{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:29:17Z","timestamp":1772796557933,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2003,3,17]],"date-time":"2003-03-17T00:00:00Z","timestamp":1047859200000},"content-version":"vor","delay-in-days":6649,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The sites for [<jats:sup>3<\/jats:sup>H]nicotine binding in fetal brains were examined after administration of nicotine into pregnant rats. Administration of unlabelled nicotine into the pregnant rats increased <jats:italic>B<\/jats:italic>max values for the sites for [<jats:sup>3<\/jats:sup>H]nicotine binding without affecting <jats:italic>K<\/jats:italic><jats:sub><jats:italic>d<\/jats:italic><\/jats:sub> values in the fetal brains. Treatment with this regimen, however, did not show any significant change in the sites for [<jats:sup>3<\/jats:sup>H]quinuclidinyl benzylate (QNB) binding. In addition, treatment with this regimen increased <jats:italic>B<\/jats:italic>max values of the sites for [<jats:sup>3<\/jats:sup>H]nicotine binding in the brains of pregnant rats. \u03b1\u2010Bungarotoxin had no effect on the sites for [<jats:sup>3<\/jats:sup>H]nicotine binding.<\/jats:p><jats:p>It is inferred, therefore, that a similar response is elicited by nicotine binding sites to administered nicotine in both the fetal and maternal brains. Furthermore, a possible effect of nicotine in pregnant rats may be the facilitation of the development of nicotine acetylcholine receptors in the fetal brain.<\/jats:p><\/jats:sec>","DOI":"10.1016\/0736-5748(85)90046-2","type":"journal-article","created":{"date-parts":[[2003,4,25]],"date-time":"2003-04-25T01:23:41Z","timestamp":1051233821000},"page":"567-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":91,"title":["Effect of maternal nicotine on the development of sites for [<sup>3<\/sup>H]nicotine binding in the fetal brain"],"prefix":"10.1002","volume":"3","author":[{"given":"N.","family":"Hagino","sequence":"first","affiliation":[{"name":"Department of Cellular and Structural Biology The University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive San Antonio TX 78284 U.S.A."}]},{"given":"J.W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cellular and Structural Biology The University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive San Antonio TX 78284 U.S.A."}]}],"member":"311","published-online":{"date-parts":[[2003,3,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"e_1_2_1_3_1","first-page":"817","article-title":"Effects of chronic nicotine infusion on tolerance development and nicotine receptors","volume":"226","author":"Marks M.J.","year":"1983","journal-title":"J. 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