{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T01:42:45Z","timestamp":1772761365526,"version":"3.50.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1981,1,1]],"date-time":"1981-01-01T00:00:00Z","timestamp":347155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1981,1,1]],"date-time":"1981-01-01T00:00:00Z","timestamp":347155200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[1981,1]]},"DOI":"10.1016\/0042-6822(81)90525-0","type":"journal-article","created":{"date-parts":[[2006,6,29]],"date-time":"2006-06-29T13:50:10Z","timestamp":1151589010000},"page":"28-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Revertants of an ASV-transformed rat cell line have lost the complete provirus or sustained mutations insrc"],"prefix":"10.1016","volume":"108","author":[{"given":"Harold E.","family":"Varmus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Quintrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Wyke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0042-6822(81)90525-0_bib1","first-page":"5350","article-title":"Method of detection of specific RNA's in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes","volume":"74","author":"Alwine","year":"1977"},{"key":"10.1016\/0042-6822(81)90525-0_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0003-2697(76)80049-8","article-title":"Methyl-mercury as a reversible denaturing agent for agarose gel electrophoresis","volume":"70","author":"Bailey","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/0042-6822(81)90525-0_bib3","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0092-8674(79)90272-1","article-title":"Loss of integrated viral DNA sequences in polyoma-transformed cells in associated with an active viral A gene function","volume":"17","author":"Basilico","year":"1979","journal-title":"Cell"},{"key":"10.1016\/0042-6822(81)90525-0_bib4","first-page":"394","article-title":"Host range mutants of polyoma virus","volume":"67","author":"Benjamin","year":"1970"},{"key":"10.1016\/0042-6822(81)90525-0_bib5","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/0042-6822(77)90496-2","article-title":"Different mechanisms for morphologic reversion of a clonal population of murine sarcoma virus-transformed nonproducer cells","volume":"77","author":"Bensinger","year":"1977","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.bi.47.070178.000343","article-title":"Retroviruses","volume":"47","author":"Bishop","year":"1978","journal-title":"Annu Rev. Biochem."},{"key":"10.1016\/0042-6822(81)90525-0_bib7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0092-8674(74)90042-7","article-title":"Virogenic nontransformed cells isolated following infection of normal rat kidney cells with B77 strain of Rous sarcoma virus","volume":"3","author":"Boettiger","year":"1974","journal-title":"Cell"},{"key":"10.1016\/0042-6822(81)90525-0_bib8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/0042-6822(74)90412-7","article-title":"Reversion and induction of Rous sarcoma virus expression in virus-transformed baby hamster kidney cells","volume":"62","author":"Boettiger","year":"1974","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib9","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/269346a0","article-title":"Identification of a transformation-specific antigen induced by an avian sarcoma virus","volume":"269","author":"Brugge","year":"1977","journal-title":"Nature (London)"},{"key":"10.1016\/0042-6822(81)90525-0_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0042-6822(77)90208-2","article-title":"The distribution of virus-specific RNA in Rous sarcoma virus-induced hamster tumor cells","volume":"83","author":"Brugge","year":"1977","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib11","first-page":"2021","article-title":"Protein kinase activity associated with avian sarcoma virussrc gene product","volume":"75","author":"Collett","year":"1978"},{"key":"10.1016\/0042-6822(81)90525-0_bib12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/281195a0","article-title":"Thesrc gene product of transformed and morphologically reverted ASV-infected mammalian cells","volume":"281","author":"Collett","year":"1979","journal-title":"Nature (London)"},{"key":"10.1016\/0042-6822(81)90525-0_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0092-8674(78)90084-3","article-title":"A sequence of at least 104 nucleotides is transposed from the 5\u2032 terminus of the avian sarcoma virus genome to the 5\u2032 termini of smaller viral mRNA's","volume":"15","author":"Cordell","year":"1978","journal-title":"Cell"},{"key":"10.1016\/0042-6822(81)90525-0_bib14","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0042-6822(74)90411-5","article-title":"The