{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:12:02Z","timestamp":1760969522820,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T00:00:00Z","timestamp":1487116800000},"content-version":"vor","delay-in-days":7716,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p>Otocephaly is a lethal malformation of the first and second branchial arches, which consists of ventromedial displacement of the external ear structures (synotia), mandibular aplasia (agnathia), absence of the tongue (aglossia), and microstomia. We present the first complete description of the temporal bone findings in a case of otocephalus. A three\u2010dimensional computer\u2010assisted reconstruction of the right temporal bone was performed, allowing a unique graphic analysis. An extremely low\u2010lying middle fossa tegmen was noted with malrotation of the middle ear structures. Severe ossicular malformations were also found. An anomalous course of the internal carotid artery was noted with indentation of the basal turn of the cochlea. All three layers of the otic capsule were incompletely developed. Cochlear bony dehiscences were noted. These findings are consistent with early arrest of fetal development and malrotation caused by lack of growth pressure from the mandibular arch. Implications of these findings in the embryologic development of the ear are discussed.<\/jats:p>","DOI":"10.1016\/s0194-59989670282-6","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T13:36:29Z","timestamp":1664372189000},"page":"44-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Otocephalus: Histopathology and Three\u2010Dimensional Reconstruction"],"prefix":"10.1002","volume":"114","author":[{"given":"Raul","family":"Hinojosa","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\/Head and Neck Surgery University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"J. Douglas","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Mayo Clinic Jacksonville Jacksonville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Brecht","sequence":"additional","affiliation":[{"name":"Elkhart Clinic Elkhart Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Robb","sequence":"additional","affiliation":[{"name":"Biodynamics Research Unit Mayo Clinic and Mayo Foundation Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,15]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"141","volume-title":"Handbook of congenital malformations.","author":"Rubin A","year":"1967"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1973.00780020130014"},{"key":"e_1_2_5_4_1","first-page":"913","article-title":"Histopathology of the temporal bones in mandibulofacial dysostosis (Treacher\u2010Collins syndrome)","volume":"72","author":"Sando I","year":"1968","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196810000-00002"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-6111(89)90285-1"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(75)90155-6"},{"key":"e_1_2_5_8_1","first-page":"121","article-title":"Genetic and developmental studies of a new mouse mutation that produces otocephaly","volume":"5","author":"Juriloff DM","year":"1985","journal-title":"J Craniofac Genet Dev Biol"},{"key":"e_1_2_5_9_1","first-page":"736","article-title":"Otocephaly: Report of a case with ultrasound findings","volume":"81","author":"Dao AH","year":"1988","journal-title":"J Tenn Med Assoc"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1985.4.7.377"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809125106"},{"key":"e_1_2_5_12_1","first-page":"211","article-title":"Agnathia associated with pharyngeal isthmus atresia and hydramnios","volume":"78","author":"Johnson WW","year":"1961","journal-title":"Arch Pediatr"},{"key":"e_1_2_5_13_1","first-page":"111","volume-title":"Otolaryngology. Vol I: Basic sciences and related disciplines.","author":"Davis J","year":"1973"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1963.00750020345016"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)33264-3"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199001000-00001"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0194-59989670282-6","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/S0194-59989670282-6","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0194-59989670282-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:31:08Z","timestamp":1760967068000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/S0194-59989670282-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1016\/S0194-59989670282-6"],"URL":"https:\/\/doi.org\/10.1016\/s0194-59989670282-6","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[1996,1]]},"assertion":[{"value":"1994-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}