{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:57:32Z","timestamp":1762160252002},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1981,9,1]],"date-time":"1981-09-01T00:00:00Z","timestamp":368150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[1981,9]]},"DOI":"10.1016\/0041-008x(91)90236-8","type":"journal-article","created":{"date-parts":[[2004,9,28]],"date-time":"2004-09-28T12:16:40Z","timestamp":1096373800000},"page":"334-345","source":"Crossref","is-referenced-by-count":42,"title":["Aberrant methylation of liver DNA in rats during hepatotoxicity"],"prefix":"10.1016","volume":"60","author":[{"given":"Louis R.","family":"Barrows","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald C.","family":"Shank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0041-008X(91)90236-8_BIB1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1021\/jo01079a026","article-title":"Synthesis of potential anticancer agents. XXV. Preparation of 6-alkoxy-2-aminopurines","volume":"25","author":"Balsiger","year":"1960","journal-title":"J. Org. Chem."},{"article-title":"Methylation of DNA in hydrazine-treated rats and mice","year":"1980","author":"Barrows","key":"10.1016\/0041-008X(91)90236-8_BIB2"},{"key":"10.1016\/0041-008X(91)90236-8_BIB3","first-page":"324","article-title":"Chemical modification of DNA in rats treated with hydrazine","volume":"45","author":"Barrows","year":"1978","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/0041-008X(91)90236-8_BIB4","first-page":"110","article-title":"DNA methylation in hydrazine-treated animals","volume":"21","author":"Barrows","year":"1980"},{"key":"10.1016\/0041-008X(91)90236-8_BIB5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/carcin\/1.7.595","article-title":"A comprehensive quantitative analysis of methylated and ethylated DNA using high pressure liquid chromatography","volume":"1","author":"Beranek","year":"1980","journal-title":"Carcinogenesis"},{"key":"10.1016\/0041-008X(91)90236-8_BIB6","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/194488a0","article-title":"Pulmonary tumours in mice induced by oral isoniazid and its metabolites","volume":"194","author":"Biancifiori","year":"1962","journal-title":"Nature (London)"},{"key":"10.1016\/0041-008X(91)90236-8_BIB7","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0005-2787(71)90531-4","article-title":"Methylation of DNA in the intact animal and the effect of the carcinogens dimethylnitrosamine and ethionine","volume":"240","author":"Craddock","year":"1971","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/0041-008X(91)90236-8_BIB8","first-page":"14","article-title":"The isolation of 1-methyladenylic acid and 7-methylguanylic acid from ribonucleic acid","volume":"86","author":"Dunn","year":"1963","journal-title":"Biochem. J."},{"key":"10.1016\/0041-008X(91)90236-8_BIB9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0006-291X(63)90075-5","article-title":"The enzymatic methylation of RNA and DNA","volume":"11","author":"Gold","year":"1963","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/0041-008X(91)90236-8_BIB10","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/bjc.1974.218","article-title":"The alkylation of nucleic acids of rat and mouse in vivo by the carcinogen 1,2-dimethylhydrazine","volume":"30","author":"Hawks","year":"1974","journal-title":"Brit. J. Cancer"},{"key":"10.1016\/0041-008X(91)90236-8_BIB11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0003-2697(79)90109-X","article-title":"Quantitative high-pressure liquid chromatographic analysis of methylated purines in DNA of rats treated with chemical carcinogens","volume":"100","author":"Herron","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/0041-008X(91)90236-8_BIB12","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0006-3002(62)90988-5","article-title":"Ribonucleic acids. II. Improved preparation of rat-liver ribonucleic acid (RNA)","volume":"55","author":"Kirby","year":"1962","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/0041-008X(91)90236-8_BIB13","series-title":"The Liver: Normal and Abnormal Functions","first-page":"647","article-title":"Alcohol-induced liver injury: Pathogenetic considerations","author":"Middleton","year":"1975"},{"key":"10.1016\/0041-008X(91)90236-8_BIB14","first-page":"145","article-title":"Carbon tetrachloride hepatotoxicity","volume":"19","author":"Recknagel","year":"1967","journal-title":"Pharmacol. Rev."},{"article-title":"Relationship between metabolism and toxicity of dimethylnitrosamine in the rat","year":"1974","author":"Ruchirawat","key":"10.1016\/0041-008X(91)90236-8_BIB15"},{"key":"10.1016\/0041-008X(91)90236-8_BIB16","first-page":"331","article-title":"Hepatic carcinogenesis in CBA\/Cb\/Se mice and Cb\/Se rats by isonicotinic acid hydrazine and hydrazine sulfate","volume":"41","author":"Severi","year":"1968","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/0041-008X(91)90236-8_BIB17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1042\/bj1050521","article-title":"Similarities between the biochemical actions of cycasin and dimethylnitrosamine","volume":"105","author":"Shank","year":"1967","journal-title":"Biochem. J."},{"key":"10.1016\/0041-008X(91)90236-8_BIB18","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1021\/bi00836a019","article-title":"Chemical modification of viral ribonucleic acid. VIII. The action of methylating agents and nitrosoguanidine on polynucleotides including tobacco mosaic virus ribonucleic acid","volume":"8","author":"Singer","year":"1969","journal-title":"Biochemistry"},{"key":"10.1016\/0041-008X(91)90236-8_BIB19","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1042\/bj1100039","article-title":"Nitrosamine-induced carcinogenesis. The alkylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methane sulphonate","volume":"110","author":"Swann","year":"1968","journal-title":"Biochem. J."},{"key":"10.1016\/0041-008X(91)90236-8_BIB20","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1042\/bj1230175","article-title":"Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine","volume":"123","author":"Swann","year":"1971","journal-title":"Biochem. J."},{"key":"10.1016\/0041-008X(91)90236-8_BIB21","first-page":"36","article-title":"Presence of 7-methylguanine in microsomal and soluble rat-liver ribonucleic acid","volume":"100","author":"Villa-Trevino","year":"1966","journal-title":"Biochem. J."},{"article-title":"A study of the mechanism of acute toxic effects of hydrazine, UDMH, MMH, and SDMH","year":"1964","author":"Weir","key":"10.1016\/0041-008X(91)90236-8_BIB22"},{"key":"10.1016\/0041-008X(91)90236-8_BIB23","first-page":"34","article-title":"Acute toxicity of hydrazine and some of its methylated derivatives","volume":"13","author":"Witkin","year":"1956","journal-title":"AMA Arch. Ind. Health"},{"key":"10.1016\/0041-008X(91)90236-8_BIB24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0024-3205(70)90317-6","article-title":"Failure of arginine glutamate to inhibit lung tumor formation by isoniazid and hydrazine in mice","volume":"9","author":"Yamamoto","year":"1970","journal-title":"Life Sci."},{"key":"10.1016\/0041-008X(91)90236-8_BIB25","first-page":"391","article-title":"Effects of structure on the ability of hydrazino compounds to produce fatty livers","volume":"114","author":"Yard","year":"1955","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0041008X91902368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0041008X91902368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T09:23:09Z","timestamp":1549185789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0041008X91902368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1981,9]]}},"alternative-id":["0041008X91902368"],"URL":"https:\/\/doi.org\/10.1016\/0041-008x(91)90236-8","relation":{},"ISSN":["0041-008X"],"issn-type":[{"type":"print","value":"0041-008X"}],"subject":[],"published":{"date-parts":[[1981,9]]}}}