{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:25:28Z","timestamp":1787300728129,"version":"build-2736575974"},"reference-count":194,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Chinese Journal of Natural Medicines"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/s1875-5364(26)61204-6","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:25:09Z","timestamp":1787297109000},"page":"1068-1080","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondria-targeted natural products with potential for the treatment of mitochondria-related diseases"],"prefix":"10.1016","volume":"24","author":[{"given":"Xinyue","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuekai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonggen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-43570-y","article-title":"Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase","volume":"14","author":"Jahn","year":"2023","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/s41418-020-00657-z","article-title":"Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy","volume":"28","author":"Xian","year":"2021","journal-title":"Cell Death Differ"},{"key":"10.1016\/S1875-5364(26)61204-6_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2022.155313","article-title":"Mitochondrial quality control mechanisms as molecular targets in diabetic heart","volume":"137","author":"Chang","year":"2022","journal-title":"Metabolism"},{"issue":"9","key":"10.1016\/S1875-5364(26)61204-6_bib4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm3412","article-title":"Mitochondria as sensors and regulators of calcium signalling","volume":"13","author":"Rizzuto","year":"2012","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"8","key":"10.1016\/S1875-5364(26)61204-6_bib5","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41418-023-01187-0","article-title":"Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions","volume":"30","author":"Bernardi","year":"2023","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/cdd.2017.179","article-title":"MOMP, cell suicide as a BCL-2 family business","volume":"25","author":"Kalkavan","year":"2018","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"issue":"9","key":"10.1016\/S1875-5364(26)61204-6_bib8","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1111\/jcmm.15194","article-title":"Mitochondrial biogenesis: An update","volume":"24","author":"Popov","year":"2020","journal-title":"J Cell Mol Med"},{"issue":"7293","key":"10.1016\/S1875-5364(26)61204-6_bib9","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1038\/nature08991","article-title":"Adiponectin and AdipoR1 regulate PGC-1\u03b1 and mitochondria by Ca2+ and AMPK\/SIRT1","volume":"464","author":"Iwabu","year":"2010","journal-title":"Nature"},{"issue":"8","key":"10.1016\/S1875-5364(26)61204-6_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.328","article-title":"The protease Omi regulates mitochondrial biogenesis through the GSK3\u03b2\/PGC-1\u03b1 pathway","volume":"5","author":"Xu","year":"2014","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/S1875-5364(26)61204-6_bib11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3892\/mmr.2021.12252","article-title":"PI3K\/AKT phosphorylation activates ERR\u03b1 by upregulating PGC-1\u03b1 and PGC-1\u03b2 in gallbladder cancer","volume":"24","author":"Wang","year":"2021","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib12","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-biochem-052621-092014","article-title":"Replication and transcription of human mitochondrial DNA","volume":"93","author":"Falkenberg","year":"2024","journal-title":"Annu Rev Biochem"},{"issue":"10","key":"10.1016\/S1875-5364(26)61204-6_bib13","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1093\/nar\/gkh634","article-title":"Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA","volume":"32","author":"Wanrooij","year":"2004","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"10.1016\/S1875-5364(26)61204-6_bib14","doi-asserted-by":"crossref","first-page":"E150","DOI":"10.1002\/humu.20824","article-title":"Molecular and clinical genetics of mitochondrial diseases due to POLG mutations","volume":"29","author":"Wong","year":"2008","journal-title":"Hum Mutat"},{"key":"10.1016\/S1875-5364(26)61204-6_bib15","series-title":"GeneReviews\u00ae","article-title":"TK2-related mitochondrial DNA aaintenance defect, myopathic form","author":"Wang","year":"2012"},{"key":"10.1016\/S1875-5364(26)61204-6_bib16","series-title":"GeneReviews\u00ae","article-title":"Deoxyguanosine kinase deficiency","author":"El-Hattab","year":"2009"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.31383","article-title":"Long-term hematopoietic dysfunction in patients with large-scale mitochondrial DNA deletion syndromes","volume":"72","author":"Greenberg-Kushnir","year":"2025","journal-title":"Pediatr Blood Cancer"},{"issue":"6","key":"10.1016\/S1875-5364(26)61204-6_bib18","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/jamaneurol.2015.0178","article-title":"Impaired muscle mitochondrial biogenesis and myogenesis in spinal muscular atrophy","volume":"72","author":"Ripolone","year":"2015","journal-title":"JAMA Neurol"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/apha.14107","article-title":"Mitochondrial involvement in sarcopenia","volume":"240","author":"Affourtit","year":"2024","journal-title":"Acta Physiol (Oxf)"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/WCO.0b013e32835c5f0b","article-title":"Mitochondrial dysfunction in optic neuropathies: animal models and therapeutic options","volume":"26","author":"Carelli","year":"2013","journal-title":"Curr Opin Neurol"},{"issue":"4","key":"10.1016\/S1875-5364(26)61204-6_bib21","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrcardio.2016.203","article-title":"Expert consensus document: mitochondrial function as a therapeutic target in heart failure","volume":"14","author":"Brown","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/S1875-5364(26)61204-6_bib22","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fcvm.2020.00002","article-title":"Multiple levels of PGC-1\u03b1 dysregulation in heart failure","volume":"7","author":"Oka","year":"2020","journal-title":"Front Cardiovasc Med"},{"issue":"7","key":"10.1016\/S1875-5364(26)61204-6_bib23","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.2337\/db14-1611","article-title":"Pathophysiological mechanism of bone loss in T2DM involves inverse regulation of osteoblast function by PGC-1\u03b1 and skeletal muscle atrogenes: AdipoR1 as a potential target for reversing diabetes-induced osteopenia","volume":"64","author":"Khan","year":"2015","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/S1875-5364(26)61204-6_bib24","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/cdd.2015.86","article-title":"Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis","volume":"22","author":"Palikaras","year":"2015","journal-title":"Cell Death Differ"},{"issue":"7","key":"10.1016\/S1875-5364(26)61204-6_bib25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41419-024-06804-5","article-title":"Mitophagy-related regulated cell death: molecular mechanisms and disease implications","volume":"15","author":"Yang","year":"2024","journal-title":"Cell Death Dis"},{"issue":"2","key":"10.1016\/S1875-5364(26)61204-6_bib26","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.devcel.2011.12.014","article-title":"Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin","volume":"22","author":"Lazarou","year":"2012","journal-title":"Dev