{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T17:30:14Z","timestamp":1774805414234,"version":"3.50.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.yrtph.2022.105187","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:06:48Z","timestamp":1653091608000},"page":"105187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Evaluation of interactions in chemical mixtures containing cyanides"],"prefix":"10.1016","volume":"132","author":[{"given":"Hana","family":"Pohl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moiz","family":"Mumtaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2022.105187_bib2","first-page":"148","article-title":"A review of cyanide concentrations found in human organs: a survey of literature concerning cyanide metabolism, 'normal,' non-fatal, and fatal body cyanide levels","volume":"17","author":"Ansell","year":"1970","journal-title":"J. Forensic Med."},{"key":"10.1016\/j.yrtph.2022.105187_bib3","series-title":"Toxicological Profile for PAHs","year":"1995"},{"key":"10.1016\/j.yrtph.2022.105187_bib4","series-title":"Toxicological Profile for CDDs","year":"1998"},{"key":"10.1016\/j.yrtph.2022.105187_bib5","series-title":"Toxicological Profile for Selenium","year":"2003"},{"key":"10.1016\/j.yrtph.2022.105187_bib6","series-title":"Interaction Profile for Cyanide, Fluoride, Nitrate, and Uranium","year":"2004"},{"key":"10.1016\/j.yrtph.2022.105187_bib7","series-title":"Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures","year":"2004"},{"key":"10.1016\/j.yrtph.2022.105187_bib8","series-title":"Toxicological Profile for Cobalt","year":"2004"},{"key":"10.1016\/j.yrtph.2022.105187_bib9","series-title":"Interaction Profile for Benzene, Toluene, Ethylbenzene, and Xylene","year":"2004"},{"key":"10.1016\/j.yrtph.2022.105187_bib10","series-title":"Toxicological Profile for Cyanide","year":"2006"},{"key":"10.1016\/j.yrtph.2022.105187_bib12","series-title":"Toxicological Profile for Nitrate and Nitrate","year":"2017"},{"key":"10.1016\/j.yrtph.2022.105187_bib13","series-title":"Toxicological Profile for PBDEs","year":"2017"},{"key":"10.1016\/j.yrtph.2022.105187_bib14","series-title":"Framework for Assessing Health Impacts of Multiple Chemicals and Other Stressors","year":"2018"},{"key":"10.1016\/j.yrtph.2022.105187_bib15","series-title":"Developments in the Science and Practice of Toxicology","first-page":"583","article-title":"The influence of exposure route and species on the acute lethal toxicity and tissue concentrations of cyanide","author":"Ballantyne","year":"1983"},{"key":"10.1016\/j.yrtph.2022.105187_bib16","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1139\/y83-203","article-title":"High-dose ascorbic acid decreases detoxification of cyanide derived from amygdalin (laetrile): studies in Guinea pigs","volume":"61","author":"Basu","year":"1983","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.yrtph.2022.105187_bib17","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1471-4159.1987.tb05588.x","article-title":"31P nuclear magnetic resonance in vivo spectroscopy of the metabolic changes induced in the awake rat brain during KCN intoxication and its reversal by hydroxocobalamine","volume":"48","author":"Benabid","year":"1987","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yrtph.2022.105187_bib18","first-page":"997","article-title":"Inhalation of toxic products from fires","volume":"57","author":"Birky","year":"1981","journal-title":"Bull NY Acad Med"},{"key":"10.1016\/j.yrtph.2022.105187_bib19","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1001\/jama.1985.03350270065023","article-title":"Cyanide intoxication among silver-reclaiming workers","volume":"253","author":"Blanc","year":"1985","journal-title":"JAMA"},{"key":"10.1016\/j.yrtph.2022.105187_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/0960327184003001081","article-title":"Survival without sequelae following exposure to 500 mg\/m3 of hydrogen cyanide","volume":"3","author":"Bonsall","year":"1984","journal-title":"Hum. Toxicol."},{"issue":"9","key":"10.1016\/j.yrtph.2022.105187_bib22","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1345\/aph.1E634","article-title":"Life-threatening interaction between complementary medicines: cyanide toxicity following ingestion of amygdalin and vitamin C","volume":"39","author":"Bromley","year":"2005","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.yrtph.2022.105187_bib24","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1136\/jnnp.51.10.1345","article-title":"Dystonic-parkinsonian syndrome after cyanide poisoning: clinical and MRI findings","volume":"51","author":"Carella","year":"1988","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.yrtph.2022.105187_bib25","first-page":"170","article-title":"Threshold limit value of cyanide: a reappraisal in Indian context","volume":"8","author":"Chandra","year":"1988","journal-title":"Indian J. Environ. Protect."