{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:04:57Z","timestamp":1770822297827,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2003,4,1]],"date-time":"2003-04-01T00:00:00Z","timestamp":1049155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pathologie Biologie"],"published-print":{"date-parts":[[2003,4]]},"DOI":"10.1016\/s0369-8114(03)00038-5","type":"journal-article","created":{"date-parts":[[2003,5,28]],"date-time":"2003-05-28T00:59:59Z","timestamp":1054083599000},"page":"167-175","source":"Crossref","is-referenced-by-count":23,"title":["Platelet-mediated microvascular inflammation and thrombosis in thrombocythemia vera: a distinct aspirin-responsive arterial thrombophilia, which transforms into a bleeding diathesis at increasing platelet counts"],"prefix":"10.1016","volume":"51","author":[{"given":"J.J","family":"Michiels","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0369-8114(03)00038-5_BIB1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00000441-187815100-00001","article-title":"On a rare vasomotor neurosis of extremities and on the maladies with which it may be confounded","volume":"76","author":"Mitchell","year":"1878","journal-title":"Am J Med Sci"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB2","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/00000441-193204000-00005","article-title":"Erythromelalgia and other disturbances of the extremities accompanied by vasodilatation and burning","volume":"183","author":"Brown","year":"1932","journal-title":"Am J Med Sci"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0002-8703(38)90693-3","article-title":"Erythermalgia (erythromelalgia) of the extremities. A syndrome characterized by redness, heat and pain","volume":"16","author":"Smith","year":"1938","journal-title":"Am Heart J"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1055\/s-2007-996106","article-title":"Erythromelalgia and thrombocythemia: a disease of platelet prostaglandin metabolism. Thesis Rotterdam 1981","volume":"23","author":"Michiels","year":"1997","journal-title":"Sem Thromb Hemostas"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB5","doi-asserted-by":"crossref","first-page":"466","DOI":"10.7326\/0003-4819-102-4-466","article-title":"Erythromelalgia caused by platelet-mediated arteriolar inflammation and thrombosis in thrombocythemia","volume":"102","author":"Michiels","year":"1985","journal-title":"Ann Intern M"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0190-9622(08)80005-9","article-title":"Erythromelalgia and thrombocythemia, a causal relation","volume":"22","author":"Michiels","year":"1990","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB7","first-page":"205","article-title":"Primary and secondary erythermalgia: a critical review","volume":"33","author":"Michiels","year":"1988","journal-title":"Neth J M"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB8","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0190-9622(89)70313-3","article-title":"Idiopathic erythermalgia, a congenital disorder","volume":"21","author":"Michiels","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0140-6736(90)91710-R","article-title":"Erythromelalgia versus erythermalgia","volume":"336","author":"Michiels","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB10","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/bmj.301.6750.454","article-title":"Three types of erythromelalgia","volume":"301","author":"Drenth","year":"1990","journal-title":"Br Med J"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB11","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-4362.1994.tb04037.x","article-title":"Erythromelalgia and erythermalgia: diagnostic differentiation","volume":"33","author":"Drenth","year":"1994","journal-title":"Int J Dermatol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB12","first-page":"412","article-title":"Erythromelalgia and erythermalgia: lumpers and splitters","volume":"33","author":"Michiels","year":"1994","journal-title":"Titre?"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB13","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/ajmg.1320450426","article-title":"Hereditary erythermalgia and acquired erythromelalgia","volume":"45","author":"Van Genderen","year":"1993","journal-title":"Am J Med Genet"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB14","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1136\/bmj.298.6687.1582-a","article-title":"Erythromelalgia induced by nicardipine","volume":"298","author":"Drenth","year":"1989","journal-title":"Br Med J"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB15","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1365-2133.1992.tb00132.x","article-title":"Verapamil induced secondary erythermalgia","volume":"127","author":"Drenth","year":"1992","journal-title":"Br J Dermatol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB16","first-page":"144","article-title":"Secondary erythermalgia in systemic lupus erythematodes","volume":"20","author":"Drenth","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0002-9343(92)90696-9","article-title":"Clinical characteristics and pathophysiology of erythromelalgia and erythermalgia","volume":"93","author":"Drenth","year":"1992","journal-title":"Am J M"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB18","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000246692","article-title":"Secondary erythermalgia associated with an autoimmune