{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:59:15Z","timestamp":1792162755225,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":6742,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1997,12]]},"abstract":"<jats:p>Forty\u2010six patients with infiltrating supraglottic carcinoma were treated prospectively for cure between 1986 and 1992 with transoral laser resection of the primary. Nine primaries were classified as T1, and 37 as T2. Thirty\u2010three had staged unilateral or bilateral neck dissections, and 16 had postoperative radiotherapy. All patients were followed up for 2 to 8 years unless they died. Of the 46 patients, 33 are alive without disease, 8 died with disease, and 5 died of intercurrent disease. Among the 8 patients who died with disease, 4 had uncontrollable local or regional recurrences, and 4 had distant metastases but were free of local or regional recurrence. Calculated overall survival was 59% and adjusted survival was 72% after 5 years. Four patients had tracheostomies perioperatively, and 2 required temporary postoperative tracheostomies. The remaining 40 patients needed no artificial airway other than orotracheal intubation for the endolaryngeal intervention. Thirty\u2010seven patients relearned undisturbed deglutition within 2 weeks from surgery, and 4, within 4 weeks. However, 5 (10.9%) patients failed to relearn swallowing and consecutively underwent \u201ccompletion\u201d total laryngectomy. Among them were the two patients who had previously had unsuccessful surgical or radiologic treatment of their primaries and the patient with a history of oral cavity carcinoma. This study confirms that transoral laser resection can effectively control early supraglottic carcinoma. Tracheostomies are not routinely required, and phonatory function is not compromised. However, transoral laser resection could not steadily preserve undisturbed deglutition in the patients included In this study. Patients with histories of unsuccessful attempts of other larynx\u2010sparing therapeutic modalities or of previous major head and neck interventions were not successfully managed with transoral laser resection in this series. Criteria for patient selection remain to be established.<\/jats:p>","DOI":"10.1016\/s0194-59989770052-4","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T13:37:57Z","timestamp":1664372277000},"page":"681-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Endoscopic Laser Resection of Supraglottic Carcinoma"],"prefix":"10.1002","volume":"117","author":[{"given":"Hans edmund","family":"Eckel","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology University of Cologne Cologne Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"791","article-title":"Laser excision of carcinoma of the larynx","volume":"91","author":"Strong MS","year":"1972","journal-title":"Laryngoscope"},{"key":"e_1_2_6_3_1","first-page":"162","volume-title":"Laryngeal cancer","author":"Shapshay SM","year":"1991"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948509400607"},{"key":"e_1_2_6_5_1","first-page":"135","article-title":"Experience in endoscopic laser surgery of malignant tumours of the upper aero\u2010digestive tract","volume":"39","author":"Steiner W.","year":"1988","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949210100202"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1978.88.9.1399"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1983.93.4.429"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199106000-00019"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989010300301"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009901204"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199401000-00012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(93)90050-H"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00178101"},{"key":"e_1_2_6_15_1","first-page":"227","article-title":"Technique and results of transoral laser surgery of supraglottic carcinomas","volume":"49","author":"Rudert HH","year":"1995","journal-title":"Adv Otorhinolaryngol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197502000-00003"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199410000-00018"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556139407300505"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880160305"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0194-59989770052-4","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/S0194-59989770052-4","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/S0194-59989770052-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:50:09Z","timestamp":1760957409000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/S0194-59989770052-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,12]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,12]]}},"alternative-id":["10.1016\/S0194-59989770052-4"],"URL":"https:\/\/doi.org\/10.1016\/s0194-59989770052-4","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,12]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}