{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:33:16Z","timestamp":1784896396479,"version":"3.55.0"},"reference-count":145,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004418","name":"Vrije Universiteit Brussel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004418","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","award":["101057014"],"award-info":[{"award-number":["101057014"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.yrtph.2025.105794","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T02:49:00Z","timestamp":1740710940000},"page":"105794","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Next generation risk assessment of hair dye HC yellow no. 13: Ensuring protection from liver steatogenic effects"],"prefix":"10.1016","volume":"159","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1023-7987","authenticated-orcid":false,"given":"Sara","family":"Sepehri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8510-0970","authenticated-orcid":false,"given":"Dinja","family":"De Win","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5822-3245","authenticated-orcid":false,"given":"Anja","family":"Heymans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5672-0048","authenticated-orcid":false,"given":"Freddy","family":"Van Goethem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2927-6791","authenticated-orcid":false,"given":"Robim M.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0635-7740","authenticated-orcid":false,"given":"Vera","family":"Rogiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6685-7299","authenticated-orcid":false,"given":"Tamara","family":"Vanhaecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2025.105794_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2023.104243","article-title":"Inter-species differences between humans and other mammals in the in vitro metabolism of carbofuran and the role of human CYP enzymes","volume":"102","author":"Abass","year":"2023","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib3","series-title":"Exposure Dose Guidance for Body Weight","article-title":"Exposure dose guidance for body weight","year":"2023"},{"key":"10.1016\/j.yrtph.2025.105794_bib4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nm.3159","article-title":"PPAR\u03b3 signaling and metabolism: the good, the bad and the future","volume":"19","author":"Ahmadian","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.yrtph.2025.105794_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2021.104936","article-title":"Next generation risk assessment for skin sensitisation: a case study with propyl paraben","volume":"123","author":"Assaf Vandecasteele","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.114650","article-title":"Application of AOPs to assist regulatory assessment of chemical risks \u2013 case studies, needs and recommendations","volume":"217","author":"Bajard","year":"2023","journal-title":"Environ. Res."},{"key":"10.1016\/j.yrtph.2025.105794_bib7","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/toxsci\/kfaa048","article-title":"A next-generation risk assessment case study for coumarin in cosmetic products","volume":"176","author":"Baltazar","year":"2020","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2025.105794_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.comtox.2017.10.001","article-title":"Ab initio chemical safety assessment: a workflow based on exposure considerations and non-animal methods","volume":"4","author":"Berggren","year":"2017","journal-title":"Comput. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/toxsci\/kfad124","article-title":"Enabling novel paradigms: a biological questions-based approach to human chemical hazard and drug safety assessment","volume":"198","author":"Berridge","year":"2024","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2025.105794_bib11","doi-asserted-by":"crossref","first-page":"20321","DOI":"10.1021\/acsomega.2c02315","article-title":"Assessment of the CYP1A2 inhibition-mediated drug interaction potential for pinocembrin using in silico, in vitro, and in vivo approaches","volume":"7","author":"Bhatt","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.yrtph.2025.105794_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11040392","article-title":"The skin sensitisation of cosmetic ingredients: review of actual regulatory status","volume":"11","author":"Bialas","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.yrtph.2025.105794_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104656","article-title":"An interim internal Threshold of Toxicologic Concern (iTTC) for chemicals in consumer products, with support from an automated assessment of ToxCastTM dose response data","volume":"114","author":"Blackburn","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.mex.2020.101068","article-title":"Flow cytometric quantification of neutral lipids in a human skin stem cell-derived model of NASH","volume":"7","author":"Boeckmans","year":"2020","journal-title":"MethodsX"},{"key":"10.1016\/j.yrtph.2025.105794_bib15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s10565-020-09544-2","article-title":"Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists","volume":"37","author":"Boeckmans","year":"2021","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2021.105021","article-title":"AOP