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An alkalinizing pH; shift (exposure to 20 mM NH<jats:sub>4<\/jats:sub>C1) increased the burst active phase duration. Conversely, an acidifying shift (NH<jats:sub>4<\/jats:sub>Cl withdrawal) suppressed the electrical activity. This is the mirror image of the effects recorded in the absence of tolbutamide. Glibenclamide and quinine suppressed the alkalinization\u2010evoked hyperpolarization. This study emphasizes the differential sensitivity of different \u03b2\u2010cell ion channels to pH<jats:sub>i<\/jats:sub> and the prevalent role of K\u2010ATP channels as electrical transducers of cytoplasmic pH changes under regular physiological conditions.<\/jats:p>","DOI":"10.1016\/0014-5793(93)80471-6","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T07:41:36Z","timestamp":1027582896000},"page":"9-13","source":"Crossref","is-referenced-by-count":4,"title":["Differential modulation of pancreatic \u03b2\u2010cell bursting by intracellular pH in the presence and absence of a K\u2010ATP channel blocker"],"prefix":"10.1002","volume":"332","author":[{"given":"Rui M.","family":"Barbosa","sequence":"first","affiliation":[]},{"given":"Ant\u00f3nio P.","family":"Salgado","sequence":"additional","affiliation":[]},{"given":"Rosa M.","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds M.","family":"Ros\u00e1rio","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2001,10,29]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"49","volume-title":"Insulin Secretion","author":"Atwater I.","year":"1989"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00550880"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)81484-X"},{"key":"e_1_2_1_5_1","first-page":"203","volume-title":"Biophysics of the Pancreatic \u03b2-Cell","author":"Rosario L.M.","year":"1986"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0079-6107(89)90013-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(92)91278-X"},{"key":"e_1_2_1_8_1","author":"Rosario L.M.","year":"1993","journal-title":"Pflugers Arch. 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