{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:07:39Z","timestamp":1771564059612,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1977,1,1]],"date-time":"1977-01-01T00:00:00Z","timestamp":220924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1977,1,1]],"date-time":"1977-01-01T00:00:00Z","timestamp":220924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[1977,1]]},"DOI":"10.1016\/0042-6822(77)90292-6","type":"journal-article","created":{"date-parts":[[2004,4,20]],"date-time":"2004-04-20T23:44:32Z","timestamp":1082504672000},"page":"152-163","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":158,"title":["Efficiency of transformation of lymphocytes by Epstein-Barr virus"],"prefix":"10.1016","volume":"76","author":[{"given":"Earl","family":"Henderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Heston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0042-6822(77)90292-6_BIB1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0008-8749(72)90040-8","article-title":"Selective induction of DNA synthesis in T and B lymphocytes","volume":"4","author":"Anderson","year":"1972","journal-title":"Cell Immunol."},{"key":"10.1016\/0042-6822(77)90292-6_BIB2","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1084\/jem.132.4.702","article-title":"A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization","volume":"132","author":"Bianco","year":"1970","journal-title":"J. Exp. Med."},{"issue":"suppl 97","key":"10.1016\/0042-6822(77)90292-6_BIB3","first-page":"77","article-title":"Isolation of mononuclear cells and granulocytes from human blood","volume":"21","author":"B\u00f6yum","year":"1968","journal-title":"Scand. J. Clin. Invest."},{"key":"10.1016\/0042-6822(77)90292-6_BIB4","first-page":"740","article-title":"Transformation and chromosome changes induced by Epstein-Barr virus in normal human leukocyte cultures","volume":"63","author":"Gerber","year":"1969"},{"key":"10.1016\/0042-6822(77)90292-6_BIB5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/0090-1229(75)90076-8","article-title":"Epstein-Barr virus binding sites on lymphocyte subpopulations and the origin of lymphoblasts in cultured lymphoid cells and in the blood of patients with infectious mononucleosis","volume":"3","author":"Greaves","year":"1975","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/0042-6822(77)90292-6_BIB6","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1128\/jvi.5.3.406-409.1970","article-title":"Trypsinized placental cell cultures for the propagation of viruses and as \u201cFeeder Layers\u201d","volume":"5","author":"Grogan","year":"1970","journal-title":"J. Virol."},{"key":"10.1016\/0042-6822(77)90292-6_BIB7","first-page":"358","article-title":"Induction of permanently proliferating human lymphoblastoid lines by N-methyl-N\u2032-nitro-N-nitrosoguanidine","volume":"35","author":"Henderson","year":"1975","journal-title":"Cancer Res."},{"key":"10.1016\/0042-6822(77)90292-6_BIB8","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.157.3792.1064","article-title":"Herpes-type virus and chromosome marker in normal leukocytes after growth with irradiated Burkitt cells","volume":"157","author":"Henle","year":"1967","journal-title":"Science"},{"key":"10.1016\/0042-6822(77)90292-6_BIB9","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1084\/jem.138.6.1365","article-title":"Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors on B lymphocytes","volume":"138","author":"Jondal","year":"1973","journal-title":"J. Exp. Med."},{"key":"10.1016\/0042-6822(77)90292-6_BIB10","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1084\/jem.138.6.1398","article-title":"Comparison of the yield of infectious virus from clones of human and Simian lymphoblastoid lines transformed by Epstein-Barr virus","volume":"138","author":"Miller","year":"1973","journal-title":"J. Exp. Med."},{"key":"10.1016\/0042-6822(77)90292-6_BIB11","first-page":"1459","article-title":"Establishment of cell lines from normal adult human blood leukocytes by exposure to Epstein-Barr virus and neutralization by human sera with Epstein-Barr virus antibody","volume":"137","author":"Miller","year":"1971"},{"key":"10.1016\/0042-6822(77)90292-6_BIB12","first-page":"383","article-title":"Epstein-Barr virus: Transformation, cytopathic changes, and viral antigens in squirrel monkey and marmoset leukocytes","volume":"69","author":"Miller","year":"1972"},{"key":"10.1016\/0042-6822(77)90292-6_BIB13","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1128\/jvi.6.5.699-701.1970","article-title":"Epstein-Barr viral antigen in single cell clones of two human leukocytic lines","volume":"6","author":"Miller","year":"1970","journal-title":"J. Virol."