},{"issue":"2","key":"10.1016\/j.yrtph.2022.105187_bib26","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/toxsci\/kfg236","article-title":"Polybrominated diphenyl ethers as Ah receptor agonists and antagonists","volume":"76","author":"Chen","year":"2003","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2022.105187_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1001\/jama.1952.02930190015004","article-title":"Nitrite and thiosulfate therapy in cyanide poisoning","volume":"149","author":"Chen","year":"1952","journal-title":"JAMA"},{"issue":"1\u20133","key":"10.1016\/j.yrtph.2022.105187_bib28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0303-7207(91)90197-Z","article-title":"Cretenism, thyroid hormones and selenium","volume":"81","author":"Contempre","year":"1991","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.yrtph.2022.105187_bib29","first-page":"485","article-title":"Non-cancer occupational health risks in firefighters","volume":"Med62","author":"Crawford","year":"2012","journal-title":"Occupation"},{"issue":"2","key":"10.1016\/j.yrtph.2022.105187_bib31","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/occmed\/kqh020","article-title":"The treatment of cyanide poisoning","volume":"54","author":"Cummings","year":"2004","journal-title":"Occup. Med. (Lond.)"},{"issue":"6","key":"10.1016\/j.yrtph.2022.105187_bib32","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1136\/oemed-2013-101662","article-title":"Mortality and cancer incidence in a pooled cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950\u20132009)","volume":"71","author":"Daniels","year":"2014","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.yrtph.2022.105187_bib33","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1093\/ajcn\/24.11.1354","article-title":"Role of a dietary goitrogen in the etiology of endemic goiter on Idjwi Island","volume":"24","author":"Delange","year":"1971","journal-title":"Am. J. Clin. Nutr."},{"issue":"2\u20133","key":"10.1016\/j.yrtph.2022.105187_bib34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0378-4274(92)90151-9","article-title":"Cardiovascular, metabolic and neurologic effects of carbon monoxide and cyanide in the rat","volume":"61","author":"Dodds","year":"1992","journal-title":"Toxicol. Lett."},{"issue":"6","key":"10.1016\/j.yrtph.2022.105187_bib35","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1289\/ehp.02110s6985","article-title":"Toxicological evaluation of complex mixtures by pattern recognition: correlating chemical fingerprints to mutagenicity","volume":"110","author":"Eide","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2022.105187_bib37","series-title":"Drinking Water Criteria Document for Cyanide","year":"1986"},{"key":"10.1016\/j.yrtph.2022.105187_bib39","series-title":"Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures","year":"2000"},{"key":"10.1016\/j.yrtph.2022.105187_bib40","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/073490418800600303","article-title":"Inhalation toxicity of carbon monoxide and hydrogen cyanide gases released during the thermal decomposition of polymers","volume":"6","author":"Esposito","year":"1988","journal-title":"J. Fire Sci."},{"key":"10.1016\/j.yrtph.2022.105187_bib42","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.forsciint.2017.05.018","article-title":"Analysis of the fire deaths in Poland and influence of smoke toxicity","volume":"277","author":"Giebultowicz","year":"2017","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.yrtph.2022.105187_bib43","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/mds.870040211","article-title":"Clinical and CT scan findings in a case of cyanide intoxication","volume":"4","author":"Grandas","year":"1989","journal-title":"Mov. Disord."},{"key":"10.1016\/j.yrtph.2022.105187_bib44","doi-asserted-by":"crossref","first-page":"7197","DOI":"10.1021\/acs.est.6b06413","article-title":"Grouping of petroleum Substances as example UVCBs by ion mobility-mass spectrometry to enable chemical composition-based read-across","volume":"51","author":"Grimm","year":"2017","journal-title":"Environ. Sci. Technol."},{"issue":"2","key":"10.1016\/j.yrtph.2022.105187_bib45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1179\/oeh.2003.9.2.95","article-title":"Latent health effects in firefighters","volume":"9","author":"Haas","year":"2003","journal-title":"Int. J. Occup. Environ. Health"},{"issue":"1","key":"10.1016\/j.yrtph.2022.105187_bib46","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4037\/ccn2011799","article-title":"A review of acute cyanide poisoning with a treatment update","volume":"31","author":"Hamel","year":"2011","journal-title":"Crit. Care Nurse"},{"key":"10.1016\/j.yrtph.2022.105187_bib47","first-page":"4845","article-title":"Cyanides and nitriles","volume":"IIC","author":"Hartung","year":"1982"},{"key":"10.1016\/j.yrtph.2022.105187_bib48","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s13181-018-0688-y","article-title":"A review on ingested cyanide: risks, clinical presentation, diagnostics, and treatment challenges","volume":"15","author":"Hendry-Hofer","year":"2019","journal-title":"J. Med. Toxicol."