{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:14:27Z","timestamp":1770272067563,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":6895,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To compare the use of ibuprofen with the use of acetaminophen with codeine for posttonsillectomy management.<\/jats:p><\/jats:sec><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>We were not satisfied with our traditional pain\u2010management practice for tonsillectomy patients. We hoped to find a new approach for improved patient comfort and avoid scheduled, abusable drugs such as codeine.<\/jats:p><\/jats:sec><jats:sec><jats:title>DESIGN<\/jats:title><jats:p>Intervention, prospective, randomized control trial. Follow\u2010up was 1 month.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>University referral center; institutional pediatric practice, ambulatory.<\/jats:p><\/jats:sec><jats:sec><jats:title>PATIENTS<\/jats:title><jats:p>110 children undergoing tonsillectomy with or without other procedures. Consecutive patients were offered participation. Enrollees were randomly assigned to one of two classes and analyzed with the initial assignment. No patients withdrew for adverse effects, although 12 in group 2 used codeine and 5 of those used acetaminophen, whereas 2 in group 1 received ibuprofen.<\/jats:p><\/jats:sec><jats:sec><jats:title>INTERVENTIONS<\/jats:title><jats:p>Patients received either acetaminophen with codeine (group 1) or ibuprofen (group 2) for postoperative pain control.<\/jats:p><\/jats:sec><jats:sec><jats:title>MAIN OUTCOME MEASURES<\/jats:title><jats:p>The main outcomes, determined before initiation of the study, were assessment of (1) postoperative bleeding, (2) pain, (3) efficacy of relief of pain by drug, (4) nausea, (5) emesis, (6) readmission to hospital, (7) average temperature, and (8) highest temperature after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The only statistically significant difference is less nausea in patients receiving ibuprofen (<jats:italic>p<\/jats:italic> = 0.0049). Of note, no difference existed in postoperative bleeding, pain, or temperature control.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Ibuprofen is at least as effective as acetaminophen with codeine for postoperative pain control in children after tonsillectomy. 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