persistence of expression of virus-specific DNA in revertants of Rous sarcoma virus-transformed BHK-21 cells","volume":"62","author":"Deng","year":"1974","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib15","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0042-6822(77)90305-1","article-title":"Characteristics of virus-specific RNA in avian sarcoma virus-transformed BHK-21 cells and revertants","volume":"76","author":"Deng","year":"1977","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0042-6822(73)90130-X","article-title":"RNA species obtained from clonal lines of avian sarcoma and avian leukosis virus","volume":"54","author":"Duesberg","year":"1973","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0042-6822(80)90129-4","article-title":"Novel nonconditional mutants in thesrc gene of Rous sarcoma virus: Isolation and preliminary characterization","volume":"103","author":"Fincham","year":"1980","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib18","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1126\/science.1257745","article-title":"Elimination of the sarcoma genome from murine sarcoma virus transformed cat cells","volume":"191","author":"Frankel","year":"1976","journal-title":"Science"},{"key":"10.1016\/0042-6822(81)90525-0_bib19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0065-230X(08)61013-1","article-title":"Organization of the genomes of polyoma virus and SV40","volume":"24","author":"Fried","year":"1977","journal-title":"Advan. Cancer Res."},{"key":"10.1016\/0042-6822(81)90525-0_bib20","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/278857a0","article-title":"Mutagenesisin vitro by DNA polymerase from an RNA tumor virus","volume":"278","author":"Gopinathan","year":"1979","journal-title":"Nature (London)"},{"key":"10.1016\/0042-6822(81)90525-0_bib21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0092-8674(74)90022-1","article-title":"Transformation-defective virus mutants in a class of morphologic revertants of sarcoma virus transformed nonproducer cells","volume":"2","author":"Greenberger","year":"1974","journal-title":"Cell"},{"key":"10.1016\/0042-6822(81)90525-0_bib22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1128\/jvi.24.1.47-63.1977","article-title":"Size and genetic content of viral RNAs in avian oncovirus-infected cells","volume":"24","author":"Hayward","year":"1977","journal-title":"J. Virol."},{"key":"10.1016\/0042-6822(81)90525-0_bib23","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1128\/jvi.14.5.1235-1244.1974","article-title":"Analysis of endonucleaseEco RI fragments of DNA from lambdoid bacteriophages and other viruses by agarose gel electrophoresis","volume":"14","author":"Helling","year":"1974","journal-title":"J. Virol."},{"key":"10.1016\/0042-6822(81)90525-0_bib24","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/0092-8674(78)90064-8","article-title":"Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA, and integrated at many sites","volume":"15","author":"Hughes","year":"1978","journal-title":"Cell"},{"key":"10.1016\/0042-6822(81)90525-0_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/269175a0","article-title":"Posttranscriptional control of avian oncornavirus transforming gene sequences in mammalian cells","volume":"269","author":"Krzyzek","year":"1977","journal-title":"Nature (London)"},{"key":"10.1016\/0042-6822(81)90525-0_bib26","first-page":"3904","article-title":"Morphological revertants of an avian sarcoma virus-transformed mammalian cell line exhibit tumorigenicity and contain pp60src","volume":"76","author":"Lau","year":"1979"},{"key":"10.1016\/0042-6822(81)90525-0_bib27","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.1016\/S0021-9258(18)36045-9","article-title":"Virus-specific messenger RNAs in permissive cells infected by avian sarcoma virus","volume":"254","author":"Lee","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0042-6822(81)90525-0_bib28","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1128\/jvi.9.6.891-902.1972","article-title":"Virus-specific ribonucleic acid (RNA) in cells producing Rous sarcoma virus: Detection and characterization","volume":"9","author":"Leong","year":"1972","journal-title":"J. Virol"},{"key":"10.1016\/0042-6822(81)90525-0_bib29","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0092-8674(78)90024-7","article-title":"Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein","volume":"15","author":"Levinson","year":"1978","journal-title":"Cell"},{"key":"10.1016\/0042-6822(81)90525-0_bib30","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1126\/science.148.3678.1731","article-title":"Reversion