and IATA applied to ocular surface toxicity","volume":"125","author":"Bonneau","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib18","series-title":"A Biology-Based Dynamic Approach for the Modelling of Toxicity in Cell-Based Assays","author":"Bouhifd","year":"2010"},{"key":"10.1016\/j.yrtph.2025.105794_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/nu13051513","article-title":"From food to genes: transcriptional regulation of metabolism by lipids and carbohydrates","volume":"13","author":"Bravo-Ruiz","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.yrtph.2025.105794_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxres\/tfac087","article-title":"Risk assessment in the 21st century: where are we heading?","volume":"12","author":"Brescia","year":"2023","journal-title":"Toxicol Res (Camb)"},{"key":"10.1016\/j.yrtph.2025.105794_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2024.105579","article-title":"Adverse effects in traditional and alternative toxicity tests","volume":"148","author":"Browne","year":"2024","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202006298","article-title":"Opportunities and challenges for integrating new in vitro methodologies in hazard testing and risk assessment","volume":"17","author":"Burden","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.yrtph.2025.105794_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2021.104964","article-title":"The Threshold of Toxicological Concern (TTC) is a pragmatic tool for the safety assessment: case studies of cosmetic ingredients with low consumer exposure","volume":"123","author":"Bury","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2021.104931","article-title":"New framework for a non-animal approach adequately assures the safety of cosmetic ingredients \u2013 a case study on caffeine","volume":"123","author":"Bury","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175989","article-title":"Human skin stem cell-derived hepatic cells as in vitro drug discovery model for insulin-driven de novo lipogenesis","volume":"957","author":"Buyl","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib26","first-page":"359","article-title":"Ready for regulatory use: NAMs and NGRA for chemical safety assurance","volume":"39","author":"Carmichael","year":"2022","journal-title":"ALTEX"},{"key":"10.1016\/j.yrtph.2025.105794_bib27","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.95.22.13018","article-title":"Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis","volume":"95","author":"Cases","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yrtph.2025.105794_bib28","doi-asserted-by":"crossref","first-page":"38870","DOI":"10.1074\/jbc.M106219200","article-title":"Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members","volume":"276","author":"Cases","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yrtph.2025.105794_bib29","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/toxsci\/kfx284","article-title":"Measures of BSEP inhibition in vitro are not useful predictors of DILI","volume":"162","author":"Chan","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2025.105794_bib30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.procs.2021.04.033","article-title":"Compartmental models with application to pharmacokinetics","volume":"187","author":"Chen","year":"2021","journal-title":"Procedia Comput. Sci."},{"key":"10.1016\/j.yrtph.2025.105794_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106091","article-title":"Dysregulated lipid and fatty acid metabolism link perfluoroalkyl substances exposure and impaired glucose metabolism in young adults","volume":"145","author":"Chen","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.yrtph.2025.105794_bib32","doi-asserted-by":"crossref","first-page":"22678","DOI":"10.1074\/jbc.M704213200","article-title":"Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance","volume":"282","author":"Cheol","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yrtph.2025.105794_bib33","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s00335-017-9731-6","article-title":"Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities","volume":"29","author":"Chiu","year":"2018","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.yrtph.2025.105794_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.yrtph.2005.01.008","article-title":"Use of mode of action in risk assessment: past, present, and future","volume":"42","author":"Clewell","year":"2005","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib35","doi-asserted-by":"crossref","first-page":"173","DOI":"10.5487\/TR.2017.33.3.173","article-title":"In silico prediction of organ level toxicity: linking chemistry to adverse effects","volume":"33","author":"Cronin","year":"2017","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.yrtph.2025.105794_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2023.105483","article-title":"Exposure considerations in human safety assessment: report from an EPAA Partners' Forum","volume":"144","author":"Cronin","year":"2023","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib37","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1289\/ehp.1001931","article-title":"The future