{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:21:09Z","timestamp":1785111669295,"version":"3.55.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1016\/s0171-2985(00)80098-4","type":"journal-article","created":{"date-parts":[[2011,11,2]],"date-time":"2011-11-02T11:26:13Z","timestamp":1320233173000},"page":"461-469","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Phenotypic Pattern of B cells in the Appendix: Reduced Intensity of CD 19 Expression"],"prefix":"10.1016","volume":"201","author":[{"given":"Eli","family":"Somekh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Serour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arkadi","family":"Gorenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Vohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S0171-2985(00)80098-4_bib1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1046\/j.1365-2567.1996.d01-727.x","article-title":"Distribution of beta 7 integrins in human intestinal mucosa and organized gut-associated lymphoid tissue","volume":"89","author":"Farstadt","year":"1996","journal-title":"Immunology"},{"key":"10.1016\/S0171-2985(00)80098-4_bib2","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/gut.26.7.672","article-title":"Gut associated lymphoid tissue: A morphological and immunocytochemical study of the human appendix","volume":"26","author":"Spencer","year":"1985","journal-title":"Gut."},{"key":"10.1016\/S0171-2985(00)80098-4_bib3","first-page":"19","article-title":"Immunocompetence of normal human appendiceal lymphoid cells: in vitro studies","volume":"60","author":"Kawanishi","year":"1987","journal-title":"Immunology"},{"key":"10.1016\/S0171-2985(00)80098-4_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1600-065X.1986.tb01503.x","article-title":"The Ly-1 B cell lineage","volume":"1986","author":"Herzenberg","year":"1986","journal-title":"Immunol. Rev."},{"key":"10.1016\/S0171-2985(00)80098-4_bib5","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0167-5699(91)90136-H","article-title":"The development and repertoire of B-1 cells","volume":"12","author":"Kantor","year":"1991","journal-title":"Immunol. Today"},{"key":"10.1016\/S0171-2985(00)80098-4_bib6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1126\/science.3105057","article-title":"Rheumtoid factor secretion from human Leu 1 + B cells","volume":"236","author":"Hardy","year":"1987","journal-title":"Science"},{"key":"10.1016\/S0171-2985(00)80098-4_bib7","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1073\/pnas.81.8.2494","article-title":"Ly-1 B cells: Functionally distinct lymphocytes that secrete IgM autoantibodies","volume":"81","author":"Hayakawa","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/S0171-2985(00)80098-4_bib8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0090-1229(90)90136-E","article-title":"Possible immunoregulatory role for CD8+ B cells","volume":"56","author":"Raveche","year":"1990","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/S0171-2985(00)80098-4_bib9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0165-2478(93)90182-2","article-title":"CD8+ B cells and the immune system","volume":"38","author":"Lydyard","year":"1993","journal-title":"Immunol. Lett."},{"key":"10.1016\/S0171-2985(00)80098-4_bib10","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/art.1780310509","article-title":"B cells expressing CDS are increased in Sjogren's syndrome","volume":"31","author":"Dauphinee","year":"1988","journal-title":"Arthritis Rheum."},{"key":"10.1016\/S0171-2985(00)80098-4_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0167-5699(87)90235-0","article-title":"CDS positive B cells in rheumatoid arthritis and chronic lymphocytic leukemia","volume":"8","author":"Lydyard","year":"1987","journal-title":"Immunol. Today"},{"key":"10.1016\/S0171-2985(00)80098-4_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/ard.46.1.17","article-title":"CDS positive B cells in patients with rheumatoid arthritis.: PMA mediated enhancement of detection","volume":"46","author":"Youinou","year":"1987","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/S0171-2985(00)80098-4_bib13","first-page":"37","article-title":"CD8 positive B cells in rheumatoid arthritis and chronic lymphocytic leukemia","volume":"8","author":"Paglieroni","year":"1988","journal-title":"Am. J. Hematol."},{"key":"10.1016\/S0171-2985(00)80098-4_bib14","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.4049\/jimmunol.146.5.1503","article-title":"A human CD8+ B cell clone that secretes an itiotype- specific high affinity IgM monoclonal antibody","volume":"146","author":"Vander","year":"1991","journal-title":"J. Immunol."},{"key":"10.1016\/S0171-2985(00)80098-4_bib15","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1046\/j.1365-3083.1997.d01-166.x","article-title":"Preferential localization of human CDS+ B cells in the peritoneal cavity","volume":"46","author":"Nisitani","year":"1997","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/S0171-2985(00)80098-4_bib16","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1046\/j.1365-2249.1997.4541352.x","article-title":"Human peritoneal B-1 cells and the influence of continuous ambulatory peritoneal dialysis on peritoneal and peripheral blood mononuclear cells (PBMC) composition and immunoglobulin levels","volume":"109","author":"Donze","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/S0171-2985(00)80098-4_bib17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/intimm\/5.8.809","article-title":"Induction of CDS antigen on human CDS- B cells by stimulation with Staphylococcus aureus Cowan strain I","volume":"5","author":"Morikawa","year":"1993","journal-title":"Int. Immunol."},{"key":"10.1016\/S0171-2985(00)80098-4_bib18","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1128\/iai.65.1.122-126.1997","article-title":"Marked reduction of mouse peritoneal CDS+ B cells intraperitoneal administration of lipopolysaccharide","volume":"65","author":"Paeng","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/S0171-2985(00)80098-4_bib19","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/eji.1830240628","article-title":"Expression of CDS and CD38 by human CDS- B cells: requirement for special stimuli","volume":"24","author":"Zupo","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/S0171-2985(00)80098-4_bib20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00004836-199512000-00006","article-title":"Appendectomy and tonsillectomy in patients with inflammatory bowel disease","volume":"21","author":"Smithson","year":"1995","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/S0171-2985(00)80098-4_bib21","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1084\/jem.184.2.707","article-title":"Role of appendix in the development of inflammatory bowel disease in TCR-alpha mutant mice","volume":"184","author":"Mizoguchi","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/S0171-2985(00)80098-4_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4049\/jimmunol.158.1.55","article-title":"RAG1 and RAG2 in developing rabbit appendix subpopulations","volume":"158","author":"Fuschiotti","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/S0171-2985(00)80098-4_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/cimm.1997.1216","article-title":"Neonatal appendectomy impairs mucosal immunity in rabbits","volume":"182","author":"Dasso","year":"1997","journal-title":"Cell Immunol."},{"key":"10.1016\/S0171-2985(00)80098-4_bib24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/978-1-4615-2492-2_42","article-title":"The appendix functions as a mammalian bursal equivalent in the developing rabbit","volume":"355","author":"Weinstein","year":"1994","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/S0171-2985(00)80098-4_bib25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1172\/JCI115284","article-title":"Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis","volume":"88","author":"Fujihashi","year":"1991","journal-title":"J. Clin. Invest."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298500800984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298500800984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:19:58Z","timestamp":1759249198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298500800984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":25,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S0171298500800984"],"URL":"https:\/\/doi.org\/10.1016\/s0171-2985(00)80098-4","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenotypic Pattern of B cells in the Appendix: Reduced Intensity of CD 19 Expression","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0171-2985(00)80098-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Urban & Fischer Verlag. Published by Elsevier GmbH All rights reserved.","name":"copyright","label":"Copyright"}]}}