{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:56:12Z","timestamp":1780379772336,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1992,4,1]],"date-time":"1992-04-01T00:00:00Z","timestamp":702086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology Biochemistry and Behavior"],"published-print":{"date-parts":[[1992,4]]},"DOI":"10.1016\/0091-3057(92)90223-3","type":"journal-article","created":{"date-parts":[[2002,12,14]],"date-time":"2002-12-14T16:04:53Z","timestamp":1039881893000},"page":"755-759","source":"Crossref","is-referenced-by-count":87,"title":["Effects of nicotine on the threshold for rewarding brain stimulation in rats"],"prefix":"10.1016","volume":"41","author":[{"given":"David","family":"Huston-Lyons","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conan","family":"Kornetsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/0091-3057(92)90223-3_BIB1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1748-1716.1981.tb06827.x","article-title":"Effects of single injections of nicotine on the ascending dopamine pathways in the rat: Evidence for increases of dopamine turnover in the mesostriatal and mesolimbic dopamine neurons","volume":"112","author":"Andersson","year":"1981","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/0091-3057(92)90223-3_BIB2","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/0024-3205(87)90575-3","article-title":"Naloxone attenuation of the effect of cocaine on rewarding brain stimulation","volume":"40","author":"Bain","year":"1987","journal-title":"Life Sci."},{"key":"10.1016\/0091-3057(92)90223-3_BIB3","first-page":"149","article-title":"Naloxone antagonism of the effects of MDMA \u201cecstasy\u201d on rewarding brain stimulation","volume":"28","author":"Bird","year":"1986","journal-title":"Pharmacologist"},{"key":"10.1016\/0091-3057(92)90223-3_BIB4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0165-6147(87)90031-9","article-title":"Recent progress in identifying nicotinic cholinoceptors in mammalian brain","volume":"8","author":"Clarke","year":"1987","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/0091-3057(92)90223-3_BIB5","first-page":"701","article-title":"Evidence that mesolimbic dopaminergic activation underlies the locomotor stimulant action of nicotine in rats","volume":"246","author":"Clarke","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/0091-3057(92)90223-3_BIB6","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1476-5381.1985.tb11081.x","article-title":"Electrophysiological actions of nicotine on substantia nigra single units","volume":"85","author":"Clarke","year":"1985","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/0091-3057(92)90223-3_BIB7","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF00427826","article-title":"Nicotine does not improve discrimination of brain stimulation reward by rats","volume":"79","author":"Clarke","year":"1983","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/0091-3057(92)90223-3_BIB8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/BF00432037","article-title":"Effects of nicotine and d-amphetamine on intracranial self-stimulation in a shuttle box test in rats","volume":"84","author":"Clarke","year":"1984","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/0091-3057(92)90223-3_BIB9","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0006-8993(85)90456-1","article-title":"Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons","volume":"348","author":"Clarke","year":"1985","journal-title":"Brain Res."},{"key":"10.1016\/0091-3057(92)90223-3_BIB10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00439446","article-title":"Differential effects of cholinergic drugs on discriminative cues and self-stimulation produced by electrical stimulation of the ventral tegmental area","volume":"97","author":"Druhan","year":"1989","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/0091-3057(92)90223-3_BIB11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.831268","article-title":"Morphine lowering of self-stimulation thresholds: Lack of tolerance with long-term administration","volume":"195","author":"Esposito","year":"1980","journal-title":"Science"},{"key":"10.1016\/0091-3057(92)90223-3_BIB12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF00427648","article-title":"Effects of d-amphetamine and naloxone on brain stimulation reward","volume":"69","author":"Esposito","year":"1980","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/0091-3057(92)90223-3_BIB13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1146\/annurev.pa.18.040178.000345","article-title":"Drugs and reinforcement mechanisms: A critical review of the catecholamine theory","volume":"18","author":"Fibiger","year":"1978","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/0091-3057(92)90223-3_BIB14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF01243356","article-title":"Increases in dopamine utilization in certain limbic dopamine terminal populations after a short period of intermittent exposure of male rats to cigarette smoke","volume":"67","author":"Fuxe","year":"1986","journal-title":"J. Neural Trans."},{"key":"10.1016\/0091-3057(92)90223-3_BIB15","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0006-8993(76)90077-9","article-title":"Nicotinic effect of acetylcholine on the release of newly synthesized [3H]dopamine in rat striatal slices and cat caudate nucleus","volume":"106","author":"Giorguieff","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/0091-3057(92)90223-3_BIB16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1748-1716.1986.tb07988.x","article-title":"Nicotinic effects on the firing pattern of midbrain dopamine neurons","volume":"128","author":"Grenhoff","year":"1986","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/0091-3057(92)90223-3_BIB17","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/0024-3205(88)90036-7","article-title":"Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis","volume":"42","author":"Hernandez","year":"1988","journal-title":"Life Sci."