{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:48:18Z","timestamp":1770518898821,"version":"3.49.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[1979,1,1]],"date-time":"1979-01-01T00:00:00Z","timestamp":283996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mechanisms of Ageing and Development"],"published-print":{"date-parts":[[1979,1]]},"DOI":"10.1016\/0047-6374(79)90126-x","type":"journal-article","created":{"date-parts":[[2003,2,12]],"date-time":"2003-02-12T03:46:19Z","timestamp":1045021579000},"page":"143-162","source":"Crossref","is-referenced-by-count":148,"title":["Age pigments, cell loss and hippocampal function"],"prefix":"10.1016","volume":"9","author":[{"given":"K.R.","family":"Brizzee","sequence":"first","affiliation":[]},{"given":"J.M.","family":"Ordy","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/0047-6374(79)90126-X_BIB1","author":"Botwinick","year":"1974"},{"key":"10.1016\/0047-6374(79)90126-X_BIB2","article-title":"Learning and aging","author":"Arenberg","year":"1977"},{"key":"10.1016\/0047-6374(79)90126-X_BIB3","first-page":"580","article-title":"Intellectual abilities","author":"Botwinick","year":"1977"},{"key":"10.1016\/0047-6374(79)90126-X_BIB4","first-page":"384","article-title":"Age differences in human memory","author":"Craik","year":"1977"},{"key":"10.1016\/0047-6374(79)90126-X_BIB5","first-page":"179","article-title":"A physiological perspective of the psychology of aging","author":"Woodruff","year":"1975"},{"key":"10.1016\/0047-6374(79)90126-X_BIB6","article-title":"Stress, disease, aging and behavior","author":"Eisdorfer","year":"1977"},{"key":"10.1016\/0047-6374(79)90126-X_BIB7","first-page":"177","article-title":"Aging of the autonomic nervous system and trends in its age changes","author":"Frolkis","year":"1977"},{"key":"10.1016\/0047-6374(79)90126-X_BIB8","first-page":"219","article-title":"Psychophysiology of aging","author":"Marsh","year":"1977"},{"key":"10.1016\/0047-6374(79)90126-X_BIB9","first-page":"401","article-title":"Gross morphometric analyses and quantitative histology of the aging brain","author":"Brizzee","year":"1975"},{"key":"10.1016\/0047-6374(79)90126-X_BIB10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0022-510X(68)90154-8","article-title":"Observations on the brains of non-demented old people","volume":"9","author":"Tomlinson","year":"1968","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/0047-6374(79)90126-X_BIB11","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0022-510X(70)90063-8","article-title":"Observations on the brains of demented old people","volume":"11","author":"Tomlinson","year":"1970","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/0047-6374(79)90126-X_BIB12","first-page":"25","article-title":"Morphological changes and dementia in old age","author":"Tomlinson","year":"1977"},{"key":"10.1016\/0047-6374(79)90126-X_BIB13","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1192\/bjp.114.512.797","article-title":"The association between quantitative measures of dementia and of senile changes in the cerebral grey matter of elderly subjects","volume":"114","author":"Blessed","year":"1968","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/0047-6374(79)90126-X_BIB14","first-page":"1","article-title":"The limbic system in Alzheimer's disease","volume":"85","author":"Hooper","year":"1976","journal-title":"Am. J. Pathol."},{"key":"10.1016\/0047-6374(79)90126-X_BIB15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0022-510X(75)90135-5","article-title":"Cell counts in the human cerebral cortex using a traditional and an automatic method","volume":"25","author":"Henderson","year":"1975","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/0047-6374(79)90126-X_BIB16","first-page":"177","article-title":"An examination of cerebral cortex and brain stem aging","author":"Brody","year":"1976"},{"key":"10.1016\/0047-6374(79)90126-X_BIB17","first-page":"183","article-title":"Some quantitative cerebral findings in normal and demented old people","author":"Tomlinson","year":"1976"},{"key":"10.1016\/0047-6374(79)90126-X_BIB18","first-page":"229","article-title":"Quantitative assessment of changes in neuron and glia cell packing density and lipofuscin accumulation with age in the cerebral cortex of a non-human primate (Macaca mulatta)","author":"Brizzee","year":"1976"},{"key":"10.1016\/0047-6374(79)90126-X_BIB19","first-page":"141","article-title":"Quantitative histological studies on aging changes in cerebral cortex of rhesus monkey and albino rat with notes on effects of prolonged low-dose ionizing irradiation in the rat","volume":"40","author":"Brizzee","year":"1973"},{"key":"10.1016\/0047-6374(79)90126-X_BIB20","author":"Friede","year":"1966"},{"key":"10.1016\/0047-6374(79)90126-X_BIB21","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/geronj\/29.4.366","article-title":"Early appearance and regional differences in intraneuronal and extraneuronal lipofuscin accumulation with age in the brain of a nonhuman primate","volume":"29","author":"Brizzee","year":"1974","journal-title":"J. Gerontol."