{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:32:56Z","timestamp":1762270376279},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1978,5,1]],"date-time":"1978-05-01T00:00:00Z","timestamp":262828800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European Journal of Pharmacology"],"published-print":{"date-parts":[[1978,5]]},"DOI":"10.1016\/0014-2999(78)90069-9","type":"journal-article","created":{"date-parts":[[2002,12,14]],"date-time":"2002-12-14T07:48:03Z","timestamp":1039852083000},"page":"133-143","source":"Crossref","is-referenced-by-count":248,"title":["Benzodiazepines: Potentiation of a GABA inhibitory response in the dorsal raphe nucleus"],"prefix":"10.1016","volume":"49","author":[{"given":"Dorothy W.","family":"Gallager","sequence":"first","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/0014-2999(78)90069-9_BIB1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1476-5381.1977.tb16740.x","article-title":"Alterations in brain 5-hydroxytryptamine metabolism during the \u201cwithdrawal\u201d phase after chronic treatment with diazepam and bromazepam","volume":"60","author":"Agarwal","year":"1977","journal-title":"Brit. J. Pharmacol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB2","series-title":"Pharmacology and the Future of Man","first-page":"269","article-title":"Studies on the physiological activity of 5HT neurons","volume":"Vol. 4","author":"Aghajanian","year":"1973"},{"key":"10.1016\/0014-2999(78)90069-9_BIB3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0006-8993(74)90954-8","article-title":"L-Tryptophan as a selective histochemical marker for serotonergic neurons in single-cell recording studies","volume":"81","author":"Aghajanian","year":"1974","journal-title":"Brain Res."},{"key":"10.1016\/0014-2999(78)90069-9_BIB4","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0024-3205(72)90153-1","article-title":"Lysergic acid diethylamide and serotonin: direct actions in serotonin-containing neurons","volume":"11","author":"Aghajanian","year":"1972","journal-title":"Life Sci."},{"key":"10.1016\/0014-2999(78)90069-9_BIB5","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1016\/S0021-9258(18)94012-3","article-title":"Elevation of \u03b3-aminobutyric acid in brain: selective inhibition of \u03b3-aminobutyric-\u03b1-ketoglutarate transaminase","volume":"236","author":"Baxter","year":"1961","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0014-2999(78)90069-9_BIB6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.2042-7158.1973.tb09150.x","article-title":"The reflection of ejecting and retaining currents in the time-course of neuronal responses to microelectrophoretically applied drugs","volume":"25","author":"Bradshaw","year":"1973","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB7","first-page":"560","article-title":"Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity","volume":"185","author":"Bunney","year":"1973","journal-title":"J. Pharmacol. Exptl. Therap."},{"key":"10.1016\/0014-2999(78)90069-9_BIB8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0006-8993(76)90297-3","article-title":"Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the \u03b1-antagonist piperoxane","volume":"112","author":"Cedarbaum","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/0014-2999(78)90069-9_BIB9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0024-3205(68)90368-8","article-title":"The effect of immobilization stress on the activity of central monoamine neurons","volume":"7","author":"Corrodi","year":"1968","journal-title":"Life Sci."},{"key":"10.1016\/0014-2999(78)90069-9_BIB10","article-title":"Mechanism of action of benzodiazepines","volume":"Vol. 14","author":"Costa","year":"1975"},{"key":"10.1016\/0014-2999(78)90069-9_BIB11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0024-3205(75)90501-9","article-title":"New concepts on the mechanism of action of benzodiazepines","volume":"17","author":"Costa","year":"1975","journal-title":"Life Sci."},{"key":"10.1016\/0014-2999(78)90069-9_BIB12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/BF00241731","article-title":"In vivo inactivation of GABA and other inhibitory amino acids in the cat nervous system","volume":"25","author":"Curtis","year":"1976","journal-title":"Exp. Brain Res."},{"issue":"Suppl. 