Cell"},{"issue":"7565","key":"10.1016\/S1875-5364(26)61204-6_bib27","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature14893","article-title":"The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy","volume":"524","author":"Lazarou","year":"2015","journal-title":"Nature"},{"issue":"13","key":"10.1016\/S1875-5364(26)61204-6_bib28","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022112799","article-title":"FBXL4 ubiquitin ligase deficiency promotes mitophagy by elevating NIX levels","volume":"42","author":"Elcocks","year":"2023","journal-title":"EMBO J"},{"key":"10.1016\/S1875-5364(26)61204-6_bib29","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.redox.2017.11.004","article-title":"DUSP1 alleviates cardiac ischemia\/reperfusion injury by suppressing the Mff-required mitochondrial fission and Bnip3-related mitophagy via the JNK pathways","volume":"14","author":"Jin","year":"2018","journal-title":"Redox Biol"},{"key":"10.1016\/S1875-5364(26)61204-6_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1544241","article-title":"Review of FUNDC1-mediated mitochondrial autophagy in Alzheimer\u2019s disease","volume":"17","author":"Shi","year":"2025","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib31","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.molcel.2014.02.034","article-title":"A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy","volume":"54","author":"Chen","year":"2014","journal-title":"Mol Cell"},{"issue":"11","key":"10.1016\/S1875-5364(26)61204-6_bib32","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.7150\/ijbs.95853","article-title":"Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia\/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy","volume":"20","author":"Wang","year":"2024","journal-title":"Int J Biol Sci"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib33","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/15548627.2019.1628520","article-title":"PHB2 (prohibitin 2) promotes PINK1-PRKN\/Parkin-dependent mitophagy by the PARL-PGAM5-PINK1 axis","volume":"16","author":"Yan","year":"2020","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1186\/s12951-025-03420-z","article-title":"Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance","volume":"23","author":"Wang","year":"2025","journal-title":"J Nanobiotechnology"},{"issue":"5","key":"10.1016\/S1875-5364(26)61204-6_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051772","article-title":"PINK1\/Parkin mediated mitophagy, Ca2+ signalling, and ER-mitochondria contacts in Parkinson\u2019s disease","volume":"21","author":"Barazzuol","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/S1875-5364(26)61204-6_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101405","article-title":"Phase-separated protein droplets of amyotrophic lateral sclerosis-associated p62\/SQSTM1 mutants show reduced inner fluidity","volume":"297","author":"Faruk","year":"2021","journal-title":"J Biol Chem"},{"key":"10.1016\/S1875-5364(26)61204-6_bib37","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ibneur.2025.07.011","article-title":"OPTN deficiency through CRISPR\/Cas9 downregulates autophagy and mitophagy in a SOD1-G93A-expressing transgenic cell line","volume":"19","author":"Wen","year":"2025","journal-title":"IBRO Neurosci Rep"},{"key":"10.1016\/S1875-5364(26)61204-6_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2025.101385","article-title":"Mitophagy: a key regulator of radiotherapy resistance in the tumor immune microenvironment","volume":"105","author":"Xia","year":"2025","journal-title":"Mol Aspects Med"},{"issue":"8","key":"10.1016\/S1875-5364(26)61204-6_bib39","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1016\/j.apsb.2024.05.012","article-title":"Mitophagy and cGAS-STING crosstalk in neuroinflammation","volume":"14","author":"Zhou","year":"2024","journal-title":"Acta Pharm Sin B"},{"issue":"17","key":"10.1016\/S1875-5364(26)61204-6_bib40","doi-asserted-by":"crossref","first-page":"7115","DOI":"10.1074\/jbc.M116.762567","article-title":"The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure","volume":"292","author":"Lee","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/S1875-5364(26)61204-6_bib41","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3389\/fphys.2019.00517","article-title":"Mitofusins: disease gatekeepers and hubs in mitochondrial quality control by E3 ligases","volume":"10","author":"Escobar-Henriques","year":"2019","journal-title":"Front Physiol"},{"issue":"4","key":"10.1016\/S1875-5364(26)61204-6_bib42","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1080\/15548627.2015.1034408","article-title":"Deubiquitinating enzymes regulate PARK2-mediated mitophagy","volume":"11","author":"Wang","year":"2015","journal-title":"Autophagy"},{"issue":"9","key":"10.1016\/S1875-5364(26)61204-6_bib43","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.celrep.2016.02.011","article-title":"Reciprocal degradation of YME1L and OMA1 adapts mitochondrial proteolytic activity during stress","volume":"14","author":"Rainbolt","year":"2016","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/S1875-5364(26)61204-6_bib44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00401-005-0002-3","article-title":"Dysregulation of mitochondrial fusion and fission: an emerging concept in neurodegeneration","volume":"111","author":"Frank","year":"2006","journal-title":"Acta Neuropathol"},{"issue":"2","key":"10.1016\/S1875-5364(26)61204-6_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/apha.14026","article-title":"MFN2: Shaping mitochondria and cardiac adaptations to hypoxia","volume":"239","author":"Burtscher","year":"2023","journal-title":"Acta Physiol (Oxf)"},{"issue":"7859","key":"10.1016\/S1875-5364(26)61204-6_bib46","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41586-021-03510-6","article-title":"Distinct fission signatures predict mitochondrial degradation or biogenesis","volume":"593","author":"Kleele","year":"2021","journal-title":"Nature"},{"issue":"10","key":"10.1016\/S1875-5364(26)61204-6_bib47","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1038\/s41418-020-0540-1","article-title":"JNK1 and ERK1\/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction","volume":"27","author":"Simula","year":"2020","journal-title":"Cell Death Differ"},{"issue":"9","key":"10.1016\/S1875-5364(26)61204-6_bib48","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.jacbts.2023.04.006","article-title":"Syntaxin 17 protects against heart failure through recruitment of CDK1 to promote DRP1-dependent mitophagy","volume":"8","author":"Xu","year":"2023","journal-title":"JACC Basic Transl Sci"},{"issue":"13","key":"10.1016\/S1875-5364(26)61204-6_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110155","article-title":"SIRT2 regulates mitochondrial dynamics and reprogramming via MEK1-ERK-DRP1 and AKT1-DRP1 axes","volume":"37","author":"Cha","year":"2021","journal-title":"Cell Rep"},{"issue":"8","key":"10.1016\/S1875-5364(26)61204-6_bib50","doi-asserted-by":"crossref","first-page":"5586","DOI":"10.1007\/s12035-018-1464-3","article-title":"Neuroprotective mitochondrial remodeling by AKAP121\/PKA protects HT22 cell from glutamate-induced oxidative stress","volume":"56","author":"Zhang","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.1016\/S1875-5364(26)61204-6_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107414","article-title":"Alternative splicing of Mff regulates AMPK-mediated