{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T17:02:59Z","timestamp":1758906179737,"version":"3.44.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1-6","license":[{"start":{"date-parts":[[1988,1,1]],"date-time":"1988-01-01T00:00:00Z","timestamp":567993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1988,1,1]],"date-time":"1988-01-01T00:00:00Z","timestamp":567993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Steroid Biochemistry"],"published-print":{"date-parts":[[1988]]},"DOI":"10.1016\/0022-4731(88)90073-8","type":"journal-article","created":{"date-parts":[[2003,2,12]],"date-time":"2003-02-12T00:53:41Z","timestamp":1045011221000},"page":"33-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["1\u03b1,25 (OH)2 vitamin D3: A steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms"],"prefix":"10.1016","volume":"30","author":[{"given":"Leonor","family":"Cancela","sequence":"first","affiliation":[]},{"given":"Ilka","family":"Nemere","sequence":"additional","affiliation":[]},{"given":"Anthony W.","family":"Norman","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/0022-4731(88)90073-8_BIB1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev.nu.04.070184.002425","article-title":"Vitamin D: metabolism and biological actions","volume":"4","author":"Henry","year":"1984","journal-title":"A. Rev. Nutr."},{"key":"10.1016\/0022-4731(88)90073-8_BIB2","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1210\/endo-110-4-1347","article-title":"Demonstration and organ distribution of the 1,25-dihydroxyvitamin D3-binding protein in fish (A. anguilla)","volume":"110","author":"Marcocci","year":"1982","journal-title":"Endocrinology"},{"key":"10.1016\/0022-4731(88)90073-8_BIB3","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1749-6632.1981.tb15501.x","article-title":"Molecular actions of 1,25-dihydroxy-vitamin D3: new cultured cell models","volume":"372","author":"Haussler","year":"1981","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/0022-4731(88)90073-8_BIB4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1146\/annurev.nu.06.070186.002523","article-title":"VitaminD receptors: nature and function","volume":"6","author":"Haussler","year":"1986","journal-title":"A. Rev. Nutr."},{"key":"10.1016\/0022-4731(88)90073-8_BIB5","doi-asserted-by":"crossref","first-page":"10,931","DOI":"10.1016\/S0021-9258(18)60906-8","article-title":"Synthesis in virto of 1,25-dihydroxyvitamin D3 and 24, 25-dihy-droxyvitamin D3 by interferon-\u03b3 stimulated normal human bone marrow and alveolar macrophages","volume":"262","author":"Reichel","year":"1987","journal-title":"J. biol. Chem."},{"key":"10.1016\/0022-4731(88)90073-8_BIB6","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1126\/science.451538","article-title":"Evidence for extrarenal la-hydroxylation of 25-dihydroxyvitamin D3 in pregnancy","volume":"204","author":"Gray","year":"1979","journal-title":"Science"},{"key":"10.1016\/0022-4731(88)90073-8_BIB7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/281317a0","article-title":"1\u03b1-25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3in virto synthesis by human decidua and placenta","volume":"281","author":"Weisman","year":"1979","journal-title":"Nature"},{"key":"10.1016\/0022-4731(88)90073-8_BIB8","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1210\/jcem-60-5-880","article-title":"In Vitro metabolism of 25-hydroxycholecalciferol by isolated cells from human decidua","volume":"60","author":"Delvin","year":"1985","journal-title":"J. clin. Endocr. Metab."},{"key":"10.1016\/0022-4731(88)90073-8_BIB9","first-page":"201","article-title":"1\u03b1,25-dihydroxyvitamin D3 and 1\u03b1-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells","volume":"80","author":"Honma","year":"1983"},{"key":"10.1016\/0022-4731(88)90073-8_BIB10","first-page":"21","article-title":"Suppression of in vivo growth of human cancer solid tumor xenographs by 1,25 (OH)2D3","volume":"47","author":"Eisman","year":"1987","journal-title":"Cancer Res."