{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:17:03Z","timestamp":1779344223424,"version":"3.51.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1992,7,1]],"date-time":"1992-07-01T00:00:00Z","timestamp":709948800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1992,7]]},"DOI":"10.1016\/0092-8674(92)90536-l","type":"journal-article","created":{"date-parts":[[2004,8,5]],"date-time":"2004-08-05T15:25:56Z","timestamp":1091719556000},"page":"93-104","source":"Crossref","is-referenced-by-count":1058,"title":["A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction"],"prefix":"10.1016","volume":"70","author":[{"given":"Giuliana","family":"Pelicci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Lanfrancone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Grignani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"McGlade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Cavallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Forni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildo","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Grignani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony","family":"Pawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier","family":"Giuseppe Pelicci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0092-8674(92)90536-L_BIB1","first-page":"267","article-title":"Characterization of human and mouse c-fes cDNA clones and identification of the 5\u2032 end of the gene","volume":"5","author":"Alcalay","year":"1990","journal-title":"Oncogene"},{"key":"10.1016\/0092-8674(92)90536-L_BIB2","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1128\/MCB.5.5.1122","article-title":"Human cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxyterminal two-thirds of pp60c-src","volume":"5","author":"Anderson","year":"1985","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90536-L_BIB3","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.2173144","article-title":"Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors","volume":"250","author":"Anderson","year":"1990","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90536-L_BIB4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0092-8674(89)90182-7","article-title":"PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells","volume":"57","author":"Auger","year":"1989","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB5","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1021\/bi00291a023","article-title":"Nucleotide sequences of complementary deoxyribonucleic acids for the pro alpha 1 chain of human type I procollagen. Statistical evaluation of structures that are conserved during evolution","volume":"22","author":"Bernard","year":"1983","journal-title":"Biochemistry"},{"key":"10.1016\/0092-8674(92)90536-L_BIB6","first-page":"3816","article-title":"Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation","volume":"87","author":"Bjorge","year":"1990"},{"key":"10.1016\/0092-8674(92)90536-L_BIB7","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1126\/science.6293052","article-title":"New method for detecting cellular transforming genes","volume":"218","author":"Blair","year":"1982","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90536-L_BIB8","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1146\/annurev.bi.49.070180.004521","article-title":"Structurally distinct collagen types","volume":"49","author":"Bornstein","year":"1980","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/0092-8674(92)90536-L_BIB9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0092-8674(91)90639-G","article-title":"Oncogenes and signal transduction","volume":"64","author":"Cantley","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB10","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0092-8674(84)90440-9","article-title":"Construction and applications of a highly transmissible murine retrovirus shuttle vector","volume":"37","author":"Cepko","year":"1984","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/310337a0","article-title":"Human pro alpha 1(I) collagen gene structure reveals evolutionary conservation of a pattern of introns and exons","volume":"310","author":"Chu","year":"1984","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90536-L_BIB12","doi-asserted-by":"crossref","first-page":"7835","DOI":"10.1016\/S0021-9258(17)42869-9","article-title":"Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro","volume":"259","author":"Cooper","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(92)90536-L_BIB13","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.2466336","article-title":"Role of phosphatidylinositol kinase in PDGF receptor signal transduction","volume":"243","author":"Coughlin","year":"1989","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90536-L_BIB14","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.1708917","article-title":"Presence of an SH2 domain in the actin-binding protein tensin","volume":"252","author":"Davis","year":"1991","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90536-L_BIB15","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/343377a0","article-title":"Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases","volume":"343","author":"Ellis","year":"1990","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90536-L_BIB16","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1126\/science.7355290","article-title":"Collagen: molecular diversity in the body's protein scaffold","volume":"207","author":"Eyre","year":"1980","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90536-L_BIB17","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0092-8674(91)90409-R","article-title":"cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of