{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:40:04Z","timestamp":1770813604895,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1990,9,1]],"date-time":"1990-09-01T00:00:00Z","timestamp":652147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1990,9,1]],"date-time":"1990-09-01T00:00:00Z","timestamp":652147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunological Methods"],"published-print":{"date-parts":[[1990,9]]},"DOI":"10.1016\/0022-1759(90)90034-s","type":"journal-article","created":{"date-parts":[[2002,12,28]],"date-time":"2002-12-28T08:37:37Z","timestamp":1041064657000},"page":"227-237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["A sandwich type enzyme-linked immunosorbent assay for proliferating cell nuclear antigen (PCNA)\/cyclin using monoclonal antibodies"],"prefix":"10.1016","volume":"132","author":[{"given":"Yoshinari","family":"Takasaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Ohgaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Kodama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ogata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikazu","family":"Shirai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Ichi","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0022-1759(90)90034-S_BIB1","first-page":"1575","article-title":"Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins","volume":"84","author":"Almendral","year":"1987"},{"key":"10.1016\/0022-1759(90)90034-S_BIB2","first-page":"97","article-title":"Separation of leukocytes from blood and bone mallow","volume":"21","author":"B\u00f6yum","year":"1968","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/0022-1759(90)90034-S_BIB3","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0014-5793(84)80315-4","article-title":"Coordinated synthesis of the nuclear protein cyclin and DNA in serum-stimulated quiescent 3T3 cells","volume":"169","author":"Bravo","year":"1984","journal-title":"FEBS Lett."},{"key":"10.1016\/0022-1759(90)90034-S_BIB4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1083\/jcb.84.3.795","article-title":"Search for differencial polypeptide synthesis throughout the cell cycle of HeLa cells","volume":"84","author":"Bravo","year":"1980","journal-title":"J. Cell Biol."},{"key":"10.1016\/0022-1759(90)90034-S_BIB5","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1002\/j.1460-2075.1984.tb02276.x","article-title":"Induction of the nuclear protein \u201ccyclin\u201d in quiescent mouse 3T3 cells stimulated by serum and growth factors. Correlation with DNA synthesis","volume":"3","author":"Bravo","year":"1984","journal-title":"EMBO J."},{"key":"10.1016\/0022-1759(90)90034-S_BIB6","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/326515a0","article-title":"Cyclin\/PCNA is the auxiliary protein of DNA polymerase-\u03b4","volume":"326","author":"Bravo","year":"1987","journal-title":"Nature"},{"key":"10.1016\/0022-1759(90)90034-S_BIB7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0145-2126(84)90135-8","article-title":"Cyclin: a nuclear protein whose level correlates directly with the proliferative stage of normal as well as transformed cells","volume":"8","author":"Celis","year":"1984","journal-title":"Leukemia Res."},{"key":"10.1016\/0022-1759(90)90034-S_BIB8","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1016\/S0021-9258(18)50805-X","article-title":"Isolation and Characterization of nuclear ribonucleoprotein complexes using human-nuclear ribonucleoprotein antibodies","volume":"254","author":"Douvas","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0022-1759(90)90034-S_BIB9","first-page":"733","article-title":"Analysis of proliferative grade using anti-PCNA\/cyclin monoclonal antibodies in fixed, embedded tissues","volume":"34","author":"Garcia","year":"1989","journal-title":"Am. J. Pathol."},{"key":"10.1016\/0022-1759(90)90034-S_BIB10","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/27.8.90074","article-title":"The use of avidin-biotin interaction in immunoenzymatic techniques","volume":"27","author":"Guesdon","year":"1979","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/0022-1759(90)90034-S_BIB11","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.4049\/jimmunol.123.4.1548","article-title":"A new mouse myeloma cell line which has lost immunoglobulin expression but permits the constraction of antibody in secreting hybrid cell lines","volume":"123","author":"Kearney","year":"1979","journal-title":"J. Immunol."},{"key":"10.1016\/0022-1759(90)90034-S_BIB12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0022-1759(88)90441-3","article-title":"Monoclonal antibodies to proliferating cell nuclear antigen (PCNA)\/cyclin as probes for proliferating cells by immunofluorescence microscopy and flow cytometry","volume":"109","author":"Kurki","year":"1988","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/0022-1759(90)90034-S_BIB13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0022-1759(90)90034-S_BIB14","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/309374a0","article-title":"Identity of proliferating cell nuclear antigen and cyclin","volume":"309","author":"Mathews","year":"1984","journal-title":"Nature"},{"key":"10.1016\/0022-1759(90)90034-S_BIB15","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/j.1460-2075.1987.tb04802.x","article-title":"Molecular cloning of cDNA coding for rat proliferating cell nuclear antigen (PCNA)\/cyclin","volume":"6","author":"Matsumoto","year":"1987","journal-title":"EMBO J."