use of in vitro data in risk assessment to set human exposure standards: challenging problems and familiar solutions","volume":"118","author":"Crump","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2025.105794_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108235","article-title":"Associations between perfluoroalkyl substances and the severity of non-alcoholic fatty liver disease","volume":"180","author":"David","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.yrtph.2025.105794_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20043473","article-title":"The role of \u201cphysiologically based pharmacokinetic model (PBPK)\u201d new approach methodology (NAM) in pharmaceuticals and environmental chemical risk assessment","volume":"20","author":"Deepika","year":"2023","journal-title":"Int. J. Environ. Res. Publ. Health"},{"key":"10.1016\/j.yrtph.2025.105794_bib41","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.comtox.2018.06.001","article-title":"Principles underpinning the use of new methodologies in the risk assessment of cosmetic ingredients","volume":"7","author":"Dent","year":"2018","journal-title":"Comput. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2021.105026","article-title":"Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients","volume":"125","author":"Dent","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib43","series-title":"Determining Modes of Action for Biologically Based Risk Assessments","year":"1999"},{"key":"10.1016\/j.yrtph.2025.105794_bib44","series-title":"Case Study on Use of an Integrated Approach for Testing and Assessment (IATA) for Systemic Toxicity of Phenoxyethanol when Included at 1% in a Body Lotion","author":"Directorate","year":"2021"},{"key":"10.1016\/j.yrtph.2025.105794_bib45","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3390\/molecules28020776","article-title":"Evaluation of free online ADMET tools for academic or small biotech environments","volume":"28","author":"Dulsat","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.yrtph.2025.105794_bib46","doi-asserted-by":"crossref","unstructured":"DumontCoralie, PrietoPilar, AsturiolDavid, WorthAndrew. Review of the Availability of In Vitro and In Silico Methods for Assessing Dermal Bioavailability. Https:\/\/HomeLiebertpubCom\/Aivt 2015;1:147\u2013164. https:\/\/doi.org\/10.1089\/AIVT.2015.0003.","DOI":"10.1089\/aivt.2015.0003"},{"key":"10.1016\/j.yrtph.2025.105794_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1345992","article-title":"Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure","volume":"15","author":"Ebmeyer","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib48","unstructured":"Elabscience.com. Triglyceride (TG) colorimetric assay kit (Single Reagent, GPO-PAP Method) E-BC-K261-M, 1\u201312."},{"key":"10.1016\/j.yrtph.2025.105794_bib49","series-title":"Committee for Medicinal Products for Human Use (CHMP) Guideline on the Reporting of Physiologically Based Pharmacokinetic (PBPK) Modelling and Simulation","year":"2018"},{"key":"10.1016\/j.yrtph.2025.105794_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1289\/EHP6664","article-title":"Cytotoxicity burst? Differentiating specific from nonspecific effects in tox21 in vitro reporter gene assays","volume":"128","author":"Escher","year":"2020","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2025.105794_bib52","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI14006","article-title":"CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism","volume":"108","author":"Febbraio","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.yrtph.2025.105794_bib53","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.dld.2007.10.002","article-title":"A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease","volume":"40","author":"Fern\u00e1ndez-Miranda","year":"2008","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.yrtph.2025.105794_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2023.1098432","article-title":"Application of a new approach methodology (NAM)-based strategy for genotoxicity assessment of data-poor compounds","volume":"5","author":"Fortin","year":"2023","journal-title":"Front. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113559","article-title":"New approach methodologies: a quantitative in vitro to in vivo extrapolation case study with PFASs","volume":"172","author":"Fragki","year":"2023","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib56","author":"Gadaleta"},{"key":"10.1016\/j.yrtph.2025.105794_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104755","article-title":"Read-across can increase confidence in the Next Generation Risk Assessment for skin sensitisation: a case study with resorcinol","volume":"117","author":"Gautier","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib58","first-page":"439","article-title":"Applying a next generation risk assessment framework for skin sensitisation to inconsistent new approach methodology information","volume":"40","author":"Gilmour","year":"2023","journal-title":"ALTEX - Alternat. Animal Experiment."