{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:28:19Z","timestamp":1783542499321,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[1992,6,1]],"date-time":"1992-06-01T00:00:00Z","timestamp":707356800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cell"],"published-print":{"date-parts":[[1992,6]]},"DOI":"10.1016\/0092-8674(92)90643-q","type":"journal-article","created":{"date-parts":[[2004,5,4]],"date-time":"2004-05-04T10:14:26Z","timestamp":1083665666000},"page":"1227-1236","source":"Crossref","is-referenced-by-count":970,"title":["Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases"],"prefix":"10.1016","volume":"69","author":[{"given":"Jongkyeong","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calvin J.","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald R.","family":"Crabtree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Blenis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/0092-8674(92)90643-Q_BIB1","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1128\/MCB.9.9.3850","article-title":"Sequence and expression of chicken and mouse rsk: homologs of the Xenopus laevis ribosomal S6 kinase","volume":"9","author":"Alcorta","year":"1989","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB2","doi-asserted-by":"crossref","first-page":"15277","DOI":"10.1016\/S0021-9258(18)98613-8","article-title":"Pro-Leu-Ser\/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase","volume":"266","author":"Alvarez","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB3","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0021-9258(17)31236-X","article-title":"Purification and characterization of a novel protein phosphatase highly specific for ribosomal protein S6","volume":"264","author":"Andres","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB4","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/S0021-9258(19)57284-2","article-title":"Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells","volume":"263","author":"Ballou","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB5","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/349348a0","article-title":"MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways","volume":"349","author":"Ballou","year":"1991","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB6","first-page":"8550","article-title":"Molecular structure of a major insulin\/mitogen-activated 70-kDa S6 protein kinase","volume":"87","author":"Banerjee","year":"1990"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB7","first-page":"9231","article-title":"Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin","volume":"87","author":"Bierer","year":"1990"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB8","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1126\/science.1700475","article-title":"Probing immunosuppressant action with a nonnatural immunophilin ligand","volume":"250","author":"Bierer","year":"1990","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB9","first-page":"445","article-title":"Growth-regulated signal transduction by the MAP kinases and RSKs","volume":"3","author":"Blenis","year":"1991","journal-title":"Cancer Cells"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB10","first-page":"7621","article-title":"Regulation of a ribosomal protein S6 kinase activity by the Rous sarcoma virus transforming protein, serum, or phorbol ester","volume":"82","author":"Blenis","year":"1985"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB11","first-page":"279","article-title":"Distinct mechanisms for the activation of the RSK kinase\/MAP2 kinase\/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis","volume":"2","author":"Blenis","year":"1991","journal-title":"Cell Growth Diff."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1126\/science.2164259","article-title":"An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control","volume":"249","author":"Boulton","year":"1990","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0165-6147(91)90555-7","article-title":"FK506 and rapamycin: novel pharmacological probes of the immune response","volume":"12","author":"Chang","year":"1991","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB14","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1128\/MCB.10.6.3204","article-title":"Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation","volume":"10","author":"Chen","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB15","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1128\/MCB.11.4.1861","article-title":"Regulation of pp90rsk phosphorylation and S6 phosphotransferase activity in Swiss 3T3 cells by growth factor-, phorbol ester-, and cAMP-mediated signal transduction","volume":"11","author":"Chen","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB16","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1128\/MCB.12.3.915","article-title":"Nuclear localization and regulation of the erk- and rsk-encoded protein kinases","volume":"12","author":"Chen","year":"1992","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB17","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1128\/MCB.11.4.1868","article-title":"Coordinate regulation of pp90rsk and a distinct protein-serine\/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro","volume":"11","author":"Chung","year":"1991","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB18","first-page":"4981","article-title":"Mitogen-activated Swiss mouse 3T3 RSK kinase I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity","volume":"88","author":"Chung","year":"1991"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB19","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1091\/mbc.2.12.965","article-title":"Extracellular signal-regulated kinases: ERKs in progress","volume":"2","author":"Cobb","year":"1991","journal-title":"Cell Regul."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB20","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4049\/jimmunol.144.4.1418","article-title":"The immunosuppressive macrolides FK506 and rapamycin act as reciprocal antagonists in murine T cells","volume":"144","author":"Dumont","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB21","doi-asserted-by":"crossref","first-page":"251","DOI":"10.4049\/jimmunol.144.1.251","article-title":"Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK506 and rapamycin","volume":"144","author":"Dumont","year":"1990","journal-title":"J. Immunol."