{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T20:14:12Z","timestamp":1786392852532,"version":"build-2736575974"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2002,12]]},"DOI":"10.1016\/s1043661802002323","type":"journal-article","created":{"date-parts":[[2002,12,2]],"date-time":"2002-12-02T16:07:09Z","timestamp":1038845229000},"page":"525-531","source":"Crossref","is-referenced-by-count":44,"title":["EFFECTS OF A BICARBONATE-ALKALINE MINERAL WATER ON GASTRIC FUNCTIONS AND FUNCTIONAL DYSPEPSIA: A PRECLINICAL AND CLINICAL STUDY"],"prefix":"10.1016","volume":"46","author":[{"given":"MICHELE","family":"BERTONI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FILIPPO","family":"OLIVERI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARTA","family":"MANGHETTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ELENA","family":"BOCCOLINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIA GRAZIA","family":"BELLOMINI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CORRADO","family":"BLANDIZZI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"FERRUCCIO","family":"BONINO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARIO","family":"DEL TACCA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 182","key":"10.1016\/S1043661802002323_BIB1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3109\/00365529109109531","article-title":"Dyspepsia: organic causes and differential characteristics from functional dyspepsia","volume":"26","author":"Richter","year":"1991","journal-title":"Scand. J. Gastroenterol."},{"issue":"Suppl. II","key":"10.1016\/S1043661802002323_BIB2","first-page":"37","article-title":"Functional gastroduodenal disorders","volume":"45","author":"Talley","year":"1999","journal-title":"Gut"},{"key":"10.1016\/S1043661802002323_BIB3","first-page":"145","article-title":"Functional dyspepsia: a classification with guidelines for diagnosis and management","volume":"4","author":"Talley","year":"1991","journal-title":"Gastroenterol. Int."},{"key":"10.1016\/S1043661802002323_BIB4","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7326\/0003-4819-134-9_Part_2-200105011-00004","article-title":"Dyspepsia","volume":"134","author":"Bytzer","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/S1043661802002323_BIB5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.med.49.1.475","article-title":"Dyspepsia: current understanding and management","volume":"49","author":"Agreus","year":"1997","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/S1043661802002323_BIB6","doi-asserted-by":"crossref","first-page":"918","DOI":"10.2165\/00003495-199345060-00005","article-title":"Functional dyspepsia: current treatment recommendations","volume":"45","author":"Holtmann","year":"1993","journal-title":"Drugs"},{"issue":"Suppl. 182","key":"10.1016\/S1043661802002323_BIB7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/00365529109109534","article-title":"Gastrointestinal motor disturbances in functional dyspepsia","volume":"26","author":"Malagelada","year":"1991","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/S1043661802002323_BIB8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1046\/j.1365-2036.2000.00742.x","article-title":"Comparative effects of levosulpiride and cisapride on gastric emptying and symptoms in patients with functional dyspepsia and gastroparesis","volume":"14","author":"Mansi","year":"2000","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/S1043661802002323_BIB9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00004836-198904000-00011","article-title":"Drug treatment of functional dyspepsia. A meta-analysis of randomized controlled trials","volume":"11","author":"Dobrilla","year":"1989","journal-title":"J. Clin. Gastroenterol."},{"key":"10.1016\/S1043661802002323_BIB10","first-page":"261","article-title":"Influence of mineral waters on functional dyspepsia","volume":"129","author":"Grossi","year":"1989","journal-title":"Clin. Ther."},{"key":"10.1016\/S1043661802002323_BIB11","first-page":"199","article-title":"Dyspeptic syndrome. Aspects of physiopathology","volume":"137","author":"Grassi","year":"1991","journal-title":"Clin. Ther."},{"key":"10.1016\/S1043661802002323_BIB12","first-page":"727","article-title":"Water supplementation enhances the effect of high-fiber diet on stool frequency and laxative consumption in adult patients with functional dyspepsia","volume":"48","author":"Anti","year":"1998","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/S1043661802002323_BIB13","first-page":"63","article-title":"Effect of alkaline-earth water on gastric emptying time in patients with anorganic dyspepsia","volume":"121","author":"Stanghellini","year":"1987","journal-title":"Clin. Ther."},{"key":"10.1016\/S1043661802002323_BIB14","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-2999(99)00212-5","article-title":"CCK-1 and CCK-2 receptors regulate gastric pepsinogen secretion","volume":"373","author":"Blandizzi","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1043661802002323_BIB15","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1023\/A:1026626519534","article-title":"Acid-independent gastroprotective effects of lansoprazole in experimental mucosal injury","volume":"44","author":"Blandizzi","year":"1999","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/S1043661802002323_BIB16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0014-2999(96)00214-2","article-title":"Camostate- and caerulein-induced delay of gastric emptying in the rat: effect of CCK receptor antagonists","volume":"306","author":"Varga","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S1043661802002323_BIB17","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1136\/gut.18.6.442","article-title":"Calcium stimulation of gastrin and gastric secretion: effect of small doses of calcium carbonate","volume":"18","author":"Behar","year":"1977","journal-title":"Gut"},{"key":"10.1016\/S1043661802002323_BIB18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF02430525","article-title":"Effects of graded amounts of intragastric calcium on acid secretion, gastrin release, and gastric emptying in normal and duodenal ulcer subjects","volume":"28","author":"Barclay","year":"1983","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/S1043661802002323_BIB19","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/BF00607914","article-title":"Effect of nifedipine on gastric acid secretion and gastrin release in healthy man","volume":"28","author":"Caldara","year":"1985","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/S1043661802002323_BIB20","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1159\/000199249","article-title":"Influence of verapamil on gastric acid secretion and gastrin release in dogs","volume":"32","author":"Grimm","year":"1985","journal-title":"Digestion"},{"key":"10.1016\/S1043661802002323_BIB21","unstructured":"Walsh JH. Gastrointestinal hormones. In: Johnson LR, ed. Physiology of the gastrointestinal tract. 3rd edn. New York: Raven Press, 1994: 1\u201331."},{"key":"10.1016\/S1043661802002323_BIB22","first-page":"G1025","article-title":"Inhibition of gastric emptying by acids depends on pH, titrable acidity, and length of intestine exposed to acid","volume":"259","author":"Lin","year":"1990","journal-title":"Am. J. Physiol."},{"key":"10.1016\/S1043661802002323_BIB23","unstructured":"Mayer EA. The physiology of gastric storage and emptying. In: Johnson LR, ed. Physiology of the gastrointestinal tract. 3rd edn. New York: Raven Press, 1994: 929\u201376."},{"key":"10.1016\/S1043661802002323_BIB24","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3181\/00379727-161-40481","article-title":"Effect of gastrin on electrical activity of antrum and duodenum of dogs","volume":"161","author":"Strunz","year":"1979","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/S1043661802002323_BIB25","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/BF01308367","article-title":"Abnormal gastric emptying response to pentagastrin in duodenal ulcer disease","volume":"26","author":"Dubois","year":"1981","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/S1043661802002323_BIB26","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.pa.31.040191.002345","article-title":"Cholecystokinin antagonists","volume":"31","author":"Woodruff","year":"1991","journal-title":"Annu. Rev. Pharmacol. Toxicol."}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661802002323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661802002323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T07:51:38Z","timestamp":1554191498000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661802002323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["S1043661802002323"],"URL":"https:\/\/doi.org\/10.1016\/s1043661802002323","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}