phosphorylation, mitochondrial fission and antiviral response","volume":"209","author":"Hanada","year":"2024","journal-title":"Pharmacol Res"},{"issue":"14","key":"10.1016\/S1875-5364(26)61204-6_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25147782","article-title":"De Novo DNM1L mutation in a patient with encephalopathy, cardiomyopathy and fatal non-epileptic paroxysmal refractory vomiting","volume":"25","author":"Berti","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/S1875-5364(26)61204-6_bib53","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/jmedgenet-2015-103500","article-title":"Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy","volume":"53","author":"Koch","year":"2016","journal-title":"J Med Genet"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib54","first-page":"3","article-title":"Mitochondrial electron transport chain, ROS generation and uncoupling (Review)","volume":"44","author":"Zhao","year":"2019","journal-title":"Int J Mol Med"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib55","article-title":"ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib56","article-title":"Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice","volume":"14","author":"Venit","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/S1875-5364(26)61204-6_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114335","article-title":"Effect of Sirt3 on hippocampal MnSOD activity, mitochondrial function, physiology, and cognition in an aged murine model","volume":"444","author":"Allen","year":"2023","journal-title":"Behav Brain Res"},{"issue":"17","key":"10.1016\/S1875-5364(26)61204-6_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23179655","article-title":"cAMP\/PKA signaling modulates mitochondrial supercomplex organization","volume":"23","author":"Signorile","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib59","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13023-020-1297-9","article-title":"Molecular basis of Leigh syndrome: a current look","volume":"15","author":"Schubert Baldo","year":"2020","journal-title":"Orphanet J Rare Dis"},{"issue":"Pt 2","key":"10.1016\/S1875-5364(26)61204-6_bib60","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1042\/bj3180401","article-title":"Altered mitochondrial function in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations","volume":"318","author":"James","year":"1996","journal-title":"Biochem J"},{"issue":"10","key":"10.1016\/S1875-5364(26)61204-6_bib61","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s00109-021-02110-1","article-title":"Modelling of BCS1L-related human mitochondrial disease in Drosophila melanogaster","volume":"99","author":"Brischigliaro","year":"2021","journal-title":"J Mol Med (Berl)"},{"issue":"Suppl 3","key":"10.1016\/S1875-5364(26)61204-6_bib62","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1007\/s10545-009-9020-y","article-title":"Aberrant synthesis of ATP synthase resulting from a novel deletion in mitochondrial DNA in an African patient with progressive external ophthalmoplegia","volume":"33","author":"van der Westhuizen","year":"2010","journal-title":"J Inherit Metab Dis"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib63","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd1330","article-title":"Neurodegenerative diseases and oxidative stress","volume":"3","author":"Barnham","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/S1875-5364(26)61204-6_bib64","article-title":"The role of oxidative stress in cardiac disease: from physiological response to injury factor","volume":"2020","author":"D'Oria","year":"2020","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"10.1016\/S1875-5364(26)61204-6_bib65","doi-asserted-by":"crossref","DOI":"10.1172\/JCI136055","article-title":"Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity","volume":"131","author":"Sharma","year":"2021","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/S1875-5364(26)61204-6_bib66","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"10.1016\/S1875-5364(26)61204-6_bib67","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0161-5890(01)00108-0","article-title":"Calcium and oxidative stress: from cell signaling to cell death","volume":"38","author":"Ermak","year":"2002","journal-title":"Mol Immunol"},{"issue":"7","key":"10.1016\/S1875-5364(26)61204-6_bib68","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nm1263","article-title":"Caspase-independent cell death","volume":"11","author":"Kroemer","year":"2005","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/S1875-5364(26)61204-6_bib69","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1128\/MCB.22.9.3003-3013.2002","article-title":"Calpain-mediated Bid cleavage and calpain-independent Bak modulation: two separate pathways in cisplatin-induced apoptosis","volume":"22","author":"Mandic","year":"2002","journal-title":"Mol Cell Biol"},{"issue":"5412","key":"10.1016\/S1875-5364(26)61204-6_bib70","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1126\/science.284.5412.339","article-title":"Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD","volume":"284","author":"Wang","year":"1999","journal-title":"Science"},{"issue":"11","key":"10.1016\/S1875-5364(26)61204-6_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2024.101034","article-title":"Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury","volume":"14","author":"Yang","year":"2024","journal-title":"J Pharm Anal"},{"key":"10.1016\/S1875-5364(26)61204-6_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156982","article-title":"Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury","volume":"145","author":"Pu","year":"2025","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib73","first-page":"311","article-title":"Zishen Huoxue decoction (ZSHX) alleviates ischemic myocardial injury (MI) via Sirt5-\u03b2-tubulin mediated synergistic mechanism of \u201cmitophagy-unfolded protein response\u201d and mitophagy","volume":"23","author":"Chang","year":"2025","journal-title":"Chin J Nat Med"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib74","doi-asserted-by":"crossref","first-page":"188","DOI":"10.7150\/ijms.100523","article-title":"Exploiting mitochondria by triggering a faulty unfolded protein response leads to effective cardioprotection","volume":"22","author":"Shen","year":"2025","journal-title":"Int J Med Sci"},{"issue":"2","key":"10.1016\/S1875-5364(26)61204-6_bib75","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/ng.2851","article-title":"Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling","volume":"46","author":"Logan","year":"2014","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib76","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molmed.2019.10.007","article-title":"Regulation of mitochondrial ATP production: Ca2+ signaling and quality control","volume":"26","author":"Boyman","year":"2020","journal-title":"Trends Mol Med"},{"key":"10.1016\/S1875-5364(26)61204-6_bib77","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/978-3-030-12457-1_29","article-title":"ER-mitochondria calcium transfer, organelle contacts and neurodegenerative diseases","volume":"1131","author":"Vallese","year":"2020","journal-title":"Adv Exp Med Biol"},{"issue":"4","key":"10.1016\/S1875-5364(26)61204-6_bib78","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10456-024-09938-4","article-title":"Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction","volume":"27","author":"Pang","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/S1875-5364(26)61204-6_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1422686","article-title":"Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality","volume":"15","author":"Pang","year":"2024","journal-title":"Front