P13-kinase to the PDGF \u03b2-receptor","volume":"65","author":"Escobedo","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB18","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1128\/MCB.8.8.3345","article-title":"Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity","volume":"8","author":"Gould","year":"1988","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90536-L_BIB19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1126\/science.3291115","article-title":"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains","volume":"241","author":"Hanks","year":"1988","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90536-L_BIB20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1083\/jcb.91.3.205s","article-title":"Extracellular matrix","volume":"91","author":"Hay","year":"1981","journal-title":"J. Cell biol."},{"key":"10.1016\/0092-8674(92)90536-L_BIB21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0092-8674(90)90220-9","article-title":"PDGF \u03b2-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex","volume":"61","author":"Kaplan","year":"1990","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB22","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/0092-8674(89)90510-2","article-title":"Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins","volume":"58","author":"Kazlauskas","year":"1989","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB23","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1126\/science.2157284","article-title":"Binding of GAP to activated PDGF receptors","volume":"247","author":"Kazlauskas","year":"1990","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90536-L_BIB24","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1126\/science.1708916","article-title":"SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins","volume":"252","author":"Koch","year":"1991","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90536-L_BIB25","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1128\/MCB.12.3.1366","article-title":"Multiple SH2 mediated interactions in v-src transformed cells","volume":"12","author":"Koch","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90536-L_BIB26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1083\/jcb.108.2.229","article-title":"The scanning model for translation: an update","volume":"108","author":"Kozak","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1016\/0092-8674(92)90536-L_BIB27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0092-8674(90)90013-5","article-title":"Association between the PDGF receptor and members of the src family of tyrosine kinases","volume":"62","author":"Kypta","year":"1990","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB28","first-page":"621","article-title":"Novel protein-tyrosine kinase cDNAs related to fps\/fOs and eph cloned using anti-phosphotyrosine antibody","volume":"3","author":"Letwin","year":"1988","journal-title":"Oncogene"},{"key":"10.1016\/0092-8674(92)90536-L_BIB29","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1128\/MCB.12.3.991","article-title":"SH2 domains of the p85 alfasubunit of phosphatidyinositol 3-kinase regulate binding to growth factor receptors","volume":"12","author":"McGlade","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90536-L_BIB30","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/0092-8674(89)90047-0","article-title":"EGF induces tyrosine phosphorylation of phospholipase C-II: a potential mechanism of EGF receptor signaling","volume":"57","author":"Margolis","year":"1989","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB31","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1126\/science.1694307","article-title":"Binding of transforming protein p47gag-crk to a broad range of phosphotyrosine containing proteins","volume":"248","author":"Matsuda","year":"1990","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90536-L_BIB32","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/332272a0","article-title":"A novel viral oncogene with structural similarity to phospholipase C","volume":"332","author":"Mayer","year":"1988","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90536-L_BIB33","first-page":"2638","article-title":"Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity","volume":"87","author":"Mayer","year":"1990"},{"key":"10.1016\/0092-8674(92)90536-L_BIB34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/0092-8674(89)90048-2","article-title":"Phospholipase C-\u03b3 is a substrate for the PDGF and EGF receptor protein tyrosine kinases in vivo and in vitro","volume":"57","author":"Meisenhelder","year":"1989","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB35","first-page":"8622","article-title":"Src homology region 2 domains direct protein-protein interactions in signal transduction","volume":"87","author":"Moran","year":"1990"},{"key":"10.1016\/0092-8674(92)90536-L_BIB36","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1128\/MCB.11.4.1804","article-title":"Protein-tyrosine kinases regulate the phosphorylation, protein interactions, subcellular distribution, and activity of p21 ras GTPase-activating protein","volume":"11","author":"Moran","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90536-L_BIB37","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1128\/MCB.10.5.2359","article-title":"Platelet-derived growth factor (PDGF)-dependent association of phospholypase C-\u03b3 with the PDGF receptor signaling complex","volume":"10","author":"Morrison","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90536-L_BIB38","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/313241a0","article-title":"Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells","volume":"313","author":"Mulcahy","year":"1985","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90536-L_BIB39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0092-8674(91)90411-Q","article-title":"Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T\/pp60c-src complexes, and P13-kinase","volume":"65","author":"Otsu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB40_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJM197907053010104","article-title":"The biosynthesis of collagen and its disorders","volume":"301","author":"Prockop","year":"1979","journal-title":"N. Engl. J. Mod."