},{"key":"10.1016\/j.yrtph.2022.105187_bib49","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1152\/ajplegacy.1948.153.2.348","article-title":"Enzymatic conversion of cyanide to thiocyanate","volume":"153","author":"Himwich","year":"1948","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.yrtph.2022.105187_bib50","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/brain\/113.1.223","article-title":"Konzo, an epidemic upper motor neuron disease studied in Tanzania","volume":"113","author":"Howlett","year":"1990","journal-title":"Brain"},{"key":"10.1016\/j.yrtph.2022.105187_bib52","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0378-4274(95)03521-4","article-title":"Modification of cyanide toxicodynamics: mechanistic based antidote development","volume":"82\u201383","author":"Isom","year":"1995","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.yrtph.2022.105187_bib53","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0735-6757(87)90360-3","article-title":"Toxic smoke inhalation: cuanide poisoning in five victems","volume":"5","author":"Jones","year":"1987","journal-title":"Am. J. Emerg. Med."},{"key":"10.1016\/j.yrtph.2022.105187_bib54","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0300-483X(83)90065-3","article-title":"Effects of 4-dimethylaminophenol, Co2EDTA, or NaNO2 on cerebral blood flow and sinus blood homeostasis of dogs in connection with acute cyanide poisoning","volume":"26","author":"Klimmek","year":"1983","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2022.105187_bib55","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/BF00347867","article-title":"Comparison of hydroxylamine, 4-dimethylaminophenol and nitrite protection against cyanide poisoning in mice","volume":"49","author":"Kruszyna","year":"1982","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2022.105187_bib56","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/jn\/100.9.1111","article-title":"Interactions of methionine, vitamin E, and antioxidants in selenium toxicity in the rat","volume":"100","author":"Levander","year":"1970","journal-title":"J. Nutr."},{"key":"10.1016\/j.yrtph.2022.105187_bib57","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0272-0590(87)90046-7","article-title":"Effect of exposure to single or multiple combinations of the predominant toxic gases and low oxygen atmospheres produced in fires","volume":"9","author":"Levin","year":"1987","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.yrtph.2022.105187_bib58","series-title":"Proc SPI Annu Tech\/Mark Conf 31st (Polyurethanes 88)","first-page":"240","article-title":"Toxicological effects of different time exposures to the fire gases: carbon monoxide or hydrogen cyanide or to carbon monoxide combined with hydrogen cyanide or carbon dioxide","author":"Levin","year":"1988"},{"key":"10.1016\/j.yrtph.2022.105187_bib59","series-title":"Proc SPI Annu Tech\/Mark Conf, 31st(Polyurethanes 88)","first-page":"249","article-title":"Further studies of the toxicological effects of different time exposures to the individual and combined fire gases - carbon monoxide, hydrogen cyanide, carbon dioxide and reduced oxygen","author":"Levin","year":"1988"},{"key":"10.1016\/j.yrtph.2022.105187_bib60","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/ajcp\/18.12.965","article-title":"Cyanide poisoning: report of a case with recovery","volume":"18","author":"Liebowitz","year":"1948","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.yrtph.2022.105187_bib62","series-title":"Updated Petroleum Hydrocarbon Fraction Toxicity Values for the VPH\/EPH\/APH Methodology","year":"2003"},{"issue":"1","key":"10.1016\/j.yrtph.2022.105187_bib63","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1006\/faat.1994.1081","article-title":"Antagonism of the lethal effects of cyanide by a synthetic water-soluble cobalt(III) porphyrin compound","volume":"23","author":"McGuinn","year":"1994","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.yrtph.2022.105187_bib64","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0300-483X(89)90068-1","article-title":"Thiosulfate and hydroxocobalamin prophylaxix in progressive cyanide poisoning in Guinea pigs","volume":"54","author":"Mengel","year":"1989","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2022.105187_bib66","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1177\/074823379200800604","article-title":"A