{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:49:27Z","timestamp":1779353367548,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1995,3,1]],"date-time":"1995-03-01T00:00:00Z","timestamp":794016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2004,7,20]],"date-time":"2004-07-20T00:00:00Z","timestamp":1090281600000},"content-version":"vor","delay-in-days":3429,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell"],"published-print":{"date-parts":[[1995,3]]},"DOI":"10.1016\/0092-8674(95)90298-8","type":"journal-article","created":{"date-parts":[[2004,7,22]],"date-time":"2004-07-22T15:46:18Z","timestamp":1090511178000},"page":"949-957","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":938,"title":["REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons"],"prefix":"10.1016","volume":"80","author":[{"given":"Jayhong A","family":"Chong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Tapia-Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J","family":"Toledo-Aral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingcong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C","family":"Boutros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yelena M","family":"Altshuller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Frohman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan D","family":"Kraner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Mandel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/0092-8674(95)90298-8_BIB1","series-title":"Cellular Interactions in Development: A Practical Approach","first-page":"153","article-title":"Using the two-hybrid system to detect protein-protein interactions","author":"Bartel","year":"1994"},{"key":"10.1016\/0092-8674(95)90298-8_BIB2","first-page":"3608","article-title":"The evolutionarily conserved Kr\u00fcppel-associated box domain defines a subfamily of eukaryotic multifingered proteins","volume":"88","author":"Bellefroid","year":"1991"},{"key":"10.1016\/0092-8674(95)90298-8_BIB3","first-page":"11163","article-title":"Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage","volume":"91","author":"Choo","year":"1994"},{"key":"10.1016\/0092-8674(95)90298-8_BIB4","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1146\/annurev.bi.61.070192.004341","article-title":"Zinc proteins: enzymes, storage proteins, transcription factors, and replication proteins","volume":"61","author":"Coleman","year":"1992","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/0092-8674(95)90298-8_BIB5","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1083\/jcb.122.4.915","article-title":"Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways","volume":"4","author":"D'Arcangelo","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/0092-8674(95)90298-8_BIB6","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","article-title":"Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei","volume":"11","author":"Dignam","year":"1983","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/0092-8674(95)90298-8_BIB7","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1126\/science.8066465","article-title":"Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo","volume":"265","author":"Dowell","year":"1994","journal-title":"Science"},{"issue":"9","key":"10.1016\/0092-8674(95)90298-8_BIB8","first-page":"4757","article-title":"Two systems of glucose repression of the promoter GAL1 in Saccharomyces cervisiae","volume":"10","author":"Flick","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/0092-8674(95)90298-8_BIB9","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/0076-6879(93)18026-9","article-title":"Rapid amplification of cDNA for generation of full-length cDNA ends: thermal RACE","volume":"218","author":"Frohman","year":"1993","journal-title":"Meth. Enzymol."},{"key":"10.1016\/0092-8674(95)90298-8_BIB10","first-page":"8998","article-title":"Rapid production of full length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer","volume":"85","author":"Frohman","year":"1988"},{"key":"10.1016\/0092-8674(95)90298-8_BIB11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1242\/dev.110.2.589","article-title":"Isolation of the mouse Hox-2.9 gene: analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm","volume":"110","author":"Frohman","year":"1990","journal-title":"Development"},{"key":"10.1016\/0092-8674(95)90298-8_BIB12","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1101\/gad.7.5.723","article-title":"Cell interactions and gene interactions in peripheral neurogenesis","volume":"7","author":"Ghysen","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/0092-8674(95)90298-8_BIB13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0092-8674(94)90145-7","article-title":"Roads to neuralness: embryonic neural induction as derepression of a default state","volume":"77","author":"Green","year":"1994","journal-title":"Cell"},{"key":"10.1016\/0092-8674(95)90298-8_BIB14","first-page":"2424","article-title":"Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor","volume":"73","author":"Green","year":"1976"},{"key":"10.1016\/0092-8674(95)90298-8_BIB15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0092-8674(93)90381-Y","article-title":"Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons","volume":"75","author":"Guillemot","year":"1993","journal-title":"Cell"},{"key":"10.1016\/0092-8674(95)90298-8_BIB16","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1002\/j.1460-2075.1993.tb05934.x","article-title":"Functional domains of the Drosophila engrailed protein","volume":"12","author":"Han","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/0092-8674(95)90298-8_BIB17","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev.cb.09.110193.002403","article-title":"Transcriptional repression in eukaryotes","volume":"9","author":"Herschbach","year":"1993","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1016\/0092-8674(95)90298-8_BIB18","doi-asserted-by":"crossref","first-page":"17987","DOI":"10.1016\/S0021-9258(17)46802-5","article-title":"Neuron-specific expression of the human dopamine \u03b2-hydroxylase gene requires both the cAMP-response element and a silencer region","volume":"268","author":"Ishiguro","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0092-8674(95)90298-8_BIB19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0896-6273(95)90235-X","article-title":"Maggot's hair and bug's eye: role of cell interactions and intrinsic factors in cell fate specification","volume":"14","author":"Jan","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/0092-8674(95)90298-8_BIB20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0092-8674(86)90609-4","article-title":"Bifunctional messenger RNAs in eukaryotes","volume":"47","author":"Kozak","year":"1986","journal-title":"Cell"},{"issue":"Suppl. 2","key":"10.1016\/0092-8674(95)90298-8_BIB21","first-page":"27","article-title":"Molecular studies of two voltage dependent sodium channels expressed in the nervous system","volume":"12","author":"Kraner","year":"1991","journal-title":"Biomed. Res."