},{"key":"10.1016\/j.yrtph.2025.105794_bib59","doi-asserted-by":"crossref","DOI":"10.1289\/EHP11372","article-title":"Metabolic signatures of youth exposure to mixtures of per- and polyfluoroalkyl substances: a multi-cohort study","volume":"131","author":"Goodrich","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.yrtph.2025.105794_bib61","series-title":"School of Mathematics FACULTY of MATHEMATICS and PHYSICAL SCIENCES Uncertainty Quantification in Next Generation Risk Assessment","author":"Gosling","year":"2013"},{"key":"10.1016\/j.yrtph.2025.105794_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100603","article-title":"A key role for the transporter OAT1 in systemic lipid metabolism","volume":"296","author":"Granados","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yrtph.2025.105794_bib63","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1007\/s00204-020-02868-2","article-title":"Screening of repeated dose toxicity data in safety evaluation reports of cosmetic ingredients issued by the Scientific Committee on Consumer Safety between 2009 and 2019","volume":"94","author":"Gustafson","year":"2020","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib64","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.2105\/AJPH.2017.303771","article-title":"Chemical risk assessment: traditional vs public health perspectives","volume":"107","author":"Gwinn","year":"2017","journal-title":"Am. J. Publ. Health"},{"key":"10.1016\/j.yrtph.2025.105794_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104020","article-title":"Implications of PFAS definitions using fluorinated pharmaceuticals","volume":"25","author":"Hammel","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.yrtph.2025.105794_bib66","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00204-020-02939-4","article-title":"Cross-species analysis of hepatic cytochrome P450 and transport protein expression","volume":"95","author":"Hammer","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib67","doi-asserted-by":"crossref","unstructured":"Hara E, Zeng W. Flutamide exacerbates steatosis and promotes early hepatocarcinogenesis in high-fat diet-fed non-obese steatotic rats: Insights from clustering analysis of mitophagy regulators AMBRA1 and LC3 2024. https:\/\/doi.org\/10.21203\/rs.3.rs-4371202\/v1.","DOI":"10.21203\/rs.3.rs-4371202\/v1"},{"key":"10.1016\/j.yrtph.2025.105794_bib68","series-title":"Science Approach Document Bioactivity Exposure Ratio : Application in Priority Setting and Risk Assessment","first-page":"1","year":"2021"},{"key":"10.1016\/j.yrtph.2025.105794_bib69","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1021\/acs.chemrestox.1c00037","article-title":"Quantitative in vitro-to- in vivo extrapolation: nominal versus freely dissolved concentration","volume":"34","author":"Henneberger","year":"2021","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib70","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3109\/10408444.2013.811215","article-title":"Hepatotoxicity: a scheme for generating chemical categories for read-across, structural alerts and insights into mechanism(s) of action","volume":"43","author":"Hewitt","year":"2013","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib71","first-page":"499","article-title":"Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks","volume":"39","author":"Hoffmann","year":"2022","journal-title":"ALTEX"},{"key":"10.1016\/j.yrtph.2025.105794_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.721507","article-title":"Lipidomic analyses reveal modulation of lipid metabolism by the PFAS perfluoroundecanoic acid (PFUnDA) in non-obese diabetic mice","volume":"12","author":"Hy\u00f6tyl\u00e4inen","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.yrtph.2025.105794_bib73","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s40726-023-00269-4","article-title":"PFAS exposures and the human metabolome: a systematic review of epidemiological studies","volume":"9","author":"India-Aldana","year":"2023","journal-title":"Curr. Pollut. Rep."},{"key":"10.1016\/j.yrtph.2025.105794_bib74","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1038\/psp.2013.41","article-title":"Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development","volume":"2","author":"Jones","year":"2013","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.107838","article-title":"Alteration of hepato-lipidomic homeostasis in A\/J mice fed an environmentally relevant PFAS mixture","volume":"173","author":"Khan","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.yrtph.2025.105794_bib76","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.tiv.2011.03.013","article-title":"Evaluation of the multipotent character of human foreskin-derived precursor cells","volume":"25","author":"De Kock","year":"2011","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.yrtph.2025.105794_bib77","first-page":"3309","article-title":"Mesoderm-derived stem cells: the link between the transcriptome and their differentiation potential","volume":"21","author":"De Kock","year":"2012","journal-title":"Https:\/\/HomeLiebertpubCom\/Scd"},{"key":"10.1016\/j.yrtph.2025.105794_bib78","series-title":"Dyes and Pigments - Novel Applications and Waste Treatment","article-title":"Structure and properties of dyes and pigments","author":"Kumar","year":"2021"},{"key":"10.1016\/j.yrtph.2025.105794_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.comtox.2022.100242","article-title":"In silico prediction of dermal absorption from non-dietary exposure to plant protection products","volume":"24","author":"Kuster","year":"2022","journal-title":"Comput. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib80","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.cell.2017.10.037","article-title":"Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling","volume":"171","author":"Lee","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.yrtph.2025.105794_bib81","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1021\/acs.chemrestox.2c00311","article-title":"Quantifying analogue suitability for SAR-based read-across toxicological assessment","volume":"36","author":"Lester","year":"2023","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2022.105293","article-title":"Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods","volume":"137","author":"Lizarraga","year":"2023","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib83","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1155\/2013\/692071","article-title":"Role of the plasma membrane transporter of organic cations OCT1 and its genetic variants in modern liver pharmacology","volume":"2013","author":"Lozano","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.yrtph.2025.105794_bib84","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1021\/acs.est.9b01608","article-title":"Mass spectrometry-based metabolomics reveals occupational exposure to per- and polyfluoroalkyl substances relates to oxidative stress, fatty acid \u03b2-oxidation disorder, and kidney injury in a manufactory in China","volume":"53","author":"Lu","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.yrtph.2025.105794_bib85","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1021\/acs.chemrestox.8b00112","article-title":"Adverse outcome pathway-driven analysis of liver steatosis in vitro: a case study with cyproconazole","volume":"31","author":"Luckert","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2023.100282","article-title":"The research progress of next generation risk assessment in cosmetic ingredients and the implications for traditional Chinese medicine risk assessment","volume":"8","author":"Luo","year":"2023","journal-title":"Pharmacol. Res. - Mod. Chin. Med."},{"key":"10.1016\/j.yrtph.2025.105794_bib87","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/toxsci\/kfad012","article-title":"A pragmatic framework for the application of new approach methodologies in one health toxicological risk assessment","volume":"192","author":"Magurany","year":"2023","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2025.105794_bib88","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.3390\/ijms19051529","article-title":"The CD36-ppar\u03b3 pathway in metabolic disorders","volume":"19","author":"Mar\u00e9chal","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yrtph.2025.105794_bib89","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/toxsci\/kfac068","article-title":"Are non-animal systemic safety assessments protective? A Toolbox and workflow","volume":"189","author":"Middleton","year":"2022","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2025.105794_bib91","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cmet.2007.05.005","article-title":"Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver","volume":"6","author":"Monetti","year":"2007","journal-title":"Cell Metab."},{"key":"10.1016\/j.yrtph.2025.105794_bib92","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2019.00899","article-title":"Vienna LiverTox workspace\u2014a set of machine learning models for prediction of interactions profiles of small molecules with transporters relevant for regulatory agencies","volume":"7","author":"Montanari","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.yrtph.2025.105794_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104746","article-title":"Application of physiologically based kinetic (PBK) modelling in the next generation risk assessment of dermally applied consumer products","volume":"63","author":"Moxon","year":"2020","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.yrtph.2025.105794_bib94","doi-asserted-by":"crossref","DOI":"10.3390\/ph16030409","article-title":"In vitro hepatic models to assess herb\u2013drug interactions: approaches and challenges","volume":"16","author":"N","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.yrtph.2025.105794_bib95","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1421601","article-title":"Next-generation risk assessment read-across case study: application of a 10-step framework to derive a safe concentration of daidzein in a body lotion","volume":"15","author":"Najjar","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib96","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.toxlet.2017.11.014","article-title":"Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone","volume":"284","author":"Natale","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.yrtph.2025.105794_bib97","series-title":"Neutral Red Uptake Assay SCOPE of the METHOD the Method Relates to the Method Is Situated in Basic Research Specify the Type of Cells\/tissues\/organs","year":"2022"},{"key":"10.1016\/j.yrtph.2025.105794_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153826","article-title":"A