},{"key":"10.1016\/0092-8674(92)90536-L_BIB40_2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM197907123010204","article-title":"The biosynthesis of collagen and its disorders","volume":"301","author":"Prockop","year":"1979","journal-title":"N. Engl. J. Mod."},{"key":"10.1016\/0092-8674(92)90536-L_BIB41","doi-asserted-by":"crossref","DOI":"10.1002\/j.1460-2075.1992.tb05181.x","article-title":"Tyr 721 regulates specific binding of the CSF-1 receptor kinase insert to P13-kinase SH2 domains: a model for SH2-mediated receptor target interactions","volume":"11","author":"Reedijk","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(92)90536-L_BIB42","author":"Sambrook","year":"1989"},{"key":"10.1016\/0092-8674(92)90536-L_BIB43","series-title":"Atlas of Protein Sequence and Structure","author":"Schwartz","year":"1979"},{"key":"10.1016\/0092-8674(92)90536-L_BIB44","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0092-8674(86)90450-2","article-title":"Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene","volume":"47","author":"Shtivelman","year":"1986","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB45","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0092-8674(91)90410-Z","article-title":"Cloning of P13 kinase-associated p85 utilizing a novel method for expression\/cloning of target proteins for receptor tyrosine kinases","volume":"65","author":"Skolnik","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB46","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/320540a0","article-title":"Requirement for c-ras proteins during viral oncogene transformation","volume":"320","author":"Smith","year":"1986","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90536-L_BIB47","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0378-1119(88)90005-4","article-title":"Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase","volume":"67","author":"Smith","year":"1991","journal-title":"Gene"},{"key":"10.1016\/0092-8674(92)90536-L_BIB48","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/332269a0","article-title":"Sequence similarity of phospholipase C with the non-catalytic region of src","volume":"332","author":"Stahl","year":"1988","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90536-L_BIB49","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1128\/MCB.7.3.1280","article-title":"Human recipent cell for oncogene transfection studies","volume":"7","author":"Tainsky","year":"1987","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90536-L_BIB50","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1126\/science.2821624","article-title":"A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants","volume":"238","author":"Trahey","year":"1987","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90536-L_BIB51","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0092-8674(90)90801-K","article-title":"Signal transduction by receptors with tyrosine kinase activity","volume":"61","author":"Ullrich","year":"1990","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90536-L_BIB52","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/335090a0","article-title":"Cloning of bovine GAP and its interaction with oncogenic ras p21","volume":"335","author":"Vogel","year":"1988","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90536-L_BIB53","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1128\/MCB.9.7.2934","article-title":"Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholypase C-\u03b3 in quiescent BALB\/c 3T3 cells","volume":"9","author":"Wahl","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90536-L_BIB54","first-page":"327","article-title":"Phosphoinositide metabolism and the control of cell proliferation","volume":"948","author":"Whitman","year":"1988","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/0092-8674(92)90536-L_BIB55","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/332644a0","article-title":"Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate","volume":"332","author":"Whitman","year":"1988","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90536-L_BIB56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1432-1033.1986.tb10139.x","article-title":"Substrate specificity of protein kinase C. Use of synthetic peptides corresponding to physiological sites as probes for substrate recognition requirements","volume":"161","author":"Woodgett","year":"1986","journal-title":"Eur. J. Biochem."}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:009286749290536L?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:009286749290536L?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T21:11:41Z","timestamp":1624569101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/009286749290536L"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,7]]}},"alternative-id":["009286749290536L"],"URL":"https:\/\/doi.org\/10.1016\/0092-8674(92)90536-l","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1992,7]]}}}