{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T12:47:14Z","timestamp":1759063634904},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1980,11,1]],"date-time":"1980-11-01T00:00:00Z","timestamp":341884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1980,11]]},"DOI":"10.1016\/0092-8674(80)90172-5","type":"journal-article","created":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T06:14:50Z","timestamp":1083651290000},"page":"243-255","source":"Crossref","is-referenced-by-count":139,"special_numbering":"P1","title":["Molecular engineering of the herpes simplex virus genome: Insertion of a second L-S junction into the genome causes additional genome inversions"],"prefix":"10.1016","volume":"22","author":[{"given":"Edward S.","family":"Mocarski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard E.","family":"Post","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Roizman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0092-8674(80)90172-5_BIB1","first-page":"3755","article-title":"Cloning of the active thymidine kinase gene of herpes simplex virus type 1 in Escherichia coli K-12","volume":"76","author":"Colbere-Garapin","year":"1979"},{"key":"10.1016\/0092-8674(80)90172-5_BIB2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1099\/0022-1317-33-1-125","article-title":"A partial denaturation map of herpes simplex virus type 1 DNA: evidence for inversions of the unique DNA regions","volume":"33","author":"Delius","year":"1976","journal-title":"J. Gen. Virol."},{"key":"10.1016\/0092-8674(80)90172-5_BIB3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1099\/0022-1317-2-3-357","article-title":"Characterization of herpes simplex virus strains differing in their effect on social behavior of infected cells","volume":"3","author":"Ejercito","year":"1968","journal-title":"J. Gen. Virol."},{"key":"10.1016\/0092-8674(80)90172-5_BIB4","doi-asserted-by":"crossref","DOI":"10.1099\/0022-1317-49-2-235","article-title":"Mapping of the thymidine kinase gene of type 1 and type 2 herpes simplex viruses using intertypic recombinants","author":"Halliburton","year":"1980","journal-title":"J. Gen. Virol."},{"key":"10.1016\/0092-8674(80)90172-5_BIB5","first-page":"4243","article-title":"Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short segments","volume":"72","author":"Hayward","year":"1975"},{"key":"10.1016\/0092-8674(80)90172-5_BIB6","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1128\/JVI.29.2.448-457.1979","article-title":"Anatomy of herpes simplex virus DNA. XII. Accumulation of head to tail concatemers in nuclei of infected cells and their role in the generation of the four isomeric arrangements of viral DNA","volume":"29","author":"Jacob","year":"1979","journal-title":"J. Virol."},{"key":"10.1016\/0092-8674(80)90172-5_BIB7","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1128\/JVI.8.2.125-132.1971","article-title":"Size, composition and structure of the DNA of subtypes 1 and 2 herpes simplex virus","volume":"8","author":"Kieff","year":"1971","journal-title":"J. Virol."},{"key":"10.1016\/0092-8674(80)90172-5_BIB8","series-title":"Demonstration of regions of obligatory and non-obligatory identity in diploid regions of the genome by sequence replacement and insertion","first-page":"3896","article-title":"Molecular genetics of herpes simplex virus","volume":"75","author":"Knipe","year":"1978"},{"key":"10.1016\/0092-8674(80)90172-5_BIB9","first-page":"85","article-title":"Influence of DEAE-dextran treatment and cellular \u201cage\u201d on infection by herpes simplex virus DNA","volume":"2","author":"Laithier","year":"1974"},{"key":"10.1016\/0092-8674(80)90172-5_BIB10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1128\/JVI.32.2.429-441.1979","article-title":"Bam I, Kpn I and Sal I restriction enzyme maps of the DNAs of herpes simplex virus strains Justin and F: occurrence of heterogeneities in defined regions of the viral DNA","volume":"32","author":"Locker","year":"1979","journal-title":"J. Virol."},{"key":"10.1016\/0092-8674(80)90172-5_BIB11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/0092-8674(77)90039-3","article-title":"Protein expression in E. coli minicells by recombinant plasmids","volume":"10","author":"Meagher","year":"1977","journal-title":"Cell"},{"key":"10.1016\/0092-8674(80)90172-5_BIB12","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1128\/JVI.26.2.389-410.1978","article-title":"Anatomy of HSV DNA. XI. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 \u00d7 HSV-2 recombinants","volume":"26","author":"Morse","year":"1978","journal-title":"J. Virol."},{"key":"10.1016\/0092-8674(80)90172-5_BIB13","first-page":"4201","article-title":"Cloning of the reiterated and non-reiterated herpes simplex virus 1 sequences as Bam Hl fragments","volume":"77","author":"Post","year":"1980"},{"key":"10.1016\/0092-8674(80)90172-5_BIB14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0092-8674(79)90023-0","article-title":"The structure and isomerization of herpes simplex virus genomes","volume":"16","author":"Roizman","year":"1979","journal-title":"Cell"},{"key":"10.1016\/0092-8674(80)90172-5_BIB15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1128\/JVI.2.1.83-84.1968","article-title":"Preparation of herpes simplex virus of high titer","volume":"2","author":"Roizman","year":"1968","journal-title":"J. Virol."},{"key":"10.1016\/0092-8674(80)90172-5_BIB16","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1128\/JVI.29.2.677-697.1979","article-title":"Molecular genetics of herpes simplex virus. II. Mapping of the major viral glycoproteins and of the genetic loci specifying the social behavior of infected cells","volume":"29","author":"Ruyechan","year":"1979","journal-title":"J. Virol."},{"key":"10.1016\/0092-8674(80)90172-5_BIB17","first-page":"667","article-title":"Inverted repetitions in the chromosome of herpes simplex virus","volume":"39","author":"Sheldrick","year":"1975"},{"key":"10.1016\/0092-8674(80)90172-5_BIB18","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1128\/JVI.15.6.1487-1497.1975","article-title":"Anatomy of herpes virus DNA. II. Size, composition and arrangement of inverted terminal repetitions","volume":"15","author":"Wadsworth","year":"1975","journal-title":"J. Virol."},{"key":"10.1016\/0092-8674(80)90172-5_BIB19","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1128\/JVI.27.2.374-387.1978","article-title":"Structure of the joint region and the termini of the DNA of herpes simplex virus type 1","volume":"27","author":"Wagner","year":"1978","journal-title":"J. Virol."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0092867480901725?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0092867480901725?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T21:39:25Z","timestamp":1585777165000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0092867480901725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,11]]}},"alternative-id":["0092867480901725"],"URL":"https:\/\/doi.org\/10.1016\/0092-8674(80)90172-5","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1980,11]]}}}