},{"key":"10.1016\/0022-1759(90)90034-S_BIB16","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.4049\/jimmunol.121.6.2228","article-title":"Autoantibody to a nuclear antigen in proliferating cells","volume":"121","author":"Miyachi","year":"1978","journal-title":"J. Immunol."},{"key":"10.1016\/0022-1759(90)90034-S_BIB17","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/1523-1747.ep12319857","article-title":"Expression of proliferating cell nuclear antigen\/cyclin in human keratinocytes","volume":"93","author":"Miyagawa","year":"1989","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/0022-1759(90)90034-S_BIB18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/BF00917495","article-title":"Activated peripheral blood mononuclear cells detected by murine monoclonal antibodies to proliferating cell nuclear antigen in active lupus patients","volume":"10","author":"Murashima","year":"1990","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/0022-1759(90)90034-S_BIB19","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.4049\/jimmunol.135.4.2623","article-title":"Purification and N-terminal amino acid sequence of proliferating cell nuclear antigen (PCNA)\/cyclin and development of ELISA for anti-PCNA antibodies","volume":"135","author":"Ogata","year":"1985","journal-title":"J. Immunol."},{"key":"10.1016\/0022-1759(90)90034-S_BIB20","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0014-4827(87)90020-6","article-title":"Monoclonal antibodies to a nuclear protein (PCNA\/cyclin) associated with DNA replication","volume":"168","author":"Ogata","year":"1987","journal-title":"Exp. Cell Res."},{"key":"10.1016\/0022-1759(90)90034-S_BIB21","series-title":"Selected methods in cellular immunology","first-page":"351","author":"Oi","year":"1980"},{"key":"10.1016\/0022-1759(90)90034-S_BIB22","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/326517a0","article-title":"Functional identity of proliferating cell nuclear antigen and a DNA polymerase-\u03b4 auxiliary protein","volume":"326","author":"Plerich","year":"1987","journal-title":"Nature"},{"key":"10.1016\/0022-1759(90)90034-S_BIB23","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0002-9343(72)90064-2","article-title":"Mixed connective tissue disease: an apparantly distinct rheumatic diseases syndrome associated with a specific antibody to extractable nuclear antigen (ENA)","volume":"52","author":"Sharp","year":"1972","journal-title":"Am. J. Med."},{"key":"10.1016\/0022-1759(90)90034-S_BIB24","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1084\/jem.154.6.1899","article-title":"A nuclear antigen associated with cell proliferation and blast transformation. Its distribution in synchronized cells","volume":"154","author":"Takasaki","year":"1981","journal-title":"J. Exp. Med."},{"key":"10.1016\/0022-1759(90)90034-S_BIB25","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1084\/jem.159.4.981","article-title":"Characterization of proliferating cell nuclear antigen recognized by autoantibodies in lupus sera","volume":"159","author":"Takasaki","year":"1984","journal-title":"J. Exp. Med."},{"key":"10.1016\/0022-1759(90)90034-S_BIB26","first-page":"655","article-title":"Proliferating cell nuclear antigen in blast crisis cells of patients with chronic myeroid leukemia","volume":"73","author":"Takasaki","year":"1984","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/0022-1759(90)90034-S_BIB27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00224731","article-title":"Proliferating cell nuclear antigen (PCNA\/Cyclin) immunocytochemistry as a labeling index in mouse lung tissue","volume":"256","author":"Thaete","year":"1989","journal-title":"Cell Tissue Res."}],"container-title":["Journal of Immunological Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:002217599090034S?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:002217599090034S?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:19:10Z","timestamp":1762067950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/002217599090034S"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,9]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,9]]}},"alternative-id":["002217599090034S"],"URL":"https:\/\/doi.org\/10.1016\/0022-1759(90)90034-s","relation":{},"ISSN":["0022-1759"],"issn-type":[{"value":"0022-1759","type":"print"}],"subject":[],"published":{"date-parts":[[1990,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A sandwich type enzyme-linked immunosorbent assay for proliferating cell nuclear antigen (PCNA)\/cyclin using monoclonal antibodies","name":"articletitle","label":"Article Title"},{"value":"Journal of Immunological Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/0022-1759(90)90034-S","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1990 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}