in hamster cells transformed by Rous sarcoma virus","volume":"148","author":"Macpherson","year":"1965","journal-title":"Science"},{"key":"10.1016\/0042-6822(81)90525-0_bib31","series-title":"Fundamental Techniques in Virology","first-page":"24","article-title":"Agar suspension culture for quantitation of transformed cells","author":"Macpherson","year":"1969"},{"key":"10.1016\/0042-6822(81)90525-0_bib32","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/270631a0","article-title":"Subgenomic, cellular Rous sarcoma virus RNAs contain oligonucleotides from the 3\u2032 half and the 5\u2032 terminus of virion RNA","volume":"270","author":"Mellon","year":"1977","journal-title":"Nature (London)"},{"key":"10.1016\/0042-6822(81)90525-0_bib33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/ijc.2910110114","article-title":"Effect of 3-methylcholanthrene and dimethylnitrosamine on anchorage dependence of rat fibroblasts chronically infected with Rauscher leukemia virus","volume":"11","author":"Mishra","year":"1973","journal-title":"Int. J. Cancer"},{"key":"10.1016\/0042-6822(81)90525-0_bib34","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/0042-6822(78)90390-2","article-title":"Revertants of mouse cells transformed by murine sarcoma virus. V. Loss of MSV-specific nucleotide sequences from cellular RNA","volume":"91","author":"Nomura","year":"1978","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib35","first-page":"126","article-title":"Growth control in cultured cells: Selection of sublines with increased sensitivity to contact inhibition and decreased tumor-producing ability","volume":"60","author":"Pollack","year":"1968"},{"key":"10.1016\/0042-6822(81)90525-0_bib36","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0092-8674(79)90102-8","article-title":"Cellular regulation of mammalian sarcoma virus expression: A gene regulation model for oncogenesis","volume":"16","author":"Porzig","year":"1979","journal-title":"Cell"},{"key":"10.1016\/0042-6822(81)90525-0_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/0022-2836(80)90218-1","article-title":"The structure of viral RNAs in mammalian cells infected with avian sarcoma virus","author":"Quintrell","year":"1980","journal-title":"J. Mol. Biol."},{"key":"10.1016\/0042-6822(81)90525-0_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/newbio240019a0","article-title":"Retransformation of ts SV40 transformants by murine sarcoma virus at non-permissive temperature","volume":"240","author":"Renger","year":"1972","journal-title":"Nature New Biol."},{"key":"10.1016\/0042-6822(81)90525-0_bib39","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1128\/jvi.29.1.170-178.1979","article-title":"Analysis of integrated avian RNA tumor virus DNA in transformed chicken, duck and quail fibroblasts","volume":"29","author":"Sabran","year":"1979","journal-title":"J. Virol."},{"key":"10.1016\/0042-6822(81)90525-0_bib40","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/0092-8674(78)90063-6","article-title":"Mapping unintegrated avian sarcoma virus DNA: Termini of linear DNA bear 300 nucleotides present once or twice in two species of circular DNA","volume":"15","author":"Shank","year":"1978","journal-title":"Cell"},{"key":"10.1016\/0042-6822(81)90525-0_bib41","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0022-2836(75)80083-0","article-title":"Detection of specific sequences among DNA fragments separated by gel electrophoresis","volume":"38","author":"Southern","year":"1975","journal-title":"J. Mol. Biol."},{"key":"10.1016\/0042-6822(81)90525-0_bib42","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1128\/jvi.23.1.133-141.1977","article-title":"Complementation rescue of Rous sarcoma virus from transformed mammalian cells by polyethylene glycol-mediated cell fusion","volume":"23","author":"Steimer","year":"1977","journal-title":"J. Virol."},{"key":"10.1016\/0042-6822(81)90525-0_bib43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0092-8674(78)90134-4","article-title":"Isolation and characterization of T antigen-negative revertants from a line of transformed rat cells containing one copy of the SV40 genome","volume":"13","author":"Steinberg","year":"1978","journal-title":"Cell"},{"key":"10.1016\/0042-6822(81)90525-0_bib44","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/260170a0","article-title":"DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA","volume":"260","author":"Stehelin","year":"1976","journal-title":"Nature (London)"},{"key":"10.1016\/0042-6822(81)90525-0_bib45","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1128\/jvi.11.2.218-222.1973","article-title":"Characterization of morphologic revertants of murine and avian sarcoma virus-transformed cells","volume":"11","author":"Stephenson","year":"1973","journal-title":"J. Virol."