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The C3H\/<jats:italic>lpr<\/jats:italic> autoimmune mouse was chosen to study the permeability of capillaries in the stria vascularis because this mouse model has demonstrated abnormalities of the stria vascularis and shifts in the auditory brain stem response threshold during active disease. C3H\/<jats:italic>lpr<\/jats:italic> mice with active disease were compared with younger mice without disease, as well as age\u2010matched C3H\/HeJ control mice. The mice were injected with the tracer ferritin and examined by transmission electron microscopy to evaluate the integrity of the capillary tight junctions in the stria vascularis. Four of five mice with active disease were noted to have extensive leakage of ferritin into the perivascular tissues. Neither the young, disease\u2010free autoimmune mice nor the nonautoimmune control mice demonstrated vessel leakage. Thickening of the basement membrane was also noted in the diseased animals. The results imply that active disease leads to a breakdown in the blood\u2010endolymph barrier, which could underlie the hearing loss accompanying autoimmune and other immune diseases.<\/jats:p>","DOI":"10.1016\/s0194-59989770026-3","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T13:22:23Z","timestamp":1664371343000},"page":"530-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Breakdown of Stria Vascularis Blood\u2010Labyrinth Barrier in C3H\/<i>lpr<\/i> Autoimmune Disease Mice"],"prefix":"10.1002","volume":"117","author":[{"given":"David W.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery and the Oregon Hearing Research Center Oregon Health Sciences University Portland Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis 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