{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:53:01Z","timestamp":1792533181614,"version":"4.5.0"},"reference-count":14,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.yrtph.2024.105597","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T09:19:06Z","timestamp":1709889546000},"page":"105597","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["GARDskin dose-response assay and its application in conducting Quantitative Risk Assessment (QRA) for fragrance materials using a Next Generation Risk Assessment (NGRA) framework"],"prefix":"10.1016","volume":"149","author":[{"given":"Shashikiran","family":"Donthamsetty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Forreryd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Sterchele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Gradin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Johansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrika","family":"Mattson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Api","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Ladics","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.yrtph.2024.105597_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yrtph.2007.10.008","article-title":"Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients","volume":"52","author":"Api","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.yrtph.2024.105597_bib2","article-title":"RIFM fragrance ingredient safety assessment, anisyl alcohol, CAS registry number 105-13-5","volume":"134","author":"Api","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2024.105597_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104805","article-title":"Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials","volume":"118","author":"Api","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2024.105597_bib4","article-title":"GARD\u2122skin and GARD\u2122potency: a proof-of-concept study investigating applicability domain for agrochemical formulations","year":"2024","journal-title":"RTP (Regul. Toxicol. Pharmacol.)"},{"key":"10.1016\/j.yrtph.2024.105597_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.comtox.2018.06.001","article-title":"Principles underpinning the use of new methodologies in the risk assessment of cosmetic ingredients","volume":"7","author":"Dent","year":"2018","journal-title":"Computational Toxicology"},{"key":"10.1016\/j.yrtph.2024.105597_bib6","series-title":"GARDskin Assay Protocol","year":"2021"},{"issue":"1","key":"10.1016\/j.yrtph.2024.105597_bib7","first-page":"53","article-title":"Exploration of the GARD\u2122skin applicability domain: indirectly acting haptens, hydrophobic substances and UVCBs","volume":"40","author":"Forreryd","year":"2023","journal-title":"ALTEX"},{"issue":"3","key":"10.1016\/j.yrtph.2024.105597_bib8","first-page":"425","article-title":"The GARD\u2122skin assay: Investigation of the applicability domain for metals","volume":"40","author":"Forreryd","year":"2023","journal-title":"ALTEX"},{"key":"10.1016\/j.yrtph.2024.105597_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104721","article-title":"Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients","volume":"116","author":"Gilmour","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"1","key":"10.1016\/j.yrtph.2024.105597_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-98247-7","article-title":"Quantitative assessment of sensitizing potency using a DR adaptation of GARDskin","volume":"11","author":"Gradin","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.yrtph.2024.105597_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2131\/jts.44.13","article-title":"Sensitivity of KeratinoSensTM and h-CLAT for detecting minute amounts of sensitizers to evaluate botanical extract","volume":"44","author":"Nishijo","year":"2019","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2024.105597_bib13","series-title":"Supporting Document to the Genomic Allergen Rapid Detection Test Method for Skin Sensitisation (GARD\u2122skin), Described in Test Guideline 442E. OECD Series on Testing and Assessment, No. 357","year":"2022"},{"key":"10.1016\/j.yrtph.2024.105597_bib14","series-title":"Vitro Skin Sensitisation: in Vitro Skin Sensitisation Assays Addressing the Key Event on Activation of Dendritic Cells on the Adverse Outcome Pathway for Skin Sensitisation. OECD Guidelines for the Testing of Chemicals","article-title":"Test No. 442E","year":"2023"},{"issue":"4","key":"10.1016\/j.yrtph.2024.105597_bib15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.14573\/altex.1701101","article-title":"The GARD platform for potency assessment of skin sensitizing chemicals","volume":"34","author":"Zeller","year":"2017","journal-title":"ALTEX"}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230024000382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230024000382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T13:18:43Z","timestamp":1717766323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230024000382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":14,"alternative-id":["S0273230024000382"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2024.105597","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GARDskin dose-response assay and its application in conducting Quantitative Risk Assessment (QRA) for fragrance materials using a Next Generation Risk Assessment (NGRA) framework","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2024.105597","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105597"}}