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB22","doi-asserted-by":"crossref","first-page":"13711","DOI":"10.1016\/S0021-9258(18)80057-6","article-title":"In vivo phosphorylation and activation of ribosomal protein S6 kinases during Xenopus oocyte maturation","volume":"264","author":"Erikson","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB23","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1016\/S0021-9258(18)38072-4","article-title":"Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6","volume":"266","author":"Erikson","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB24","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/352803a0","article-title":"Nuclear association of a T-cell transcription factor blocked by FK506 and cyclosporin A","volume":"352","author":"Flanagan","year":"1991","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB25","doi-asserted-by":"crossref","first-page":"5541","DOI":"10.1128\/MCB.11.11.5541","article-title":"Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini","volume":"11","author":"Grove","year":"1991","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB26","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/341758a0","article-title":"A receptor for the immunosuppressant FK506 is a cis-trans peptidylprolyl isomerase","volume":"341","author":"Harding","year":"1989","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB27","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1126\/science.1715094","article-title":"Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast","volume":"253","author":"Heitman","year":"1991","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB28","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1128\/MCB.7.4.1338","article-title":"Phosphorylation of the Saccharomyces cerevisiae equivalent of ribosomal protein S6 has no detectable effect on growth","volume":"7","author":"Johnson","year":"1987","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB29","first-page":"3377","article-title":"A Xenopus ribosomal protein S6 kinase has two apparent kinase domains that are each similar to distinct protein kinases","volume":"85","author":"Jones","year":"1988"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB30","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/jcp.1041480210","article-title":"Heat shock induces two distinct S6 protein kinase activities in quiescent mammalian fibroblasts","volume":"148","author":"Jurivich","year":"1991","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB31","first-page":"7365","article-title":"Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily","volume":"87","author":"Kozma","year":"1990"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB32","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1002\/j.1460-2075.1991.tb07759.x","article-title":"Independent regulation of HNF-1\u03b1 and HNF-1\u03b2 by retinoic acid in F9 teratocarcinoma cells","volume":"10","author":"Kuo","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB33","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","article-title":"Calcineurin is a common target of cyclophilincyclosporin A and FKBP-FK506 complexes","volume":"66","author":"Liu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB34","series-title":"When worlds collide: immunosuppressants meet protein phosphatases","first-page":"823","volume":"66","author":"McKeon","year":"1991"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0167-5699(05)80040-4","article-title":"Rapamycin: FK506's fraternal twin or distant cousin?","volume":"12","author":"Morris","year":"1991","journal-title":"Immunol. Today"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB36","doi-asserted-by":"crossref","first-page":"22460","DOI":"10.1016\/S0021-9258(18)45727-4","article-title":"Three forms of phosphatase type 1 in Swiss 3T3 fibroblasts","volume":"265","author":"Olivier","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB37","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/353670a0","article-title":"Phosphorylation of c-jun mediated by MAP kinases","volume":"353","author":"Pulverer","year":"1991","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB38","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1126\/science.1702904","article-title":"Chemistry and biology of the immunophilins and their immunosuppressive ligands","volume":"251","author":"Schreiber","year":"1991","journal-title":"Science"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB39","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/341755a0","article-title":"A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin","volume":"341","author":"Siekierka","year":"1989","journal-title":"Nature"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB40","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0167-4889(97)90012-4","article-title":"Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6","volume":"1092","author":"Sturgill","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB41","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1128\/MCB.10.6.2787","article-title":"Two distinct enzymes contribute to biphasic S6 phosphorylation in serum-stimulated chicken embryo fibroblasts","volume":"10","author":"Sweet","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB42","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/0006-291X(70)91086-7","article-title":"Preparation and some properties of active subunits from rat liver ribosomes","volume":"38","author":"Terao","year":"1970","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/0092-8674(92)90643-Q_BIB43","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0092-8674(92)90075-N","article-title":"Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases","volume":"68","author":"Thomas","year":"1992","journal-title":"Cell"},{"key":"10.1016\/0092-8674(92)90643-Q_BIB44","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0092-8674(92)90076-O","article-title":"ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK","volume":"68","author":"Wood","year":"1992","journal-title":"Cell"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:009286749290643Q?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:009286749290643Q?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T09:13:43Z","timestamp":1705137223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/009286749290643Q"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["009286749290643Q"],"URL":"https:\/\/doi.org\/10.1016\/0092-8674(92)90643-q","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}