{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:19:05Z","timestamp":1764782345887,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"vor","delay-in-days":7628,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1996,2]]},"abstract":"<jats:p>This article presents recent data on several environmental toxins: lead, carbon disulfide, asbestos, arsenic, ozone, cadmium, vinyl chloride, fiuorocarbons, freon, and pesticides. These environmental toxins produce both hypertension and cardiac arrhythmias in most studies, and they are not necessarily related to primary lung disease and secondary heart disease. The possible mechanisms that could cause the cardiovascular diseases include (1) damage to the endothelial barrier in the vascular system, (2) activation of leukocytes and platelets, (3) initiation of plaque formation, (4) stimulation of the inflammatory response, (5) kidney\u2010related hypertension, and (6) direct damage to cardiac and blood vessel tissue. Recommendations are that more animal, human cultured cell, and epidemiologic studies should be conducted on the environmental toxins identified in this article.<\/jats:p>","DOI":"10.1016\/s0194-59989670167-5","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T13:30:38Z","timestamp":1664371838000},"page":"209-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cardiovascular Effects of Environmental Chemicals"],"prefix":"10.1002","volume":"114","author":[{"given":"Aubrey E.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Physiology University of South Alabama Mobile Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-2447-6_17"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.93100177"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700200509"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199305000-00016"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1993.10718306"},{"key":"e_1_2_3_7_1","first-page":"3203","article-title":"Lead \u2013\u2010 a possible risk factor of increased blood pressure and cardiovascular disease","volume":"155","author":"M\u00f8ller LF","year":"1993","journal-title":"Ugeskr Laeger"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00381107"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/20.4.978"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/3430985"},{"key":"e_1_2_3_11_1","first-page":"465","article-title":"Cardiotoxicity in the workplace","volume":"7","author":"Benowitz NL","year":"1992","journal-title":"Occup Med"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0048-9697(92)90224-G"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.2307\/3430883"},{"key":"e_1_2_3_14_1","first-page":"287","article-title":"Effects of exposure to carbon disulphide on low density lipoprotein cholesterol concentration and diastolic blood pressure","volume":"49","author":"Egeland GM","year":"1992","journal-title":"Br J Ind Med"},{"key":"e_1_2_3_15_1","first-page":"225","article-title":"Regional cerebral blood flow after long\u2010term exposure to carbon disulfide","volume":"649","author":"Aaserud O","year":"1992","journal-title":"Ann NY Acad Sci"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/21.4.745"},{"key":"e_1_2_3_17_1","first-page":"785","article-title":"The importance of lung function, non\u2010malignant diseases associated with asbestos, and symptoms as predictors of ischaemic heart disease in shipyard workers exposed to asbestos","volume":"50","author":"Sand\u2010en A","year":"1993","journal-title":"Br J Ind Med"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02783182"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.1.8111607"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0048-9697(93)90402-R"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.9191133"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116079"},{"key":"e_1_2_3_23_1","first-page":"134","article-title":"Exposure to vinyl chloride monomer: Results of a cohort study after a seven year followup. The French VCM Group","volume":"49","author":"Laplanche A","year":"1992","journal-title":"Br J Ind Med"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700210212"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480040117044"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/096032719201100206"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.86.2.699"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0194-59989670167-5","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/S0194-59989670167-5","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0194-59989670167-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:43:14Z","timestamp":1760971394000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/S0194-59989670167-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,2]]}},"alternative-id":["10.1016\/S0194-59989670167-5"],"URL":"https:\/\/doi.org\/10.1016\/s0194-59989670167-5","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1996,2]]},"assertion":[{"value":"1995-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}