{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:21:27Z","timestamp":1784222487373,"version":"3.55.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.yrtph.2024.105714","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T02:11:29Z","timestamp":1727921489000},"page":"105714","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Quantitative risk assessments of skin sensitization for 26 allergens in different consumer products in the Saudi market"],"prefix":"10.1016","volume":"153","author":[{"given":"Adnan S.","family":"AL-Mussallam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawan S.","family":"Alshathri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Desmedt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad S.","family":"Aldawsari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Deconinck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omniyah A.","family":"Alharthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah T.","family":"Bawazir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2024.105714_bib2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/DER.0b013e3182a5d8bc","article-title":"Allergy to cosmetics","volume":"24","author":"Alani","year":"2013","journal-title":"Dermatitis"},{"key":"10.1016\/j.yrtph.2024.105714_bib3","first-page":"9","article-title":"Prevalence and risk factors of self-reported perfume sensitivity in Saudi Arabia","author":"Alrasheed","year":"2021","journal-title":"Healthcare (Switzerland)"},{"key":"10.1016\/j.yrtph.2024.105714_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yrtph.2007.10.008","article-title":"Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients","volume":"52","author":"Api","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2024.105714_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104805","article-title":"Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials","volume":"118","author":"Api","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2024.105714_bib6","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0278-6915(96)00059-2","article-title":"The local lymph node assay: a viable alternative to currently accepted skin sensitization tests","volume":"34","author":"Basketter","year":"1996","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2024.105714_bib7","first-page":"S1","article-title":"A toxicologic and dermatologic assessment of cyclic and non-cyclic terpene alcohols when used as fragrance ingredients","volume":"46","author":"Belsito","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2024.105714_bib8","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0273-2300(03)00003-5","article-title":"The safety assessment of fragrance materials","volume":"37","author":"Bickers","year":"2003","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.yrtph.2024.105714_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-0536.2007.01292.x","article-title":"Recommendation to include fragrance mix 2 and hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) in the European baseline patch test series","volume":"58","author":"Bruze","year":"2008","journal-title":"Contact dermatitis"},{"key":"10.1016\/j.yrtph.2024.105714_bib10","unstructured":"COMMISSION REGULATION (EU) 2017\/1410 - of 2 August 2017 - Amending Annexes II and III to Regulation (EC) No 1223\/2009 of the European Parliament and of the Council on Cosmetic Products."},{"key":"10.1016\/j.yrtph.2024.105714_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/DER.0000000000000463","article-title":"Contact allergy and other adverse effects","volume":"31","author":"de Groot","year":"2020","journal-title":"Dermatitis"},{"key":"10.1016\/j.yrtph.2024.105714_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-0536.1997.tb00418.x","article-title":"Adverse reactions to fragrances","volume":"36","author":"De Groot","year":"1997","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2024.105714_bib14","series-title":"Directorate General for Health & Consumers. Opinion On Fragrance Allergens In Cosmetic Products","year":"2012"},{"key":"10.1016\/j.yrtph.2024.105714_bib15","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1600-0536.2011.01889.x","article-title":"Deodorants are the leading cause of allergic contact dermatitis to fragrance ingredients","volume":"64","author":"Heisterberg","year":"2011","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2024.105714_bib17","unstructured":"IFRA Standards Library. https:\/\/ifrafragrance.org\/safe-use\/library."},{"key":"10.1016\/j.yrtph.2024.105714_bib20","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1034\/j.1600-0536.2003.00126.x","article-title":"Hydroxyisohexyl 3-cyclohexene carboxaldehyde- known as Lyral\u00ae: quantitative aspects and risk assessment of an important fragrance allergen","volume":"48","author":"Johansen","year":"2003","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2024.105714_bib21","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.ijheh.2011.12.009","article-title":"Contact allergens for armpits\u2014allergenic fragrances specified on deodorants","volume":"215","author":"Klaschka","year":"2012","journal-title":"Int. J. Hyg Environ. Health"},{"key":"10.1016\/j.yrtph.2024.105714_bib22","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1080\/15287394.2018.1543232","article-title":"Determination of fragrance allergens and their dermal sensitization quantitative risk assessment (QRA) in 107 spray perfumes","volume":"81","author":"Lim","year":"2018","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1016\/j.yrtph.2024.105714_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2022.105260","article-title":"Quantitative risk assessment of allergens leaching from menstrual hygiene products","volume":"135","author":"Marcelis","year":"2022","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2024.105714_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/cosmetics9020032","article-title":"Occurrence of allergens in cosmetics for sensitive skin","volume":"9","author":"Martins","year":"2022","journal-title":"Cosmetics"},{"key":"10.1016\/j.yrtph.2024.105714_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/DER.0000000000000854","article-title":"Weight of evidence approach for skin sensitization potency categorization of fragrance ingredients","volume":"33","author":"Na","year":"2022","journal-title":"Dermatitis"},{"key":"10.1016\/j.yrtph.2024.105714_bib26","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1600-0536.2011.01877.x","article-title":"Fragrance allergens in \u2018specific\u2019 cosmetic products","volume":"64","author":"Nardelli","year":"2011","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.yrtph.2024.105714_bib27","unstructured":"Of the European parliament and of the Council as regards the use in cosmetic products of certain substances classified as carcinogenic, Mutagenic or Toxic for Reproduction (Text with EEA Relevance)."},{"key":"10.1016\/j.yrtph.2024.105714_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s40521-020-00275-7","article-title":"Hazardous effects, and risk assessment of fragrances in consumer products","volume":"8","author":"Pastor-Nieto","year":"2021","journal-title":"Current Treatment Options in Allergy"},{"key":"10.1016\/j.yrtph.2024.105714_bib30","author":"Ter Burg"},{"key":"10.1016\/j.yrtph.2024.105714_bib31","first-page":"59","article-title":"Regulation (EC) No 1223\/2009 of the European parliament and of the Council of 30 november 2009 on cosmetic products","volume":"L342","year":"2009","journal-title":"Off. J. Eur. Union"},{"key":"10.1016\/j.yrtph.2024.105714_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1184289","article-title":"Advancing the understanding of allergic contact dermatitis: from pathophysiology to novel therapeutic approaches","volume":"10","author":"Tramontana","year":"2023","journal-title":"Front. Med."},{"key":"10.1016\/j.yrtph.2024.105714_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17072404","article-title":"Contact allergy\u2014emerging allergens and public health impact","volume":"17","author":"Uter","year":"2020","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.yrtph.2024.105714_bib34","author":"Wijnhoven"},{"key":"10.1016\/j.yrtph.2024.105714_bib35","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1097\/DER.0000000000000371","article-title":"Genital allergic contact dermatitis","volume":"29","author":"Yale","year":"2018","journal-title":"Dermatitis"}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230024001557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230024001557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T06:50:44Z","timestamp":1755067844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230024001557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":29,"alternative-id":["S0273230024001557"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2024.105714","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative risk assessments of skin sensitization for 26 allergens in different consumer products in the Saudi market","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2024.105714","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105714"}}