{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:25:54Z","timestamp":1762269954517},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2001,12,14]],"date-time":"2001-12-14T00:00:00Z","timestamp":1008288000000},"content-version":"vor","delay-in-days":3812,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FEBS Letters"],"published-print":{"date-parts":[[1991,7,8]]},"abstract":"<jats:p>Recent studies indicated that the formation of a major constituent of Alzheimer's disease (AD) senile plaques, called \u03b2A4\u2010peptide, does not result from normal processing of its precursor, amyloid precursor protein (APP). Since proteolytic cleavage of APP inside its \u03b2A4 sequence was found to be part of APP processing the formation of the \u03b2A4\u2010peptide seems to be prevented under normal conditions. We considered whether in AD one of the endogenous proteinase inhibitors might interfere with APP processing. After we had recently found that cultured human neuronal cells synthesize the most potent of the known human proteinase inhibitors, \u03b1\u20102\u2010macroglobulin (\u03b12M), upon stimulation with the inflammatory mediator interleukin\u20106 (IL\u20106) we now investigated whether \u03b12M and IL\u20106 could be detected in AD brains. Here we report that AD cortical senile plaques display strong \u03b12M and IL\u20106 immunoreactivity while no such immunoreactivity was found in age\u2010matched control brains. Strong perinuclear \u03b12M immunoreactivity in hippocampal CAI neurons of Alzheimer's disease brains indicates that neuronal cells are the site of \u03b12M synthesis in AD brains. We did not detect elevated IL\u20106 or \u03b12M levels in the cerebrospinal fluid of AD patients. Our data indicate that a sequence of immunological events which seem to be restricted to the local cortical environment is part of AD pathology.<\/jats:p>","DOI":"10.1016\/0014-5793(91)80737-n","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:43:20Z","timestamp":1027583000000},"page":"111-114","source":"Crossref","is-referenced-by-count":395,"title":["Interleukin\u20106 and \u03b1\u20102\u2010macroglobulin indicate an acute\u2010phase state in Alzheimer's disease cortices"],"prefix":"10.1002","volume":"285","author":[{"given":"Joachim","family":"Bauer","sequence":"first","affiliation":[]},{"given":"Sylvia","family":"Strauss","sequence":"additional","affiliation":[]},{"given":"Ursula","family":"Schreiter-Gasser","sequence":"additional","affiliation":[]},{"given":"Ursula","family":"Ganter","sequence":"additional","affiliation":[]},{"given":"Petra","family":"Schlegel","sequence":"additional","affiliation":[]},{"given":"Irene","family":"Witt","sequence":"additional","affiliation":[]},{"given":"Benedikt","family":"Yolk","sequence":"additional","affiliation":[]},{"given":"Mathias","family":"Berger","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,12,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.58.070189.001443"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(89)90072-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.40.020189.000401"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(91)90010-U"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/349704a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1691865"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2111583"},{"key":"e_1_2_1_9_1","author":"Ganter U.","year":"1991","journal-title":"FEBS Lett."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1987.tb13574.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1987.tb10004.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.4.1134.1134"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.5.1537"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01721287"},{"key":"e_1_2_1_15_1","author":"Bauer J.","year":"1991","journal-title":"Ann. Hematol. (Blut)"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2650621"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830190418"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0968-0004(82)90135-9"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1983.tb07823.x"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(84)80987-4"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)88957-8"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00426a018"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(88)90182-8"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(86)90231-9"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04622.x"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687397"}],"container-title":["FEBS Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793%2891%2980737-N","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2F0014-5793(91)80737-N","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/0014-5793%2891%2980737-N","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T16:28:59Z","timestamp":1694881739000},"score":1,"resource":{"primary":{"URL":"https:\/\/febs.onlinelibrary.wiley.com\/doi\/10.1016\/0014-5793%2891%2980737-N"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7,8]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,7,8]]}},"alternative-id":["10.1016\/0014-5793(91)80737-N"],"URL":"https:\/\/doi.org\/10.1016\/0014-5793(91)80737-n","archive":["Portico"],"relation":{},"ISSN":["0014-5793","1873-3468"],"issn-type":[{"value":"0014-5793","type":"print"},{"value":"1873-3468","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7,8]]}}}