},{"key":"10.1016\/0091-3057(92)90223-3_BIB18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0014-2999(86)90629-1","article-title":"Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats","volume":"132","author":"Imperato","year":"1986","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/0091-3057(92)90223-3_BIB19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF00187264","article-title":"The effects of nicotine on locomotor behavior in non-tolerant rats: A multivariate assessment","volume":"93","author":"Jerome","year":"1987","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/0091-3057(92)90223-3_BIB20","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0091-3057(89)90069-5","article-title":"The effects of amfonelic acid alone and in combination with naloxone on brain-stimulation reward","volume":"32","author":"Knapp","year":"1989","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/0091-3057(92)90223-3_BIB21","series-title":"The neurobiology of opiate reward processes","first-page":"237","article-title":"Effects of opiates on rewarding brain stimulation","author":"Kornetsky","year":"1983"},{"key":"10.1016\/0091-3057(92)90223-3_BIB22","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0028-3908(82)90107-1","article-title":"Stimulation of nigrostriatal dopamine neurones by nicotine","volume":"21","author":"Lichtensteiger","year":"1982","journal-title":"Neuropharmacology"},{"key":"10.1016\/0091-3057(92)90223-3_BIB23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0006-8993(89)91518-7","article-title":"Nicotine infused into the nucleus accumbens increases synaptic dopamine as measured by in vivo microdialysis","volume":"476","author":"Mifsud","year":"1989","journal-title":"Brain Res."},{"key":"10.1016\/0091-3057(92)90223-3_BIB24","first-page":"1322","article-title":"Reversal of morphine induced facilitation on rewarding electrical brain-stimulation by naloxone: Evidence for direct pharmacological activation of opiate receptors","volume":"13","author":"Moolten","year":"1987","journal-title":"Soc. Neurosci. Abstr."},{"key":"10.1016\/0091-3057(92)90223-3_BIB25","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1037\/h0032830","article-title":"Effects of cholinergic agonists and antagonists on self-stimulation behavior in the rat","volume":"79","author":"Newman","year":"1972","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/0091-3057(92)90223-3_BIB26","first-page":"189","article-title":"Comparison of muscarinic and nicotinic cholinergic agonists on self-stimulation behavior","volume":"166","author":"Olds","year":"1969","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/0091-3057(92)90223-3_BIB27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0091-3057(81)90251-3","article-title":"Effects of chronic naloxone treatment on brain-stimulation reward","volume":"14","author":"Perry","year":"1981","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/0091-3057(92)90223-3_BIB28","first-page":"229","article-title":"Effects of nicotine on self-stimulation in rats","volume":"176","author":"Pradhan","year":"1971","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/0091-3057(92)90223-3_BIB29","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0006-8993(82)90499-1","article-title":"Enhancement of [3H]dopamine release and its [3H]metabolites in rat striatum by nicotinic drugs","volume":"242","author":"Sakurai","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/0091-3057(92)90223-3_BIB30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0149-7634(88)80068-X","article-title":"Opiate antagonists and rewarding brain stimulation","volume":"12","author":"Schaefer","year":"1988","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/0091-3057(92)90223-3_BIB31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0028-3908(86)90033-X","article-title":"Task-specific effects of nicotine in rats: Intracranial self-stimulation and locomotor activity","volume":"25","author":"Schaefer","year":"1986","journal-title":"Neuropharmacology"},{"key":"10.1016\/0091-3057(92)90223-3_BIB32","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/j.1471-4159.1984.tb02818.x","article-title":"Presynaptic nicotine cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain","volume":"42","author":"Schwartz","year":"1984","journal-title":"J. Neurochem."},{"key":"10.1016\/0091-3057(92)90223-3_BIB33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-8993(78)90253-6","article-title":"Catecholamine theories of reward: A critical review","volume":"152","author":"Wise","year":"1978","journal-title":"Brain Res."}],"container-title":["Pharmacology Biochemistry and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0091305792902233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0091305792902233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,31]],"date-time":"2019-03-31T20:20:49Z","timestamp":1554063649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0091305792902233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,4]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992,4]]}},"alternative-id":["0091305792902233"],"URL":"https:\/\/doi.org\/10.1016\/0091-3057(92)90223-3","relation":{},"ISSN":["0091-3057"],"issn-type":[{"value":"0091-3057","type":"print"}],"subject":[],"published":{"date-parts":[[1992,4]]}}}