},{"key":"10.1016\/0022-4731(88)90073-8_BIB11","first-page":"4990","article-title":"Differentiation of mouse myeloid leukemia cells induced by 1,25-dihydroxyvitamin D3","volume":"78","author":"Abe","year":"1981"},{"key":"10.1016\/0022-4731(88)90073-8_BIB12","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/BF02556718","article-title":"Bone vitamin D-dependent calcium binding protein is localized in chondrocytes of growth-plate cartilage","volume":"38","author":"Zhou","year":"1986","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/0022-4731(88)90073-8_BIB13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF00499828","article-title":"Vitamin D-dependent calcium-binding protein (CaBP-9K) in rat growth cartilage","volume":"84","author":"Balmain","year":"1986","journal-title":"Histochemistry"},{"issue":"Suppl. 1","key":"10.1016\/0022-4731(88)90073-8_BIB14","article-title":"Demonstration of a high affinity receptor for 1,25 (OH)2D3 in rat pancreas","volume":"2","author":"Ishida","year":"1987","journal-title":"J. Bone Mineral Res."},{"key":"10.1016\/0022-4731(88)90073-8_BIB15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1210\/endo-112-1-290","article-title":"Vitamin D-dependent calcium-binding protein in the rat brain: biochemical and immunocytochemical characterization","volume":"112","author":"Feldman","year":"1983","journal-title":"Endocrinology"},{"key":"10.1016\/0022-4731(88)90073-8_BIB16","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/0006-8993(81)91054-4","article-title":"Specific neurons in the chick central nervous system strain with an antibody against chicken intestinal vitamin D-dependent calcium-binding protein","volume":"222","author":"Roth","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/0022-4731(88)90073-8_BIB17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0006-291X(84)90719-8","article-title":"1,25-Dihydroxyvitamin D3 receptors in a subset of mitotically active lymphocytes from rat thymus","volume":"121","author":"Provvedini","year":"1984","journal-title":"Biochem. biophys. Res. Commun."},{"key":"10.1016\/0022-4731(88)90073-8_BIB18","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1210\/endo-114-6-2167","article-title":"1\u201325-Dihydroxyvitamin D3 receptors in the semniferous tubules of the rat testis increase at puberty","volume":"114","author":"Walters","year":"1984","journal-title":"Endocrinology"},{"key":"10.1016\/0022-4731(88)90073-8_BIB19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0022-2828(86)80983-X","article-title":"1,25-Dihydroxyvitamin D3 receptors identified in the rat heart","volume":"18","author":"Walters","year":"1986","journal-title":"J. molec. Cell. Cardiol."},{"key":"10.1016\/0022-4731(88)90073-8_BIB20","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1016\/S0021-9258(18)93278-3","article-title":"The association of a metabolite of vitamin D3 with intestinal mucosa chromatin in vivo","volume":"243","author":"Haussler","year":"1968","journal-title":"J. biol. Chem."},{"key":"10.1016\/0022-4731(88)90073-8_BIB21","first-page":"155","article-title":"Chromosomal receptor for a vitamin D metabolite","volume":"62","author":"Haussler","year":"1969"},{"key":"10.1016\/0022-4731(88)90073-8_BIB22","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1093\/ajcn\/24.11.1346","article-title":"Evidence for a new kidney-produced hormone, 1,25-dihydroxycholecalciferol, the proposed biologically active form of vitamin D","volume":"24","author":"Norman","year":"1971","journal-title":"Am. J. clin. Nutr."},{"key":"10.1016\/0022-4731(88)90073-8_BIB23","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/0024-3205(73)90120-3","article-title":"1\u03b1,25-Dihy-droxyvitamin D3 receptor: competitive binding of vitamin D analogs","volume":"13","author":"Brumbaugh","year":"1973","journal-title":"Life Sci."},{"key":"10.1016\/0022-4731(88)90073-8_BIB24","doi-asserted-by":"crossref","first-page":"8382","DOI":"10.1016\/S0021-9258(19)40769-2","article-title":"Structural requirements for the interaction of 1\u03b1,25 (OH)2 vitamin D3 with its chick intestinal receptor system","volume":"250","author":"Procsal","year":"1975","journal-title":"J. biol. Chem."