{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:01:11Z","timestamp":1786114871682,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.yrtph.2026.106174","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:46:30Z","timestamp":1783467990000},"page":"106174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Acute oral toxicity and systemic pathological effects of methiopropamine in female ICR mice"],"prefix":"10.1016","volume":"171","author":[{"given":"Ghabilan","family":"Muniandy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Gibbons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng-Wee","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norizal","family":"Mohd Noor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suwharthi","family":"Latsheni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Rohi","family":"Ghazali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0702-0309","authenticated-orcid":false,"given":"Norazrina","family":"Azmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.yrtph.2026.106174_bib1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/PAF.0000000000000170","article-title":"A fatal case of isolated methiopropamine (1-(Thiophen-2-yl)-2-Methylaminopropane) toxicity","volume":"36","author":"Anne","year":"2015","journal-title":"Am. J. Forensic Med. Pathol"},{"key":"10.1016\/j.yrtph.2026.106174_bib2","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00414-024-03201-7","article-title":"Understanding methiopropamine, a new psychoactive substance: an in-depth review on its chemistry, pharmacology and implications to human health","volume":"138","author":"Bunaim","year":"2024","journal-title":"Int. J. Leg. Med."},{"issue":"3","key":"10.1016\/j.yrtph.2026.106174_bib4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/bcp.14183","article-title":"How deaths can help clinicians and policy\u2010makers understand the risks of novel psychoactive substances","volume":"86","author":"Corkery","year":"2020","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"7","key":"10.1016\/j.yrtph.2026.106174_bib5","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/j.1360-0443.2009.02564.x","article-title":"A review of the clinical pharmacology of methamphetamine","volume":"104","author":"Cruickshank","year":"2009","journal-title":"Addiction"},{"issue":"9","key":"10.1016\/j.yrtph.2026.106174_bib6","first-page":"758","article-title":"Acute methiopropamine intoxication after \u201cSynthacaine\u201d consumption","volume":"40","author":"Daveluy","year":"2016","journal-title":"J. Anal. Toxicol."},{"issue":"5","key":"10.1016\/j.yrtph.2026.106174_bib7","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00414-020-02302-3","article-title":"Methiopropamine and its acute behavioral effects in mice: is there a gray zone in new psychoactive substances users?","volume":"134","author":"De-Giorgio","year":"2020","journal-title":"Int. J. Leg. Med."},{"issue":"1","key":"10.1016\/j.yrtph.2026.106174_bib8","first-page":"134","article-title":"\u201cSynthacaines\u201d: a mosaic of substances for a wide range of effects, from a case","volume":"29","author":"Deslandes","year":"2017","journal-title":"Toxicol. Anal. et Clin."},{"key":"10.1016\/j.yrtph.2026.106174_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.forsciint.2014.04.017","article-title":"A 3-year review of new psychoactive substances in casework","volume":"243","author":"Elliott","year":"2014","journal-title":"Forensic Sci. Int."},{"issue":"3","key":"10.1016\/j.yrtph.2026.106174_bib11","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00414-018-1891-8","article-title":"Phenotypic effects of chronic and acute use of methiopropamine in a mouse model","volume":"133","author":"Foti","year":"2018","journal-title":"Int. J. Leg. Med."},{"issue":"2","key":"10.1016\/j.yrtph.2026.106174_bib12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.34172\/ahj.2023.1411","article-title":"New psychoactive substances: a potential threat to developing countries","volume":"15","author":"Hasan","year":"2023","journal-title":"Addict. Health"},{"issue":"3","key":"10.1016\/j.yrtph.2026.106174_bib13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s13181-014-0399-y","article-title":"Acute toxicity associated with analytically confirmed recreational use of methiopropamine (1-(thiophen-2-yl)-2-methylaminopropane)","volume":"10","author":"Lee","year":"2014","journal-title":"J. Med. Toxicol."