{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:44:58Z","timestamp":1761630298090,"version":"3.44.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1982,9,1]],"date-time":"1982-09-01T00:00:00Z","timestamp":399686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1982,9,1]],"date-time":"1982-09-01T00:00:00Z","timestamp":399686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004937","name":"Bundesministerium f\u00fcr Forschung und Technologie","doi-asserted-by":"publisher","award":["PTB8127"],"award-info":[{"award-number":["PTB8127"]}],"id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Gene"],"published-print":{"date-parts":[[1982,9]]},"DOI":"10.1016\/0378-1119(82)90004-x","type":"journal-article","created":{"date-parts":[[2003,2,11]],"date-time":"2003-02-11T22:07:18Z","timestamp":1045001238000},"page":"179-183","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["The nucleotide sequence of cDNA coding for preproinsulin from the primate Macacafascicularis"],"prefix":"10.1016","volume":"19","author":[{"given":"Waldemar","family":"Wetekam","sequence":"first","affiliation":[]},{"given":"J\u00fcrgen","family":"Groneberg","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Leineweber","sequence":"additional","affiliation":[]},{"given":"Friedrich","family":"Wengenmayer","sequence":"additional","affiliation":[]},{"given":"Ernst-Ludwig","family":"Winnacker","sequence":"additional","affiliation":[]}],"member":"78","reference":[{"key":"10.1016\/0378-1119(82)90004-X_BIB1","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/282525a0","article-title":"Nucleotide sequence of a cDNA clone encoding human preproinsulin","volume":"282","author":"Bell","year":"1979","journal-title":"Nature"},{"key":"10.1016\/0378-1119(82)90004-X_BIB2","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/nar\/7.6.1513","article-title":"A rapid alkaline extraction procedure for screening recombinant plasmid DNA","volume":"7","author":"Birnboim","year":"1979","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/0378-1119(82)90004-X_BIB3","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.1016\/S0021-9258(19)69003-4","article-title":"Messenger RNA sequence and primary structure of preproinsulin in a primitive vertebrate, the atlantic hagfish","volume":"256","author":"Chan","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0378-1119(82)90004-X_BIB4","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1210\/endo-96-3-637","article-title":"Pancreatic beta cell culture: preparation of purified monolayers","volume":"96","author":"Chick","year":"1975","journal-title":"Endocrinology"},{"key":"10.1016\/0378-1119(82)90004-X_BIB5","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1126\/science.7001633","article-title":"Comparison of the nucleic acid sequence of anglerfish and mammalian insulin m-RNA's from cloned c-DNA's","volume":"210","author":"Hobart","year":"1980","journal-title":"Science"},{"key":"10.1016\/0378-1119(82)90004-X_BIB6","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/271278a0","article-title":"Relaxin and its structural relationship to insulin","volume":"271","author":"Isaacs","year":"1978","journal-title":"Nature"},{"key":"10.1016\/0378-1119(82)90004-X_BIB7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0378-1119(90)90325-L","article-title":"Cloning of carp preproinsulin cDNA in the bacterial plasmid pBR322","volume":"9","author":"Liebscher","year":"1980","journal-title":"Gene"},{"key":"10.1016\/0378-1119(82)90004-X_BIB8","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0092-8674(79)90071-0","article-title":"The structure and evolution of the two non-allelic rat preproinsulin genes","volume":"18","author":"Lomedico","year":"1979","journal-title":"Cell"},{"key":"10.1016\/0378-1119(82)90004-X_BIB9","first-page":"499","article-title":"Sequencing end-labeled DNA with base specific chemical cleavages","volume":"Vol. 65","author":"Maxam","year":"1980"},{"key":"10.1016\/0378-1119(82)90004-X_BIB10","first-page":"41","article-title":"Addition of homopolymers to the 3'-ends of duplex DNA with terminal transferase","volume":"Vol. 68","author":"Nelson","year":"1979"},{"key":"10.1016\/0378-1119(82)90004-X_BIB11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0092-8674(80)90641-8","article-title":"The evolution of genes: the chicken preproinsulin gene","volume":"20","author":"Perler","year":"1980","journal-title":"Cell"},{"key":"10.1016\/0378-1119(82)90004-X_BIB12","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1016\/S0021-9258(19)44991-0","article-title":"Determination of the amino acid sequence of the monkey, sheep and dog proinsulin C-peptides by a semi-micro Ed- man degradation procedure","volume":"247","author":"Peterson","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0378-1119(82)90004-X_BIB13","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0021-9258(17)40889-1","article-title":"The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin","volume":"253","author":"Rinderknecht","year":"1978","journal-title":"J. Biol. Chem."},{"key":"10.1016\/0378-1119(82)90004-X_BIB14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1126\/science.6927840","article-title":"Nucleotide sequence of human preproinsulin complementary DNA","volume":"208","author":"Sures","year":"1980","journal-title":"Science"},{"key":"10.1016\/0378-1119(82)90004-X_BIB15","first-page":"77","article-title":"Complete nucleotide sequence of the Escherichia coli plasmid pBR322","volume":"43","author":"Sutcliffe","year":"1979"},{"key":"10.1016\/0378-1119(82)90004-X_BIB16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0378-1119(80)90135-3","article-title":"3'-End labeling of DNA with [\u03b1-32P]cordycepin-5''-triphosphate","volume":"10","author":"Tu","year":"1980","journal-title":"Gene"},{"key":"10.1016\/0378-1119(82)90004-X_BIB17","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.325648","article-title":"Rat insulin genes: Construction of plasmids containing the coding sequences","volume":"196","author":"Ullrich","year":"1977","journal-title":"Science"},{"key":"10.1016\/0378-1119(82)90004-X_BIB18","first-page":"3727","article-title":"A bacterial clone synthesizing proinsulin","volume":"75","author":"Villa-Komaroff","year":"1978"}],"container-title":["Gene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:037811198290004X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:037811198290004X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T07:01:24Z","timestamp":1757487684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/037811198290004X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,9]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,9]]}},"alternative-id":["037811198290004X"],"URL":"https:\/\/doi.org\/10.1016\/0378-1119(82)90004-x","relation":{},"ISSN":["0378-1119"],"issn-type":[{"type":"print","value":"0378-1119"}],"subject":[],"published":{"date-parts":[[1982,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The nucleotide sequence of cDNA coding for preproinsulin from the primate Macacafascicularis","name":"articletitle","label":"Article Title"},{"value":"Gene","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/0378-1119(82)90004-X","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1982 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}