{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T13:49:21Z","timestamp":1773323361813,"version":"3.50.1"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020970","name":"Johnson and Johnson Consumer Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.yrtph.2025.105941","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:22:49Z","timestamp":1757766169000},"page":"105941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The skin sensitization prediction model: an algorithm for real-world prediction of skin sensitization risk and minimization of human sensitization testing"],"prefix":"10.1016","volume":"164","author":[{"given":"Ladan","family":"Fakhrzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otto","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Cork","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Khaiat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teginder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evren","family":"Atillasoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yrtph.2025.105941_bib1","unstructured":"U.S. Food and Drug Administration. Guidance for Industry - Skin Irritation and Sensitization Testing of Generic Transdermal Drug Products (Draft Guidance). February (Accessed 1 May 2022)."},{"key":"10.1016\/j.yrtph.2025.105941_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104805","article-title":"Updating exposure assessment for skin sensitization quantitative risk assessment for fragrance materials","volume":"118","author":"Api","year":"2020","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105941_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/15569520902938032","article-title":"The human repeated insult patch test in the 21st century: a commentary","volume":"28","author":"Basketter","year":"2009","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105941_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2021.104867","article-title":"Draize human repeat insult patch test (HRIPT): seven decades of pitfalls and progress","volume":"121","author":"Bormann","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105941_bib5","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.yrtph.2018.03.003","article-title":"International regulatory requirements for skin sensitization testing","volume":"95","author":"Daniel","year":"2018","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105941_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.comtox.2018.06.001","article-title":"Principles underpinning the use of new methodologies in the risk assessment of cosmetic ingredients","volume":"7","author":"Dent","year":"2018","journal-title":"Comput. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105941_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2022.105159","article-title":"Next generation risk assessment for skin allergy: decision making using new approach methodologies","volume":"131","author":"Gilmour","year":"2022","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105941_bib8","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/10408444.2018.1429385","article-title":"Non-animal methods to predict skin sensitization (I): the cosmetics Europe database<sup\/>","volume":"48","author":"Hoffmann","year":"2018","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.yrtph.2025.105941_bib9","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/toxsci\/59.2.198","article-title":"Skin sensitization testing in potency and risk assessment","volume":"59","author":"Kimber","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.yrtph.2025.105941_bib10","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1590\/S0080-62342009000300027","article-title":"Confusions and ambiguities in the classification of adverse events in the clinical research","volume":"43","author":"Marodin","year":"2009","journal-title":"Rev. Esc. Enferm. USP"},{"key":"10.1016\/j.yrtph.2025.105941_bib11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.yrtph.2007.10.019","article-title":"A review of critical factors in the conduct and interpretation of the human repeat insult patch test","volume":"52","author":"McNamee","year":"2008","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105941_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152421","article-title":"The way forward for assessing the human health safety of cosmetics in the EU - workshop proceedings","volume":"436","author":"Rogiers","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.yrtph.2025.105941_bib13","article-title":"The SCCS notes of guidance for the testing of cosmetic ingredients and their safety evaluation","volume":"127","year":"2021","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.yrtph.2025.105941_bib14","doi-asserted-by":"crossref","first-page":"546","DOI":"10.2307\/4584864","article-title":"The patch test in contact dermatitis","volume":"59","author":"Schwartz","year":"1944","journal-title":"Publ. Health Rep."},{"key":"10.1016\/j.yrtph.2025.105941_bib16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/cosmetics3020014","article-title":"Safety evaluation of cosmetic ingredients regarding their skin sensitization potential","volume":"3","author":"Steiling","year":"2016","journal-title":"Cosmetics"},{"issue":"Suppl. 1","key":"10.1016\/j.yrtph.2025.105941_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0536.2011.02004_2.x","article-title":"The critical review of methodologies and approaches to assess the inherent skin sensitization potential (skin allergies) of chemicals Part I","volume":"66","author":"Thyssen","year":"2012","journal-title":"Contact Dermat."},{"key":"10.1016\/j.yrtph.2025.105941_bib18","unstructured":"U.S. Food and Drug Administration. Guidance for industry and FDA reviewers\/staff: Premarket Notification [501(k)] submissions for testing for skin sensitization to chemicals in natural rubber products. January 13. https:\/\/www.fda.gov\/downloads\/MedicalDevices\/DeviceRegulationandGuidance\/GuidanceDocuments\/ucm073793.pdf. (Accessed 1 May 2022)."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230025001734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230025001734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T21:44:30Z","timestamp":1773265470000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230025001734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"alternative-id":["S0273230025001734"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2025.105941","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The skin sensitization prediction model: an algorithm for real-world prediction of skin sensitization risk and minimization of human sensitization testing","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2025.105941","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105941"}}