workflow to practically apply true dose considerations to in vitro testing for next generation risk assessment","volume":"505","author":"Nicol","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2025.105794_bib100","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2019.00680","article-title":"CD 36: focus on epigenetic and post-transcriptional regulation","volume":"10","author":"Niculite","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.yrtph.2025.105794_bib101","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1152\/physrev.00025.2013","article-title":"The organic anion transporter (OAT) family: a systems biology perspective","volume":"95","author":"Nigam","year":"2015","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yrtph.2025.105794_bib102","series-title":"Case Study on the Use of Integrated Approaches for Testing and Assessment for Systemic Toxicity Arising from Cosmetic Exposure to Caffeine Series on Testing and Assessment No. 321 JT03465717 OFDE. ENV\/JM\/MONO","year":"2020"},{"key":"10.1016\/j.yrtph.2025.105794_bib103","series-title":"OCDE\/OECD 497 OECD GUIDELINE for TESTING of CHEMICALS Defined Approaches for Skin Sensitisation","year":"2023"},{"key":"10.1016\/j.yrtph.2025.105794_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130808","article-title":"Evaluation of the individual and combined toxicity of perfluoroalkyl substances to human liver cells using biomarkers of oxidative stress","volume":"281","author":"Ojo","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.yrtph.2025.105794_bib105","first-page":"1","article-title":"Predicting human dermal drug concentrations using PBPK modeling and simulation: clobetasol propionate case study","volume":"25","author":"van Osdol","year":"2024","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.yrtph.2025.105794_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2022.105161","article-title":"Read-across and new approach methodologies applied in a 10-step framework for cosmetics safety assessment \u2013 a case study with parabens","volume":"132","author":"Ouedraogo","year":"2022","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib107","first-page":"419","article-title":"Next-generation risk assessment of chemicals - rolling out a human-centric testing strategy to drive 3R implementation: the RISK-hunt3r project perspective","volume":"39","author":"Pallocca","year":"2022","journal-title":"ALTEX"},{"key":"10.1016\/j.yrtph.2025.105794_bib108","article-title":"The transcription factor RXRA regulates lipid metabolism in 1 duck myoblasts by the CD36 network","author":"Pan","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.yrtph.2025.105794_bib109","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/toxsci\/kfz201","article-title":"Utility of in vitro bioactivity as a lower bound estimate of in vivo adverse effect levels and in risk-based prioritization","volume":"173","author":"Paul Friedman","year":"2020","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2025.105794_bib110","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.00561","article-title":"In silico toxicology data resources to support read-across and (Q)SAR","volume":"10","author":"Pawar","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2020.109192","article-title":"A comparative study on the in vitro biotransformation of medicagenic acid using human liver microsomes and S9 fractions","volume":"328","author":"Peeters","year":"2020","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.yrtph.2025.105794_bib112","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2016.00442","article-title":"A New Structure-Activity Relationship (SAR) Model for predicting drug-induced liver injury, based on statistical and expert-based structural alerts","volume":"7","author":"Pizzo","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105133","article-title":"Effective exposure of chemicals in in vitro cell systems: a review of chemical distribution models","volume":"73","author":"Proen\u00e7a","year":"2021","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.yrtph.2025.105794_bib114","first-page":"221","article-title":"Predictive performance of next generation human physiologically based kinetic (PBK) models based on in vitro and in silico input data","volume":"39","author":"Punt","year":"2022","journal-title":"ALTEX - Alternat. Animal Experiment."},{"key":"10.1016\/j.yrtph.2025.105794_bib115","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/j.gastro.2008.03.078","article-title":"Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled fatty liver improvement with rosiglitazone therapy (FLIRT) trial","volume":"135","author":"Ratziu","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yrtph.2025.105794_bib116","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1089\/scd.2013.0157","article-title":"Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals","volume":"23","author":"Rodrigues","year":"2014","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.yrtph.2025.105794_bib117","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.dib.2016.03.069","article-title":"Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples","volume":"7","author":"Rodrigues","year":"2016","journal-title":"Data