{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:18:48Z","timestamp":1762067928185,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":7107,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1996,12]]},"abstract":"<jats:p>Our study focuses on a series of 1344 cases of carcinoma of the oral cavity and oropharynx treated between 1973 and 1992. Brachytherapy was always performed with iridium 192, either alone or in combination with external\u2010beam irradiation or with surgery for the treatment of the primary tumor. For the oral cavity, we studied 565 cases of mobile tongue. The local control and overall survival rates, respectively, at 5 years are as follows: for T1, 92% and 70%; for T2, 62% and 42%; and for T3, 50% and 29%. For the subgroup T1T2N0, there was a better prognosis for treatment by brachytherapy of the primary lesion alone (<jats:italic>p<\/jats:italic> &lt; 0.0001). Two hundred seven cases of floor\u2010of\u2010mouth carcinoma have been reported. The T3T4 patients were not considered surgical candidates. The local control and overall survival rates, respectively, at 5 years are as follows: for T1, 97% and 71%; for T2, 72% and 42%; and for T3, 51% and 35%. Ninety\u2010seven patients were treated by postoperative brachytherapy. These were patients for whom the margins after surgery were positive or narrow. A technique termed the <jats:italic>modified bridge<\/jats:italic> is described for lesions located in the mandible. Carcinomas of the buccal mucosa are rare in our country; only 42 cases were treated in this comparison of two techniques, and the overall survival rate was 48%. Epidermoid carcinomas of the oropharynx have nearly always been treated by a combination of external\u2010beam irradiation and brachytherapy because of the bilateral node risk. Seventy\u2010two patients with epidermoid cancers of the base of the tongue had an overall survival rate of 44%. The tonsil, soft palate, and pillars benefited from the use of the loop technique of brachytherapy combined with external\u2010beam irradiation. Three hundred sixty\u2010one patients were treated. Among these patients were two groups with different prognoses. Patients with tonsil, soft palate, and posterior pillar carcinomas had a local control rate of 84% and an overall survival rate of 57%. Conversely, the anterior pillar and the pharyngoglossal sulcus have a local control rate of only 65% and an overall survival rate of 38%. Statistical analysis revealed the prognostic factors for local control. The complications were classified into four grades: minor (20%), moderate (9%), major (4%), or inducing death (0.2%). The bone complications of grade 2 or 3 are more frequent for the floor of the mouth than for other locations.<\/jats:p>","DOI":"10.1016\/s0194-59989670006-2","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T13:21:47Z","timestamp":1664371307000},"page":"519-526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Role of Interstitial Brachytherapy in Oral and Oropharyngeal Carcinoma: Reflection of a Series of 1344 Patients Treated at the Time of Initial Presentation"],"prefix":"10.1002","volume":"115","author":[{"given":"Monique","family":"Pernot","sequence":"first","affiliation":[{"name":"Department of Brachytherapy Centre Alexis Vautrin Vand\u0153uvre Les Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvette","family":"Hoffstetter","sequence":"additional","affiliation":[{"name":"Department of Brachytherapy Centre Alexis Vautrin Vand\u0153uvre Les Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Peiffert","sequence":"additional","affiliation":[{"name":"Department of Brachytherapy Centre Alexis Vautrin Vand\u0153uvre Les Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Aletti","sequence":"additional","affiliation":[{"name":"Department of Radiophysics Centre Alexis Vautrin Vand\u0153uvre Les Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Lapeyre","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Centre Alexis Vautrin Vand\u0153uvre Les Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Marchal","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Centre Alexis Vautrin Vand\u0153uvre Les Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Luporsi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Centre Alexis Vautrin Vand\u0153uvre Les Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Bey","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Centre Alexis Vautrin Vand\u0153uvre Les Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"volume-title":"Dosim\u00e9trie en curietherapie.","year":"1982","author":"Dutreix A","key":"e_1_2_6_2_1"},{"volume-title":"Modern brachytherapy.","year":"1987","author":"Pierquin B","key":"e_1_2_6_3_1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(95)01557-W"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90643-V"},{"key":"e_1_2_6_6_1","first-page":"101","volume-title":"Brachytherapy from radium to optimization.","author":"Gerbaulet A","year":"1994"},{"issue":"1","key":"e_1_2_6_7_1","first-page":"130","article-title":"Primary radiotherapy in the treatment of stage I and II oral tongue cancers: importance of the production delivered with interstitial therapy","volume":"17","author":"Wendt CD","year":"1988","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(92)80125-3"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0964-1955(94)90095-7"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(89)90039-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800715)46:2<386::AID-CNCR2820460229>3.0.CO;2-9"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.184.1.1609090"},{"key":"e_1_2_6_13_1","first-page":"101","article-title":"Carcinomes \u00e9pidermo\u00efdes de la base de langue. Apropos de 108 cas trait\u00e9s au Centre Alexis Vautrin","volume":"7","author":"Hoffstetter S","year":"1986","journal-title":"J Eur Radiother"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(87)80229-3"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(89)90106-3"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(85)90211-1"},{"key":"e_1_2_6_17_1","first-page":"798","article-title":"Interstitial brachytherapy in the treatment of posterior pharyngeal wall epidermoid carcinoma","volume":"116","author":"Ardiet JM","year":"1990","journal-title":"J Cancer Res Clin Oncol"},{"key":"e_1_2_6_18_1","first-page":"15","article-title":"Facteur temps en curieth\u00e9rapie: l'exemple des carcinomes \u00e9pidermo\u00efdes de la langue mobile","volume":"77","author":"Mazeron JJ","year":"1990","journal-title":"Bull Cancer Radiother"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-8140(90)90114-C"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90553-3"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0194-59989670006-2","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/S0194-59989670006-2","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0194-59989670006-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:54:43Z","timestamp":1760968483000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/S0194-59989670006-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,12]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1996,12]]}},"alternative-id":["10.1016\/S0194-59989670006-2"],"URL":"https:\/\/doi.org\/10.1016\/s0194-59989670006-2","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1996,12]]},"assertion":[{"value":"1995-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}