232","key":"10.1016\/0014-2999(78)90069-9_BIB13","first-page":"1","article-title":"Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons","volume":"62","author":"Dahlstr\u00f6m","year":"1964","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/0014-2999(78)90069-9_BIB14","first-page":"179","article-title":"Neurotransmitter Amino Acids","author":"Davidson","year":"1976"},{"key":"10.1016\/0014-2999(78)90069-9_BIB15","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.2042-7158.1976.tb04163.x","article-title":"Benzodiazepines: GABA and glycine receptors on single neurons in the rat medulla","volume":"28","author":"Dray","year":"1976","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB16","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0006-8993(76)90108-6","article-title":"Diazepam and chlordiazepoxide: powerful GABA antagonists in explants of rat cerebellum","volume":"107","author":"G\u00e4hwiler","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/0014-2999(78)90069-9_BIB17","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0014-2999(76)90145-X","article-title":"Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin","volume":"39","author":"Gallager","year":"1976","journal-title":"European J. Pharmacol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB18","series-title":"The Benzodiazepines","author":"Garattini","year":"1973"},{"key":"10.1016\/0014-2999(78)90069-9_BIB19","first-page":"131","article-title":"Possible involvement of GABA in the central actions of benzodiazepines","volume":"Vol. 12","author":"Haefely","year":"1975"},{"key":"10.1016\/0014-2999(78)90069-9_BIB20","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1476-5381.1971.tb07066.x","article-title":"Role of transmitter uptake mechanisms in synaptic neurotransmission","volume":"41","author":"Iversen","year":"1971","journal-title":"Brit. J. Pharmacol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB21","series-title":"Metabolic Compartmentation and Neurotransmission","first-page":"65","article-title":"Uptake and localization of transmitter amino acids in the nervous system","author":"Iversen","year":"1975"},{"key":"10.1016\/0014-2999(78)90069-9_BIB22","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1111\/j.1471-4159.1971.tb09600.x","article-title":"GABA uptake in slices and homogenates and the effects of some inhibitors","volume":"18","author":"Iversen","year":"1971","journal-title":"J. Neurochem."},{"key":"10.1016\/0014-2999(78)90069-9_BIB23","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1111\/j.2042-7158.1975.tb09539.x","article-title":"Altered 5-HT metabolism with clonazepam, diazepam and diphenylhydantoin","volume":"27","author":"Jenner","year":"1975","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1126\/science.163.3862.32","article-title":"Biogenic amines and the states of sleep","volume":"163","author":"Jouvet","year":"1969","journal-title":"Science"},{"key":"10.1016\/0014-2999(78)90069-9_BIB25","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/0028-3908(72)90076-7","article-title":"Cerebellar involvement in the anti-epileptic action of diazepam","volume":"11","author":"Julien","year":"1972","journal-title":"Neuropharmacol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB26","series-title":"The rat brain: a stereotaxic atlas","author":"K\u00f6nig","year":"1970"},{"key":"10.1016\/0014-2999(78)90069-9_BIB27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0014-2999(74)90045-4","article-title":"Noradrenergic neurons: morphine inhibition of spontaneous activity","volume":"25","author":"Korf","year":"1974","journal-title":"European J. Pharmacol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB28","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/269072a0","article-title":"Are benzodiazepines GABA antagonists?","volume":"269","author":"Kozhechkin","year":"1977","journal-title":"Nature"},{"key":"10.1016\/0014-2999(78)90069-9_BIB29","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1152\/physrev.1974.54.2.418","article-title":"Chemical nature of synaptic transmission in vertebrates","volume":"54","author":"Krnjevi\u0107","year":"1974","journal-title":"Physiol. Rev."},{"key":"10.1016\/0014-2999(78)90069-9_BIB30","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1471-4159.1975.tb04411.x","article-title":"Structure and biological activity of a series of conformationally restricted analogues of GABA","volume":"25","author":"Krogsgaard-Larson","year":"1975","journal-title":"J. Neurochem."},{"key":"10.1016\/0014-2999(78)90069-9_BIB31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0014-2999(74)90071-5","article-title":"Benzodiazepines and barbiturates: turnover charges in central 5-hydrocytryptamine pathways","volume":"26","author":"Lidbrink","year":"1974","journal-title":"European J. Pharmacol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00426826","article-title":"Head twitches induced by benzodiazepines and the role of biogenic amines","volume":"49","author":"Nakamura","year":"1976","journal-title":"Psychopharmacology"},{"key":"10.1016\/0014-2999(78)90069-9_BIB33","first-page":"543","article-title":"Release of glycine and gamma-aminobutyric acid from synaptosomes prepared from rat central nervous tissue","volume":"35","author":"Nelson-Kraus","year":"1976"},{"key":"10.1016\/0014-2999(78)90069-9_BIB34","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1471-4159.1977.tb10726.x","article-title":"Effect of diazepam and pentobarbital on amino-oxyacetic acid-induced accumulation of GABA","volume":"29","author":"Pericic","year":"1978","journal-title":"J. Neurochem."