},{"issue":"1","key":"10.1016\/j.yrtph.2026.106174_bib14","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1002\/cpph.43","article-title":"The irwin test and Functional Observational Battery (FOB) for assessing the effects of compounds on behavior, physiology, and safety pharmacology in rodents","volume":"83","author":"Mathiasen","year":"2018","journal-title":"Curr. Protoc. Pharmacol."},{"issue":"1","key":"10.1016\/j.yrtph.2026.106174_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1021\/acs.chas.0c00096","article-title":"A review of the LD50 and its current role in hazard communication","volume":"28","author":"Morris-Schaffer","year":"2020","journal-title":"ACS Chem. Health Safe."},{"key":"10.1016\/j.yrtph.2026.106174_bib16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.cbi.2019.03.017","article-title":"Methiopropamine, a methamphetamine analogue, produces neurotoxicity via dopamine receptors","volume":"305","author":"Nguyen","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.yrtph.2026.106174_bib17","series-title":"OECD Guidelines for the Testing of Chemicals, Section 4","article-title":"Test no. 425: acute oral toxicity: up-and-down procedure","year":"2022"},{"key":"10.1016\/j.yrtph.2026.106174_bib18","series-title":"Drug Bioavailability","author":"Price","year":"2023"},{"key":"10.1016\/j.yrtph.2026.106174_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2019.106591","article-title":"The functional observational battery and modified Irwin test as global neurobehavioral assessments in the rat: pharmacological validation data and a comparison of methods","volume":"98","author":"Redfern","year":"2019","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.yrtph.2026.106174_bib20","series-title":"Sympathomimetic Toxicity","author":"Schaffer","year":"2025"},{"key":"10.1016\/j.yrtph.2026.106174_bib21","series-title":"A Practical Guide to the Histology of the Mouse","author":"Scudamore","year":"2014"},{"issue":"21","key":"10.1016\/j.yrtph.2026.106174_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222112002","article-title":"Comparative neuropharmacology and pharmacokinetics of methamphetamine and its thiophene analog methiopropamine in rodents","volume":"22","author":"Tuv","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yrtph.2026.106174_bib23","series-title":"Current NPS Threats Volume VII July 2024","year":"2024"},{"key":"10.1016\/j.yrtph.2026.106174_bib25","series-title":"Amphetamine Toxicity","author":"Vasan","year":"2024"},{"issue":"1","key":"10.1016\/j.yrtph.2026.106174_bib26","doi-asserted-by":"crossref","DOI":"10.1186\/s40035-021-00278-7","article-title":"Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration","volume":"11","author":"Verma","year":"2022","journal-title":"Transl. Neurodegener."},{"issue":"10","key":"10.1016\/j.yrtph.2026.106174_bib27","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1007\/s00216-013-6741-4","article-title":"2-Methiopropamine, a thiophene analogue of methamphetamine: studies on its metabolism and detectability in the rat and human using GC-MS and LC-(HR)-MS techniques","volume":"405","author":"Welter","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"issue":"7","key":"10.1016\/j.yrtph.2026.106174_bib28","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1080\/15563650.2018.1538519","article-title":"Acute toxicity following analytically confirmed use of the novel psychoactive substance (NPS) methiopropamine. A report from the Identification of Novel psychoActive substances (IONA) study","volume":"57","author":"White","year":"2019","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.yrtph.2026.106174_bib29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.bbr.2016.05.060","article-title":"The expression of methiopropamine-induced locomotor sensitization requires dopamine D2, but not D1, receptor activation in the rat","volume":"311","author":"Yoon","year":"2016","journal-title":"Behav. Brain Res."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230026001479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230026001479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:28:37Z","timestamp":1785968917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230026001479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":26,"alternative-id":["S0273230026001479"],"URL":"https:\/\/doi.org\/10.1016\/j.yrtph.2026.106174","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute oral toxicity and systemic pathological effects of methiopropamine in female ICR mice","name":"articletitle","label":"Article Title"},{"value":"Regulatory Toxicology and Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yrtph.2026.106174","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106174"}}