},{"key":"10.1016\/0047-6374(79)90126-X_BIB22","series-title":"Autofluorescent and ultrastructural studies","first-page":"127","article-title":"The amount and distribution of pigments in neurons and glia of the cerebral cortex","volume":"24","author":"Brizzee","year":"1969"},{"key":"10.1016\/0047-6374(79)90126-X_BIB23","first-page":"152","article-title":"Aging, brain function and behavior","author":"Walker","year":"1975"},{"key":"10.1016\/0047-6374(79)90126-X_BIB24","first-page":"211","article-title":"Aging changes in morphology of cortical dendrites","author":"Feldman","year":"1976"},{"key":"10.1016\/0047-6374(79)90126-X_BIB25","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/geronj\/32.1.3","article-title":"Patterns of astroglial hypertrophy and neuronal degeneration in the hippocampus of aged, memory-deficient rats","volume":"32","author":"Landfield","year":"1977","journal-title":"J. Gerontol."},{"key":"10.1016\/0047-6374(79)90126-X_BIB26","first-page":"1","article-title":"Behavioral processes","author":"Botwinick","year":"1975"},{"key":"10.1016\/0047-6374(79)90126-X_BIB27","first-page":"125","article-title":"Age differences in learning and memory","author":"Walsh","year":"1975"},{"key":"10.1016\/0047-6374(79)90126-X_BIB28","first-page":"357","article-title":"Motivation and activity","author":"Elias","year":"1977"},{"key":"10.1016\/0047-6374(79)90126-X_BIB29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/03610737508257956","article-title":"Avoidance learning, behavior genetics and aging: a critical review and comment on methodology","volume":"1","author":"Sprott","year":"1975","journal-title":"Exp. Aging Res."},{"key":"10.1016\/0047-6374(79)90126-X_BIB30","first-page":"313","article-title":"Memory processes and the hippocampus","author":"Isaacson","year":"1975"},{"key":"10.1016\/0047-6374(79)90126-X_BIB31","year":"1975"},{"key":"10.1016\/0047-6374(79)90126-X_BIB32","year":"1975"},{"key":"10.1016\/0047-6374(79)90126-X_BIB33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(08)60700-X","article-title":"Do hippocampal lesions produce amnesia in animals?","volume":"19","author":"Iversen","year":"1976","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/0047-6374(79)90126-X_BIB34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/scientificamerican0677-82","article-title":"Spatial memory","volume":"236","author":"Olton","year":"1977","journal-title":"Sci. Am."},{"key":"10.1016\/0047-6374(79)90126-X_BIB35","first-page":"145","article-title":"Changes in learning and memory during aging","author":"Gold","year":"1975"},{"key":"10.1016\/0047-6374(79)90126-X_BIB36","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1159\/000212260","article-title":"Age differences in short-term memory and cell loss in the cortex of the rat","volume":"24","author":"Ordy","year":"1978","journal-title":"Gerontology"},{"issue":"285","key":"10.1016\/0047-6374(79)90126-X_BIB37","article-title":"Synaptic modifiability in middle-aged and senescent rats","volume":"3","author":"Barnes","year":"1977","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1016\/0047-6374(79)90126-X_BIB38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0531-5565(73)90017-X","article-title":"Ultrastructural age changes in hippocampal neurons, synapses and neuroglia","volume":"8","author":"Hasan","year":"1973","journal-title":"Exp. Gerontol."},{"key":"10.1016\/0047-6374(79)90126-X_BIB39","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/aja.1001450110","article-title":"Loss of synapses in the dentate gyrus of the senescent rat","volume":"145","author":"Bondareff","year":"1976","journal-title":"Am. J. Anat."},{"key":"10.1016\/0047-6374(79)90126-X_BIB40","first-page":"29","article-title":"Survival data for a colony of male Fischer rats","volume":"15","author":"Chesky","year":"1975","journal-title":"Gerontologist"},{"key":"10.1016\/0047-6374(79)90126-X_BIB41","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/0091-3057(76)90203-3","article-title":"Behavioral and biochemical effect of neonatal treatment of rat with 6-hydroxydopa","volume":"4","author":"McLean","year":"1976","journal-title":"Pharmacol. Biochem. Behavior"},{"key":"10.1016\/0047-6374(79)90126-X_BIB42","series-title":"I. The albino rat. A topography of the cortical areas","first-page":"221","article-title":"Connections of the cerebral cortex","volume":"84","author":"Krieg","year":"1946"},{"key":"10.1016\/0047-6374(79)90126-X_BIB43","first-page":"384","article-title":"A Fortran IV program for computing all possible multiple regressions","volume":"8","author":"Hansche","year":"1976","journal-title":"Behavior Res. Meth. Instrum."