Pharmacol"},{"issue":"43","key":"10.1016\/S1875-5364(26)61204-6_bib80","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000039996","article-title":"The effect of unhealthy lifestyle on the pathogenesis of sick sinus syndrome: a life-guiding review","volume":"103","author":"Chang","year":"2024","journal-title":"Medicine (Baltimore)"},{"issue":"5","key":"10.1016\/S1875-5364(26)61204-6_bib81","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41401-020-00518-y","article-title":"Drp1-dependent mitochondrial fission in cardiovascular disease","volume":"42","author":"Jin","year":"2021","journal-title":"Acta Pharmacol Sin"},{"issue":"6","key":"10.1016\/S1875-5364(26)61204-6_bib82","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.bbadis.2016.03.009","article-title":"The impact of cardiac ischemia\/reperfusion on the mitochondria-cytoskeleton interactions","volume":"1862","author":"Bagur","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/S1875-5364(26)61204-6_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2024.106650","article-title":"Microtubules and cardiovascular diseases: insights into pathology and therapeutic strategies","volume":"175","author":"Wu","year":"2024","journal-title":"Int J Biochem Cell Biol"},{"issue":"8","key":"10.1016\/S1875-5364(26)61204-6_bib84","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1002\/ptr.7175","article-title":"Salidroside protects cardiac function in mice with diabetic cardiomyopathy via activation of mitochondrial biogenesis and SIRT3","volume":"35","author":"Li","year":"2021","journal-title":"Phytother Res"},{"key":"10.1016\/S1875-5364(26)61204-6_bib85","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.phymed.2018.10.031","article-title":"Salidroside stimulates the Sirt1\/PGC-1\u03b1 axis and ameliorates diabetic nephropathy in mice","volume":"54","author":"Xue","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/S1875-5364(26)61204-6_bib86","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5276096","article-title":"Salidroside delays cellular senescence by stimulating mitochondrial biogenesis partly through a miR-22\/SIRT-1 pathway","volume":"2019","author":"Mao","year":"2019","journal-title":"Oxid Med Cell Longev"},{"issue":"8","key":"10.1016\/S1875-5364(26)61204-6_bib87","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.metabol.2013.02.007","article-title":"Berberine improves insulin resistance in cardiomyocytes via activation of 5\u2032-adenosine monophosphate-activated protein kinase","volume":"62","author":"Chang","year":"2013","journal-title":"Metabolism"},{"key":"10.1016\/S1875-5364(26)61204-6_bib88","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.fitote.2016.02.001","article-title":"Research progress on berberine with a special focus on its oral bioavailability","volume":"109","author":"Liu","year":"2016","journal-title":"Fitoterapia"},{"issue":"7","key":"10.1016\/S1875-5364(26)61204-6_bib89","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1039\/C7FO00127D","article-title":"Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect on exercise endurance","volume":"8","author":"Chen","year":"2017","journal-title":"Food Funct"},{"key":"10.1016\/S1875-5364(26)61204-6_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108804","article-title":"Resveratrol improves muscle regeneration in obese mice through enhancing mitochondrial biogenesis","volume":"98","author":"Niu","year":"2021","journal-title":"J Nutr Biochem"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib92","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/biof.1410","article-title":"Metabolism and pharmacokinetics of resveratrol and pterostilbene","volume":"44","author":"Wang","year":"2018","journal-title":"Biofactors"},{"issue":"18","key":"10.1016\/S1875-5364(26)61204-6_bib93","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.1111\/bph.16403","article-title":"Ginsenoside Rh4 prevents endothelial dysfunction as a novel AMPK activator","volume":"181","author":"Zhang","year":"2024","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib94","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091039","article-title":"\u03b2-Lapachone ameliorates lipotoxic cardiomyopathy in acyl CoA synthase transgenic mice","volume":"9","author":"Jeong","year":"2014","journal-title":"PLoS One"},{"issue":"23","key":"10.1016\/S1875-5364(26)61204-6_bib95","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1111\/bph.14019","article-title":"Tetrahydrocannabinolic acid is a potent PPAR\u03b3 agonist with neuroprotective activity","volume":"174","author":"Nadal","year":"2017","journal-title":"Br J Pharmacol"},{"issue":"12","key":"10.1016\/S1875-5364(26)61204-6_bib96","doi-asserted-by":"crossref","first-page":"9595","DOI":"10.1007\/s11033-020-06019-9","article-title":"Lauric acid alleviates insulin resistance by improving mitochondrial biogenesis in THP-1 macrophages","volume":"47","author":"Tham","year":"2020","journal-title":"Mol Biol Rep"},{"issue":"10","key":"10.1016\/S1875-5364(26)61204-6_bib97","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1007\/s11010-023-04892-z","article-title":"Dihydroartemisinin suppresses glioma growth by repressing ERR\u03b1-mediated mitochondrial biogenesis","volume":"479","author":"Zhang","year":"2024","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib98","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1186\/s13046-024-03101-z","article-title":"Shikonin blocks CAF-induced TNBC metastasis by suppressing mitochondrial biogenesis through GSK-3\u03b2\/NEDD4-1 mediated phosphorylation-dependent degradation of PGC-1\u03b1","volume":"43","author":"Fan","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"issue":"6","key":"10.1016\/S1875-5364(26)61204-6_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065896","article-title":"Berberine rescues D-ribose-induced Alzheimer\u2019s pathology via promoting mitophagy","volume":"24","author":"Wang","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/S1875-5364(26)61204-6_bib100","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41401-022-00956-w","article-title":"Tetrahydroberberrubine retards heart aging in mice by promoting PHB2-mediated mitophagy","volume":"44","author":"Wang","year":"2023","journal-title":"Acta Pharmacol Sin"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib101","doi-asserted-by":"crossref","first-page":"547","DOI":"10.7150\/ijms.90484","article-title":"Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome","volume":"21","author":"Liu","year":"2024","journal-title":"Int J Med Sci"},{"key":"10.1016\/S1875-5364(26)61204-6_bib102","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jare.2024.10.030","article-title":"Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy","volume":"75","author":"Wang","year":"2025","journal-title":"J Adv Res"},{"key":"10.1016\/S1875-5364(26)61204-6_bib103","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153958","article-title":"Tanshinone I inhibits metastasis of cervical cancer cells by inducing BNIP3\/NIX-mediated mitophagy and reprogramming mitochondrial metabolism","volume":"98","author":"Cui","year":"2022","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib104","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/15548627.2023.2261758","article-title":"Artesunate