{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:05:43Z","timestamp":1793761543302,"version":"4.6.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.yrtph.2023.105458","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T21:34:45Z","timestamp":1689284085000},"page":"105458","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Skin sensitisation prediction using read-across, an illustrative next generation risk assessment (NGRA) case study for vanillin"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0497-4094","authenticated-orcid":false,"given":"Fran\u00e7oise","family":"Gautier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hind","family":"Assaf Vandecasteele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fleur","family":"Tourneix","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin","family":"van Vliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Al\u00e9p\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Bury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2023.105458_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2021.105094","article-title":"A 10-step framework for use of read-across (RAX) in next generation risk assessment (NGRA) for cosmetics safety assessment","volume":"129","author":"Alexander-White","year":"2022","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2023.105458_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2021.104936","article-title":"Next generation risk assessment for skin sensitisation: a case study with propyl paraben","volume":"123","author":"Assaf Vandecasteele","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.yrtph.2023.105458_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1034\/j.1600-0536.2001.045002089.x","article-title":"Human potency predictions for aldehydes using the local lymph node assay","volume":"45","author":"Basketter","year":"2001","journal-title":"Contact Dermatitis"},{"issue":"1","key":"10.1016\/j.yrtph.2023.105458_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/DER.0000000000000003","article-title":"Categorization of chemicals according to their relative human skin sensitizing potency","volume":"25","author":"Basketter","year":"2014","journal-title":"Dermatitis"},{"key":"10.1016\/j.yrtph.2023.105458_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3390\/cosmetics9020038","article-title":"Skin sensitization testing: the ascendancy of non-animal methods","volume":"9","author":"Basketter","year":"2022","journal-title":"Cosmetics"},{"issue":"3","key":"10.1016\/j.yrtph.2023.105458_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/10629369408029901","article-title":"Multivariate QSAR analysis of a skin sensitisation database","volume":"2","author":"Cronin","year":"1994","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.yrtph.2023.105458_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.comtox.2022.100213","article-title":"A review of in silico toxicology approaches to support the safety assessment of cosmetics-related materials","volume":"21","author":"Cronin","year":"2022","journal-title":"Comput. Toxicol."},{"key":"10.1016\/j.yrtph.2023.105458_bib9","first-page":"59","article-title":"Regulation (EC) No 1223\/2009 of the European parliament and of the council of 30 november 2009 on cosmetic products","year":"2009","journal-title":"Off. J. EU"},{"key":"10.1016\/j.yrtph.2023.105458_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0273-2300(02)00021-1","article-title":"Application of the risk assessment paradigm to the induction of allergic contact dermatitis","volume":"37","author":"Felter","year":"2003","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2023.105458_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104755","article-title":"Read-across can increase confidence in the Next Generation Risk Assessment for skin sensitisation: a case study with resorcinol","volume":"117","author":"Gautier","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.yrtph.2023.105458_bib15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/jat.3730","article-title":"Comparison of the metabolism of 10 chemicals in human and pig skin explants","volume":"39","author":"G\u00e9ni\u00e8s","year":"2019","journal-title":"J. Appl. Toxicol."},{"issue":"2","key":"10.1016\/j.yrtph.2023.105458_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/jat.3905","article-title":"Comparison of the metabolism of 10 cosmetics-relevant chemicals in EpiSkin\u2122 S9 subcellular fractions and in vitro human skin explants","volume":"40","author":"G\u00e9ni\u00e8s","year":"2020","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.yrtph.2023.105458_bib17","article-title":"Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients toxicol","volume":"6","author":"Gilmour","year":"2020","journal-title":"Pharmacology"},{"issue":"1","key":"10.1016\/j.yrtph.2023.105458_bib18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/j.1365-2133.2008.08866.x","article-title":"Prediction of chemical absorption into and through the skin from cosmetic and dermatological formulations","volume":"160","author":"Gr\u00e9goire","year":"2009","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"10.1016\/j.yrtph.2023.105458_bib19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.yrtph.2003.07.001","article-title":"Proposal for a risk assessment methodology for skin sensitisation based on sensitisation potency data","volume":"38","author":"Griem","year":"2003","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.yrtph.2023.105458_bib20","first-page":"230","article-title":"Closed epicutaneous test","volume":"28","author":"Ishihara","year":"1986","journal-title":"Skin Res."},{"issue":"6","key":"10.1016\/j.yrtph.2023.105458_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1034\/j.1600-0536.2002.470601.x","article-title":"The local lymph node assay: past, present and future","volume":"47","author":"Kimber","year":"2002","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2023.105458_bib22","first-page":"53","article-title":"Screening of fragrance materials for allergenicity in the Guinea pig. I. Comparison of four testing methods","volume":"28","author":"Klecak","year":"1977","journal-title":"J. Soc. Cosm. Chem. Jap."