{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:31:29Z","timestamp":1774686689046,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4734,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Our goal was to describe the course of parathyroid hormone (PTH) after surgery for primary hyperparathyroidism (PHPT). PTH levels drop to low values after parathyroidectomy for PHPT. However, in some patients, a rebound transient increase in PTH concentrations can occur.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>A prospective study included 72 patients who underwent surgical exploration for PHPT. A single adenoma was found in 57 patients (79.1%), 2 adenomas were found in 2 (2.7%), and parathyroid hyperplasia was found in 13 (18.05%). The postoperative PTH secretion was studied in those patients who had an adenoma excised.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>This phenomenon was noted in 18 (31.6%) patients between 4 and 12 weeks, although total calcium concentrations were normal (9.3 \u00b1 0.6\u00a0mg\/ dL). Before surgery these patients had a more remarkable hyperparathyroidism (clinical and biochemical) than the others, but differences were not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Postoperative increases in PTH concentration can occur after successful parathyroidectomy. These increases are transient and do not indicate persistent or recurrent disease.<\/jats:p><\/jats:sec>","DOI":"10.1016\/s0194-59980300088-3","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T13:22:19Z","timestamp":1664371339000},"page":"771-776","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transient Rise in Intact Parathyroid Hormone Concentration after Surgery for Parathyroid Adenoma"],"prefix":"10.1002","volume":"128","author":[{"given":"M. J.","family":"Ferrer\u2010Ramirez","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Arroyo","family":"Domingo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"L\u00f3pez\u2010Moll\u00e1","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Izquierdo","family":"Sol\u00e1","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Pastor","family":"Garz\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Ari\u00f1o","family":"Morillas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Mijares","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658526"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658524"},{"key":"e_1_2_7_4_1","first-page":"109","article-title":"Intraoperative fall in plasma levels of intact parathyroid hormone after removal of one enlarged parathyroid gland in hyperparathyroid patients","volume":"157","author":"Bergenfelz A","year":"1991","journal-title":"Eur J Surg"},{"key":"e_1_2_7_5_1","first-page":"827","article-title":"Functional recovery of the parathyroid glands after surgery for primary hyperparathyroidism","volume":"116","author":"Bergenfelz A","year":"1994","journal-title":"Surgery"},{"key":"e_1_2_7_6_1","first-page":"898","article-title":"Parathyroid metabolism after operative treatment of hypercalcemic (primary) hyperparathyroidissm","volume":"102","author":"Irvin GL","year":"1987","journal-title":"Surgery"},{"key":"e_1_2_7_7_1","first-page":"1021","article-title":"Parathyroid hormone: before and after parathyroidectomy","volume":"100","author":"Duh Q","year":"1986","journal-title":"Surgery"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.1998.92004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02067339"},{"key":"e_1_2_7_10_1","first-page":"153","article-title":"Postoperative course of serum parathyroid hormone and calcium after surgery for primary hyperparathyroidism","volume":"55","author":"Debruyne F","year":"2001","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"e_1_2_7_11_1","first-page":"1121","article-title":"Intraoperative measurement of parathyroid hormone in the surgical management of hyperparathyroidism","volume":"104","author":"Nussbaum SR","year":"1988","journal-title":"Surgery"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(96)80040-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830524"},{"key":"e_1_2_7_14_1","first-page":"665","article-title":"Persistent elevated serum levels of intact parathyroid hormone after operation for sporadic parathyroid adenoma: evidence of detrimental effects of severe parathyroid disease","volume":"83","author":"Bergenfelz A","year":"1996","journal-title":"Surgery"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.1997.tb00946.x"},{"key":"e_1_2_7_16_1","first-page":"128","article-title":"Skeletal remineralization after surgery for primary and secondary hyperparathyroidism","volume":"107","author":"Abugassa S","year":"1990","journal-title":"Surgery"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010219"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-83-5-1043"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110714"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118701"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0194-59980300088-3","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/S0194-59980300088-3","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0194-59980300088-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:05:55Z","timestamp":1760954755000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/S0194-59980300088-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["10.1016\/S0194-59980300088-3"],"URL":"https:\/\/doi.org\/10.1016\/s0194-59980300088-3","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}