{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:19:12Z","timestamp":1760660352629,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"vor","delay-in-days":5039,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","resmedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Medicine"],"published-print":{"date-parts":[[1999,10]]},"DOI":"10.1016\/s0954-6111(99)90043-4","type":"journal-article","created":{"date-parts":[[2004,5,25]],"date-time":"2004-05-25T08:03:47Z","timestamp":1085472227000},"page":"744-751","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Inflammatory markers in acute exacerbations of obstructive pulmonary disease: predictive value in relation to smoking history"],"prefix":"10.1016","volume":"93","author":[{"given":"I.","family":"Dahl\u00e9n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Janson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bj\u00f6rnsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"St\u00e5lenheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.G.B.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Venge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0954-6111(99)90043-4_BIB1","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1164\/ajrccm\/142.4.863","article-title":"Quantitation of mast cells and eosinophils in the bronchial mucosa of symptomatic atopic asthmatics and healthy control subjects using immunohistochemistry","volume":"142","author":"Djukanovic","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB2","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1056\/NEJM199010113231505","article-title":"Eosinophilic inflammation in asthma","volume":"323","author":"Bousquet","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB3","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/0091-6749(93)90078-T","article-title":"Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease","volume":"92","author":"Lacoste","year":"1993","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB4","first-page":"254","article-title":"The effects of chronic bronchitis and chronic air-flow obstruction on lung cell populations recovered by bronchoalveolar lavage","volume":"132","author":"Martin","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1136\/thx.51.3.267","article-title":"Airways obstruction, chronic expectoration, and rapid decline of FEV1 in smokers are associated with increased levels of sputum neutrophils","volume":"51","author":"Stanescu","year":"1996","journal-title":"Thorax"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB6","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1136\/thx.50.4.360","article-title":"Bronchial inflammation in chronic bronchitis assessed by measurement of cell products in bronch ial lavage fluid","volume":"50","author":"Riise","year":"1995","journal-title":"Thorax"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB7","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1164\/ajrccm\/148.5.1226","article-title":"Airway inflammation in smokers with nonobstructive and obstructive chronic bronchitis","volume":"148","author":"Linden","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB8","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1365-2222.1996.tb00606.x","article-title":"Airway eosinophilia and expression of interleukin-5 protein in asthma and in exacerbations of chronic bronchitis","volume":"26","author":"Saetta","year":"1996","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB9","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1164\/ajrccm.150.6.7952628","article-title":"Airway eosinophilia in chronic bronchitis during exacerbations","volume":"150","author":"Saetta","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB10","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1081-1206(10)63029-3","article-title":"Serum eosinophil cationic protein levels and bronchodilator responses at acute asthma exacerbation","volume":"79","author":"Lee","year":"1997","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0954-6111(06)80223-4","article-title":"Blood eosinophil count as risk factor for relapse in acute asthma","volume":"86","author":"Janson","year":"1992","journal-title":"Respir Med"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB12","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1164\/ajrccm.153.5.8630596","article-title":"Eosinophil and neutrophil activity in asthma in a one-year trial with inhaled budesonide","volume":"153","author":"Pedersen","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB13","first-page":"S22","article-title":"Standardized lung function testing","volume":"19","author":"European Community for Coal and Steel","year":"1983","journal-title":"Clin Respir Physiol"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB14","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.4049\/jimmunol.134.3.1875","article-title":"Human eosinophil peroxidase: purification and characterization","volume":"134","author":"Carlson","year":"1985","journal-title":"J Immunol"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0022-1759(94)90044-2","article-title":"The development of an assay for human neutrophil lipocalin (HNL)-to be used as a specific marker of neutrophil activity in vivo and vitro","volume":"171","author":"Xu","year":"1994","journal-title":"J Immunol Methods"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB16","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1164\/ajrccm.155.5.9154853","article-title":"Corticosteroid reversibility in COPD is related to features of asthma","volume":"155","author":"Chanez","year":"1997","journal-title":"Am J Resp Crit Care Med"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB17","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1164\/ajrccm.158.5.9804028","article-title":"Sputum