},{"key":"10.1016\/0092-8674(95)90298-8_BIB22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0896-6273(92)90218-3","article-title":"Silencing the type II sodium channel gene: a model for neural-specific gene regulation","volume":"9","author":"Kraner","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/0092-8674(95)90298-8_BIB23","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/0092-8674(95)90298-8_BIB24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1128\/mr.56.4.543-560.1992","article-title":"Silencers, silencing, and heritable transcriptional states","volume":"56","author":"Laurenson","year":"1992","journal-title":"Microbiol. Rev."},{"key":"10.1016\/0092-8674(95)90298-8_BIB25","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0092-8674(94)90025-6","article-title":"On neuronal specificity and the molecular basis of perception","volume":"79","author":"Lewin","year":"1994","journal-title":"Cell"},{"key":"10.1016\/0092-8674(95)90298-8_BIB26","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1126\/science.8266075","article-title":"Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system","volume":"262","author":"Li","year":"1993","journal-title":"Science"},{"key":"10.1016\/0092-8674(95)90298-8_BIB27","first-page":"1460","article-title":"Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene","volume":"90","author":"Li","year":"1993"},{"key":"10.1016\/0092-8674(95)90298-8_BIB28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/346076a0","article-title":"Drosophila Kr\u00fcppel protein is a transcriptional repressor","volume":"346","author":"Licht","year":"1990","journal-title":"Nature"},{"key":"10.1016\/0092-8674(95)90298-8_BIB29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1113\/jphysiol.1994.sp020370","article-title":"Na channel misexpression accelerates K channel development in embryonic Xenopus laevis skeletal muscle","volume":"480","author":"Lindsell","year":"1994","journal-title":"J. Physiol."},{"key":"10.1016\/0092-8674(95)90298-8_BIB30","first-page":"8839","article-title":"Accurate initiation at RNA polymerase II promoters in extracts from Saccharomyces cerevisiae","volume":"84","author":"Lue","year":"1987"},{"key":"10.1016\/0092-8674(95)90298-8_BIB31","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.ne.16.030193.001543","article-title":"Molecular basis of neuralspecific gene expression","volume":"16","author":"Mandel","year":"1993","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/0092-8674(95)90298-8_BIB32","first-page":"924","article-title":"Selective induction of brain type II Na+ channels by nerve growth factor","volume":"85","author":"Mandel","year":"1988"},{"key":"10.1016\/0092-8674(95)90298-8_BIB33","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0896-6273(90)90097-Y","article-title":"Neuron-specific expression of the rat brain type II sodium channel gene is directed by upstream regulatory elements","volume":"4","author":"Maue","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/0092-8674(95)90298-8_BIB34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0896-6273(92)90219-4","article-title":"A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells","volume":"9","author":"Mori","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/0092-8674(95)90298-8_BIB35","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1523\/JNEUROSCI.12-03-00691.1992","article-title":"A neural-specific GAP-43 core promoter located between unusual DNA elements that interact to regulate its activity","volume":"12","author":"Nedivi","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/0092-8674(95)90298-8_BIB36","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1126\/science.2028256","article-title":"Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 \u00c5","volume":"252","author":"Pavletich","year":"1991","journal-title":"Science"},{"key":"10.1016\/0092-8674(95)90298-8_BIB37","author":"Sambrook","year":"1989"},{"key":"10.1016\/0092-8674(95)90298-8_BIB38","first-page":"998","article-title":"DNA sequencing with chain terminating inhibitors","volume":"74","author":"Sanger","year":"1977"},{"key":"10.1016\/0092-8674(95)90298-8_BIB39","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF00340712","article-title":"High efficiency transformation of intact yeast cells using single stranded nucleic acid as a carrier","volume":"16","author":"Schiestl","year":"1989","journal-title":"Curr. Genet."},{"key":"10.1016\/0092-8674(95)90298-8_BIB40","series-title":"Methods in Yeast Genetics","author":"Sherman","year":"1986"},{"key":"10.1016\/0092-8674(95)90298-8_BIB41","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0896-6273(95)90317-8","article-title":"A single pulse of nerve growth factor triggers long term neuronal excitability through sodium channel gene induction","volume":"14","author":"Toledo-Aral","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/0092-8674(95)90298-8_BIB42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/364121a0","article-title":"Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast","volume":"364","author":"Wang","year":"1993","journal-title":"Nature"},{"key":"10.1016\/0092-8674(95)90298-8_BIB43","first-page":"761","article-title":"The myo D gene family: nodal point during specification of the muscle cell lineage","volume":"251","author":"Weintraub","year":"1991","journal-title":"Nature"},{"key":"10.1016\/0092-8674(95)90298-8_BIB44","first-page":"4514","article-title":"The Kr\u00fcppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression","volume":"91","author":"Witzgall","year":"1994"},{"key":"10.1016\/0092-8674(95)90298-8_BIB45","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0896-6273(90)90117-X","article-title":"Analysis of SCG10 gene expression in transgenic mice reveals that neural specificity is achieved through selective derepression","volume":"4","author":"Wuenschell","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/0092-8674(95)90298-8_BIB46","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/373074a0","article-title":"A transcription factor controlling development of peripheral sense organs in C. elegans","volume":"373","author":"Zhao","year":"1995","journal-title":"Nature"}],"container-title":["Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0092867495902988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:0092867495902988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T18:57:13Z","timestamp":1757444233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/0092867495902988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":46,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["0092867495902988"],"URL":"https:\/\/doi.org\/10.1016\/0092-8674(95)90298-8","relation":{},"ISSN":["0092-8674"],"issn-type":[{"value":"0092-8674","type":"print"}],"subject":[],"published":{"date-parts":[[1995,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons","name":"articletitle","label":"Article Title"},{"value":"Cell","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/0092-8674(95)90298-8","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1995","name":"copyright","label":"Copyright"}]}}