},{"key":"10.1016\/0042-6822(81)90525-0_bib46","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0042-6822(77)90344-0","article-title":"Characterization of DNA complementary to nucleotide sequences adjacent to poly(A) at the 3\u2032 terminus of the avian sarcoma virus genome","volume":"79","author":"Tal","year":"1977","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib47","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0042-6822(60)90038-6","article-title":"The control of cellular morphology in embryonic cells infected with Rous sarcoma virusin vitro","volume":"10","author":"Temin","year":"1960","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib48","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0042-6822(77)90389-0","article-title":"A very sensitive biochemical assay for detecting and quantitating avian oncornaviruses","volume":"80","author":"Tereba","year":"1977","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib49","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1099\/0022-1317-44-1-245","article-title":"Loss of proviral DNA sequences in a revertant of Kirsten sarcoma virus-transformed murine fibroblasts","volume":"44","author":"Trainor","year":"1979","journal-title":"J. Gen Virol."},{"key":"10.1016\/0042-6822(81)90525-0_bib50","series-title":"Fundamental Techniques in Virology","first-page":"198","article-title":"Focus assay of Rous sarcoma virus","author":"Vogt","year":"1969"},{"key":"10.1016\/0042-6822(81)90525-0_bib51","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/0042-6822(71)90092-4","article-title":"Spontaneous segregation of non-transforming viruses from cloned sarcoma viruses","volume":"46","author":"Vogt","year":"1971","journal-title":"Virology"},{"key":"10.1016\/0042-6822(81)90525-0_bib52","first-page":"341","article-title":"Genetics of RNA tumor viruses","volume":"Vol. 9","author":"Vogt","year":"1977"},{"key":"10.1016\/0042-6822(81)90525-0_bib53","first-page":"5812","article-title":"Recombination between viral and cellular sequences generates transforming sarcoma virus","volume":"75","author":"Wang","year":"1978"},{"key":"10.1016\/0042-6822(81)90525-0_bib54","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/0092-8674(77)90163-5","article-title":"The size and genetic composition of virus-specific RNAs in the cytoplasm of cell producing avian sarcoma-leukosis viruses","volume":"12","author":"Weiss","year":"1977","journal-title":"Cell"},{"key":"10.1016\/0042-6822(81)90525-0_bib55","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0014-4827(71)80030-7","article-title":"A method of isolating cells incapable of multiplication in suspension culture","volume":"66","author":"Wyke","year":"1971","journal-title":"Exp. Cell Res."},{"key":"10.1016\/0042-6822(81)90525-0_bib56","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0014-4827(71)80031-9","article-title":"Phenotypic variation and its control in polyoma-transformed BHK-21 cells","volume":"66","author":"Wyke","year":"1971","journal-title":"Exp. Cell Res."},{"key":"10.1016\/0042-6822(81)90525-0_bib57","first-page":"297","article-title":"A mutant of Rous sarcoma virus (Type 0) causing fusiform cell transformation","volume":"135","author":"Yoshii","year":"1970"},{"key":"10.1016\/0042-6822(81)90525-0_bib58","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1099\/0022-1317-43-2-447","article-title":"Reversion of Kirsten sarcoma virus transformed human cells: Elimination of the sarcoma virus nucleotide sequences","volume":"43","author":"Yang","year":"1979","journal-title":"J. Gen. Virol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0042682281905250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0042682281905250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T16:33:51Z","timestamp":1757349231000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0042682281905250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["0042682281905250"],"URL":"https:\/\/doi.org\/10.1016\/0042-6822(81)90525-0","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[1981,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Revertants of an ASV-transformed rat cell line have lost the complete provirus or sustained mutations insrc","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/0042-6822(81)90525-0","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1981 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}