib32","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mrgentox.2006.03.002","article-title":"Reliable Comet assay measurements for detecting DNA damage induced by ionising radiation and chemicals","volume":"605","author":"Kumaravel","year":"2006","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"key":"10.1016\/j.yrtph.2019.02.009_bib33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.fct.2015.12.025","article-title":"Toxicological assessment of nattokinase derived from Bacillus subtilis var. natto","volume":"88","author":"Lampe","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib34","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.molcatb.2016.10.006","article-title":"Purification and characterization of a fibrinolytic enzyme from the food-grade fungus, Neurospora sitophila","volume":"134","author":"Liu","year":"2016","journal-title":"J. Mol. Catal. B Enzym."},{"key":"10.1016\/j.yrtph.2019.02.009_bib35","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.ijbiomac.2016.09.048","article-title":"Biochemical characterization of a novel fibrinolytic enzyme from Cordyceps militaris","volume":"94","author":"Liu","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib36","first-page":"63","volume":"vol. 3","author":"Mallick","year":"2015"},{"key":"10.1016\/j.yrtph.2019.02.009_bib37","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1590\/0001-3765201720160650","article-title":"Hepatic toxicity caused by PLGA-microspheres containing usnic acid from the lichen Cladonia substellata (AHTI) during pregnancy in Wistar rats","volume":"89","author":"Marinho","year":"2017","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.yrtph.2019.02.009_bib38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.pharep.2015.04.010","article-title":"Liver sinusoidal endothelial cells (LSECs) function and NAFLD; NO-based therapy targeted to the liver","volume":"67","author":"Maslak","year":"2015","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.yrtph.2019.02.009_bib39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.32635\/2176-9745.RBC.2007v53n2.1814","article-title":"C\u00e2ncer e trombose: uma revis\u00e3o da literatura Cancer and thrombosis\u202f: a literature review","volume":"53","author":"Meis","year":"2007","journal-title":"Revista Brasileira de Cancerologia"},{"key":"10.1016\/j.yrtph.2019.02.009_bib40","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jbiosc.2013.10.019","article-title":"Purification and characterization of a novel fibrinolytic \u03b1 chymotrypsin like serine metalloprotease from the edible mushroom, Lyophyllum shimeji","volume":"117","author":"Moon","year":"2014","journal-title":"J. Biosci. Bioeng."},{"key":"10.1016\/j.yrtph.2019.02.009_bib41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.yrtph.2019.02.009_bib42","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.toxicon.2007.12.008","article-title":"Characterization of a novel pro-coagulant metalloprotease (RVBCMP) possessing \u03b1-fibrinogenase and tissue haemorrhagic activity from venom of Daboia russelli russelli (Russell's viper): evidence of distinct coagulant and haemorrhagic sites in RVBCMP","volume":"51","author":"Mukherjee","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.yrtph.2019.02.009_bib43","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.biochi.2012.02.027","article-title":"Bafibrinase: a non-toxic, non-hemorrhagic, direct-acting fibrinolytic serine protease from Bacillus sp. strain AS-S20-I exhibits in vivo anticoagulant activity and thrombolytic potency","volume":"94","author":"Mukherjee","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.yrtph.2019.02.009_bib44","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jchromb.2016.04.046","article-title":"Purification of a fibrinolytic protease from Mucor subtilissimus UCP 1262 by aqueous two-phase systems (PEG\/sulfate)","volume":"1025","author":"Nascimento","year":"2016","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.yrtph.2019.02.009_bib45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4236\/aer.2015.33009","article-title":"Production and characterization of new fibrinolytic protease from mucor subtillissimus UCP 1262 in solid-state fermentation","volume":"3","author":"Nascimento","year":"2015","journal-title":"Adv. Enzym. Res."},{"key":"10.1016\/j.yrtph.2019.02.009_bib46","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00449-017-1781-3","article-title":"Purification, biochemical, and structural characterization of a novel fibrinolytic enzyme from Mucor subtilissimus UCP 1262","volume":"40","author":"Nascimento","year":"2017","journal-title":"Bioproc. Biosyst. Eng."},{"key":"10.1016\/j.yrtph.2019.02.009_bib47","series-title":"OECD Guideline for Testing of Chemicals, Test N\u00ba 423: Acute Oral Toxicity, Acute Toxic Class Method","author":"OECD (Organisation for Economic Co-operation and Development)","year":"2001"},{"key":"10.1016\/j.yrtph.2019.02.009_bib48","series-title":"Guidelines for the Testing of Chemicals, Test N\u00ba 474: Mammalian Erytrocyte Micronucleus Test","author":"OECD (Organisation for Economic Co-operation and Development)","year":"2014"},{"key":"10.1016\/j.yrtph.2019.02.009_bib49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.11.021","article-title":"The current state of serum biomarkers of hepatotoxicity","volume":"245","author":"Ozer","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2019.02.009_bib50","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1590\/S1414-81452007000100006","article-title":"Clientes com doen\u00e7a renal cr\u00f4nica: avalia\u00e7\u00e3o de enfermagem sobre a compet\u00eancia para o autocuidado","volume":"11","author":"Pacheco","year":"2007","journal-title":"Escola Anna Nery"},{"key":"10.1016\/j.yrtph.2019.02.009_bib51","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.rbr.2017.01.002","article-title":"Relapsing polychondritis: prevalence of cardiovascular diseases and its risk factors, and general disease features according to gender","volume":"57","author":"Pallo","year":"2017","journal-title":"Rev. Bras. Reumatol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib52","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.procbio.2013.03.017","article-title":"Purification and characterization of three thermostable alkaline fibrinolytic serine proteases from the polychaete Cirriformia tentaculata","volume":"48","author":"Park","year":"2013","journal-title":"Process Biochem."