},{"key":"10.1016\/0042-6822(77)90292-6_BIB14","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1128\/am.20.2.259-262.1970","article-title":"Rapid semiquantitative method for screening large numbers of virus samples by negative staining electron microscopy","volume":"20","author":"Monroe","year":"1970","journal-title":"Appl. Microbial."},{"key":"10.1016\/0042-6822(77)90292-6_BIB15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1099\/0022-1317-17-2-233","article-title":"Assay of the infectivity of Epstein-Barr virus by transformation of human leucocytes in vitro","volume":"17","author":"Moss","year":"1972","journal-title":"J. Gen. Viral."},{"key":"10.1016\/0042-6822(77)90292-6_BIB16","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/jnci\/52.4.1081","article-title":"B-Cell characteristics of human peripheral and cord blood lymphocytes transformed by Epstein-Barr virus","volume":"52","author":"Pattengale","year":"1974","journal-title":"J. Nat. Cancer Inst."},{"key":"10.1016\/0042-6822(77)90292-6_BIB17","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/ijc.2910030619","article-title":"Transformation of foetal human leukocytes in vitro by filtrates of a human leukaemic cell line containing herpes-like virus","volume":"3","author":"Pope","year":"1968","journal-title":"Int. J. Cancer"},{"key":"10.1016\/0042-6822(77)90292-6_BIB18","first-page":"493","article-title":"A simple method of estimating fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Amer. J. Hyg."},{"key":"10.1016\/0042-6822(77)90292-6_BIB19","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/ijc.2910140603","article-title":"Observations on the type of infection by Epstein-Barr virus in peripheral lymphoid cells of patients with infectious mononucleosis","volume":"14","author":"Rickinson","year":"1974","journal-title":"Int. J. Cancer"},{"key":"10.1016\/0042-6822(77)90292-6_BIB20","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1128\/jvi.15.5.1065-1072.1975","article-title":"Assay for Epstein-Barr virus based on stimulation of DNA synthesis in mixed leukocytes from human umbilical cord blood","volume":"15","author":"Robinson","year":"1975","journal-title":"J. Virol."},{"key":"10.1016\/0042-6822(77)90292-6_BIB21","doi-asserted-by":"crossref","first-page":"742","DOI":"10.4049\/jimmunol.114.2_Part_2.742","article-title":"Synergistic effects on DNA synthesis of phytohemagglutinin in human peripheral blood lymphocytes","volume":"114","author":"Schmidtke","year":"1975","journal-title":"J. Immanol."},{"key":"10.1016\/0042-6822(77)90292-6_BIB22","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1182\/blood.V42.6.939.939","article-title":"Enhanced binding of neuraminidasetreated sheep erythrocytes to human T lymphocytes","volume":"42","author":"Weiner","year":"1973","journal-title":"Blood"},{"key":"10.1016\/0042-6822(77)90292-6_BIB23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0140-6736(73)90196-7","article-title":"Isolation of normal T cells in chronic lymphatic leukaemia","volume":"20","author":"Wybran","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/0042-6822(77)90292-6_BIB24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/ijc.2910170207","article-title":"Clonal transformation of human leukocytes by Epstein-Barr virus in soft agar","volume":"17","author":"Yamamoto","year":"1976","journal-title":"Int. J. Cancer"},{"key":"10.1016\/0042-6822(77)90292-6_BIB25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/ijc.2910150303","article-title":"Lymphoblastoid transformation and kinetics of appearance of viral nuclear antigen (EBNA) in cord blood lymphocytes infected by Epstein-Barr virus","volume":"15","author":"Yata","year":"1975","journal-title":"Int. J. Cancer"}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0042682277902926?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0042682277902926?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T15:57:34Z","timestamp":1757347054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0042682277902926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1977,1]]}},"alternative-id":["0042682277902926"],"URL":"https:\/\/doi.org\/10.1016\/0042-6822(77)90292-6","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[1977,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficiency of transformation of lymphocytes by Epstein-Barr virus","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/0042-6822(77)90292-6","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1977 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}