disorder of undetermined significance","volume":"190","author":"Drenth","year":"1995","journal-title":"Dermatology"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB19","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1007\/BF01957497","article-title":"Acute secondary erythermalgia and hypertension in children","volume":"154","author":"Drenth","year":"1995","journal-title":"Eur J Pediatr"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/00000372-199602000-00005","article-title":"Cutaneous pathology in primary erythermalgia","volume":"18","author":"Drenth","year":"1996","journal-title":"Am J Dermatol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB21","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1067\/mjd.2000.109301","article-title":"Erythromelalgia: new theories and new therapies","volume":"43","author":"Cohen","year":"2000","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB22","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1365-2559.1984.tb02379.x","article-title":"Histopathology of erythromelalgia in thrombocythemia","volume":"8","author":"Michiels","year":"1984","journal-title":"Histopathology"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1055\/s-2007-996109","article-title":"Erythromelalgia: a pathognomonic microvascular thrombotic complication in essential thrombocythemia and polycythemia vera","volume":"23","author":"Van Genderen","year":"1997","journal-title":"Thromb Hemostas"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1055\/s-0038-1650579","article-title":"Erythromelalgia in essential thrombocythemia is characterized by platelet activation and endothelial cell damage but not by thrombin generation","volume":"76","author":"Van Genderen","year":"1996","journal-title":"Thromb Haemostas"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB25","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1055\/s-0038-1653752","article-title":"Platelet consumption in thrombocythemia complicated by erythromelalgia: reversal by aspirin","volume":"73","author":"Van Genderen","year":"1995","journal-title":"Thromb Haemostas"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB26","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1046\/j.1365-2141.1999.01224.x","article-title":"Thromboxane-dependent platelet activation in vivo precedes arterial thrombosis in thrombocythemia: a rationale for the use of low-dose aspirin as an antithrombotic agent","volume":"104","author":"Van Genderen","year":"1999","journal-title":"Brit J Haematol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB27","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1212\/WNL.43.6.1107","article-title":"Transient neurologic and ocular manifestations in primary thombocythemia","volume":"43","author":"Michiels","year":"1993","journal-title":"Neurology"},{"issue":"Suppl. 1","key":"10.1016\/S0369-8114(03)00038-5_BIB28","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/10428199609074362","article-title":"Atypical transient ischemic attacks in thrombocythemia of various myloroliferative disorders","volume":"22","author":"Michiels","year":"1996","journal-title":"Leukemia and Lymphoma"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB29","first-page":"1622","article-title":"Die prophylaxe vascul\u00e4rer komplikationen bei polycythaemia vera und prim\u00e4rer thrombozyth\u00e4mie mit niedrigdosierter acetylsalicyls\u00e4ure","volume":"113","author":"Fr\u00f6hli","year":"1983","journal-title":"Schweiz Med Wochenschr"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB30","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/0002-8703(91)91019-J","article-title":"Thrombocythemia and coronary artery disease","volume":"22","author":"Scheffer","year":"1991","journal-title":"Am Heart J"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB31","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1055\/s-2007-996107","article-title":"Proposal for revised diagnostic criteria of essential thrombocythemia and polycythemia vera by the thrombocythemia vera study group","volume":"23","author":"Michiels","year":"1997","journal-title":"Thromb Hemostas"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB32","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF02982575","article-title":"Clinical and pathological criteria for the diagnosis of essential thrombocythemia, polycythemia vera and idiopathic mylofibrosis (anogenic myeloid metaplasia)","volume":"76","author":"Michiels","year":"2002","journal-title":"Int J Hematol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/107602969900500107","article-title":"Normal life expectancy and thrombosis-free survival in aspirin treated essential thrombocythemia","volume":"5","author":"Michiels","year":"1999","journal-title":"Clin Appl Thromb Hemostas"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB34","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1055\/s-2007-996111","article-title":"Aspirin in essential thrombocythemia:status quo and quo vadis","volume":"23","author":"Griesshammer","year":"1997","journal-title":"Thromb Hemostas"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0300-2977(98)00143-0","article-title":"Diagnosis, pathogenesis and treatment of the myloproliferative disorders essential thrombocythemia, polycythemia vera and essential megakaryocytic gramulocytic metaplasia and mylofibrosis","volume":"54","author":"Michiels","year":"1999","journal-title":"Neth J