sensitizes human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagy","volume":"20","author":"Ma","year":"2024","journal-title":"Autophagy"},{"issue":"14","key":"10.1016\/S1875-5364(26)61204-6_bib105","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.7150\/ijbs.102424","article-title":"Targeting mitochondria by lipid-selenium conjugate drug results in malate\/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression","volume":"20","author":"Chang","year":"2024","journal-title":"Int J Biol Sci"},{"issue":"18","key":"10.1016\/S1875-5364(26)61204-6_bib106","doi-asserted-by":"crossref","first-page":"9559","DOI":"10.1039\/D2FO01761J","article-title":"Fucoxanthin ameliorated myocardial fibrosis in STZ-induced diabetic rats and cell hypertrophy in HG-induced H9c2 cells by alleviating oxidative stress and restoring mitophagy","volume":"13","author":"Zheng","year":"2022","journal-title":"Food Funct"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib108","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1158\/0008-5472.CAN-22-2370","article-title":"PINK1-mediated mitophagy promotes oxidative phosphorylation and redox homeostasis to induce drug-tolerant persister cancer cells","volume":"83","author":"Li","year":"2023","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib109","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12989-023-00556-4","article-title":"Polystyrene nanoplastic exposure induces excessive mitophagy by activating AMPK\/ULK1 pathway in differentiated SH-SY5Y cells and dopaminergic neurons in vivo","volume":"20","author":"Huang","year":"2023","journal-title":"Part Fibre Toxicol"},{"issue":"9","key":"10.1016\/S1875-5364(26)61204-6_bib110","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.13366","article-title":"Thymoquinone (Tq) protects necroptosis induced by autophagy\/mitophagy-dependent oxidative stress in human bronchial epithelial cells exposed to cigarette smoke extract (CSE)","volume":"44","author":"Dera","year":"2020","journal-title":"J Food Biochem"},{"issue":"47","key":"10.1016\/S1875-5364(26)61204-6_bib111","article-title":"Aloe emodin alleviates radiation-induced heart disease via blocking P4HB lactylation and mitigating kynurenine metabolic disruption","volume":"11","author":"Ouyang","year":"2024","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib112","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41413-024-00390-0","article-title":"Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis","volume":"13","author":"Fan","year":"2025","journal-title":"Bone Res"},{"issue":"8","key":"10.1016\/S1875-5364(26)61204-6_bib113","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1080\/15548627.2015.1056970","article-title":"A novel autophagy\/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission","volume":"11","author":"Zhou","year":"2015","journal-title":"Autophagy"},{"issue":"18","key":"10.1016\/S1875-5364(26)61204-6_bib114","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.1074\/jbc.RA118.006506","article-title":"The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1\u2019s association with the mitochondrial protein TOM20","volume":"294","author":"Zhang","year":"2019","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib115","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.molcel.2017.03.008","article-title":"Celastrol-induced Nur77 interaction with TRAF2 alleviates inflammation by promoting mitochondrial ubiquitination and autophagy","volume":"66","author":"Hu","year":"2017","journal-title":"Mol Cell"},{"issue":"10","key":"10.1016\/S1875-5364(26)61204-6_bib116","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3390\/cells13100872","article-title":"Melatonin ameliorates post-stroke cognitive impairment in mice by inhibiting excessive mitophagy","volume":"13","author":"Shi","year":"2024","journal-title":"Cells"},{"key":"10.1016\/S1875-5364(26)61204-6_bib117","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.freeradbiomed.2024.01.007","article-title":"Breviscapine protects against pathological cardiac hypertrophy by targeting FOXO3a-mitofusin-1 mediated mitochondrial fusion","volume":"212","author":"Lin","year":"2024","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1016\/S1875-5364(26)61204-6_bib118","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jss.2016.02.013","article-title":"Effect of breviscapine against hepatic ischemia reperfusion injury","volume":"203","author":"Lin","year":"2016","journal-title":"J Surg Res"},{"issue":"7","key":"10.1016\/S1875-5364(26)61204-6_bib119","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/10715762.2019.1623883","article-title":"Protective effect of hyperoside against renal ischemia-reperfusion injury via modulating mitochondrial fission, oxidative stress, and apoptosis","volume":"53","author":"Wu","year":"2019","journal-title":"Free Radic Res"},{"key":"10.1016\/S1875-5364(26)61204-6_bib120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jare.2022.07.002","article-title":"Paeonol protects against doxorubicin-induced cardiotoxicity by promoting Mfn2-mediated mitochondrial fusion through activating the PKC\u03b5-Stat3 pathway","volume":"47","author":"Ding","year":"2023","journal-title":"J Adv Res"},{"issue":"13","key":"10.1016\/S1875-5364(26)61204-6_bib121","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1111\/jcmm.17398","article-title":"Matrine alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial dysfunction and inflammation via SIRT3\/OPA1 pathway","volume":"26","author":"Yuan","year":"2022","journal-title":"J Cell Mol Med"},{"issue":"11","key":"10.1016\/S1875-5364(26)61204-6_bib122","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s00592-019-01366-x","article-title":"Diallyl trisulfide attenuates hyperglycemia-induced endothelial apoptosis by inhibition of Drp1-mediated mitochondrial fission","volume":"56","author":"Hao","year":"2019","journal-title":"Acta Diabetol"},{"key":"10.1016\/S1875-5364(26)61204-6_bib123","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3119953","article-title":"Mangiferin inhibits PDGF-BB-induced proliferation and migration of rat vascular smooth muscle cells and alleviates neointimal formation in mice through the AMPK\/Drp1 axis","volume":"2021","author":"Wu","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/S1875-5364(26)61204-6_bib124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuro.2021.02.002","article-title":"Anti-inflammatory and neuroprotective effects of natural cordycepin in rotenone-induced PD models through inhibiting Drp1-mediated mitochondrial fission","volume":"84","author":"Zhang","year":"2021","journal-title":"Neurotoxicology"},{"issue":"12","key":"10.1016\/S1875-5364(26)61204-6_bib125","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1038\/s41401-021-00623-6","article-title":"Caffeine promotes angiogenesis through modulating endothelial mitochondrial dynamics","volume":"42","author":"Wang","year":"2021","journal-title":"Acta Pharmacol Sin"},{"issue":"8","key":"10.1016\/S1875-5364(26)61204-6_bib126","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.7150\/ijbs.41768","article-title":"Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway","volume":"16","author":"Deng","year":"2020","journal-title":"Int J Biol Sci"},{"issue":"8","key":"10.1016\/S1875-5364(26)61204-6_bib127","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1002\/ptr.7838","article-title":"Kaempferol induces mitochondrial dysfunction and mitophagy by activating the LKB1\/AMPK\/MFF pathway in