},{"key":"10.1016\/0022-4731(88)90073-8_BIB25","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/0003-9861(77)90134-5","article-title":"The chick intestinal cytosol binding protein for 1,25-dihydroxyvitamin D3: a study of analog binding","volume":"179","author":"Kream","year":"1979","journal-title":"Archs Biochem. Biophys."},{"key":"10.1016\/0022-4731(88)90073-8_BIB26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1210\/edrv-3-4-331","article-title":"The vitamin D endocrine system: steroid metabolism, hormone receptors and biological response","volume":"3","author":"Norman","year":"1982","journal-title":"Endocr. Rev."},{"key":"10.1016\/0022-4731(88)90073-8_BIB27","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1126\/science.3029866","article-title":"Molecular cloning of complementary DNA encoding the avian receptor for vitamin D","volume":"235","author":"McDonnell","year":"1987","journal-title":"Science"},{"key":"10.1016\/0022-4731(88)90073-8_BIB28","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1210\/endo-120-3-1173","article-title":"Measurement of 1,25 (OH)2D3 receptor turnover by dense amino acid labelling: changes during receptor upregulation by vitamin D metabolites","volume":"120","author":"Costa","year":"1987","journal-title":"Endocrinology"},{"key":"10.1016\/0022-4731(88)90073-8_BIB29","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/j.1460-2075.1986.tb04300.x","article-title":"The chicken oestrogen receptor sequence: homology with v-erb-A and the human oestrogen and glucocorticoid receptors","volume":"5","author":"Krust","year":"1986","journal-title":"EMBO J."},{"key":"10.1016\/0022-4731(88)90073-8_BIB30","doi-asserted-by":"crossref","first-page":"10,087","DOI":"10.1016\/S0021-9258(17)39216-5","article-title":"Biochemical characterization of positive cooperativity in the binding of 1\u03b1,25-dihydroxyvitamin D3 to its chick intestinal chromatin receptor","volume":"260","author":"Wilhelm","year":"1985","journal-title":"J. biol. Chem."},{"key":"10.1016\/0022-4731(88)90073-8_BIB31","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0003-9861(68)90491-8","article-title":"Actinomycin D inhibition of vitamin D3 induced calcium-binding protein (CaBP) formation in chick duodenal mucosa","volume":"126","author":"Corradino","year":"1968","journal-title":"Archs Biochem. Biophys"},{"key":"10.1016\/0022-4731(88)90073-8_BIB32","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/0006-291X(73)91468-X","article-title":"Studies on the mode of action of calciferol. VI. Effect of 1,25-dihydroxyvitamin D3 on RNA synthesis in the intestinal mucosa","volume":"54","author":"Tsai","year":"1973","journal-title":"Biochem. biophys. Res. Commun."},{"key":"10.1016\/0022-4731(88)90073-8_BIB33","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/246100a0","article-title":"Vitamin D-induced synthesis of mRNA for calcium-binding protein","volume":"246","author":"Emtage","year":"1973","journal-title":"Nature"},{"key":"10.1016\/0022-4731(88)90073-8_BIB34","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/0022-4731(83)90373-4","article-title":"Rat duodenal calcium binding protein mRNA: induction by l,25 (OH)2D3","volume":"19","author":"Desplan","year":"1983","journal-title":"J. steroid Biochem."},{"key":"10.1016\/0022-4731(88)90073-8_BIB35","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/0003-9861(86)90515-1","article-title":"Analysis of the mRNA coding for the chick vitamin D-induced calbindin and its regulation by 1,25-dihydroxyvitamin D3","volume":"248","author":"King","year":"1986","journal-title":"Archs Biochem. Biophys."},{"key":"10.1016\/0022-4731(88)90073-8_BIB36","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1042\/bj2350585","article-title":"The purification and complete amino acid sequence of the 9000 Mr Ca2+ binding protein from rat placenta","volume":"235","author":"MacManus","year":"1986","journal-title":"Biochem. J."},{"key":"10.1016\/0022-4731(88)90073-8_BIB37","first-page":"E483","article-title":"Rat calcium binding proteins: distribution, development and vitamin D dependence","volume":"243","author":"Thomasset","year":"1982","journal-title":"Am. J. Physiol."