},{"key":"10.1016\/j.yrtph.2019.02.009_bib53","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41569-018-0080-2","article-title":"Prevention of atherothrombotic events in patients with diabetes mellitus: from antithrombotic therapies to new-generation glucose-lowering drugs","volume":"16","author":"Patti","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib54","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.thromres.2004.01.012","article-title":"Lonofibrase, a novel \u03b1-fibrinogenase from Lonomia obliqua caterpillars","volume":"113","author":"Pinto","year":"2004","journal-title":"Thromb. Res."},{"key":"10.1016\/j.yrtph.2019.02.009_bib55","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.colsurfb.2017.05.052","article-title":"Evaluation of cytotoxicity of hematite nanoparticles in bacteria and human cell lines","volume":"157","author":"Rajendran","year":"2017","journal-title":"Colloids Surfaces B Biointerfaces"},{"key":"10.1016\/j.yrtph.2019.02.009_bib56","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/CIRCRESAHA.111.261701","article-title":"Dynamical systems approach to endothelial heterogeneity","volume":"111","author":"Regan","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.yrtph.2019.02.009_bib57","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1773-2247(05)50065-0","article-title":"Usnic acid-loaded nanocapsules: an evaluation of cytotoxicity","volume":"15","author":"Santos","year":"2005","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib58","first-page":"S5","volume":"vol. 76","author":"Schinoni","year":"2003"},{"key":"10.1016\/j.yrtph.2019.02.009_bib59","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jphotobiol.2018.03.018","article-title":"Green synthesis of silver nanoparticles using leaf extract of Acalypha hispida and its application in blood compatibility","volume":"182","author":"Selvakumar","year":"2018","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib60","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jchromb.2018.04.040","article-title":"In vitro thrombolytic activity of a purified fibrinolytic enzyme from Chlorella vulgaris","volume":"1092","author":"Silva","year":"2018","journal-title":"J. Chromatogr. B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.yrtph.2019.02.009_bib61","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.yrtph.2018.07.013","article-title":"Emerging technologies for food and drug safety","volume":"98","author":"Slikker","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib62","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00436-013-3304-8","article-title":"Nematicidal activity of three novel extracellular proteases of the nematophagous fungus Monacrosporium sinense","volume":"112","author":"Soares","year":"2013","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.yrtph.2019.02.009_bib63","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.nrl.2010.12.018","article-title":"\u00bfEs el cociente normalizado internacional un factor pron\u00f3stico de mortalidad en hemorragias intracerebrales?","volume":"26","author":"Sousa","year":"2011","journal-title":"Neurologia"},{"key":"10.1016\/j.yrtph.2019.02.009_bib64","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ijbiomac.2015.12.059","article-title":"A fibrinolytic protease AfeE from Streptomyces sp. CC5, with potent thrombolytic activity in a mouse model","volume":"85","author":"Sun","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib65","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1016\/j.transproceed.2018.02.135","article-title":"Effect of prolactin on biochemical and morphological parameters of rabbit liver in warm ischemia","volume":"50","author":"Szulc-Musio\u0142","year":"2018","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.yrtph.2019.02.009_bib66","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.3748\/wjg.v19.i23.3534","article-title":"Liver-spleen axis: intersection between immunity, infections and metabolism","volume":"19","author":"Tarantino","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib67","series-title":"Ecotoxicologia aqu\u00e1tica: princ\u00edpios e aplica\u00e7\u00f5es, S\u00e3o Carlos, cap","first-page":"327","article-title":"Genotoxicidade ambiental","volume":"vol. 14","author":"Umbunzeiro","year":"2006"},{"key":"10.1016\/j.yrtph.2019.02.009_bib68","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbpb.2011.01.004","article-title":"A novel alkaline serine protease with fibrinolytic activity from the polychaete, Neanthes japonica","volume":"159","author":"Wang","year":"2011","journal-title":"Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology"},{"key":"10.1016\/j.yrtph.2019.02.009_bib69","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00253-010-3020-6","article-title":"Aspartic proteinases from Mucor spp. in cheese manufacturing","volume":"89","author":"Yegin","year":"2011","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib70","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6750-12-36","article-title":"Thrombolytic effects of Douchi Fibrinolytic enzyme from Bacillus subtilis LD-8547 in vitro and in vivo","volume":"12","author":"Yuan","year":"2012","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.yrtph.2019.02.009_bib71","article-title":"Impact of anticoagulant choice on hospitalized bleeding risk when treating cancer-associated venous thromboembolism","volume":"0\u20132","author":"Zakai","year":"2018","journal-title":"J. Thromb. Haemostasis"},{"issue":"7","key":"10.1016\/j.yrtph.2019.02.009_bib72","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.nrl.2016.07.005","article-title":"Prognostic factors and analysis of mortality due to brain haemorrhages associated with vitamin K antagonist oral anticoagulants. Results from the TAC registry","volume":"33","author":"Zapata-Wainberg","year":"2018","journal-title":"Neurologia"}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230019300546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230019300546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T21:40:33Z","timestamp":1662932433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230019300546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":69,"alternative-id":["S0273230019300546"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2019.02.009","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of acute exposure in swiss mice (Mus musculus) to a fibrinolytic protease produced by Mucor subtilissimus UCP 1262: An histomorphometric, genotoxic and cytological approach","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2019.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}