breast precancerous lesions","volume":"37","author":"Cao","year":"2023","journal-title":"Phytother Res"},{"key":"10.1016\/S1875-5364(26)61204-6_bib128","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.biopha.2018.08.113","article-title":"Salvianolic acid B renders glioma cells more sensitive to radiation via Fis-1-mediated mitochondrial dysfunction","volume":"107","author":"Chen","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"33","key":"10.1016\/S1875-5364(26)61204-6_bib129","doi-asserted-by":"crossref","first-page":"23740","DOI":"10.1074\/jbc.M113.487686","article-title":"Piceatannol enhances cisplatin sensitivity in ovarian cancer via modulation of p53, X-linked inhibitor of apoptosis protein (XIAP), and mitochondrial fission","volume":"288","author":"Farrand","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/S1875-5364(26)61204-6_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119285","article-title":"Rg1 improves Alzheimer\u2019s disease by regulating mitochondrial dynamics mediated by the AMPK\/Drp1 signaling pathway","volume":"340","author":"Zhang","year":"2025","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/S1875-5364(26)61204-6_bib131","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ejphar.2017.07.041","article-title":"Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia\/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK","volume":"815","author":"Li","year":"2017","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib132","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-33333-6","article-title":"Mechanism of rotenone binding to respiratory complex I depends on ligand flexibility","volume":"13","author":"Pereira","year":"2023","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/S1875-5364(26)61204-6_bib133","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1007\/s11427-024-2834-8","article-title":"Berberine dissociates mitochondrial complex I by SIRT3-dependent deacetylation of NDUFS1 to improve hepatocellular glucose and lipid metabolism","volume":"68","author":"Wang","year":"2025","journal-title":"Sci China Life Sci"},{"issue":"11","key":"10.1016\/S1875-5364(26)61204-6_bib134","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41419-019-2041-z","article-title":"The natural compound gracillin exerts potent antitumor activity by targeting mitochondrial complex II","volume":"10","author":"Min","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/S1875-5364(26)61204-6_bib135","article-title":"Miltirone exhibits antileukemic activity by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction pathways","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/S1875-5364(26)61204-6_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2025.109920","article-title":"Curcumin mitigates obesity-driven dysbiosis and liver steatosis while promoting browning and thermogenesis in white adipose tissue of high-fat diet-fed mice","volume":"143","author":"Chiu","year":"2025","journal-title":"J Nutr Biochem"},{"key":"10.1016\/S1875-5364(26)61204-6_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108898","article-title":"Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPAR\u03b3 activation-dependent manner","volume":"100","author":"Tanaka","year":"2022","journal-title":"J Nutr Biochem"},{"issue":"18","key":"10.1016\/S1875-5364(26)61204-6_bib138","doi-asserted-by":"crossref","first-page":"9415","DOI":"10.7150\/thno.112661","article-title":"Alisol A ameliorates vascular cognitive impairment via AMPK\/NAMPT\/SIRT1-mediated regulation of cholesterol and autophagy","volume":"15","author":"Xu","year":"2025","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/S1875-5364(26)61204-6_bib139","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20150130","article-title":"A biophysical study on molecular physiology of the uncoupling proteins of the central nervous system","volume":"35","author":"Hoang","year":"2015","journal-title":"Biosci Rep"},{"key":"10.1016\/S1875-5364(26)61204-6_bib140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.brainres.2012.07.028","article-title":"Leonurine protects brain injury by increased activities of UCP4, SOD, CAT and Bcl-2, decreased levels of MDA and Bax, and ameliorated ultrastructure of mitochondria in experimental stroke","volume":"1474","author":"Liu","year":"2012","journal-title":"Brain Res"},{"issue":"11","key":"10.1016\/S1875-5364(26)61204-6_bib141","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.504","article-title":"Combination therapy targeting ectopic ATP synthase and 26S proteasome induces ER stress in breast cancer cells","volume":"5","author":"Chang","year":"2014","journal-title":"Cell Death Dis"},{"issue":"26","key":"10.1016\/S1875-5364(26)61204-6_bib142","doi-asserted-by":"crossref","first-page":"14766","DOI":"10.1073\/pnas.97.26.14766","article-title":"Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F0F1-ATPase","volume":"97","author":"Salomon","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/S1875-5364(26)61204-6_bib143","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1021\/pr700742h","article-title":"Targeting therapy for breast carcinoma by ATP synthase inhibitor aurovertin B","volume":"7","author":"Huang","year":"2008","journal-title":"J Proteome Res"},{"issue":"7","key":"10.1016\/S1875-5364(26)61204-6_bib144","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3390\/md20070418","article-title":"The marine-derived macrolactone mandelalide A is an indirect activator of AMPK","volume":"20","author":"Mattos","year":"2022","journal-title":"Mar Drugs"},{"issue":"29","key":"10.1016\/S1875-5364(26)61204-6_bib145","article-title":"CryoEM structure with ATP synthase enables late-stage diversification of cruentaren A","volume":"29","author":"Dou","year":"2023","journal-title":"Chemistry"},{"issue":"34","key":"10.1016\/S1875-5364(26)61204-6_bib146","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1073\/pnas.0706290104","article-title":"Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols","volume":"104","author":"Gledhill","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/S1875-5364(26)61204-6_bib147","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/sj.bjp.0703397","article-title":"Inhibition of mitochondrial proton F0F1-ATPase\/ATP synthase by polyphenolic phytochemicals","volume":"130","author":"Zheng","year":"2000","journal-title":"Br J Pharmacol"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib148","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1017\/S0007114507352604","article-title":"Differential effect of dietary antioxidant classes (carotenoids, polyphenols, vitamins C and E) on lutein absorption","volume":"97","author":"Reboul","year":"2007","journal-title":"Br J Nutr"},{"key":"10.1016\/S1875-5364(26)61204-6_bib149","doi-asserted-by":"crossref","first-page":"9961","DOI":"10.2147\/IJN.S276355","article-title":"Pharmacology and pharmacokinetics of vitamin E: nanoformulations to enhance bioavailability","volume":"15","author":"Mohd Zaffarin","year":"2020","journal-title":"Int J Nanomedicine"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib150","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/1389200214666131229111336","article-title":"Pharmacokinetics and biotransformation of tea polyphenols","volume":"15","author":"Qiao","year":"2014","journal-title":"Curr Drug Metab"},{"key":"10.1016\/S1875-5364(26)61204-6_bib151","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000171008","article-title":"Bioavailability of