weight-of-evidence approach for assessing interactions in chemical mixtures","volume":"8","author":"Mumtaz","year":"1992","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.yrtph.2022.105187_bib68","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3181\/00379727-81-19831","article-title":"Antidotal efficacy of vitamin B12 (hydroxo-cobalamin) in experimental cyanide poisoning","volume":"81","author":"Mushett","year":"1952","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1016\/j.yrtph.2022.105187_bib70","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0300-483X(86)90073-9","article-title":"Synergistic lethality induced by the combination of carbon monoxide and cyanide","volume":"40","author":"Norris","year":"1986","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2022.105187_bib71","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/brain\/91.2.215","article-title":"An ataxic neuropathy in Nigeria: a clinical, biochemical and electrophysiological study","volume":"91","author":"Osuntokun","year":"1968","journal-title":"Brain"},{"key":"10.1016\/j.yrtph.2022.105187_bib72","first-page":"215","article-title":"Chronic cyanide neurotoxicity and neuropathy in Nigerians","volume":"2","author":"Osuntokun","year":"1972","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.yrtph.2022.105187_bib73","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/0006-291X(79)91188-4","article-title":"Partial prevention by cyanide of selenium poisoning in rats","volume":"90","author":"Palmer","year":"1979","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.yrtph.2022.105187_bib74","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1021\/es5055918","article-title":"High exposure of California firefighters to polybrominated diphenyl ethers","volume":"vol. 49","author":"Park","year":"2015","journal-title":"Environ. Sci. Technol"},{"key":"10.1016\/j.yrtph.2022.105187_bib75","doi-asserted-by":"crossref","DOI":"10.1289\/EHP4555","article-title":"A chemical category-based prioritization approach for selecting 75 per- and polyfluoroalkyl Substances (PFAS) for tiered toxicity and toxicokinetic testing","volume":"127","author":"Patlewicz","year":"2019","journal-title":"Environ. Health Perspect."},{"issue":"1","key":"10.1016\/j.yrtph.2022.105187_bib76","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/toxsci\/kfj186","article-title":"Interactions of polybrominated diphenyl ethers with the Aryl hydrocarbon receptor pathway","volume":"92","author":"Peters","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"2","key":"10.1016\/j.yrtph.2022.105187_bib77","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.toxlet.2005.12.002","article-title":"Antagonism of TCDD-induced ethoxyresorufin-O-deethylation activity by polybrominated diphenyl ethers (PBDEs) in primary Cynomolgus monkey (Macaca fascicularis)","volume":"164","author":"Peters","year":"2006","journal-title":"Hepatocytes Toxicol Lett"},{"issue":"2","key":"10.1016\/j.yrtph.2022.105187_bib78","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1136\/oemed-2019-105962","article-title":"Mortality in a cohort of US firefighters from san francisco, Chicago and philadelphia: an update","volume":"77","author":"Pinkerton","year":"2020","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.yrtph.2022.105187_bib79","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.yrtph.2011.01.013","article-title":"The impact of CYP2E1 genetic variability on risk assessment of VOC mixtures","volume":"59","author":"Pohl","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2022.105187_bib80","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1080\/00039896.1984.10545871","article-title":"Intoxication by cyanide in fires: a study in monkeys using polyacrylonitrile","volume":"39","author":"Purser","year":"1984","journal-title":"Arch. Environ. Health"},{"key":"10.1016\/j.yrtph.2022.105187_bib81","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1212\/WNL.39.1.142","article-title":"Cyanide-induced parkinsonism clinical MRI and 6 fluorodopa Fd positron emission tomography pet studies","volume":"39","author":"Rosenberg","year":"1989","journal-title":"Neurology"},{"key":"10.1016\/j.yrtph.2022.105187_bib82","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.0954-6820.1967.tb07252.x","article-title":"A case of chronic poisoning with potassium cyanide?","volume":"181","author":"Sandberg","year":"1967","journal-title":"Acta Med. Scand."