{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:34:00Z","timestamp":1774452840408,"version":"3.50.1"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1974,1,1]],"date-time":"1974-01-01T00:00:00Z","timestamp":126230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Molecular Biology"],"published-print":{"date-parts":[[1974,1]]},"DOI":"10.1016\/0022-2836(74)90599-3","type":"journal-article","created":{"date-parts":[[2005,3,11]],"date-time":"2005-03-11T16:46:31Z","timestamp":1110559591000},"page":"393-420","source":"Crossref","is-referenced-by-count":200,"title":["Energy refinement of hen egg-white lysozyme"],"prefix":"10.1016","volume":"82","author":[{"given":"Michael","family":"Levitt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0022-2836(74)90599-3_BIB1","first-page":"365","volume":"167","author":"Blake","year":"1967"},{"key":"10.1016\/0022-2836(74)90599-3_BIB2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1107\/S0365110X6600269X","volume":"21","author":"Diamond","year":"1966","journal-title":"Acta Crystallogr."},{"key":"10.1016\/0022-2836(74)90599-3_BIB3","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1107\/S0567739471000986","volume":"27","author":"Diamond","year":"1971","journal-title":"Acta Crystallogr. (Sect. A)"},{"key":"10.1016\/0022-2836(74)90599-3_BIB4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0022-2836(74)90598-1","volume":"82","author":"Diamond","year":"1974","journal-title":"J. Mol. Biol."},{"key":"10.1016\/0022-2836(74)90599-3_BIB5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/S0371-1951(59)80312-X","volume":"15","author":"Fukushima","year":"1959","journal-title":"Spectrochim Acta"},{"key":"10.1016\/0022-2836(74)90599-3_BIB6","first-page":"420","volume":"68","author":"Gibson","year":"1967"},{"key":"10.1016\/0022-2836(74)90599-3_BIB7","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.1021\/ja01483a011","volume":"83","author":"Hendrickson","year":"1961","journal-title":"J. Amer. Chem. Soc."},{"key":"10.1016\/0022-2836(74)90599-3_BIB8","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1021\/bi00820a001","volume":"9","author":"Kendrew","year":"1970","journal-title":"Biochemistry"},{"key":"10.1016\/0022-2836(74)90599-3_BIB9","author":"Levitt","year":"1972"},{"key":"10.1016\/0022-2836(74)90599-3_BIB10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0022-2836(69)90421-5","volume":"46","author":"Levitt","year":"1969","journal-title":"J. Mol. Biol."},{"key":"10.1016\/0022-2836(74)90599-3_BIB11","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1063\/1.1670007","volume":"49","author":"Lifson","year":"1968","journal-title":"J. Chem. Phys."},{"key":"10.1016\/0022-2836(74)90599-3_BIB12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0065-3233(08)60402-7","volume":"23","author":"Ramachandran","year":"1968","journal-title":"Advan. Protein Chem."},{"key":"10.1016\/0022-2836(74)90599-3_BIB13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1399-3011.1971.tb01714.x","volume":"3","author":"Ramakrishnan","year":"1971","journal-title":"Int. J. Protein Res."},{"key":"10.1016\/0022-2836(74)90599-3_BIB14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0022-2836(68)90085-5","volume":"37","author":"Richards","year":"1968","journal-title":"J. Mol. Biol."},{"key":"10.1016\/0022-2836(74)90599-3_BIB15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0371-1951(63)80096-X","volume":"19","author":"Schachtschneider","year":"1963","journal-title":"Spectrochim Acta"},{"key":"10.1016\/0022-2836(74)90599-3_BIB16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0065-3160(08)60255-5","volume":"6","author":"Scheraga","year":"1968","journal-title":"Advan. Phys. Org. Chem."},{"key":"10.1016\/0022-2836(74)90599-3_BIB17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1351\/pac196307010131","volume":"7","author":"Shimanouchi","year":"1963","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/0022-2836(74)90599-3_BIB18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0022-2852(64)90053-0","volume":"13","author":"Takahashi","year":"1964","journal-title":"J. Mol. Spectros."},{"key":"10.1016\/0022-2836(74)90599-3_BIB19","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1103\/PhysRev.38.1969","volume":"38","author":"Urey","year":"1931","journal-title":"Phys. Rev."},{"key":"10.1016\/0022-2836(74)90599-3_BIB20","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1063\/1.1674031","volume":"53","author":"Warshel","year":"1970","journal-title":"J. Chem. Phys."},{"key":"10.1016\/0022-2836(74)90599-3_BIB21","series-title":"Steric Effects in Organic Chemistry","first-page":"523","author":"Westheimer","year":"1956"}],"container-title":["Journal of Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0022283674905993?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0022283674905993?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T05:20:38Z","timestamp":1548652838000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0022283674905993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,1]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1974,1]]}},"alternative-id":["0022283674905993"],"URL":"https:\/\/doi.org\/10.1016\/0022-2836(74)90599-3","relation":{},"ISSN":["0022-2836"],"issn-type":[{"value":"0022-2836","type":"print"}],"subject":[],"published":{"date-parts":[[1974,1]]}}}