carotenoids","volume":"103","author":"McLaren","year":"2012","journal-title":"World Rev Nutr Diet"},{"issue":"8","key":"10.1016\/S1875-5364(26)61204-6_bib152","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1002\/ptr.70008","article-title":"Potential candidates of natural antioxidants from herbs for treating lung disorders: focus on redox balance and natural products","volume":"39","author":"Chang","year":"2025","journal-title":"Phytother Res"},{"key":"10.1016\/S1875-5364(26)61204-6_bib153","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.freeradbiomed.2023.03.022","article-title":"Astragaloside IV attenuates podocyte apoptosis through ameliorating mitochondrial dysfunction by up-regulated Nrf2-ARE\/TFAM signaling in diabetic kidney disease","volume":"203","author":"Shen","year":"2023","journal-title":"Free Radic Biol Med"},{"issue":"11","key":"10.1016\/S1875-5364(26)61204-6_bib154","doi-asserted-by":"crossref","first-page":"6241","DOI":"10.1002\/ptr.7269","article-title":"The protective effect of harpagoside on angiotensin II (Ang II)-induced blood-brain barrier leakage in vitro","volume":"35","author":"Lu","year":"2021","journal-title":"Phytother Res"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib155","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12890-022-01988-y","article-title":"Peroxiredoxin 6 mediates the protective function of curcumin pretreatment in acute lung injury induced by serum from patients undergoing one-lung ventilation in vitro","volume":"22","author":"Li","year":"2022","journal-title":"BMC Pulm Med"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib156","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10735-023-10176-z","article-title":"Orientin alleviates ox-LDL-induced oxidative stress, inflammation and apoptosis in human vascular endothelial cells by regulating Sestrin 1 (SESN1)-mediated autophagy","volume":"55","author":"Gao","year":"2024","journal-title":"J Mol Histol"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib157","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.chembiol.2023.02.003","article-title":"Ainsliadimer A induces ROS-mediated apoptosis in colorectal cancer cells via directly targeting peroxiredoxin 1 and 2","volume":"30","author":"Lv","year":"2023","journal-title":"Cell Chem Biol"},{"issue":"38","key":"10.1016\/S1875-5364(26)61204-6_bib158","article-title":"Ponicidin promotes hepatocellular carcinoma mitochondrial apoptosis by stabilizing Keap1-PGAM5 complex","volume":"11","author":"Zhao","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/S1875-5364(26)61204-6_bib159","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/s12885-016-2516-6","article-title":"Silibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis","volume":"16","author":"Kim","year":"2016","journal-title":"BMC Cancer"},{"issue":"6","key":"10.1016\/S1875-5364(26)61204-6_bib160","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1271\/bbb.67.1215","article-title":"Pro-oxidative properties of flavonoids in human lymphocytes","volume":"67","author":"Yen","year":"2003","journal-title":"Biosci Biotechnol Biochem"},{"issue":"12","key":"10.1016\/S1875-5364(26)61204-6_bib161","doi-asserted-by":"crossref","first-page":"3786","DOI":"10.1002\/jcp.25861","article-title":"Chrysin induces death of prostate cancer cells by inducing ROS and ER stress","volume":"232","author":"Ryu","year":"2017","journal-title":"J Cell Physiol"},{"issue":"7","key":"10.1016\/S1875-5364(26)61204-6_bib162","doi-asserted-by":"crossref","first-page":"e720","DOI":"10.1038\/cddis.2013.217","article-title":"Saikosaponin-d, a novel SERCA inhibitor, induces autophagic cell death in apoptosis-defective cells","volume":"4","author":"Wong","year":"2013","journal-title":"Cell Death Dis"},{"issue":"5","key":"10.1016\/S1875-5364(26)61204-6_bib163","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1182\/blood-2007-12-126946","article-title":"Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells","volume":"112","author":"Balakrishnan","year":"2008","journal-title":"Blood"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib164","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3324\/haematol.2011.046466","article-title":"Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin\u2019s lymphoma B cells","volume":"97","author":"Jacquemin","year":"2012","journal-title":"Haematologica"},{"issue":"28","key":"10.1016\/S1875-5364(26)61204-6_bib165","doi-asserted-by":"crossref","first-page":"11662","DOI":"10.1073\/pnas.1102635108","article-title":"miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia","volume":"108","author":"Siegel","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib166","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.694","article-title":"Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation","volume":"9","author":"Han","year":"2021","journal-title":"Pharmacol Res Perspect"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib167","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/35048073","article-title":"The mitochondrion in apoptosis: how Pandora\u2019s box opens","volume":"2","author":"Zamzami","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib168","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13046-017-0514-4","article-title":"Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2","volume":"36","author":"Xu","year":"2017","journal-title":"J Exp Clin Cancer Res"},{"issue":"2","key":"10.1016\/S1875-5364(26)61204-6_bib169","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.abb.2011.05.015","article-title":"Redox reactions of the FAD-containing apoptosis-inducing factor (AIF) with quinoidal xenobiotics: a mechanistic study","volume":"512","author":"Misevi\u010dien\u0117","year":"2011","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/S1875-5364(26)61204-6_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117111","article-title":"Bongkrekic acid alleviates airway inflammation via breaking the mPTP\/mtDAMPs\/RAGE feedback loop in a steroid-insensitive asthma model","volume":"177","author":"Chen","year":"2024","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib171","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.80","article-title":"Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury","volume":"5","author":"Kim","year":"2014","journal-title":"Cell Death Dis"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib172","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1002\/ptr.8434","article-title":"Pubescenoside D ameliorates myocardial ischemia-reperfusion injury via preventing the dissociation of HK2 and promoting mitophagy by targeting GSK-3\u03b2","volume":"39","author":"Xiao","year":"2025","journal-title":"Phytother Res"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib173","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3390\/molecules24030543","article-title":"The cardiotoxicity induced by arsenic trioxide is alleviated by salvianolic acid A via maintaining calcium homeostasis and inhibiting endoplasmic reticulum stress","volume":"24","author":"Wang","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/S1875-5364(26)61204-6_bib174","article-title":"Luteolin improves cardiac dysfunction in heart failure rats by regulating sarcoplasmic reticulum Ca2+-ATPase 2a","volume":"7","author":"Hu","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib175","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00210-024-03292-4","article-title":"Ginsenoside Rb1 reduced ischemic stroke-induced