},{"key":"10.1016\/0022-4731(88)90073-8_BIB38","doi-asserted-by":"crossref","first-page":"16,943","DOI":"10.1016\/S0021-9258(19)75981-X","article-title":"Regulation of calbindin-D28kDa gene expression by 1,25-dihydroxyvitamin D3 is correlated to receptor occupancy","volume":"261","author":"Theofan","year":"1986","journal-title":"J. biol. Chem."},{"key":"10.1016\/0022-4731(88)90073-8_BIB39","doi-asserted-by":"crossref","first-page":"7311","DOI":"10.1016\/S0021-9258(17)38392-8","article-title":"Effects of \u03b1-amanitin and cycloheximide on 1,25-dihydroxyvitamin D3-dependent calbindin-D28K and its mRNA in vitamin D3-replete chick intestine","volume":"261","author":"Theofan","year":"1986","journal-title":"J. biol. Chem."},{"key":"10.1016\/0022-4731(88)90073-8_BIB40","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1210\/endo-115-4-1476","article-title":"Calcium transport in perfused duodena from normal chicks: enhancement within fourteen minutes of exposure to 1,25-dihydroxyvitamin D3","volume":"115","author":"Nemere","year":"1984","journal-title":"Endocrinology"},{"key":"10.1016\/0022-4731(88)90073-8_BIB41","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1210\/endo-119-3-1406","article-title":"Parathyroid hormone stimulates calcium transport in perfused duodena from normal chicks: comparison with the rapid (transcaltachic) effect of 1,25-dihydroxyvitamin D3","volume":"119","author":"Nemere","year":"1986","journal-title":"Endocrinology"},{"key":"10.1016\/0022-4731(88)90073-8_BIB42","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0022-4731(86)90322-5","article-title":"Biological activity of the vitamin D metabolites and analogs: dose-response study of 45Ca transport in an isolated chick duodenum perfusion system","volume":"25","author":"Yoshimoto","year":"1986","journal-title":"J. steroid Biochem."},{"key":"10.1016\/0022-4731(88)90073-8_BIB43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jbmr.5650020204","article-title":"Rapid action of 1,25-dihydroxyvitamin D3 on calcium transport in perfused chick duodenum: effect of inhibitors","volume":"2","author":"Nemere","year":"1987","journal-title":"J. Bone Mineral Res."},{"key":"10.1016\/0022-4731(88)90073-8_BIB44","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jbmr.5650020302","article-title":"The rapid, hormonally stimulated transport of calcium (transcaltachia)","volume":"2","author":"Nemere","year":"1987","journal-title":"J. Bone Mineral Res."},{"key":"10.1016\/0022-4731(88)90073-8_BIB45","doi-asserted-by":"crossref","first-page":"16,106","DOI":"10.1016\/S0021-9258(18)66684-0","article-title":"1,25-Dihydroxyvitamin D3-mediated intestinal calcium transport: biochemical identification of lysosomes containing calcium and calcium-binding protein (calbindin-D28k)","volume":"261","author":"Nemere","year":"1986","journal-title":"J. biol. Chem."}],"container-title":["Journal of Steroid Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0022473188900738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0022473188900738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T10:22:10Z","timestamp":1757326930000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0022473188900738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988]]},"references-count":45,"journal-issue":{"issue":"1-6","published-print":{"date-parts":[[1988]]}},"alternative-id":["0022473188900738"],"URL":"https:\/\/doi.org\/10.1016\/0022-4731(88)90073-8","relation":{},"ISSN":["0022-4731"],"issn-type":[{"type":"print","value":"0022-4731"}],"subject":[],"published":{"date-parts":[[1988]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"1\u03b1,25 (OH)2 vitamin D3: A steroid hormone capable of producing pleiotropic receptor-mediated biological responses by both genomic and nongenomic mechanisms","name":"articletitle","label":"Article Title"},{"value":"Journal of Steroid Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/0022-4731(88)90073-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1988 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}