},{"key":"10.1016\/0047-6374(79)90126-X_BIB44","first-page":"2","article-title":"Time of neuron origin in the hippocampal region: An autoradiographic study in the mouse","author":"Angevine","year":"1965","journal-title":"Exp. Neurol. (Suppl.)"},{"key":"10.1016\/0047-6374(79)90126-X_BIB45","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/geronj\/28.1.63","article-title":"Age differences in retention of concurrent discrimination problems in monkeys","volume":"28","author":"Medin","year":"1973","journal-title":"J. Gerontol."},{"key":"10.1016\/0047-6374(79)90126-X_BIB46","first-page":"600","article-title":"Pain-aggression","author":"Ulrich","year":"1967"},{"key":"10.1016\/0047-6374(79)90126-X_BIB47","year":"1972"},{"key":"10.1016\/0047-6374(79)90126-X_BIB48","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3758\/BF03330795","article-title":"Septal lesions","volume":"9","author":"Wetzel","year":"1967","journal-title":"Psychonomic Sci."},{"key":"10.1016\/0047-6374(79)90126-X_BIB49","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0091-6773(77)90965-8","article-title":"Changes in neuron number and size and glia number in the young, adult and aging rat medial occipital cortex","volume":"20","author":"Diamond","year":"1977","journal-title":"Behavioral Biol."},{"key":"10.1016\/0047-6374(79)90126-X_BIB50","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0531-5565(72)90005-8","article-title":"Neuron survival in the aging mouse","volume":"7","author":"Johnson","year":"1972","journal-title":"Exp. Gerontol."},{"key":"10.1016\/0047-6374(79)90126-X_BIB51","first-page":"369","article-title":"Age pigment: A biochemical indicator of intracellular aging","author":"Siakotos","year":"1975"},{"key":"10.1016\/0047-6374(79)90126-X_BIB52","first-page":"25","article-title":"Univariate and multivariate models for evaluating long-term changes in neurobiological development, maturity and aging","volume":"40","author":"Ordy","year":"1973"},{"key":"10.1016\/0047-6374(79)90126-X_BIB53","first-page":"215","article-title":"Anatomical brain changes induced by environment","author":"Diamond","year":"1976"},{"key":"10.1016\/0047-6374(79)90126-X_BIB54","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/cne.901370309","article-title":"The effects of environmental complexity on the histology of the rat hippocampus","volume":"137","author":"Walsh","year":"1969","journal-title":"J. Com. Neurol."},{"key":"10.1016\/0047-6374(79)90126-X_BIB55","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0091-6773(75)90161-3","article-title":"Morphological changes in the young, adult and aging rat cerebral cortex, hippocampus and diencephalon","volume":"14","author":"Diamond","year":"1975","journal-title":"Behavioral Biol."},{"key":"10.1016\/0047-6374(79)90126-X_BIB56","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1037\/h0083740","article-title":"Effects of selective hippocampal damage on avoidance behavior in the rat","volume":"12","author":"Kimura","year":"1958","journal-title":"Can. J. Psychol."},{"key":"10.1016\/0047-6374(79)90126-X_BIB57","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/207109b0","article-title":"Hippocampal ablation in rats: effects of intertrial interval","volume":"207","author":"Jarrard","year":"1965","journal-title":"Nature"},{"key":"10.1016\/0047-6374(79)90126-X_BIB58","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1037\/h0022858","article-title":"Response perseveration interpretation of passive-avoidance deficits in hippocampectomized rats","volume":"61","author":"Kimble","year":"1966","journal-title":"J. Comp. Physiol. Psychol."}],"container-title":["Mechanisms of Ageing and Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:004763747990126X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:004763747990126X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:50:43Z","timestamp":1553734243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/004763747990126X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":58,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["004763747990126X"],"URL":"https:\/\/doi.org\/10.1016\/0047-6374(79)90126-x","relation":{},"ISSN":["0047-6374"],"issn-type":[{"value":"0047-6374","type":"print"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}