},{"key":"10.1016\/0014-2999(78)90069-9_BIB35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF00507844","article-title":"Effects of two benzodiazepines, phenobarbitone and baclofen on synaptic transmission in the cat cuneate nucleus","volume":"294","author":"Polc","year":"1976","journal-title":"Naunyn-Schmiedeb. Arch. Pharmacol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF00504702","article-title":"The effect of diazepam on spinal cord activities: possible sites and mechanisms of action","volume":"284","author":"Polc","year":"1974","journal-title":"Naunyn-Schmiedeb. Arch. Exptl. Pathol. Pharmakol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB37","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1016\/0006-2952(74)90033-1","article-title":"\u03b3-Aminobutyric acid and nervous system function \u2014 a perspective","volume":"23","author":"Roberts","year":"1974","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/0014-2999(78)90069-9_BIB38","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/00000542-196701000-00007","article-title":"Micromethods in neuropharmacology: an approach to the study of anesthesia","volume":"28","author":"Salmoiraghi","year":"1967","journal-title":"Anesthesiology"},{"key":"10.1016\/0014-2999(78)90069-9_BIB39","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1528-1157.1975.tb04747.x","article-title":"Effects of anticonvulsant drugs on the cerebral enzymes metabolizing GABA","volume":"16","author":"Sawaya","year":"1975","journal-title":"Epilepsia (Amst.)"},{"key":"10.1016\/0014-2999(78)90069-9_BIB40","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0028-3908(74)90057-4","article-title":"Regional levels of GABA and glutamate in mousebrain following exposure to pain","volume":"13","author":"Sherman","year":"1974","journal-title":"Neuropharmacology"},{"key":"10.1016\/0014-2999(78)90069-9_BIB41","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/0028-3908(76)90007-1","article-title":"Antagonism of diazepam agonist central anticholinergic drug-induced hyperactivity in mice: involvement of a GABA mechanism","volume":"15","author":"Soubrie","year":"1976","journal-title":"Neuropharmacology"},{"key":"10.1016\/0014-2999(78)90069-9_BIB42","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/266732a0","article-title":"Benzodiazepine receptors in rat brain","volume":"266","author":"Squires","year":"1977","journal-title":"Nature"},{"key":"10.1016\/0014-2999(78)90069-9_BIB43","series-title":"The Benzodiazepines","first-page":"299","article-title":"Anti-anxiety action of benzodiazepines. Decrease in activity of serotonin neurons in the punishment system","author":"Stein","year":"1973"},{"key":"10.1016\/0014-2999(78)90069-9_BIB44","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/260346a0","article-title":"Antagonistic effects of GABA and benzodiazepines on vestibular and cerebellar neurones","volume":"260","author":"Steiner","year":"1976","journal-title":"Nature"},{"key":"10.1016\/0014-2999(78)90069-9_BIB45","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0006-8993(75)90276-0","article-title":"Inhibition of both noradrenergic and serotonergic neurons in brain by the \u03b1-adrenergic agonist clonidine","volume":"91","author":"Svensson","year":"1975","journal-title":"Brain Res."},{"key":"10.1016\/0014-2999(78)90069-9_BIB46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.194312","article-title":"Physiological evidence for habenula as major link between forebrain and midbrain raphe","volume":"197","author":"Wang","year":"1977","journal-title":"Science"},{"key":"10.1016\/0014-2999(78)90069-9_BIB47","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/264365a0","article-title":"Stimulation of pontine reticular formation suppresses firing of serotonergic neurones in the dorsal raphe","volume":"264","author":"Wang","year":"1977","journal-title":"Nature"},{"issue":"Suppl. 31","key":"10.1016\/0014-2999(78)90069-9_BIB48","first-page":"34","article-title":"Serotonin: a possible mediator of behavioral suppression induced by anxiety","volume":"11","author":"Wise","year":"1970","journal-title":"Dis. Nerv. Syst."},{"key":"10.1016\/0014-2999(78)90069-9_BIB49","first-page":"2246","article-title":"Interaction of benzodiazepines with central nervous glycine receptors: possible mechanism of action","volume":"71","author":"Young","year":"1974"}],"container-title":["European Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0014299978900699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0014299978900699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T19:05:58Z","timestamp":1622574358000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0014299978900699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,5]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1978,5]]}},"alternative-id":["0014299978900699"],"URL":"https:\/\/doi.org\/10.1016\/0014-2999(78)90069-9","relation":{},"ISSN":["0014-2999"],"issn-type":[{"value":"0014-2999","type":"print"}],"subject":[],"published":{"date-parts":[[1978,5]]}}}