{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:52:03Z","timestamp":1788558723568,"version":"build-2803163510"},"reference-count":25,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010721","name":"Ironwood Pharmaceuticals Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Gastroenterology &amp; Hepatology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/s2468-1253(23)00398-9","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T18:30:03Z","timestamp":1704738603000},"page":"238-250","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Efficacy and safety of linaclotide in treating functional constipation in paediatric patients: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial"],"prefix":"10.1016","volume":"9","author":[{"given":"Carlo","family":"Di Lorenzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Khlevner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Rodriguez-Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna Y","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Ando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey S","family":"Hyams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Nurko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A","family":"Benninga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella E","family":"Hewson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Saps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/S2468-1253(23)00398-9_bib1","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1053\/j.gastro.2016.02.015","article-title":"Childhood functional gastrointestinal disorders: child\/adolescent","volume":"150","author":"Hyams","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/S2468-1253(23)00398-9_bib2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41575-019-0222-y","article-title":"Management of functional constipation in children and adults","volume":"17","author":"Vriesman","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/S2468-1253(23)00398-9_bib3","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1053\/j.gastro.2016.02.016","article-title":"Childhood functional gastrointestinal disorders: neonate\/toddler","volume":"150","author":"Benninga","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/S2468-1253(23)00398-9_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10215087","article-title":"Systematic review of pediatric functional gastrointestinal disorders (Rome IV criteria)","volume":"10","author":"Vernon-Roberts","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/S2468-1253(23)00398-9_bib5","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jpeds.2018.02.029","article-title":"Prevalence of functional defecation disorders in children: a systematic review and meta-analysis","volume":"198","author":"Koppen","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/S2468-1253(23)00398-9_bib6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jpeds.2019.06.059","article-title":"Quality of life in children with functional constipation: a systematic review and meta-analysis","volume":"214","author":"Vriesman","year":"2019","journal-title":"J Pediatr"},{"key":"10.1016\/S2468-1253(23)00398-9_bib7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/MPG.0000000000000266","article-title":"Evaluation and treatment of functional constipation in infants and children: evidence-based recommendations from ESPGHAN and NASPGHAN","volume":"58","author":"Tabbers","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/S2468-1253(23)00398-9_bib8","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1542\/peds.2009-1009","article-title":"Long-term prognosis for childhood constipation: clinical outcomes in adulthood","volume":"126","author":"Bongers","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/S2468-1253(23)00398-9_bib9","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-2036.2008.03884.x","article-title":"Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation\u2014a 12-week, randomized, double-blind, placebo-controlled study","volume":"29","author":"Quigley","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/S2468-1253(23)00398-9_bib11","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1053\/j.gastro.2014.09.005","article-title":"Prucalopride is no more effective than placebo for children with functional constipation","volume":"147","author":"Mugie","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/S2468-1253(23)00398-9_bib12","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.cgh.2021.04.005","article-title":"Lubiprostone for pediatric functional constipation: randomized, controlled, double-blind study with long-term extension","volume":"20","author":"Benninga","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/S2468-1253(23)00398-9_bib14","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1056\/NEJMoa1010863","article-title":"Two randomized trials of linaclotide for chronic constipation","volume":"365","author":"Lembo","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/S2468-1253(23)00398-9_bib15","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1038\/ajg.2012.255","article-title":"A 12-week, randomized, controlled trial with a 4-week randomized withdrawal period to evaluate the efficacy and safety of linaclotide in irritable bowel syndrome with constipation","volume":"107","author":"Rao","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/S2468-1253(23)00398-9_bib16","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1038\/ajg.2012.254","article-title":"Linaclotide for irritable bowel syndrome with constipation: a 26-week, randomized, double-blind, placebo-controlled trial to evaluate efficacy and safety","volume":"107","author":"Chey","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/S2468-1253(23)00398-9_bib17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/MPG.0000000000003296","article-title":"Intestinal guanylate cyclase-C mRNA expression in duodenum and colon of children","volume":"73","author":"Cohen","year":"2021","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/S2468-1253(23)00398-9_bib18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0016-5085(88)90423-4","article-title":"Age-related differences in receptors for Escherichia coli heat-stable enterotoxin in the small and large intestine of children","volume":"94","author":"Cohen","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1016\/S2468-1253(23)00398-9_bib19","doi-asserted-by":"crossref","first-page":"S645","DOI":"10.14309\/01.ajg.0000594132.11221.16","article-title":"Linaclotide safety and efficacy in children aged 6 to 17 years with functional constipation","volume":"114","author":"Di Lorenzo","year":"2019","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/S2468-1253(23)00398-9_bib20","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.jval.2023.03.129","article-title":"CO55 psychometric evaluation of the measurement properties of a pediatric clinical outcome assessment for functional constipation: data from a phase 3 clinical trial","volume":"26","author":"Taylor","year":"2023","journal-title":"Value Health"},{"key":"10.1016\/S2468-1253(23)00398-9_bib21","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3109\/00365529709011203","article-title":"Stool form scale as a useful guide to intestinal transit time","volume":"32","author":"Lewis","year":"1997","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/S2468-1253(23)00398-9_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/ajg.2017.230","article-title":"Low-dose linaclotide (72 \u03bcg) for chronic idiopathic constipation: a 12-week, randomized, double-blind, placebo-controlled trial","volume":"113","author":"Schoenfeld","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/S2468-1253(23)00398-9_bib23","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1365-2036.2010.04273.x","article-title":"Systematic review: impact of constipation on quality of life in adults and children","volume":"31","author":"Belsey","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/S2468-1253(23)00398-9_bib24","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.2147\/IJGM.S274568","article-title":"Review of treatment options for irritable bowel syndrome with constipation and chronic idiopathic constipation","volume":"14","author":"Patel","year":"2021","journal-title":"Int J Gen Med"},{"key":"10.1016\/S2468-1253(23)00398-9_bib26","doi-asserted-by":"crossref","DOI":"10.1111\/nmo.13294","article-title":"Recommendations for pharmacological clinical trials in children with functional constipation: the Rome foundation pediatric subcommittee on clinical trials","volume":"30","author":"Koppen","year":"2018","journal-title":"Neurogastroenterol Motil"},{"key":"10.1016\/S2468-1253(23)00398-9_bib27","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1053\/j.gastro.2014.10.024","article-title":"Treating constipation with prucalopride: one size does not fit all","volume":"147","author":"Nurko","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/S2468-1253(23)00398-9_bib28","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.14309\/ajg.0000000000001334","article-title":"Efficacy of linaclotide in reducing abdominal symptoms of bloating, discomfort, and pain: a phase 3B trial using a novel abdominal scoring system","volume":"116","author":"Chang","year":"2021","journal-title":"Am J Gastroenterol"}],"container-title":["The Lancet Gastroenterology &amp; Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468125323003989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2468125323003989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T05:05:30Z","timestamp":1762837530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2468125323003989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S2468125323003989"],"URL":"https:\/\/doi.org\/10.1016\/s2468-1253(23)00398-9","relation":{},"ISSN":["2468-1253"],"issn-type":[{"value":"2468-1253","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy and safety of linaclotide in treating functional constipation in paediatric patients: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial","name":"articletitle","label":"Article Title"},{"value":"The Lancet Gastroenterology & Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/S2468-1253(23)00398-9","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/S2468-1253(23)00440-5","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}