eosinophilia predicts benefit from prednisone in smokers with chronic obstructive bronchitis","volume":"158","author":"Pizzichini","year":"1998","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB18","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1164\/ajrccm.155.2.9032192","article-title":"Effects of inhaled and oral glucocorticoids on inflammatory indices in asthma and COPD","volume":"155","author":"Keatings","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB19","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1164\/ajrccm\/146.3.638","article-title":"Relationship of skin test reactivity and eosinophilia to level of pulmonary function in a community-based population study","volume":"146","author":"Mensinga","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000237239","article-title":"Eosinophils in allergy: role in disease, degranulation, and cytokines","volume":"109","author":"Martin","year":"1996","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB21","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1164\/ajrccm.154.1.8680684","article-title":"Cellular infiltration of the airways in asthma of varying severity","volume":"154","author":"Synek","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB22","first-page":"139","article-title":"Eosinophil activity in bronchial asthma","volume":"15","author":"Venge","year":"1994"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB23","doi-asserted-by":"crossref","first-page":"S66","DOI":"10.1164\/ajrccm\/143.3_Pt_2.S66","article-title":"The role of the eosinophil in asthma","volume":"143","author":"Holgate","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB24","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000237545","article-title":"Eosinophils and eosinophil-associated cytokines in allergic inflammation","volume":"113","author":"Kay","year":"1997","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB25","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1136\/thx.48.8.845","article-title":"Cytokines. 3. Cytokines in asthma","volume":"48","author":"Robinson","year":"1993","journal-title":"Thorax"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0954-6111(96)90243-7","article-title":"Eosinophil peroxidase: a new serum marker of atopy and bronchial hyper-responsiveness","volume":"90","author":"Bj\u00f6rnsson","year":"1996","journal-title":"Respir Med"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB27","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0091-6749(96)70182-3","article-title":"Urinary eosinophil protein X in children with atopic asthma: a useful marker of antiinflammatory treatment","volume":"97","author":"Kristjansson","year":"1996","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB28","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/j.1398-9995.1997.tb02605.x","article-title":"Urinary eosinophil protein X in relation to disease activity in childhood asthma","volume":"52","author":"Lugosi","year":"1997","journal-title":"Allergy"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB29","first-page":"459","article-title":"Bronchial hyperreactivity in response to inhalation of ultrasonically nebulized solutions of distilled water and saline","volume":"63","author":"Schoeffel","year":"1981","journal-title":"BMJ"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB30","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1164\/ajrccm.154.4.8887576","article-title":"Spontaneous and induced sputum to measure indices of airway inflammation in asthma","volume":"154","author":"Pizzichini","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB31","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1164\/ajrccm\/147.5.1126","article-title":"Cellular and biochemical analysis of induced sputum from asthmatic and from healthy subjects","volume":"147","author":"Fahy","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB32","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1164\/ajrccm.154.2.8756799","article-title":"Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements","volume":"154","author":"Pizzichini","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB33","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1183\/09031936.98.11030734","article-title":"Eosinophil cationic protein in sputum is dependent on temperature and time","volume":"11","author":"Grebski","year":"1998","journal-title":"Eur Resp J"},{"key":"10.1016\/S0954-6111(99)90043-4_BIB34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1399-3038.1997.tb00142.x","article-title":"Eosinophil cationic protein in induced sputum as a marker of inflammation in asthmatic children","volume":"8","author":"Sorva","year":"1997","journal-title":"Pediatr Allergy Immunol"}],"container-title":["Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611199900434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0954611199900434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:10:26Z","timestamp":1760609426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0954611199900434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10]]},"references-count":34,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1999,10]]}},"alternative-id":["S0954611199900434"],"URL":"https:\/\/doi.org\/10.1016\/s0954-6111(99)90043-4","relation":{},"ISSN":["0954-6111"],"issn-type":[{"type":"print","value":"0954-6111"}],"subject":[],"published":{"date-parts":[[1999,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammatory markers in acute exacerbations of obstructive pulmonary disease: predictive value in relation to smoking history","name":"articletitle","label":"Article Title"},{"value":"Respiratory Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S0954-6111(99)90043-4","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}