Brief"},{"key":"10.1016\/j.yrtph.2025.105794_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152421","article-title":"The way forward for assessing the human health safety of cosmetics in the EU - workshop proceedings","volume":"436","author":"Rogiers","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2025.105794_bib119","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1111\/j.1476-5381.2011.01724.x","article-title":"OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies","volume":"165","author":"Roth","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib120","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.biocel.2013.02.019","article-title":"The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification","volume":"45","author":"Rowland","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.yrtph.2025.105794_bib121","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00204-023-03649-3","article-title":"Impact of perfluoroalkyl substances (PFAS) and PFAS mixtures on lipid metabolism in differentiated HepaRG cells as a model for human hepatocytes","volume":"98","author":"Sadrabadi","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib123","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/1062936X.2013.773375","article-title":"Hazard Evaluation Support System (HESS) for predicting repeated dose toxicity using toxicological categories","volume":"24","author":"Sakuratani","year":"2013","journal-title":"SAR QSAR Environ. Res."},{"key":"10.1016\/j.yrtph.2025.105794_bib124","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/toxsci\/kfj057","article-title":"Identification of a critical dose level for risk assessment: developments in benchmark dose analysis of continuous endpoints","volume":"90","author":"Sand","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2025.105794_bib1","unstructured":"SCCS\/1322\/10. SCCS - Opinion on HC Yellow n\u00b0 13 2011. https:\/\/health.ec.europa.eu\/scientific-committees\/scientific-committee-consumer-safety-sccs\/sccs-opinions_en (accessed December 5, 2023)."},{"key":"10.1016\/j.yrtph.2025.105794_bib126","series-title":"SCCS Notes of Guidance for the Testing of Cosmetic Ingredients and Their Safety Evaluation 12th Revision","year":"2023"},{"key":"10.1016\/j.yrtph.2025.105794_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2023.108082","article-title":"New approach methodologies in human regulatory toxicology \u2013 not if, but how and when","volume":"178","author":"Schmeisser","year":"2023","journal-title":"Environ. Int."},{"key":"10.1016\/j.yrtph.2025.105794_bib128","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.yrtph.2017.06.011","article-title":"Lessons learned from read-across case studies for repeated-dose toxicity","volume":"88","author":"Schultz","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib129","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3109\/10408444.2014.931925","article-title":"The use of mode of action information in risk assessment: quantitative key events\/dose-response framework for modeling the dose-response for key events","volume":"44","author":"Simon","year":"2014","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib130","series-title":"PBPK modeling software from discovery through development","first-page":"1","year":"2017"},{"key":"10.1016\/j.yrtph.2025.105794_bib131","series-title":"Computational Modeling of Absorption from Complex Topical Formulations","author":"Spires","year":"2020"},{"issue":"7","key":"10.1016\/j.yrtph.2025.105794_bib132","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41594-023-01017-4","article-title":"Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2","volume":"30","author":"Suo","year":"2023","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.yrtph.2025.105794_bib133","doi-asserted-by":"crossref","first-page":"kfab113","DOI":"10.1093\/toxsci\/kfab113","article-title":"A pragmatic approach to adverse outcome pathway development and evaluation","volume":"184","author":"Svingen","year":"2021","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2025.105794_bib134","series-title":"In Silico-QSAR WG\/Final Report REPORT for the INTERNATIONAL COOPERATION on COSMETICS REGULATION in Silico Approaches for Safety Assessment of Cosmetic Ingredients","author":"Teixeira do Amaral","year":"2014"},{"key":"10.1016\/j.yrtph.2025.105794_bib135","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.biochem.77.061307.091829","article-title":"Fat and beyond: the diverse biology of PPARgamma","volume":"77","author":"Tontonoz","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.yrtph.2025.105794_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2023.105436","article-title":"From worst-case to reality \u2013 case studies illustrating tiered refinement of consumer exposure to cosmetic ingredients","volume":"143","author":"Tozer","year":"2023","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib137","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.yrtph.2015.07.012","article-title":"Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment","volume":"73","author":"Troutman","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib138","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/psp4.12893","article-title":"Mechanistic modeling of drug products applied to the skin: a workshop summary report","volume":"12","author":"Tsakalozou","year":"2023","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib140","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bbadis.2011.02.014","article-title":"PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation","volume":"1812","author":"Varga","year":"2011","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.yrtph.2025.105794_bib141","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1007\/s11095-015-1749-4","article-title":"Predicting clearance mechanism in drug discovery: extended clearance classification system (ECCS)","volume":"32","author":"Varma","year":"2015","journal-title":"Pharm. Res."