M"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB36","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1046\/j.1365-2141.1998.01021.x","article-title":"No treatment for low-risk thrombocythemia: results from a prospective study","volume":"103","author":"Ruggeri","year":"1998","journal-title":"Brit J Haematol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB37","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1200\/JCO.1990.8.3.556","article-title":"Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia","volume":"8","author":"Cortelazzo","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB38","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/sj.leu.2401270","article-title":"Major vascular complications in essential thrombocythemia: a study of the predictive factors in a series of 148 patients","volume":"13","author":"Besses","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB39","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/107602969900500301","article-title":"Acquired von Willebrand disease due to increasing platelet count can readily explain the paradox of thrombosis and bleeding in thrombocythemia","volume":"5","author":"Michiels","year":"1999","journal-title":"Clin Appl Thromb Hemostas"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB40","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1056\/NEJM199504273321704","article-title":"Hydroxyurea for patients with essential thrombocythemia and a high-risk of thrombosis","volume":"332","author":"Cortelazzo","year":"1995","journal-title":"New Eng J M"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB41","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1056\/NEJM199509213331216","article-title":"Hydroxyurea in essential thrombocythemia","volume":"333","author":"Van Genderen","year":"1995","journal-title":"New Eng J M"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/107602969900500408","article-title":"Aspirin and platelet-lowering agents for the prevention of vascular complications in essential thrombocythemia","volume":"5","author":"Michiels","year":"1999","journal-title":"Clin Appl Thromb Hemostas"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB43","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-2141.1997.d01-2127.x","article-title":"Prevention and treatment of thrombotic complications in essential thrombocythemia: efficacy and safety of aspirin","volume":"97","author":"Van Genderen","year":"1997","journal-title":"Brit J Haematol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB44","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1182\/blood.V64.5.981.981","article-title":"Acquired von Willebrand disease in the myloproliferative syndrome","volume":"64","author":"Budde","year":"1984","journal-title":"Blood"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB45","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1182\/blood.V68.6.1213.1213","article-title":"Subunit composition of plasma von Willebrand factor in patients with the myeloproloferative syndrome","volume":"68","author":"Budde","year":"1986","journal-title":"Blood"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF01698487","article-title":"Acquired von Willebrand disease as a cause of recurrent mucocutaneous bleeding in primary thrombocythemia: relationship with platelet count","volume":"69","author":"Van Genderen","year":"1994","journal-title":"Ann Hematol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB47","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1046\/j.1365-2141.1996.d01-1729.x","article-title":"The reduction of large von Willebrand factor multimers in plasma in essential thrombocythemia is related to the platelet count","volume":"93","author":"Van Genderen","year":"1996","journal-title":"Br J Hematol"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB48","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1055\/s-2007-996113","article-title":"The paradox of bleeding and thrombosis in thrombocythemia: is von Willebrand factor the link?","volume":"23","author":"Van Genderen","year":"1997","journal-title":"Semin Thromb Hemostas"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB49","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1177\/107602969900500301","article-title":"Acquired von Willebrand disease due to increasing platelet count can readily explain the paradox of thrombosis and bleeding in thrombocythemia","volume":"5","author":"Michiels","year":"1999","journal-title":"Clin Appl Thrombosis\/Hemostasis"},{"key":"10.1016\/S0369-8114(03)00038-5_BIB50","first-page":"401","article-title":"Acquired von Willebrand syndromes: clinical features, etiology, pathophysilogy, classification and management","volume":"14","author":"Michiels","year":"2001","journal-title":"Bailli\u00e8re\u2019\u2019s Clin Haematol"}],"container-title":["Pathologie Biologie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0369811403000385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0369811403000385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T10:34:09Z","timestamp":1584700449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0369811403000385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,4]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["S0369811403000385"],"URL":"https:\/\/doi.org\/10.1016\/s0369-8114(03)00038-5","relation":{},"ISSN":["0369-8114"],"issn-type":[{"value":"0369-8114","type":"print"}],"subject":[],"published":{"date-parts":[[2003,4]]}}}