apoptosis through endoplasmic reticulum stress-associated IRE1\/TRAF2\/JNK pathway","volume":"398","author":"Wei","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib176","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12967-025-06114-0","article-title":"Parthenolide improves sepsis-induced coagulopathy by inhibiting mitochondrial-mediated apoptosis in vascular endothelial cells through BRD4\/BCL-xL pathway","volume":"23","author":"Zhang","year":"2025","journal-title":"J Transl Med"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib177","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12013-014-0204-1","article-title":"Protective effects of nigranoic acid on cerebral ischemia-reperfusion injury and its mechanism involving apoptotic signaling pathway","volume":"71","author":"Feng","year":"2015","journal-title":"Cell Biochem Biophys"},{"issue":"22","key":"10.1016\/S1875-5364(26)61204-6_bib178","article-title":"Ameliorating mitochondrial dysfunction of neurons by biomimetic targeting nanoparticles mediated mitochondrial biogenesis to boost the therapy of Parkinson\u2019s disease","volume":"10","author":"Zheng","year":"2023","journal-title":"Adv Sci (Weinh)"},{"issue":"Pt 3","key":"10.1016\/S1875-5364(26)61204-6_bib179","article-title":"Dual-targeted mitophagy activation by curcumin-Zn co-delivery mediates neuroprotection in zebrafish through coordinated PINK1\/Parkin and PI3K\/AKT\/mTOR pathway regulation","volume":"221","author":"Pan","year":"2025","journal-title":"Food Res Int"},{"issue":"11","key":"10.1016\/S1875-5364(26)61204-6_bib180","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/jnr.23438","article-title":"Curcumin protects neurons against oxygen-glucose deprivation\/reoxygenation-induced injury through activation of peroxisome proliferator-activated receptor-\u03b3 function","volume":"92","author":"Liu","year":"2014","journal-title":"J Neurosci Res"},{"issue":"10","key":"10.1016\/S1875-5364(26)61204-6_bib181","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.1167\/iovs.16-19883","article-title":"Curcumin protects trabecular meshwork cells from oxidative stress","volume":"57","author":"Lin","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib182","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.maturitas.2012.02.004","article-title":"Dose-dependent effect of resveratrol on bladder cancer cells: chemoprevention and oxidative stress","volume":"72","author":"Stocco","year":"2012","journal-title":"Maturitas"},{"issue":"1","key":"10.1016\/S1875-5364(26)61204-6_bib183","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/biof.1118","article-title":"Dose-dependent bioavailability indicators for curcumin and two of its novel derivatives","volume":"40","author":"Abd el Aziz","year":"2014","journal-title":"Biofactors"},{"issue":"2","key":"10.1016\/S1875-5364(26)61204-6_bib184","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/HEP.0000000000000937","article-title":"Effect of phospholipid curcumin Meriva on liver histology and kidney disease in nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled trial","volume":"81","author":"Musso","year":"2025","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/S1875-5364(26)61204-6_bib185","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1055\/s-2006-957450","article-title":"Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers","volume":"64","author":"Shoba","year":"1998","journal-title":"Planta Med"},{"issue":"4","key":"10.1016\/S1875-5364(26)61204-6_bib187","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s12325-020-01251-y","article-title":"Silymarin as supportive treatment in liver diseases: a narrative review","volume":"37","author":"Gillessen","year":"2020","journal-title":"Adv Ther"},{"key":"10.1016\/S1875-5364(26)61204-6_bib188","author":"Jazz Pharmaceuticals"},{"key":"10.1016\/S1875-5364(26)61204-6_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114705","article-title":"A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes","volume":"162","author":"Song","year":"2023","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"10.1016\/S1875-5364(26)61204-6_bib190","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1517\/14656566.7.8.1041","article-title":"Albumin-bound paclitaxel: a next-generation taxane","volume":"7","author":"Gradishar","year":"2006","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/S1875-5364(26)61204-6_bib191","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jep.2014.09.049","article-title":"Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension","volume":"161","author":"Lan","year":"2015","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"10.1016\/S1875-5364(26)61204-6_bib192","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40261-015-0368-5","article-title":"The safety of melatonin in humans","volume":"36","author":"Andersen","year":"2016","journal-title":"Clin Drug Invest"},{"issue":"4","key":"10.1016\/S1875-5364(26)61204-6_bib193","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1021\/acs.jmedchem.4c01257","article-title":"Artificial intelligence in natural product drug discovery: current applications and future perspectives","volume":"68","author":"Gangwal","year":"2025","journal-title":"J Med Chem"},{"issue":"4","key":"10.1016\/S1875-5364(26)61204-6_bib194","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3390\/bioengineering10040463","article-title":"Production of a novel protopanaxatriol-type ginsenoside by yeast cell factories","volume":"10","author":"Zhou","year":"2023","journal-title":"Bioengineering (Basel)"},{"issue":"7","key":"10.1016\/S1875-5364(26)61204-6_bib195","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s10295-017-1937-9","article-title":"Efficient de novo synthesis of resveratrol by metabolically engineered Escherichia coli","volume":"44","author":"Wu","year":"2017","journal-title":"J Ind Microbiol Biotechnol"},{"issue":"5","key":"10.1016\/S1875-5364(26)61204-6_bib196","first-page":"323","article-title":"Network pharmacology approaches for research of Traditional Chinese Medicines","volume":"21","author":"Li","year":"2023","journal-title":"Chin J Nat Med"},{"key":"10.1016\/S1875-5364(26)61204-6_bib197","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111833","article-title":"Application of omics- and multi-omics-based techniques for natural product target discovery","volume":"141","author":"Zhang","year":"2021","journal-title":"Biomed Pharmacother"}],"container-title":["Chinese Journal of Natural Medicines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875536426612046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1875536426612046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:59:54Z","timestamp":1787299194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1875536426612046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":194,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1875536426612046"],"URL":"https:\/\/doi.org\/10.1016\/s1875-5364(26)61204-6","relation":{},"ISSN":["1875-5364"],"issn-type":[{"value":"1875-5364","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondria-targeted natural products with potential for the treatment of mitochondria-related diseases","name":"articletitle","label":"Article Title"},{"value":"Chinese Journal of Natural Medicines","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S1875-5364(26)61204-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2026 China Pharmaceutical University. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}