{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:06:28Z","timestamp":1791021988633,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004349","name":"BASF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.yrtph.2025.105841","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T06:29:12Z","timestamp":1746253752000},"page":"105841","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Not yet nixing rabbit eyes from the six: the TTT is not predicting the full range of in vivo eye irritation classifications for agrochemical formulations"],"prefix":"10.1016","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3502-1034","authenticated-orcid":false,"given":"Susanne N.","family":"Kolle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy","family":"Haase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Wareing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Kemeny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Stinchcombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee","family":"Funk-Weyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Landsiedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2025.105841_bib1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00204-013-1156-8","article-title":"Retrospective analysis of the Draize test for serious eye damage\/eye irritation: importance of understanding the in vivo endpoints under UN GHS\/EU CLP for the development and evaluation of in vitro test methods","volume":"88","author":"Adriaens","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105841_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105150","article-title":"Comparative evaluation of HET-CAM and ICE methods for objective assessment of ocular irritation caused by selected pesticide products","volume":"74","author":"Budai","year":"2021","journal-title":"Toxicol. Vitro"},{"key":"10.1016\/j.yrtph.2025.105841_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2023.105543","article-title":"Retrospective evaluation of the eye irritation potential of agrochemical formulations","volume":"146","author":"Choksi","year":"2024","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105841_bib4","series-title":"Prospective and Retrospective Evaluation of the Eye Irritation Potential of Agrochemical Formulations","author":"Choksi","year":"2021"},{"key":"10.1016\/j.yrtph.2025.105841_bib5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/15569527.2021.1910291","article-title":"Human-relevant approaches to assess eye corrosion\/irritation potential of agrochemical formulations","volume":"40","author":"Clippinger","year":"2021","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105841_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.yrtph.2017.06.014","article-title":"A retrospective analysis of in vivo eye irritation, skin irritation and skin sensitisation studies with agrochemical formulations: setting the scene for development of alternative strategies","volume":"89","author":"Corvaro","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105841_bib7","first-page":"69","article-title":"Penn state extension agronomy facts 37: adjuvants for enhancing herbicide performance","volume":"vol. 30","author":"Curran","year":"2009"},{"key":"10.1016\/j.yrtph.2025.105841_bib8","series-title":"Addendum to the Prospective and Retrospective Evaluation of the Eye Irritation Potential of Agrochemical Formulations","author":"Daniel","year":"2025"},{"key":"10.1016\/j.yrtph.2025.105841_bib9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/15569528609036295","article-title":"Correlation of animal eye test data with human experience for household products: an update","volume":"5","author":"Freeberg Fe","year":"1986","journal-title":"J. Toxicol. Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105841_bib10","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0272-0590(92)90142-5","article-title":"Bovine corneal opacity and permeability test: an in vitro assay of ocular irritancy","volume":"18","author":"Gautheron","year":"1992","journal-title":"Fund. Appl. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105841_bib11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/026119291504300307","volume":"43","author":"Kolle","year":"2015","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.yrtph.2025.105841_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yrtph.2017.01.013","volume":"85","author":"Kolle","year":"2017","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105841_bib13","first-page":"123","article-title":"Analysis of Draize eye irritation testing and its prediction by mining publicly available 2008-2014 REACH data","volume":"33","author":"Luechtefeld","year":"2016","journal-title":"ALTEX"},{"issue":"4","key":"10.1016\/j.yrtph.2025.105841_bib14","first-page":"669","article-title":"A triangular approach for the validation of new approach methods for skin sensitization","volume":"38","author":"Natsch","year":"2021","journal-title":"ALTEX"},{"key":"10.1016\/j.yrtph.2025.105841_bib15","series-title":"Test No. 405: Acute Eye Irritation\/Corrosion","year":"2023"},{"key":"10.1016\/j.yrtph.2025.105841_bib16","series-title":"Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying I) Chemicals Inducing Serious Eye Damage and Ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage","year":"2023"},{"key":"10.1016\/j.yrtph.2025.105841_bib17","series-title":"Test No. 438: Isolated Chicken Eye Test Method for Identifying I) Chemicals Inducing Serious Eye Damage and Ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage","year":"2023"},{"key":"10.1016\/j.yrtph.2025.105841_bib18","series-title":"Test No. 467: Defined Approaches for Serious Eye Damage and Eye Irritation, OECD Guidelines for the Testing of Chemicals","year":"2024"},{"key":"10.1016\/j.yrtph.2025.105841_bib19","series-title":"Test No. 492: Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage","year":"2024"},{"key":"10.1016\/j.yrtph.2025.105841_bib20","article-title":"Test No. 492B: reconstructed human cornea-like epithelium (RHCE) test method for eye hazard identification","year":"2024"},{"key":"10.1016\/j.yrtph.2025.105841_bib24","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0278-6915(95)00115-8","article-title":"The Chicken Enucleated Eye Test (CEET): a Practical (Pre)screen for the Assessment of Eye Irritation\/corrosion Potential of Test Materials","volume":"34","author":"Prinsen","year":"1996","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.yrtph.2025.105841_bib21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1177\/026119291003800109","article-title":"Experience with the HET-CAM method in the routine testing of a broad variety of chemicals and formulations","volume":"38","author":"Schrage","year":"2010","journal-title":"Altern. Lab. Anim."},{"key":"10.1016\/j.yrtph.2025.105841_bib22","series-title":"Globally Harmonized System for the Classification and Labelling of Chemicals (GHS)","year":"2023"},{"key":"10.1016\/j.yrtph.2025.105841_bib23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/15569527.2023.2275029","article-title":"Defined approaches to classify agrochemical formulations into EPA hazard categories developed using EpiOcular(TM) reconstructed human corneal epithelium and bovine corneal opacity and permeability assays","volume":"43","author":"van der Zalm","year":"2024","journal-title":"Cutan. Ocul. Toxicol."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230025000716?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230025000716?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T18:59:44Z","timestamp":1749236384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230025000716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":24,"alternative-id":["S0273230025000716"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2025.105841","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Not yet nixing rabbit eyes from the six: the TTT is not predicting the full range of in vivo eye irritation classifications for agrochemical formulations","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2025.105841","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"105841"}}