},{"issue":"September","key":"10.1016\/j.yrtph.2023.105458_bib23","article-title":"The open epicutaneous test (OET), a predictive test procedure in the Guinea pig for estimation of allergenic properties of simple chemical compounds, their mixtures and of finished cosmetic preparations","volume":"18","author":"Klecak","year":"1979","journal-title":"International Federation Societies Cosmetic Chemists"},{"key":"10.1016\/j.yrtph.2023.105458_bib24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000411610","article-title":"The Freund's Complete Adjuvant Test and the Open Epicutaneous Test. A complementary test procedure for realistic assessment of allergenic potential","volume":"14","author":"Klecak","year":"1985","journal-title":"Curr. Probl. Dermatol."},{"issue":"5","key":"10.1016\/j.yrtph.2023.105458_bib25","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/10408444.2018.1429386","article-title":"Non-animal methods to predict skin sensitisation (II): an assessment of defined approaches","volume":"48","author":"Kleinstreuer","year":"2018","journal-title":"Crit. Rev. Toxicol."},{"issue":"3","key":"10.1016\/j.yrtph.2023.105458_bib26","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/jid.1969.42","article-title":"The identification of contact allergens by animal assay. The Guinea pig maximization test","volume":"52","author":"Magnusson","year":"1969","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.yrtph.2023.105458_bib27","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1021\/acs.chemrestox.2c00286","article-title":"An end point-specific framework for read-across analog selection for human health effects","volume":"35","author":"Moustakas","year":"2022","journal-title":"Chem. Res. Toxicol."},{"issue":"2","key":"10.1016\/j.yrtph.2023.105458_bib28","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/toxsci\/kfu229","article-title":"Predicting skin sensitizer potency based on in vitro data from KeratinoSens and kinetic Peptide binding: global versus domain-based assessment","volume":"143","author":"Natsch","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2023.105458_bib29","article-title":"The adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins","year":"2014"},{"key":"10.1016\/j.yrtph.2023.105458_bib30","series-title":"Guidance Document on the Reporting of Defined Approaches to Be Used within Integrated Approaches to Testing and Assessment, OECD Series on Testing and Assessment, No. 255","year":"2017"},{"key":"10.1016\/j.yrtph.2023.105458_bib31","article-title":"Guideline No. 497","volume":"4","year":"2021"},{"key":"10.1016\/j.yrtph.2023.105458_bib32","series-title":"Chemico Skin Sensitisation: Assays Addressing the Adverse Outcome Pathway Key Event on Covalent Binding to Proteins, OECD Guidelines for the Testing of Chemicals","article-title":"Test No. 442C","year":"2022"},{"key":"10.1016\/j.yrtph.2023.105458_bib33","series-title":"In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method, OECD Guidelines for the Testing of Chemicals","article-title":"Test No. 442D","year":"2022"},{"key":"10.1016\/j.yrtph.2023.105458_bib34","series-title":"In Vitro Skin Sensitisation: in Vitro Skin Sensitisation Assays Addressing the Key Event on Activation of Dendritic Cells on the Adverse Outcome Pathway for Skin Sensitisation, OECD Guidelines for the Testing of Chemicals","article-title":"Test No. 442E","year":"2022"},{"issue":"1","key":"10.1016\/j.yrtph.2023.105458_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yrtph.2013.06.002","article-title":"Use of category approaches, read-across and (Q)SAR: general considerations","volume":"67","author":"Patlewicz","year":"2013","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"4","key":"10.1016\/j.yrtph.2023.105458_bib36","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1021\/acs.chemrestox.5b00388","article-title":"Current and future perspectives on the development, evaluation, and application of in silico approaches for predicting toxicity","volume":"29","author":"Patlewicz","year":"2016","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.yrtph.2023.105458_bib37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.yrtph.2019.05.011","article-title":"Exploring current read-across applications and needs among selected U.S. Federal Agencies","volume":"106","author":"Patlewicz","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"5","key":"10.1016\/j.yrtph.2023.105458_bib38","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1034\/j.1600-0536.2000.042005251.x","article-title":"The importance of exposure estimation in the assessment of skin sensitization risk","volume":"42","author":"Robinson","year":"2000","journal-title":"Contact Dermatitis"},{"issue":"1","key":"10.1016\/j.yrtph.2023.105458_bib39","doi-asserted-by":"crossref","first-page":"140","DOI":"10.14573\/altex.2010062","article-title":"NAM-supported read-across: from case studies to regulatory guidance in safety assessment","volume":"38","author":"Rovida","year":"2021","journal-title":"ALTEX"},{"key":"10.1016\/j.yrtph.2023.105458_bib40","series-title":"Notes of Guidance","year":"2021"},{"issue":"1","key":"10.1016\/j.yrtph.2023.105458_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1600-0536.2008.01473.x","article-title":"Read-across to rank skin sensitization potential: subcategories for the Michael acceptor domain","volume":"60","author":"Schultz","year":"2009","journal-title":"Contact Dermatitis"},{"issue":"3","key":"10.1016\/j.yrtph.2023.105458_bib42","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1248\/jhs.47.327","article-title":"Skin reaction induced by aldehydes for food flavoring agents","volume":"47","author":"Watanabe","year":"2001","journal-title":"J. Health Sci."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230023001265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230023001265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T12:35:31Z","timestamp":1759494931000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230023001265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":38,"alternative-id":["S0273230023001265"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2023.105458","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Skin sensitisation prediction using read-across, an illustrative next generation risk assessment (NGRA) case study for vanillin","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2023.105458","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105458"}}