},{"key":"10.1016\/j.yrtph.2022.105187_bib83","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0022-3565(25)28039-9","article-title":"Antagonism of experimental cyanide toxicity in relation to the in vivo activity of cytochrome oxidase","volume":"162","author":"Schubert","year":"1968","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"5","key":"10.1016\/j.yrtph.2022.105187_bib85","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1345\/aph.1K559","article-title":"Role of hydroxocobalamin in acute cyanide poisoning","volume":"42","author":"Shepherd","year":"2008","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.yrtph.2022.105187_bib86","series-title":"Casarett & Doull's Toxicology: the Basic Science of Poisons","first-page":"335","article-title":"Toxic responses of the blood","author":"Smith","year":"1996"},{"key":"10.1016\/j.yrtph.2022.105187_bib87","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.firesaf.2017.05.003","article-title":"Fire toxicity \u2013 the elephant in the room?","volume":"91","author":"Stec","year":"2017","journal-title":"Fire Saf. J."},{"issue":"4","key":"10.1016\/j.yrtph.2022.105187_bib88","doi-asserted-by":"crossref","first-page":"440","DOI":"10.5603\/EP.2017.0051","article-title":"The role of selenium in thyroid gland pathophysiology","volume":"68","author":"Stuss","year":"2017","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.yrtph.2022.105187_bib89","series-title":"Chemical and Clinical Aspects of Metal-Containing Antidotes for Poisoning by Cyanide Met Ions Life Sci Books\/9783110527872\/9783110527872-020\/9783110527872-020","author":"Suman","year":"2019"},{"key":"10.1016\/j.yrtph.2022.105187_bib90","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0041-008X(83)90307-1","article-title":"Effects of thiosulfate on cyanide pharmacokinetics in dogs","volume":"69","author":"Sylvester","year":"1983","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yrtph.2022.105187_bib91","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0140-6736(78)91398-3","article-title":"Cyanide exposure in fires","volume":"July 8","author":"Symington","year":"1978","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.yrtph.2022.105187_bib92","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0002-9378(73)90296-2","article-title":"Triglyceride synthesis by the human placenta. II. The effect of cyanide and fluoride on the incorporation of labeled palmitate into placental triglycerides","volume":"115","author":"Szabo","year":"1973","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"7","key":"10.1016\/j.yrtph.2022.105187_bib93","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/ajim.22466","article-title":"Risk of cancer among firefighters in California, 1988-2007","volume":"58","author":"Tsai","year":"2015","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.yrtph.2022.105187_bib94","article-title":"[Central nervous system lesions in chronic experimental poisoning with gaseous hydrocyanic acid]","volume":"136","author":"Valade","year":"1952","journal-title":"Bull. Acad. Natl. Med. (Paris)"},{"issue":"2","key":"10.1016\/j.yrtph.2022.105187_bib95","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/toxsci\/kfl055","article-title":"The 2005 World health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds","volume":"93","author":"Van den Berg","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2022.105187_bib96","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1210\/endo-39-2-157","article-title":"Effects of propylthiouracil and of potassium thiocyanate on the uptake of iodine by the thyroid gland of the rat","volume":"39","author":"Van der Laan","year":"1946","journal-title":"Endocrinology"},{"key":"10.1016\/j.yrtph.2022.105187_bib97","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.pa.24.040184.002315","article-title":"Cyanide intoxication and its mechanism of antagonism","volume":"24","author":"Way","year":"1984","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.yrtph.2022.105187_bib98","first-page":"505","article-title":"Leber's hereditary optic atrophy: a possible defect of cyanide metabolism","volume":"29","author":"Wilson","year":"1965","journal-title":"Clin Sci"},{"key":"10.1016\/j.yrtph.2022.105187_bib99","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF00200672","article-title":"A study on the combined action of CO and HCN in terms of concentration-time products","volume":"86","author":"Yamamoto","year":"1981","journal-title":"Z. Rechtsmed."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230022000745?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230022000745?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T12:33:32Z","timestamp":1759494812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230022000745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":85,"alternative-id":["S0273230022000745"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2022.105187","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of interactions in chemical mixtures containing cyanides","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2022.105187","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105187"}}