},{"key":"10.1016\/j.yrtph.2025.105794_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2024.153814","article-title":"A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis","volume":"505","author":"Verhoeven","year":"2024","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2025.105794_bib144","year":"2020","journal-title":"Workspace"},{"key":"10.1016\/j.yrtph.2025.105794_bib145","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/hep.22980","article-title":"Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids","volume":"50","author":"Villanueva","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.yrtph.2025.105794_bib146","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1021\/acs.chemrestox.5b00208","article-title":"Adverse outcome pathways and drug-induced liver injury testing","volume":"28","author":"Vinken","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib147","series-title":"Bioactivity:Exposure Ratio Example Comparing NAM-Based PODs to Estimates of Human Daily Intake","author":"Wambaugh","year":"2024"},{"key":"10.1016\/j.yrtph.2025.105794_bib148","doi-asserted-by":"crossref","first-page":"15575","DOI":"10.1021\/acs.est.1c06896","article-title":"A new OECD definition for per- and polyfluoroalkyl substances","volume":"55","author":"Wang","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.yrtph.2025.105794_bib149","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1021\/ci00057a005","article-title":"SMILES, a chemical language and information system: 1: introduction to methodology and encoding rules","volume":"28","author":"Weininger","year":"1988","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"10.1016\/j.yrtph.2025.105794_bib150","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2133\/dmpk.19.327","article-title":"Structure-based approaches for predicting ADME properties","volume":"19","author":"Yamashita","year":"2004","journal-title":"Drug Metabol. Pharmacokinet."},{"key":"10.1016\/j.yrtph.2025.105794_bib151","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2022.105201","article-title":"Comparison of the lower limit of benchmark dose confidence interval with no-observed-adverse-effect level by applying four different software for tumorigenicity testing of pesticides in Japan","volume":"133","author":"Yasuhiko","year":"2022","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105794_bib152","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1194\/jlr.R800018-JLR200","article-title":"Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis","volume":"49","author":"Yen","year":"2008","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.yrtph.2025.105794_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.comtox.2020.100142","article-title":"Evaluation of quantitative structure property relationship algorithms for predicting plasma protein binding in humans","volume":"17","author":"Yun","year":"2021","journal-title":"Comput. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105794_bib154","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s13318-022-00758-9","article-title":"In silico prediction of pharmacokinetic profile for human oral drug candidates which lack clinical pharmacokinetic experiment data","volume":"47","author":"Zhai","year":"2022","journal-title":"Eur. J. Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.yrtph.2025.105794_bib155","article-title":"Association of per- and polyfluoroalkyl substance exposure with fatty liver disease risk in US adults","volume":"5","author":"Zhang","year":"2023","journal-title":"JHEP Rep."},{"key":"10.1016\/j.yrtph.2025.105794_bib156","doi-asserted-by":"crossref","first-page":"e208","DOI":"10.1016\/j.jhep.2023.07.008","article-title":"Associations between per- and polyfluoroalkyl substances and adolescent non-alcoholic fatty liver disease","volume":"79","author":"Zhao","year":"2023","journal-title":"J. Hepatol."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230025000248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230025000248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T19:08:05Z","timestamp":1762283285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230025000248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":145,"alternative-id":["S0273230025000248"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2025.105794","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Next generation risk assessment of hair dye HC yellow no. 13: Ensuring protection from liver steatogenic effects","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2025.105794","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105794"}}