{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:24:52Z","timestamp":1790418292638,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tissue and Cell"],"published-print":{"date-parts":[[2002,10]]},"DOI":"10.1016\/s0040816602000356","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T19:39:34Z","timestamp":1034192374000},"page":"349-355","source":"Crossref","is-referenced-by-count":37,"title":["Spermatogenesis and blood\u2013testis barrier in rats after long-term Vitamin A deprivation"],"prefix":"10.1016","volume":"34","author":[{"given":"Alfonsina","family":"Morales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C.","family":"Cavicchia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0040816602000356_BIB1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1530\/jrf.0.1100061","article-title":"Apoptosis pattern elicited by oestradiol treatment of the seminiferous epithelium of the adult rat","volume":"110","author":"Blanco-Rodr\u0131\u0301guez","year":"1997","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/S0040816602000356_BIB2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1095\/biolreprod18.2.219","article-title":"Ultrastructural characteristics of monkey spermatogonia and preleptotene spermatocytes","volume":"8","author":"Cavicchia","year":"1978","journal-title":"Biol. Reprod."},{"key":"10.1016\/S0040816602000356_BIB3","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1095\/biolreprod17.3.390","article-title":"Further observations on the blood\u2013testis barrier in monkeys","volume":"17","author":"Dym","year":"1977","journal-title":"Biol. Reprod."},{"key":"10.1016\/S0040816602000356_BIB4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod18.1.1","article-title":"Functional morphology of the testis","volume":"18","author":"Dym","year":"1978","journal-title":"Biol. Reprod."},{"key":"10.1016\/S0040816602000356_BIB5","first-page":"105","article-title":"Electron microscopic observation on the structural components of the blood\u2013testis barriers","volume":"10","author":"Fawcett","year":"1970","journal-title":"J. Reprod. Fertil. Suppl."},{"key":"10.1016\/S0040816602000356_BIB6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1159\/000146606","article-title":"Disruption of sustentacular (Sertoli) cell tight junctions and regression of spermatogenesis in Vitamin A deficient rats","volume":"133","author":"Huang","year":"1988","journal-title":"Acta Anat. (Basel)"},{"key":"10.1016\/S0040816602000356_BIB7","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/jemt.1070200106","article-title":"Effects of Vitamin A deficiency on the inter-Sertoli cell tight junctions and on the germ cell population","volume":"20","author":"Ismail","year":"1992","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/S0040816602000356_BIB8","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/aja.1001880107","article-title":"Role of spermatogonia in the stage-synchronization of the seminiferous epithelium in Vitamin A-deficient rats","volume":"188","author":"Ismail","year":"1990","journal-title":"Am. J. Anat."},{"key":"10.1016\/S0040816602000356_BIB9","unstructured":"Kim, K.H. and Wang, Z.Q. 1993. Action of Vitamin A on the testis: role of the Sertoli cell. In: Russell, L.D. and Griswold, M.D. (eds) The Sertoli Cell. Cache River Press, Clearwater, FL, pp 517\u2013535."},{"key":"10.1016\/S0040816602000356_BIB10","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1749-6632.1952.tb26576.x","article-title":"Definition of the stages of the cycle of the seminiferous epithelium in the rat","volume":"55","author":"Leblond","year":"1952","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/S0040816602000356_BIB11","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1210\/en.138.5.2081","article-title":"The Fas system is a key regulator of germ cell apoptosis in the testis","volume":"138","author":"Lee","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/S0040816602000356_BIB12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-72005-5_1","article-title":"The establishment of spermatogenesis in the seminiferous epithelium of the pubertal golden hamster (Mesocricetus auratus)","volume":"140","author":"Miething","year":"1998","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"10.1016\/S0040816602000356_BIB13","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1210\/endo-121-1-432","article-title":"Retinol-induced stage synchronization in seminiferous tubules of the rat","volume":"121","author":"Morales","year":"1987","journal-title":"Endocrinology"},{"key":"10.1016\/S0040816602000356_BIB14","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/(SICI)1097-0177(199701)208:1<125::AID-AJA12>3.0.CO;2-5","article-title":"Morphological analysis of germ cell apoptosis during postnatal testis development in normal and Hsp 70-2 knockout mice","volume":"208","author":"Mori","year":"1997","journal-title":"Dev. Dyn."},{"key":"10.1016\/S0040816602000356_BIB15","doi-asserted-by":"crossref","first-page":"c7","DOI":"10.1083\/jcb.33.3.C7","article-title":"Hexagonal array of subunits in intercellular junctions of the mouse heart and liver","volume":"33","author":"Revel","year":"1967","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0040816602000356_BIB16","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1210\/jc.76.5.1325","article-title":"Is infancy a quiescent period of testicular development? Histological, morphometric, and functional study of the seminiferous tubules of the cebus monkey from birth to the end of puberty","volume":"76","author":"Rey","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/S0040816602000356_BIB17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1083\/jcb.17.1.208","article-title":"The use of lead citrate at high pH as electron-opaque stain in electron microscopy","volume":"17","author":"Reynolds","year":"1963","journal-title":"J. Cell Biol."},{"key":"10.1016\/S0040816602000356_BIB18","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1093\/emboj\/16.9.2262","article-title":"An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis","volume":"16","author":"Rodr\u0131\u0301guez","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/S0040816602000356_BIB19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1113\/jphysiol.1969.sp008682","article-title":"A blood\u2013testis barrier restricting passage from blood into rete testis fluid but not into lymph","volume":"200","author":"Setchell","year":"1969","journal-title":"J. Physiol."},{"key":"10.1016\/S0040816602000356_BIB20","unstructured":"Setchell, B.P. and Waites, G.M.H. 1975. The blood\u2013testis barrier. In: Hamilton, D.W. and Greep, R.O. (eds) Handbook of Physiology and Endocrinology. Williams & Wilkins, Baltimore, pp 143\u2013172."},{"key":"10.1016\/S0040816602000356_BIB21","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0022-5320(69)90033-1","article-title":"A low-viscosity epoxy resin embedding medium for electron microscopy","volume":"26","author":"Spurr","year":"1969","journal-title":"J. Ultrastruct. Res."},{"key":"10.1016\/S0040816602000356_BIB22","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1095\/biolreprod49.6.1229","article-title":"Spermatogenesis is accelerated in the immature Djungarian and Chinese hamster and rat","volume":"49","author":"van Haaster","year":"1993","journal-title":"Biol. Reprod."},{"key":"10.1016\/S0040816602000356_BIB23","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1210\/endo-128-2-697","article-title":"Retinoic acid is able to reinitiate spermatogenesis in Vitamin A-deficient rats and high replicate doses support the full development of spermatogenic cells","volume":"128","author":"van Pelt","year":"1991","journal-title":"Endocrinology"}],"container-title":["Tissue and Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816602000356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0040816602000356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T07:36:49Z","timestamp":1554795409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0040816602000356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["S0040816602000356"],"URL":"https:\/\/doi.org\/10.1016\/s0040816602000356","relation":{},"ISSN":["0040-8166"],"issn-type":[{"value":"0040-8166","type":"print"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}