{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:44:14Z","timestamp":1761007454798,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":5936,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p>In this study the prognostic importance of p53, proliferating cell nuclear antigen (PCNA), and Ki\u201067 expression was analyzed along with the clinical parameters in 35 consecutive patients with undifferentiated nasopharyngeal carcinomas. Immunohistochemistry was used to detect p53, PCNA, and Ki\u201067 staining. Among the clinical findings, stage IV disease (<jats:italic>P<\/jats:italic> = 0.01), cranial nerve paralysis (<jats:italic>P<\/jats:italic> = 0.02), and lymph node metastasis (<jats:italic>P<\/jats:italic> = 0.06) were associated with shorter survival. The p53 positivity correlated with the presence of lymph nodes, but it was not a significant factor to predict the outcome. PCNA expression was not found to be a prognostic indicator. On the other hand, the proliferative value of Ki\u201067 staining was suggestive of prognosis. A proliferation index of Ki\u201067 less than 10% indicated longer survival (<jats:italic>P<\/jats:italic> = 0.03). There was no correlation between Ki\u201067 staining and PCNA index. As a result, the prognostic value of Ki\u201067\u00a0may alert the physician to more aggressive and adjuvant treatment modalities.<\/jats:p>","DOI":"10.1016\/s0194-59980070016-7","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T13:24:04Z","timestamp":1664371444000},"page":"868-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Value of p53, Proliferating cell Nuclear Antigen, and Ki\u201067 Expression in Undifferentiated Nasopharyngeal Carcinomas"],"prefix":"10.1002","volume":"122","author":[{"given":"Erkhan","family":"Gen\u00e7","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology\u2010Head and Neck Surgery Hacettepe University Medical Faculty Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. \u015eefik","family":"Ho\u015fal","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology\u2010Head 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